Review
Immunology
Nikolaos Antonakos, Charly Gilbert, Charlotte Theroude, Irene T. Schrijver, Thierry Roger
Summary: Sepsis is a clinical syndrome characterized by dysregulated host response to infection, leading to life-threatening organ dysfunction. miRNAs play a significant role in sepsis pathophysiology and are considered promising biomarkers for its diagnosis and management.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Patrycja M. Topczewska, Zoe A. Rompe, Manuel O. Jakob, Anton Stamm, Pierre S. Leclere, Alexandra Preusser, Claudia U. Duerr, Linda Marie Laura Thole, Katja Kotsch, David Artis, Christoph S. N. Klose
Summary: Type 2 immune responses at mucosal barriers are regulated by rapidly secreted cytokines called alarmins, such as IL-33, IL-25 and TSLP. These alarmins are secreted by stromal and epithelial cells in tissues and play roles in chronic inflammatory diseases and resistance against worm infections. The receptors for alarmins are expressed by immune cells, including group 2 innate lymphoid cells (ILC2s), which produce type 2 cytokines and are linked to atopic diseases and anti-worm immunity. However, the precise contribution of the IL-33 receptor signals for ILC2 activation still needs further investigation. This study used a mouse model to specifically delete the IL-33 receptor subunit ST2 in ILC2s and found that ST2-deficient ILC2s were unresponsive to IL-33 but still responded to IL-25. ST2-deficient ILC2s produced limited amounts of IL-5 and IL-13 and were unable to support eosinophil homeostasis. Additionally, they could not expand and promote the recruitment of eosinophils during allergic lung inflammation or mount an effective type 2 immune response against worm infections. Therefore, this study highlights the importance of cell-intrinsic ST2 signals for proper activation of ILC2s and initiation of type 2 immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laura La Paglia, Mirella Vazzana, Manuela Mauro, Francesca Dumas, Antonino Fiannaca, Alfonso Urso, Vincenzo Arizza, Aiti Vizzini
Summary: Through bioinformatics and in vivo experiments, it was found that LPS induction activates the expression of multiple immune genes in granulocyte hemocytes, leading to the activation of the Nf-kB signaling pathway and downstream pro-inflammatory gene expression. The study reveals the evolutionarily conserved functional link between the Mif-Csn-Nf-kB axis in the ascidian C. robusta during LPS-mediated inflammation response, which is finely regulated by non-coding molecules such as microRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Sunglim Cho, Jiayi Dong, Li-Fan Lu
Summary: T cells are crucial for generating effective responses against microbial pathogens and tumor surveillance, but unwanted T cell activation can lead to harmful inflammation. Tight regulation by transcription factors, epigenetic regulators, and miRNAs is necessary for optimal T cell responses. Recent progress has identified key immune regulatory miRNAs controlling T cell subset differentiation and function, as well as the extrinsic role of miRNAs in regulating T cell biology through interactions with immune and non-immune cell populations. Important questions regarding the complex nature of miRNA-mediated control of T cell immunity still need further investigation.
IMMUNOLOGICAL REVIEWS
(2021)
Editorial Material
Immunology
Xinxin Wang, Yuping Lai
Summary: In this study, the authors investigate the mechanism by which pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides to induce inflammation in keratinocytes. They demonstrate that solute carrier 46A2 (SLC46A2) transports DAP-muropeptides into the cytosol, leading to NOD1 activation and subsequent skin inflammation during psoriasis.
Review
Biotechnology & Applied Microbiology
Boris Bonaventure, Caroline Goujon
Summary: DExH/D-box helicases play essential roles in nucleic acid metabolism and viral life cycles, functioning as both antiviral effectors and negative regulators of innate immune activation. They contribute to the recognition of viral signatures, production of interferons, and establishment of antiviral cellular reprogramming.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Immunology
Shenji Wu, Jinqiang Huang, Yongjuan Li, Zhe Liu, Lu Zhao
Summary: This study compared the innate immunity differences between wild-type and yellow mutant rainbow trout. The researchers identified key immune-related genes and their regulatory networks, deepening our understanding of the innate immune system of rainbow trout and providing a foundation for further research on immune mechanisms and disease resistance breeding.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Vlatka Ivanisevic, Lidia Zilic, Marina Cunko, Hana Fadiga, Ivana Munitic, Igor Jurak
Summary: The role of ADAR proteins in herpesvirus infection has not been well studied, but evidence suggests that they play a role in regulating the complex life cycle of these viruses.
