Review
Biochemistry & Molecular Biology
Hsien-Chung Chen, Wen-Chang Chang, Jian-Ying Chuang, Kwang-Yu Chang, Jing-Ping Liou, Tsung- Hsu
Summary: Eicosanoids are bioactive lipids derived from arachidonic acid in the brain, and they play diverse roles in normal physiology, including neuronal signaling, synaptic plasticity, and regulation of cerebral blood flow. Dysregulation of eicosanoids has been implicated in the development and progression of brain tumors, and understanding their role can inform the development of diagnostic, prognostic, and therapeutic approaches.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemistry & Molecular Biology
Na-Young Park, Suji Im, Qing Jiang
Summary: The study revealed that vitamin E forms and 13'-COOHs have inhibitory effects on COX-1 activity and thromboxane formation in platelets, and elucidated the mechanisms underlying their inhibition of 5-LOX. These observations are useful for understanding the role of these compounds in disease prevention and therapy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fumie Nakashima, Juan A. Gimenez-Bastida, Paula B. Luis, Sai H. Presley, Robert E. Boer, Manuel Chiusa, Takahiro Shibata, Gary A. Sulikowski, Ambra Pozzi, Claus Schneider
Summary: Consecutive oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2 produces hemiketal ei-cosanoids, HKE2 and HKD2, which promote angiogenesis by inducing endothelial cell tubulogenesis. This study identifies VEGFR2 as a mediator of HKE2-induced angiogenesis in vitro and in vivo. HKE2 treatment increases the phosphorylation of VEGFR2 and downstream kinases ERK and Akt, while HKE2-mediated effects are blocked by the VEGFR2 inhibitor vatalanib. These findings suggest a potential therapeutic strategy utilizing drugs targeting the arachidonic acid pathway for antiangiogenic therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Plant Sciences
Siqi Wang, David Yue-Wei Lee, Ying Shang, Jun Liao, Xiaotong Cao, Linlin Xie, Teng Zhang, Jing Liu, Ronghua Dai
Summary: The bioactive alkaloids from Cortex Phellodendri can inhibit the expression of LOX-5 and COX-2 simultaneously, exerting an anti-inflammatory effect on BPH. Among them, demethyleneberberine exhibited prominent inhibitory activities against both LOX-5 and COX-2 enzymes, showing potential as a drug candidate with dual-targeting properties.
Article
Plant Sciences
Xiaotong Cao, Ying Shang, Weigui Kong, Shuqing Jiang, Jun Liao, Ronghua Dai
Summary: The study showed that Anemarrhenae Rhizoma flavonoids can inhibit BPH-related inflammation by regulating AA metabolism and interfering with COX and LOX pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Poorvi Saraf, Prabhash Nath Tripathi, Manish Kumar Tripathi, Avanish Tripathi, Himanshu Verma, Digambar Kumar Waiker, Royana Singh, Sushant Kumar Shrivastava
Summary: A series of novel derivatives were synthesized and evaluated for their inhibitory potential against COX-2 and 5-LOX enzymes. Compound 6k showed the best inhibitory activity and also exhibited significant anti-inflammatory, antioxidant, and non-cardiotoxic properties.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yilin Pang, Xinjie Liu, Chenxi Zhao, Xuelian Shi, Jiawei Zhang, Tiangang Zhou, Haoning Xiong, Xiang Gao, Xiaoqing Zhao, Xingjian Yang, Guangzhi Ning, Xu Zhang, Shiqing Feng, Xue Yao
Summary: This study quantified the metabolomics of arachidonic acid (AA) in the acute phase of spinal cord injury (SCI) and found significant increases in Prostaglandin E2 (PGE2) and Leukotriene B4 (LTB4). The upregulation of Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) in the injured spinal cord tissue suggests their potential as therapeutic targets for SCI.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Organic
Shihu Qian, Yuanzheng Huang, Jiaming Li, Yanchun Zhang, Bin Zhang, Fan Jin
Summary: A novel series of indole-2-amide-derived COX-2/5-LOX dual inhibitors were designed, synthesized, and evaluated for anti-proliferative activity. Compound 7b exhibited outstanding anti-proliferative activity against A549 and HCT-116 cell lines, with attractive COX-2 and 5-LOX inhibitory activities. Further investigation confirmed that 7b could induce apoptosis of A549 cells in a dose-dependent manner.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hao-Dong Yang, Zhi-Shu Tang, Tao-Tao Xue, Huai-Li Xu, Bao-Long Hou, Ya-Ya Zhu, Zeng-Hu Su, Hong-Bo Xu
Summary: Twenty-four monoterpenoids were isolated from the root bark of Acanthopanax gracilistylus. Their structures were determined using spectroscopic analysis, and the inhibitory activities of these compounds were studied for the first time. Compound 24 showed significant inhibition against COX-2. This research also reported the presence of previously unreported compounds.
Article
Endocrinology & Metabolism
Thaise S. Martins, Bruno M. Fonseca, Irene Rebelo
Summary: This study found that M2 macrophages with anti-inflammatory characteristics can significantly increase the expression of COX-2 in hGCs, while M1 macrophages with pro-inflammatory characteristics can significantly increase the expression of 12-LOX in hGCs. In addition, CM from M2 macrophages can increase the expression of COX-2, 5-LOX and 15-LOX in COV434 cells.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Teng Wang, Yiqun Han, Haonan Li, Yanwen Wang, Tao Xue, Xi Chen, Wu Chen, Yunfei Fan, Xinghua Qiu, Jicheng Gong, Yifan Xu, Junxia Wang, Weiju Li, Tong Zhu
Summary: Short-term exposure to ambient air particulate matter (PM) is associated with changes in polyunsaturated fatty acids (PUFAs) and oxylipins derived from lipoxygenase (LOX), cytochrome P450 (CYP), and cyclooxygenase (COX) pathways in humans. These findings suggest that bioactive oxylipins could potentially serve as biomarkers and play a crucial role in mediating PM-associated systemic cardiometabolic effects.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Minakshi A. Meshram, Utkarsha O. Bhise, Priyanka N. Makhal, Venkata Rao Kaki
Summary: Inflammation is a complex pathological process leading to various diseases, with different treatments available but limitations exist. The development of new, effective, and safe anti-inflammatory agents is needed to address the shortcomings of current treatments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Fatma M. M. Abdel Bar, Amira Mira, Ahmed I. I. Foudah, Manal A. A. Alossaimi, Shatha F. F. Alkanhal, Alanoud M. M. Aldaej, Mai H. H. ElNaggar
Summary: Plants can synthesize diverse secondary metabolites with the capacity to interact with human receptors involved in diseases. Polyacetylene derivatives from Launaea capitata were investigated for their inhibitory activity against neuroinflammatory enzymes. One compound showed dual inhibition against BchE and 5-LOX enzymes. Molecular docking experiments revealed the binding affinity of the compounds and suggested polyacetylene glycosides as potential leads for developing new inhibitors against neuroinflammation enzymes.
Article
Biochemistry & Molecular Biology
Alexander Zhuravlev, Alejandro Cruz, Vladislav Aksenov, Alexey Golovanov, Jose M. Lluch, Hartmut Kuhn, Angels Gonzalez-Lafont, Igor Ivanov
Summary: This study investigates the functionality of ALOX15 in different cancer and inflammation models, and suggests that certain derivatives can inhibit its catalytic activity. Through computational simulations, the researchers identified a common pharmacophore that is critical for this allosteric inhibition.
Article
Biochemistry & Molecular Biology
Silpa Kunnappilly Paulose, Kajal Chakraborty
Summary: Cuttlefish is considered a commercially important resource, as its nutritious food is widely consumed in the southwest of Indian and Mediterranean coasts. Pharachromenone, an isolate from the cuttlefish, exhibits potent antioxidant and anti-inflammatory properties, making it a potential functional food component against oxidative stress-related inflammatory disorders.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
David Vauzour, Noemi Tejera, Colette O'Neill, Valeria Booz, Baptiste Jude, Insa M. A. Wolf, Neil Rigby, Jose Manuel Silvan, Peter J. Curtis, Aedin Cassidy, Sonia de Pascual-Teresa, Gerald Rimbach, Anne Marie Minihane
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Sean McManus, Noemi Tejera, Khader Awwad, David Vauzour, Neil Rigby, Ingrid Fleming, Aedin Cassidy, Anne Marie Minihane
JOURNAL OF LIPID RESEARCH
(2016)
Article
Nutrition & Dietetics
Noemi Tejera, David Vauzour, Monica B. Betancor, Olga Sayanova, Sarah Usher, Marianne Cochard, Neil Rigby, Noemi Ruiz-Lopez, David Menoyo, Douglas R. Tocher, Johnathan A. Napier, Anne Marie Minihane
JOURNAL OF NUTRITION
(2016)
Article
Biochemistry & Molecular Biology
Kenna E. Slim, David Vauzour, Noemi Tejera, Peter J. Voshol, Aedin Cassidy, Anne Marie Minihane
Article
Biochemistry & Molecular Biology
David Vauzour, Ildefonso Rodriguez-Ramiro, Simon Rushbrook, Ignacio R. Ipharraguerre, Damon Bevan, Susan Davies, Noemi Tejera, Pedro Mena, Sonia de Pascual-Teresa, Daniele Del Rio, Jelena Gavrilovic, Anne Marie Minihane
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Markus Griesser, Valentina Pistis, Takashi Suzuki, Noemi Tejera, Derek A. Pratt, Claus Schneider
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Noemi Tejera, William E. Boeglin, Takashi Suzuki, Claus Schneider
JOURNAL OF LIPID RESEARCH
(2012)
Article
Multidisciplinary Sciences
Steven J. McElroy, Stuart Hobbs, Michael Kallen, Noemi Tejera, Michael J. Rosen, Anatoly Grishin, Poojitha Matta, Claus Schneider, Jeffrey Upperman, Henri Ford, D. Brent Polk, Joern-Hendrik Weitkamp
Review
Nutrition & Dietetics
Marina Nikolic, Aleksandra Konic Ristic, Antonio Gonzalez-Sarrias, Geoffrey Istas, Mireia Urpi-Sarda, Margherita Dall'Asta, Laurent-Emmanuel Monfoulet, Lieselotte Cloetens, Banu Bayram, Maria Rosaria Tumolo, Mihail Chervenkov, Egeria Scoditti, Marika Massaro, Noemi Tejera, Desislava Abadjieva, Karen Chambers, Irena Krga, Francisco A. Tomas-Barberan, Christine Morand, Rodrigo Feliciano, Rocio Garcia-Villalba, Mar Garcia-Aloy, Pedro Mena
EUROPEAN JOURNAL OF NUTRITION
(2019)
Article
Microbiology
Noemi Tejera, Lisa Crossman, Bruce Pearson, Emily Stoakes, Fauzy Nasher, Bilal Djeghout, Mark Poolman, John Wain, Dipali Singh
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Matthew G. Pontifex, Anneloes Martinsen, Rasha Noureldin M. Saleh, Glenn Harden, Noemi Tejera, Michael Mueller, Chris Fox, David Vauzour, Anne-Marie Minihane
Summary: The impact of sex and menopausal status in Alzheimer's disease remains understudied, with increasing evidence of greater female risk, especially in APOE4 carriers. Experimental findings suggest that the combination of ovarian failure and APOE4 genotype exacerbates cognitive and neurological deficits in Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Teresa Diaz Calvo, Noemi Tejera, Iain McNamara, Gemma C. Langridge, John Wain, Mark Poolman, Dipali Singh
Summary: In this study, a fully curated, genome-scale metabolic model for S. epidermidis RP62A was constructed and its metabolic properties were investigated. The results showed that the strain preferred amino acids, especially proline, valine, alanine, glutamate, and arginine, for energy and biomass production. Unlike previous studies, this strain did not show significant substrate auxotrophies, although removal of proline from the media had the highest impact on growth characteristics.
Article
Microbiology
Emily Stoakes, George M. Savva, Ruby Coates, Noemi Tejera, Mark G. Poolman, Andrew J. Grant, John Wain, Dipali Singh
Summary: This study investigated the substrate utilization and energy metabolism of non-growing Campylobacter jejuni. By integrating phenotypic microarrays and genome-scale metabolic modelling, the study found that C. jejuni can survive on various substrates and produce ATP through different metabolic mechanisms. The ability to utilize a wide range of substrates may contribute to C. jejuni's success in surviving in changing environments.
Review
Oncology
Rafael Zarate, Nabil el Jaber-Vazdekis, Noemi Tejera, Jose A. Perez, Covadonga Rodriguez
CLINICAL AND TRANSLATIONAL MEDICINE
(2017)