Review
Chemistry, Organic
Dean Williams, Mohammad P. Jamshidi, Janelle Sauvageau
Summary: This study focuses on the synthesis of lipopolysaccharide biosynthesis metabolites and their synthetic analogues and probes. It reveals the activation of NF-kappa B through specific pathways by these compounds, providing a new research direction for immunomodulatory treatment approaches.
SYNTHESIS-STUTTGART
(2021)
Article
Critical Care Medicine
David G. G. Greenhalgh, Tajia L. L. Green, Debora Lim, Kiho Cho
Summary: Bacterial components can initiate compensatory anti-inflammatory responses by inducing the expression of human glucocorticoid receptors (hGR), which downregulate the inflammatory response.
Article
Agriculture, Multidisciplinary
Xiaojing Hu, Junjie Liu, Aizhen Liang, Lujun Li, Qin Yao, Zhenhua Yu, Yansheng Li, Jian Jin, Xiaobing Liu, Guanghua Wang
Summary: Investigating the impact of various tillage practices on soil microbial communities revealed that reduced tillage (RT) may help stabilize microbial network structure, alleviate potential pathogen transmission risks, and ultimately enhance crop yields.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2021)
Article
Plant Sciences
Johannes Tavoillot, Thierry Mateille, Nadine Ali, Anne-Marie Chappe, Jean-Francois Martin
Summary: Root-knot nematodes, especially Meloidogyne hapla, pose significant threats to crops, highlighting the importance of early detection for effective plant protection. Molecular tools like qPCR offer advantages in sensitivity, specificity, and cost-effectiveness. A newly developed qPCR method using SYBR Green has demonstrated specific detection of M. hapla at a reproducible level as low as 1.25 equivalent of a juvenile individual, meeting all quality standards outlined in the MIQE guidelines.
Article
Multidisciplinary Sciences
E. N. Dort, E. Layne, N. Feau, A. Butyaev, B. Henrissat, F. M. Martin, S. Haridas, A. Salamov, I. V. Grigoriev, M. Blanchette, R. C. Hamelin
Summary: Invasive plant pathogenic fungi have a global impact, and recent studies have found genomic patterns associated with specific groups of these fungi. Machine learning methods can successfully predict fungal lifestyles and traits, with the best predictive performance coming from carbohydrate-active enzymes, peptidases, and secondary metabolite clusters data. Genomic expansions in specific gene families in plant pathogens compared to non-phytopathogenic fungi were also revealed, providing insights into fungal phytopathogenicity and the potential risks of unknown fungi in the future.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Xin-xu Zhu, Wen-wu Zhang, Cheng-hua Wu, Shun-shun Wang, Fang Gao Smith, Sheng-wei Jin, Pu-hong Zhang
Summary: Sepsis, a life-threatening organ dysfunction, is caused by severe immune and metabolic dysfunction of the host when confronting infection. The concept of metabolism-associated molecular patterns (MAMPs), including free fatty acids, glucose, advanced glycation end products, and others, has brought new insights into the understanding and potential treatment of sepsis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Plant Sciences
C. G. Orfanidou, K. Moraki, P. Panailidou, L. Lotos, A. Katsiani, A. Avgelis, N. Katis, V. Maliogka
Summary: In Greek vineyards, GVA is the most prevalent virus, followed by GRSPaV and GVB. The incidence of viruses differs among self-rooted and grafted grapevine cultivars or rootstocks tested. High nucleotide diversity was observed in all three viruses, with isolates in Greece belonging to various phylogroups, suggesting multiple introductions and different transmission modes of GVA, GVB, and GRSPaV in Greece.
Article
Immunology
Kuan-Yu I, Wen-Yi Tseng, Wen-Chih Wang, Siamon Gordon, Kwai-Fong Ng, Hsi-Hsien Lin
Summary: The study demonstrates that EMR2-mediated signaling is critical for triggering the activation signal for the NLRP3 inflammasome in both THP-1 monocytic cell line and primary monocytes. Stimulation of EMR2 by its agonistic 2A1 monoclonal antibody activates a G alpha(16)-dependent PLC-beta pathway, leading to downstream Akt, MAPK, NF-kappa B, and Ca2+ mobilization, eventually resulting in K+ efflux. These findings suggest that EMR2 and its associated signaling intermediates may serve as potential targets for intervention in NLRP3 inflammasome activation in inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giulia De Lorenzo, Felice Cervone
Summary: Plants activate their immune response by recognizing and responding to microbe-associated molecular patterns (MAMPs) and pathogenicity effectors. In addition, plants also have the ability to respond to damage-associated molecular patterns (DAMPs), which can function even in the absence of pathogens and potentially enhance the immune response to MAMPs.
ESSAYS IN BIOCHEMISTRY
(2022)
Article
Veterinary Sciences
Mennat-Allah Abdelsalam, Wael Felefel, Sabreen Fadl, Mohamed Bessat
Summary: This study provides the first molecular evidence of Babesia, Theileria, and Anaplasma infections in sheep and goat populations in the North Coast region of Egypt. 73% of the samples were found to be infected with at least one of the three blood pathogenic organisms through microscopic examination. 43% of the small ruminants were infected with at least one of these pathogens according to molecular diagnosis.
