Article
Oncology
Philippa Meiser, Moritz A. Knolle, Anna Hirschberger, Gustavo P. de Almeida, Felix Bayerl, Sebastian Lacher, Anna-Marie Pedde, Sophie Flommersfeld, Julian Hoenninger, Leonhard Stark, Fabian Stoegbauer, Martina Anton, Markus Wirth, Dirk Wohlleber, Katja Steiger, Veit R. Buchholz, Barbara Wollenberg, Christina E. Zielinski, Rickmer Braren, Daniel Rueckert, Percy A. Knolle, Georgios Kaissis, Jan P. Boettcher
Summary: A study found that the clustering of immune cells within tumors, orchestrated by a specific type of immune cell called cDC1, is a unique feature associated with effective anti-cancer immunity. These clusters promote the activation and expansion of stem-like CD8+ T cells, which play a crucial role in cancer immune control. This finding has important implications for cancer therapy.
Article
Biology
Yuexin Wang, Hui Yang, Anna Jia, Yufei Wang, Qiuli Yang, Yingjie Dong, Yueru Hou, Yejin Cao, Lin Dong, Yujing Bi, Guangwei Liu
Summary: Dendritic cells (DCs) are important in anti-tumor immunity, and the mechanical sensor Piezo1 plays a role in regulating the differentiation of T(H)1 and T-reg cells in response to mechanical stiffness or inflammatory signals. Genetic deletion of Piezo1 in DCs inhibits T(H)1 cell generation and promotes T-reg cell development, leading to cancer growth. Mechanistically, Piezo1-deficient DCs regulate the secretion of cytokines TGF beta 1 and IL-12, affecting the activity of TGF beta R2-p-Smad3 and IL-12R beta 2-p-STAT4, and influencing the differentiation of T-reg and T(H)1 cells. Additionally, Piezo1 integrates metabolic and signaling pathways to orchestrate T(H)1 and T-reg lineage commitment through IL-12 and TGF beta 1 derived from DCs. Our studies provide critical insight into the role of DC-based mechanical regulation in directing T cell lineage commitment in tumor microenvironments.
Editorial Material
Cell & Tissue Engineering
Marieke Lavaert, Avinash Bhandoola
Summary: Researchers efficiently generate highly functional tumor-fighting T cells by inhibiting EZH1 expression in iPSCs in vitro.
Review
Immunology
Brigette C. Duckworth, Raymond Z. Qin, Joanna R. Groom
Summary: Lymph nodes play a critical role in immune response and immunosurveillance. Intranodal migration is essential for T cell activation and differentiation. The spatial regulation of T cell fates and the potential for promoting T-SCM differentiation are areas of focus for future research.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Huaxing Dai, Qin Fan, Ziying Fei, Qingle Ma, Qianyu Yang, Jiacheng Chu, Xuanfang Zhou, Yue Zhang, Ziliang Dong, Fang Xu, Beilei Wang, Rong Sun, Yifan Shen, Ruao Xie, Ruibin Li, Chao Wang
Summary: In this study, we investigated the immune microenvironment of the lung, liver, and spleen following the systemic administration of silica nanoparticles (SiO2 NPs). Our results showed a dramatic decrease in the number of T cells in the lung, coupled with an increase in IL-17-producing T cells frequency, a decrease in the a ss T population, and increased expression of T cells dysfunctional markers.
Review
Immunology
Jhan-Jie Peng, Limei Wang, Zhiyu Li, Cheng-Lung Ku, Ping-Chih Ho
Summary: Chimeric antigen receptor (CAR) T cells have achieved clinical success in treating hematological malignancy, but their efficacy in solid tumors remains challenging. This article reviews the metabolic stress and signaling in the tumor microenvironment that restrict the efficacy of CAR T cell therapy, and discusses novel approaches to target and rewire metabolic programming for CAR T cells. Strategies to improve the metabolic adaptability of CAR T cells and enhance their antitumor responses are also summarized.
SCIENCE IMMUNOLOGY
(2023)
Review
Cell Biology
Duy T. Nguyen, Elizabeth Ogando-Rivas, Ruixuan Liu, Theodore Wang, Jacob Rubin, Linchun Jin, Haipeng Tao, William W. Sawyer, Hector R. Mendez-Gomez, Matthew Cascio, Duane A. Mitchell, Jianping Huang, W. Gregory Sawyer, Elias J. Sayour, Paul Castillo
Summary: This article discusses the important role of the tumor microenvironment in CAR-T cell therapy and explains the advantages and limitations of preclinical models.
Review
Immunology
Guangna Liu, Wei Rui, Xueqiang Zhao, Xin Lin
Summary: CAR-T cell therapy has shown successful outcomes in hematological malignancies but faces challenges in treating solid tumors due to immunosuppressive mechanisms in the tumor microenvironment. This review summarized inhibitory factors affecting CAR-T cell function and discussed strategies to enhance CAR-T cell efficacy in solid tumor treatment by targeting these barriers.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Kristoffer H. Johansen, Dominic P. Golec, Julie H. Thomsen, Pamela L. Schwartzberg, Klaus Okkenhaug
Summary: PI3K signaling is crucial for T cell activation, differentiation, and trafficking, with PI3K delta being the dominant isoform in T cells. It regulates T cell functions by controlling adhesion receptors and their interaction with antigen-presenting cells. Understanding the role of PI3K delta in T cell migration and localization is important for potential impacts of PI3K delta inhibitors on T cell redistribution and function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Davide Raineri, Giuseppe Cappellano, Beatrice Vilardo, Federica Maione, Nausicaa Clemente, Elena Canciani, Elena Boggio, Casimiro Luca Gigliotti, Chiara Monge, Chiara Dianzani, Renzo Boldorini, Umberto Dianzani, Annalisa Chiocchetti
Summary: This study demonstrates that the loss of ICOSL promotes tumor metastasis in breast cancer and melanoma cells, while ICOS inhibits this metastasis by promoting Treg expansion. The interaction between OPN and ICOSL is particularly important in melanoma metastasis, and interfering with this binding may be a potential therapeutic approach for nonresponding or treatment-resistant patients.
Review
Oncology
Yannick Bulliard, Borje S. Andersson, Mehmet A. Baysal, Jason Damiano, Apostolia M. Tsimberidou
Summary: T cell differentiation and exhaustion play a crucial role in the design and efficacy of CAR-T cell therapy. Understanding the key regulators in T cell biology offers new opportunities for the development of next-generation CAR-T cell therapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Qingda Wang, Yang Qin, Bo Li
Summary: Immunotherapy plays a crucial role in treating malignant tumors, and CD8+ T cells are essential for the success of immunotherapy. However, continuous antigen exposure and inflammatory factors can lead to CD8+ T cell exhaustion, causing loss of control and tumor progression. This review provides insights into the mechanisms and characteristics of CD8+ T cell exhaustion. While immunotherapy can reverse exhaustion and improve antitumor effects, single immunotherapy has limitations. The review also highlights promising clues for future management of malignant tumors.
Article
Multidisciplinary Sciences
Joshua M. Gammon, Sean T. Carey, Vikas Saxena, Haleigh B. Eppler, Shannon J. J. Tsai, Christina Paluskievicz, Yanbao Xiong, Lushen Li, Marian Ackun-Farmmer, Lisa H. Tostanoski, Emily A. Gosselin, Alexis A. Yanes, Xiangbin Zeng, Robert S. Oakes, Jonathan S. Bromberg, Christopher M. Jewell
Summary: The authors have successfully promoted the production of antigen-specific regulatory T cells and prevented the occurrence of type 1 diabetes and allogenic islet transplantation by delivering immune signals to lymph nodes. Antigen-specific tolerance is an important goal in experimental immunotherapy for autoimmune diseases and organ transplantation, as it can selectively inhibit harmful immune responses without compromising protective immunity. However, the current challenge lies in the ineffective control over immune signal targeting, which limits the efficacy and causes non-specific suppression.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Darren R. Heintzman, Emilie L. Fisher, Jeffrey C. Rathmell
Summary: T cell metabolism is dynamic and highly regulated, playing a crucial role in differentiation and function patterns; the ability of cells to acquire nutrients and cope with hostile environments can limit metabolic pathways; changes in physical conditions and nutrient availability shape immune responses.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Maximilian Wiendl, Emily Becker, Tanja M. Mueller, Caroline J. Voskens, Markus F. Neurath, Sebastian Zundler
Summary: Inflammatory bowel diseases such as Crohn's disease (CD) and ulcerative colitis (UC) are multifactorial diseases with an increasing prevalence and incidence worldwide. Targeting immune cell homing has become an important pillar of IBD therapy, with potential for further therapeutic interventions. Leukocyte trafficking and tissue-derived chemokines offer untapped resources for potential therapeutic interventions in IBD.
FRONTIERS IN IMMUNOLOGY
(2021)