Article
Microbiology
Xiaohui Ju, Fang Li, Jingrui Li, Chunyan Wu, Guangtao Xiang, Xiaomin Zhao, Yuchen Nan, Dongming Zhao, Qiang Ding
Summary: The study suggests that ASFV infection causes a strong suppression of host immune responses, leading to dysregulation of host chemokine axis and metabolic pathways in porcine alveolar macrophages.
VETERINARY MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Irina Gilyazova, Dilara Asadullina, Evelina Kagirova, Ruhi Sikka, Artur Mustafin, Elizaveta Ivanova, Ksenia Bakhtiyarova, Gulshat Gilyazova, Saurabh Gupta, Elza Khusnutdinova, Himanshu Gupta, Valentin Pavlov
Summary: miRNA-146a is a single-stranded, non-coding RNA molecule that serves as a valuable biomarker for various pathological conditions. It regulates inflammatory processes, haemopoiesis, allergic responses, and other aspects of the innate immune system. Polymorphisms in miRNA-146a can influence the pathogenesis of autoimmune disorders and cancer. This review focuses on the role of miRNA-146a in regulating defence mechanisms, oncogenesis, and response to therapy by controlling critical signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Brittney Williams, Rosemary Kozar, Wei Chao
Summary: In sepsis and trauma, extracellular RNAs (exRNAs), especially exogenous ones, play a crucial role and can lead to multiple organ dysfunction. By studying exRNA profiling in the plasma of mice and humans, we can gain insights into the mechanisms and significance of exRNAs, particularly ex-miRNAs, in host immune response and potential injury during sepsis and trauma.
Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Respiratory System
Aleksandra Wardzynska, Malgorzata Pawelczyk, Joanna Rywaniak, Joanna Makowska, Joanna Jamroz-Brzeska, Marek L. Kowalski
Summary: The study found differences in serum miRNA expression between elderly asthmatics and non-elderly asthmatics, with only non-elderly asthmatics showing a relationship between selected miRNA expression and asthma control level and airway inflammation level. All asthma patients had higher levels of proinflammatory cytokines compared to controls.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Margot Raffeiner, Suayib Uestuen, Tiziana Guerra, Daniela Spinti, Maria Fitzner, Sophia Sonnewald, Susanne Baldermann, Frederik Boernke
Summary: Xanthomonas effector protein XopS enhances disease susceptibility by repressing defense gene expression and suppressing stomatal immunity through interaction with and inhibition of WRKY40, a transcriptional regulator. XopS manipulation of WRKY40 stability alters downstream gene expression and phytohormone crosstalk to promote pathogen proliferation.
Article
Cell Biology
Madison S. Strine, Mia Madel Alfajaro, Vincent R. Graziano, Jaewon Song, Leon L. Hsieh, Ryan Hill, Jun Guo, Kelli L. VanDussen, Robert C. Orchard, Megan T. Baldridge, Sanghyun Lee, Craig B. Wilen
Summary: Murine norovirus (MNoV) is a model for studying human norovirus and its mechanisms of infection. This study demonstrates that diverse strains of MNoV require tuft cells for chronic enteric infection. Additionally, interferon-lambda acts directly on tuft cells to cure chronic MNoVCR6 infection, and type I and III interferons signal together via STAT1 in tuft cells to restrict MNoVCW3 tropism.
Article
Developmental Biology
Zia Khan, Yu-Chiun Wang, Eric F. Wieschaus, Matthias Kaschube
Article
Biochemistry & Molecular Biology
Josue Baeza, James A. Dowell, Michael J. Smallegan, Jing Fan, Daniel Amador-Noguez, Zia Khan, John M. Denu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemical Research Methods
Rosalynn C. Molden, Jonathan Goya, Zia Khan, Benjamin A. Garcia
MOLECULAR & CELLULAR PROTEOMICS
(2014)
Article
Multidisciplinary Sciences
Zia Khan, Michael J. Ford, Darren A. Cusanovich, Amy Mitrano, Jonathan K. Pritchard, Yoav Gilad
Article
Multidisciplinary Sciences
Alexis Battle, Zia Khan, Sidney H. Wang, Amy Mitrano, Michael J. Ford, Jonathan K. Pritchard, Yoav Gilad
Article
Multidisciplinary Sciences
Brett W. Engelmann, Chiaowen Joyce Hsiao, John D. Blischak, Yannick Fourne, Zia Khan, Michael Ford, Yoav Gilad
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Yoong Wearn Lim, Haiyin Chen-Harris, Oleg Mayba, Steve Lianoglou, Arthur Wuster, Tushar Bhangale, Zia Khan, Sanjeev Mariathasan, Anneleen Daemen, Jens Reeder, Peter M. Haverty, William F. Forrest, Matthew Brauer, Ira Mellman, Matthew L. Albert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Editorial Material
Genetics & Heredity
Zia Khan, Christian Hammer, Ellie Guardino, G. Scott Chandler, Matthew L. Albert
Article
Immunology
Anna-Maria Herzner, Zia Khan, Eric L. Van Nostrand, Sara Chan, Trinna Cuellar, Ronald Chen, Ximo Pechuan-Jorge, Laszlo Komuves, Margaret Solon, Zora Modrusan, Benjamin Haley, Gene W. Yeo, Timothy W. Behrens, Matthew L. Albert
Summary: The study identified a synergistic induction of MDA5-dependent IFN responses with hnRNPC and ADAR deficiency, leading to dysregulation of Alu-containing introns in cells. Furthermore, some putative MDA5 ligands showed reduced editing in the absence of ADAR.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zia Khan, Christian Hammer, Jonathan Carroll, Flavia Di Nucci, Sergio Ley Acosta, Vidya Maiya, Tushar Bhangale, Julie Hunkapiller, Ira Mellman, Matthew L. Albert, Mark McCarthy, G. Scott Chandler
Summary: The study shows that using a polygenic risk score can predict the risk of cancer patients developing atezolizumab (anti-PD-L1)-induced thyroid dysfunction, which is associated with systemic response to PD-1 checkpoint blockade and longer overall survival.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Siyu Feng, Marinella G. Callow, Jean-Philippe Fortin, Zia Khan, David Bray, Mike Costa, Zhen Shi, Weiru Wang, Marie Evangelista
Summary: Novel mutant-specific inhibitors of KRAS(G12C) provide a unique opportunity to target the previously undruggable oncoprotein. Identified mutations impacting the sensitivity to the inhibitors may preexist in patients treated with KRAS(G12C) inhibitors, with some mutations interfering with critical protein-drug interfaces leading to resistance, while others demonstrate a strong sensitizing phenotype.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Zia Khan, Flavia Di Nucci, Antonia Kwan, Christian Hammer, Sanjeev Mariathasan, Vincent Rouilly, Jonathan Carroll, Magnus Fontes, Sergio Ley Acosta, Ellie Guardino, Haiyin Chen-Harris, Tushar Bhangale, Ira Mellman, Jonathan Rosenberg, Thomas Powles, Julie Hunkapiller, G. Scott Chandler, Matthew L. Albert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Meeting Abstract
Respiratory System
Diana Chang, David Choy, Tushar Bhangale, Art Wuster, Zia Khan, Amy Dressen, Karen Cuenco, Lorena Riol Blanco, Joseph R. Arron, Mark Wilson, Rajita Pappu, Tangsheng Yi, Daniel Lafkas, Tracy Staton, Fang Cai, Rebecca Bauer, Cecile Holweg, Dorothy Cheung, Hubert Chen, Joseph Lin, Alex Abbas, John Matthews, Julie Olsson, Jens Reeder, Kiran Mukhyala, Jennifer Tom, Amy Cowgill, Jan Vogel, Bill Forrest, Matt Brauer, Julie Hunkapiller, Robert R. Graham, Tim Behrens, Brian Yaspan
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Biotechnology & Applied Microbiology
Sidney H. Wang, Chiaowen Joyce Hsiao, Zia Khan, Jonathan K. Pritchard
Article
Biochemistry & Molecular Biology
Soline Chanet, Rishabh Sharan, Zia Khan, Adam C. Martin