BMC VETERINARY RESEARCH
(2023)
Review
Plant Sciences
Sylvain Cordelier, Jerome Crouzet, Guillaume Gilliard, Stephan Dorey, Magali Deleu, Sandrine Dhondt-Cordelier
Summary: This review summarizes the current knowledge on how plants detect invading pathogens through conserved invasion patterns. It highlights the influence of plasma membrane lipids in the sensing of invasion patterns and suggests combining biological and biophysical approaches to further understand their roles. The review emphasizes the importance of plasma membrane lipids in plant innate immunity.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Medicine, General & Internal
Evan Yi-Wen Yu, Zhewen Ren, Siamak Mehrkanoon, Coen D. A. Stehouwer, Marleen M. J. van Greevenbroek, Simone J. P. M. Eussen, Maurice P. Zeegers, Anke Wesselius
Summary: This study aimed to investigate the potential mediation role of circulating metabolites in relation to dietary patterns for prediabetes and type 2 diabetes. The findings suggest that adherence to a healthy dietary pattern could affect glucose metabolism status through circulating metabolites, providing novel insights into the biological mechanisms of diet on glucose metabolism and facilitating prevention strategies for type 2 diabetes.
Review
Chemistry, Multidisciplinary
Miao-miao Lin, Na Liu, Zheng-hong Qin, Yan Wang
Summary: Both mitochondrial dysfunction and neuroinflammation play significant roles in neurodegeneration and neurodegenerative diseases. There are multiple links between mitochondrial dysfunction and neuroinflammation, and their interaction is a complex and dynamic process. Understanding the specific molecular mechanisms associated with mitochondrial dysfunction and the progression of neuroinflammation in neurodegenerative diseases is of great importance for the identification of new therapeutic targets.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Plant Sciences
Evelia Fajardo-Rebollar, Karel Estrada, Ricardo Grande, Maria Julissa Ek Ramos, Gerardo Ruiz Vargas, Oscar Gabriel Villegas-Torres, A. M. Juarez, Alejandro Sanchez-Flores, Claudia Diaz-Camino
Summary: This study explored the microbiome of chilhuacle negro chili fruit, finding that the seedborne fungus Alternaria alternata is activated during fruit maturation, leading to an imbalance in the microbiome that may facilitate the establishment of opportunistic pathogenic fungi during fruit decay.
Article
Microbiology
Feifei Liu, Tuan A. Duong, Irene Barnes, Michael J. Wingfield, Shuaifei Chen
Summary: The genetic structure of isolates in the C. manginecans complex is influenced by both host association and geographic isolation, with populations on Eucalyptus showing the highest diversity. Genetic and genotypic diversity were highest in populations from China, Indonesia, and Brazil, while populations from Oman and Pakistan collected from Mangifera had the lowest genetic diversity and were clonal. The study also revealed the movement of genotypes between plant hosts and geographic regions, impacting the global distribution of this pathogen.
Article
Cell Biology
Nadia Kavrochorianou, Maria Evangelidou, Melina Markogiannaki, Michael Tovey, George Thyphronitis, Sylva Haralambous
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Immunology
Theresa Frenz, Zoe Waibler, Janin Hofmann, Matthias Hamdorf, Markus Lantermann, Boris Reizis, Michael G. Tovey, Peter Aichele, Gerd Sutter, Ulrich Kalinke
EUROPEAN JOURNAL OF IMMUNOLOGY
(2010)
Article
Biochemical Research Methods
Christophe Lallemand, Nadia Kavrochorianou, Casper Steenholdt, Klaus Bendtzen, Mark A. Ainsworth, Jean-Francois Meritet, Brigitte Blanchard, Pierre Lebon, Peter Taylor, Peter Charles, Saba Alzabin, Michael G. Tovey
JOURNAL OF IMMUNOLOGICAL METHODS
(2011)
Editorial Material
Biochemistry & Molecular Biology
Michael G. Tovey
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Meenu Wadhwa, Meena Subramanyam, Susan Goelz, Jaya Goyal, Vijay Jethwa, Wendy Jones, James G. Files, Daniel Kramer, Chris Bird, Paula Dilger, Michael Tovey, Christophe Lallemand, Robin Thorpe
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2013)
Editorial Material
Biochemistry & Molecular Biology
Michael G. Tovey
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2014)
Letter
Cell Biology
Michael G. Tovey, Meenu Wadhwa, Robin Thorpe
JOURNAL OF LEUKOCYTE BIOLOGY
(2010)
Article
Virology
Erin L. Lousberg, Cara K. Fraser, Michael G. Tovey, Kerrilyn R. Diener, John D. Hayball
JOURNAL OF VIROLOGY
(2010)
Article
Virology
Claudia N. Detje, Stefan Lienenklaus, Chintan Chhatbar, Julia Spanier, Chittappen K. Prajeeth, Claudia Soldner, Michael G. Tovey, Dirk Schlueter, Siegfried Weiss, Martin Stangel, Ulrich Kalinke
JOURNAL OF VIROLOGY
(2015)
Article
Medical Laboratory Technology
Casper Steenholdt, Mark A. Ainsworth, Michael Tovey, Tobias W. Klausen, Ole O. Thomsen, Jorn Brynskov, Klaus Bendtzen
THERAPEUTIC DRUG MONITORING
(2013)
Review
Biochemical Research Methods
Michael G. Tovey, Christophe Lallemand
Article
Biochemistry & Molecular Biology
Frederic Bloch, Benedicte Charmeteau, Michael Tovey, Jean-Francois Meritet, Corinne Desaint, Odile Launay, Pierre Lebon
EUROPEAN CYTOKINE NETWORK
(2016)
Review
Pharmacology & Pharmacy
Michael G. Tovey, Christophe Lallemand
THERAPEUTIC ADVANCES IN DRUG SAFETY
(2011)
Review
Chemistry, Medicinal
Michael G. Tovey, Christophe Lallemand