Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors

(2011) Darin J. Gustin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

(2010) Mauro Mileni et al.   JOURNAL OF MOLECULAR BIOLOGY

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

Structure based design of novel irreversible FAAH inhibitors

(2009) Jane L. Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

(2009) Mauro Mileni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

(2009) Mauro Mileni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and Development of Fatty Acid Amide Hydrolase (FAAH) Inhibitors

(2008) Mark Seierstad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors

(2008) Xueqing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA