期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 109, 期 51, 页码 21058-21063出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1214400109
关键词
PANIC-ATTAC; FAIRE-seq; metabolic imprinting
资金
- National Institutes of Health (NIH) [R01-DK55758, R01-CA112023, P01DK088761, DK081182]
- Cancer Prevention and Research Institute of Texas (CPRIT) [R1002]
- Department of Defense Fellowship USAMRMC [BC085909]
Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that the neuregulin-1 gene, encoding an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes.
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