Article
Biochemistry & Molecular Biology
Stefanie A. Ehrhardt, Matthias Zehner, Verena Kraehling, Hadas Cohen-Dvashi, Christoph Kreer, Nadav Elad, Henning Gruell, Meryem S. Ercanoglu, Philipp Schommers, Lutz Gieselmann, Ralf Eggeling, Christine Dahlke, Timo Wolf, Nico Pfeifer, Marylyn M. Addo, Ron Diskin, Stephan Becker, Florian Klein
Article
Microbiology
Hadas Cohen-Dvashi, Matthias Zehner, Stefanie Ehrhardt, Michael Katz, Nadav Elad, Florian Klein, Ron Diskin
CELL HOST & MICROBE
(2020)
Editorial Material
Immunology
Matthias Zehner, Florian Klein
Article
Allergy
Lena Fischer-Riepe, Niklas Daber, Jonas Schulte-Schrepping, Brune Caroline Veras De Carvalho, Antonella Russo, Michele Pohlen, Josephine Fischer, Achmet Imam Chasan, Marc Wolf, Thomas Ulas, Shirin Glander, Christian Schulz, Boris Skryabin, Dipl-Ing Andreas Wollbrink, Nadine Steingraeber, Christopher Stremmel, Megan Koehle, Florian Gaertner, Sabine Vettorazzi, Dirk Holzinger, Joachim Gross, Frank Rosenbauer, Monika Stoll, Silke Niemann, Jan Tuckermann, Joachim L. Schultze, Johannes Roth, Katarzyna Barczyk-Kahlert
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Christoph Kreer, Matthias Zehner, Timm Weber, Meryem S. Ercanoglu, Lutz Gieselmann, Cornelius Rohde, Sandro Halwe, Michael Korenkov, Philipp Schommers, Kanika Vanshylla, Veronica Di Cristanziano, Hanna Janicki, Reinhild Brinker, Artem Ashurov, Verena Kraehling, Alexandra Kupke, Hadas Cohen-Dvashi, Manuel Koch, Jan Mathis Eckert, Simone Lederer, Nico Pfeifer, Timo Wolf, Maria J. G. T. Vehreschild, Clemens Wendtner, Ron Diskin, Henning Gruell, Stephan Becker, Florian Klein
Article
Microbiology
Kanika Vanshylla, Veronica Di Cristanziano, Franziska Kleipass, Felix Dewald, Philipp Schommers, Lutz Gieselmann, Henning Gruell, Maike Schlotz, Meryem S. Ercanoglu, Ricarda Stumpf, Petra Mayer, Matthias Zehner, Eva Heger, Wibke Johannis, Carola Horn, Isabelle Suarez, Norma Jung, Susanne Salomon, Kirsten Alexandra Eberhardt, Birgit Gathof, Gerd Faetkenheuer, Nico Pfeifer, Ralf Eggeling, Max Augustin, Clara Lehmann, Florian Klein
Summary: The study reveals a wide spectrum of neutralizing antibody response to SARS-CoV-2, with sustained antibodies in the majority of individuals with mild COVID-19 for up to 10 months after infection.
CELL HOST & MICROBE
(2021)
Article
Medicine, Research & Experimental
Sebastian J. Theobald, Alexander Simonis, Theodoros Georgomanolis, Christoph Kreer, Matthias Zehner, Hannah S. Eisfeld, Marie-Christine Albert, Jason Chhen, Susanne Motameny, Florian Erger, Julia Fischer, Jakob J. Malin, Jessica Graeb, Sandra Winter, Andromachi Pouikli, Friederike David, Boris Boell, Philipp Koehler, Kanika Vanshylla, Henning Gruell, Isabelle Suarez, Michael Hallek, Gerd Faetkenheuer, Norma Jung, Oliver A. Cornely, Clara Lehmann, Peter Tessarz, Janine Altmueller, Peter Nuernberg, Hamid Kashkar, Florian Klein, Manuel Koch, Jan Rybniker
Summary: Our study reveals that the SARS-CoV-2 spike protein induces inflammasome formation and IL-1 beta release in macrophages from COVID-19 patients, but not in healthy individuals. Furthermore, macrophages isolated from convalescent COVID-19 patients show robust S-protein-driven inflammasome activation, indicating innate immune memory after recovery.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biochemical Research Methods
Lutz Gieselmann, Christoph Kreer, Meryem Seda Ercanoglu, Nathalie Lehnen, Matthias Zehner, Philipp Schommers, Julian Potthoff, Henning Gruell, Florian Klein
Summary: The study introduces a highly efficient high-throughput protocol for isolating pathogen-specific antibodies, covering all critical steps from sample collection to antibody production within 12-14 days.
