M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

PKM2 and the Tricky Balance of Growth and Energy in Cancer

(2011) Andrew N. Macintyre et al.   MOLECULAR CELL

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

(2010) Jian-kang Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

(2009) C. Yang et al.   CANCER RESEARCH

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect

(2009) C. V. Dang   Science Signaling

Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein

(2008) Nobukazu Shimada et al.   GENES TO CELLS

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE