Review
Cell Biology
Vicente Llorente, Pedro Velarde, Manuel Desco, Maria Victoria Gomez-Gaviro
Summary: This review summarizes the latest research on neural stem cells and their canonical niches, including their structure, behaviors, and role in neural diseases.
Article
Neurosciences
Muhammad N. Arshad, Simon Oppenheimer, Jaye Jeong, Bilge Buyukdemirtas, Janice R. Naegele
Summary: GABAergic interneurons play a crucial role in regulating adult neurogenesis and their transplantation can alleviate seizures and increase synaptic inhibition in temporal lobe epilepsy. The transplantation also affects the types of progenitor cells involved in adult neurogenesis.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Clinical Neurology
Yue Li, Weixiang Guo
Summary: Adult neurogenesis is a crucial process that generates new and functional neurons from neural stem cells throughout life. Maintaining the proper function of the neurogenic niche requires niche cells to respond to external cues and adapt their roles to influence NSC behavior. Understanding the interactive regulation of NSCs and neurogenesis by the neurogenic niche is important for maintaining the integrative process and functional integrity of the adult brain.
Review
Cell Biology
Daniel Z. Radecki, Jayshree Samanta
Summary: Oligodendrogenesis in the adult mammalian brain varies in different regions, with the subventricular zone and the subgranular zone being the primary regions of adult neurogenesis.
Article
Pharmacology & Pharmacy
Elisa Marozzi Cruz, Lucas Simoes Machado, Laura Nicoleti Zamproni, Larissa Valdemarin Bim, Paula Scanavez Ferreira, Leonardo Alves Pinto, Luiz Antonio Pessan, Eduardo Henrique Backes, Marimelia Aparecida Porcionatto
Summary: Neuronal loss is a major challenge in regenerative medicine, and providing a suitable microenvironment for neuron replacement is crucial. Gelatin methacrylate (GelMA) is an excellent biomaterial due to its biocompatibility and degradation properties. This study aims to develop GelMA-based bioinks and evaluate their ability to support neurogenesis. Incorporating extracellular matrix components, such as Geltrex (TM), is essential for promoting human neuroprogenitor cell viability. Geltrex (TM): 8% GelMA (1:1) bioink effectively maintains stemness and promotes neuronal differentiation.
Article
Biochemistry & Molecular Biology
Kathrin Barth, Verica Vasic, Brennan McDonald, Nora Heinig, Marc-Christoph Wagner, Ulrike Schumann, Cora Roehlecke, Frank Bicker, Lana Schumann, Konstantin Radyushkin, Jan Baumgart, Stefan Tenzer, Frauke Zipp, Matthias Meinhardt, Kari Alitalo, Irmgard Tegeder, Mirko H. H. Schmidt
Summary: Mature neurons, neural stem cells, and neural precursor cells secrete the neurovascular protein EGFL7 to shape the neurogenic niche of the hippocampus. Ablation of EGFL7 leads to increased neurogenesis and is correlated with elevated expression of VEGF-D. Infusion of VEGF-D increases neurogenesis, while its knockout decreases neurogenesis. Furthermore, EGFL7 knockout mice show improved spatial memory and memory consolidation in the hippocampus.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Fernando Janczur Velloso, Anna Wadhwa, Ekta Kumari, Ioana Carcea, Ozlem Gunal, Steven W. Levison
Summary: Epidemiological studies have shown that infections during pregnancy increase the risk of psychiatric disorders in offspring, and interleukin-6 (IL-6) has been implicated as a causal agent. This study aimed to investigate whether elevating IL-6 during a specific period of neural development would affect neurogenesis and lead to behavioral changes associated with neurodevelopmental disorders. The results demonstrate that transient increase in IL-6 during postnatal days 3-6 reduced neurogenesis and astrogliogenesis, and affected behavioral traits in adult male mice.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Multidisciplinary Sciences
Yujia Zhang, Jorin Riexinger, Xingyun Yang, Ellina Mikhailova, Yongcheng Jin, Linna Zhou, Hagan Bayley
Summary: A miniaturized hydrogel-based soft power source has been developed to modulate neuronal network activity without the need for metal electrodes.
Article
Multidisciplinary Sciences
Ana Gonzalez-Ramos, Eliska Waloschkova, Apostolos Mikroulis, Zaal Kokaia, Johan Bengzon, Marco Ledri, My Andersson, Merab Kokaia
Summary: This study demonstrates the potential for regulating human neuronal network activity by transplanting light-sensitive GABAergic interneurons. It provides a new avenue for controlling neurological disorders through precise temporal modulation of network excitability.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Milena Tucic, Vera Stamenkovic, Pavle Andjus
Summary: TnC plays a crucial role in regulating cell proliferation and migration during adult neurogenesis, with implications for regenerative therapies. Understanding ECM signaling in the CNS niche is essential for potential therapeutic applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Pureum Jeon, Jin A. Lee
Summary: Stress granules are membraneless cytosolic granules formed under stress conditions, containing RNA-binding proteins and RNAs. They play a role in inhibiting mRNA translation initiation and can accumulate in cytosolic inclusions associated with neurodegenerative diseases. The dysregulation of neuronal stress granules may lead to neurodegeneration, emphasizing the importance of understanding their dynamics in physiology and pathology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Binghan Xue, Xiangying Meng, Yanqing Xu, Joseph P. Y. Kao, Patrick O. Kanold
Summary: This study investigates the development of intracortical connectivity in layer 1 (L1) of the auditory cortex in mice. The results show that deep excitatory circuits are tightly linked with superficial inhibitory circuits in early development, providing a functional scaffold for the intermediate layers. There is also a transient period of high columnar hyperconnectivity after ear opening, suggesting that circuits originating in deep layers play a key role in this process.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Yongchao Wang, Wen Wen, Hui Li, Hong Xu, Mei Xu, Murong Ma, Jia Luo
Summary: This study demonstrates the importance of mesencephalic astrocyte-derived neurotrophic factor (MANF) in adult brain neurogenesis. MANF deficiency leads to increased cell proliferation and alterations in the cell cycle.
BRAIN RESEARCH BULLETIN
(2022)
Article
Cell Biology
Ziheng Zhou, Yueyang Pan, Si Zhou, Shuguang Wang, Dengwei Zhang, Ye Cao, Xiaosen Jiang, Jie Li, Linnan Zhu, Lijian Zhao, Shen Gu, Ge Lin, Zirui Dong, Hai-Xi Sun
Summary: This study investigates the mechanisms of corticogenesis by analyzing single-cell RNA sequencing data from mouse and human fetal cortexes. The study identifies a specific population of cells, called D-T-U, which undergoes direct neuronal transition from deep-layer neurons to upper-layer neurons during fetal cortical development in mice. These findings may shed light on the differences in cortical development between humans and mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)