High-throughput screening to identify inhibitors of lysine demethylases

A scintillation proximity assay for histone demethylases

(2014) Wenyu Yu et al.   ANALYTICAL BIOCHEMISTRY

An High-Throughput In Vivo Screening System to Select H3K4-Specific Histone Demethylase Inhibitors

(2014) Cecilia Mannironi et al.   PLoS One

Large-scale global identification of protein lysine methylation in vivo

(2013) Xing-Jun Cao et al.   Epigenetics

Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen

(2013) Joyce Sayegh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Throughput Virtual Screening Identifies Novel N′-(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors

(2013) Venkataswamy Sorna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome

(2013) Michael Bremang et al.   Molecular BioSystems

Histone lysine demethylases as targets for anticancer therapy

(2013) Jonas W. Højfeldt et al.   NATURE REVIEWS DRUG DISCOVERY

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

(2012) Dominica Willmann et al.   INTERNATIONAL JOURNAL OF CANCER

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Complexities of occupancy and sequence

(2012) Mary Muers   NATURE REVIEWS GENETICS

Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay

(2011) Matthew Plant et al.   ANALYTICAL BIOCHEMISTRY

A Sensitive, Homogeneous, and High-Throughput Assay for Lysine-Specific Histone Demethylases at the H3K4 Site

(2011) Chunhua Wang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties

(2011) J. Wang et al.   CANCER RESEARCH

Lysine Demethylases Inhibitors

(2011) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

(2011) Xuelai Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer

(2011) Lauren P. Blair et al.   Cancers

Development of homogeneous luminescence assays for histone demethylase catalysis and binding

(2010) Akane Kawamura et al.   ANALYTICAL BIOCHEMISTRY

Structural insights into histone lysine demethylation

(2010) Haifeng Hou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

(2010) Nathan R. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

(2010) Oliver N. F. King et al.   PLoS One

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors

(2009) Astrid Spannhoff et al.   ChemMedChem

A miniaturized screen for inhibitors of Jumonji histone demethylases

(2009) Masaaki Sakurai et al.   Molecular BioSystems

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF B

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA