期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 6, 期 6, 页码 650-654出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.5b00059
关键词
Voltage-gated sodium channels; sodium channel drugs; Na(v)1.8; SCN10A; TTX-R
Voltage-gated sodium channels, in particular Na(v)1.8, can be targeted for the treatment of neuropathic and inflammatory pain. Herein, we described the optimization of Na(v)1.8 modulator series to deliver subtype selective, state, and use-dependent chemical matter that is efficacious in preclinical models of neuropathic and inflammatory pain.
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