Article
Multidisciplinary Sciences
Maria Embgenbroich, Hendrik J. P. van der Zande, Leonie Hussaarts, Jonas Schulte-Schrepping, Leonard R. Pelgrom, Noemi Garcia-Tardon, Laura Schlautmann, Isabel Stoetzel, Kristian Handler, Joost M. Lambooij, Anna Zawistowska-Deniziak, Lisa Hoving, Karin de Ruiter, Marjolein Wijngaarden, Hanno Pijl, Ko Willems van Dijk, Bart Everts, Vanessa van Harmelen, Maria Yazdanbakhsh, Joachim L. Schultze, Bruno Guigas, Sven Burgdorf
Summary: sMR plays a direct functional role in macrophage activation and metaflammation, with increased serum sMR levels correlating with proinflammatory cytokine production and insulin resistance. These findings suggest sMR may be a potential therapeutic target for metaflammation and hyperinflammatory diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Sandro Halwe, Alexandra Kupke, Kanika Vanshylla, Falk Liberta, Henning Gruell, Matthias Zehner, Cornelius Rohde, Verena Kraehling, Michelle Gellhorn Serra, Christoph Kreer, Michael Kluever, Lucie Sauerhering, Jorg Schmidt, Zheng Cai, Fei Han, David Young, Guangwei Yang, Marek Widera, Manuel Koch, Anke Werner, Lennart Kaemper, Nico Becker, Michael S. Marlow, Markus Eickmann, Sandra Ciesek, Felix Schiele, Florian Klein, Stephan Becker
Summary: DZIF-10c is a highly potent fully human monoclonal neutralizing antibody against SARS-CoV-2, with the ability to effectively neutralize the virus and eliminate infectious particles in the lungs when administered intranasally. Its favorable pharmacokinetic profile makes it a promising candidate for clinical trials investigating topical delivery of anti-SARS-CoV-2 antibodies.
Article
Microbiology
Silke Niemann, Minh-Thu Nguyen, Johannes A. Eble, Achmet Chasan, Maria Mrakovcic, Ralph T. Bottcher, Klaus T. Preissner, Steffen Rosslenbroich, Georg Peters, Mathias Herrmann
Summary: Staphylococcus aureus, traditionally considered an extracellular pathogen, can also be taken up by host cells through a fibronectin bridge to integrin receptors. The supramolecular structure of fibronectin on the host cell surface plays a crucial role in bacterial uptake, affecting the capacity of host cells to internalize the pathogen. Understanding these mechanisms may explain differences in bacterial uptake among different cell types and clinical settings.
Article
Multidisciplinary Sciences
Meryem Seda Ercanoglu, Lutz Gieselmann, Sabrina Daehling, Nareshkumar Poopalasingam, Susanne Detmer, Manuel Koch, Michael Korenkov, Sandro Halwe, Michael Kluever, Veronica Di Cristanziano, Hanna Janicki, Maike Schlotz, Johanna Worczinski, Birgit Gathof, Henning Gruell, Matthias Zehner, Stephan Becker, Kanika Vanshylla, Christoph Kreer, Florian Klein
Summary: This study provides a detailed analysis of the B cell immunity to SARS-CoV-2 in unexposed individuals, showing no evidence of competent preexisting antibody and B cell immunity against SARS-CoV-2.
Article
Biology
Saskia-Larissa Jauch-Speer, Marisol Herrera-Rivero, Nadine Ludwig, Bruna Caroline Veras De Carvalho, Leonie Martens, Jonas Wolf, Achmet Imam Chasan, Anika Witten, Birgit Markus, Bernhard Schieffer, Thomas Vogl, Jan Rossaint, Monika Stoll, Johannes Roth, Olesja Fehler
Summary: This study identified C/EBP delta as a new regulator of S100a8 and S100a9 expression and demonstrated its regulatory effects on inflammation. The study also revealed the regulatory mechanisms of C/EBP delta on S100a8 and S100a9 expression and its association with subpopulations of human monocytes in cardiovascular patients.
Article
Microbiology
Henning Gruell, Kanika Vanshylla, Michael Korenkov, Pinkus Tober-Lau, Matthias Zehner, Friederike Munn, Hanna Janicki, Max Augustin, Philipp Schommers, Leif Erik Sander, Florian Kurth, Christoph Kreer, Florian Klein
Summary: The newly emerged Omicron sublineages BA.4/5 show reduced susceptibility to vaccinee sera, with distinct antigenic differences and escape patterns among different Omicron sublineages. However, promising antibodies with high pan-SARS-CoV-2 neutralizing potency have also been identified.
CELL HOST & MICROBE
(2022)
Correction
Microbiology
Silke Niemann, Minh-Thu Nguyen, Johannes A. Eble, Achmet I. Chasan, Maria Mrakovcic, Klaus T. Preissner, Steffen Rosslenbroich, Georg Peters, Mathias Herrmann