Article
Multidisciplinary Sciences
Shengli Ding, Jing Yang, Xuehuan Feng, Aseem Pandey, Rola Barhoumi, Dongmei Zhang, Samantha L. Bell, Yue Liu, Luciana Fachini da Costa, Allison Rice-Ficht, Robert O. Watson, Kristin L. Patrick, Qing-Ming Qin, Thomas A. Ficht, Paul de Figueiredo
Summary: This study reveals that the recruitment of host AIC proteins to forming phagosomes depends on the activity of CD44, which is crucial for the internalization of fungal pathogens into host cells.
Review
Microbiology
Sonia Vection, David O'Callaghan, Anne Keriel
Summary: CD98hc is a crucial host protein that plays a key role in the pathogenesis of infectious diseases. It can form amino acid transporters by associating with different light chains, and it is involved in mediating bacterial, apicomplexan, and viral infections.
FEMS MICROBIOLOGY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anuja Jain, Shikha Mittal, Lokesh P. Tripathi, Ruth Nussinov, Shandar Ahmad
Summary: Recognition of pathogen-derived nucleic acids by host cells is crucial for detecting pathogenic invasion and triggering immune responses. Understanding the interactions between pathogen nucleic acids and host factors is essential for therapeutic intervention.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Meng Li, Siyue Huang, Xiang David Li
Summary: Bacterial pathogens adapt their proteome to survive in host cells and secrete effector proteins to manipulate host targets. Conventional proteomics struggles to profile pathogen proteome dynamics due to excessive host proteins. Mapping pathogen-host protein-protein interactions is challenging due to low abundance and transient interactions of bacterial effectors. A new method using a bifunctional amino acid, photo-ANA, allows selective labeling of bacterial proteomes and simultaneous analysis of proteome reprogramming and pathogen-host interactions during Salmonella infection.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Zifeng Cui, Rui Tian, Zhaoyue Huang, Zhuang Jin, Lifang Li, Jiashuo Liu, Zheying Huang, Hongxian Xie, Dan Liu, Haiyan Mo, Rong Zhou, Bin Lang, Bo Meng, Haiyan Weng, Zheng Hu
Summary: Genome editing technologies have great potential in biomedical research and drug development. This study introduces a CRISPR/Cas9 tool called FrCas9 from Faecalibaculum rodentium, which has efficient and specific gene editing capabilities and can be used for the treatment of TATA-box related diseases.
NATURE COMMUNICATIONS
(2022)
Review
Biotechnology & Applied Microbiology
Paula M. Tribelli, Nancy Lopez
Summary: This review provides an overview of temperature-response mechanisms in Pseudomonas species and highlights their relevance to human and animal health as well as agricultural applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Microbiology
Zhihui Lyu, Cierra Wilson, Jiqiang Ling
Summary: Translational fidelity, the accuracy of protein synthesis, is crucial in all three domains of life. This article reviews how translational fidelity is affected by environmental stresses encountered by bacterial pathogens during host interactions, including oxidative stress, metabolic stresses, and antibiotics. The review discusses the types of translational errors and their impact on stress adaptation and fitness, as well as the roles of translational fidelity and underlying mechanisms in pathogen-host interactions. The studies covered in this review primarily focus on Salmonella enterica and Escherichia coli, but other bacterial pathogens are also discussed.
Article
Food Science & Technology
Nicola Landi, Sara Ragucci, Antimo Di Maro
Summary: Sheep milk has the highest total protein content, while goat milk is the most abundant in amino acids. Raw milk from 'Alto Casertano' is a good source of essential amino acids.
Review
Cell Biology
Johannes Westman, Sergio Grinstein
Summary: The ability of phagosomes to halt microbial growth is closely linked to their ability to acidify their luminal pH, but certain pathogens can survive and replicate inside phagosomes by targeting the pH-regulatory machinery of host cells to survive or escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Benoit Malleret, Abbas El Sahili, Matthew Zirui Tay, Guillaume Carissimo, Alice Soh Meoy Ong, Wisna Novera, Jianqing Lin, Rossarin Suwanarusk, Varakorn Kosaisavee, Trang T. T. Chu, Ameya Sinha, Shanshan Wu Howland, Yiping Fan, Jakub Gruszczyk, Wai-Hong Tham, Yves Colin, Sebastian Maurer-Stroh, Georges Snounou, Lisa F. P. Ng, Jerry Kok Yen Chan, Ann-Marie Chacko, Julien Lescar, Rajesh Chandramohanadas, Francois Nosten, Bruce Russell, Laurent Renia
Summary: This study identified CD98 heavy chain as a receptor for the PvRBP2a parasite ligand, further demonstrating its role in P. vivax reticulocyte invasion. The interaction between CD98 and PvRBP2a suggests its potential as a vaccine target against P. vivax malaria.
NATURE MICROBIOLOGY
(2021)
Review
Immunology
Brenda B. Daroz, Luis G. V. Fernandes, Maria F. Cavenague, Leandro T. Kochi, Felipe J. Passalia, Maria B. Takahashi, Edson G. Nascimento Filho, Aline F. Teixeira, Ana L. T. O. Nascimento
Summary: Leptospirosis is a widespread zoonotic disease of human and veterinary concern caused by pathogenic Leptospira spp. Investigating surface proteins of the bacterium provides insights into host-pathogen interactions for better understanding of the mechanisms involved.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Microbiology
Vera Vozandychova, Pavla Stojkova, Kamil Hercik, Pavel Rehulka, Jiri Stulik
Summary: Ubiquitination, similar to phosphorylation and acetylation, plays a crucial role in regulating various cell processes. Understanding how pathogens manipulate host ubiquitination processes is important for vaccine development and disease treatment. Pathogenic bacteria encode effector proteins targeting the host ubiquitin machinery to disrupt host defense processes.
Review
Biology
Hajarooba Gnanagobal, Javier Santander
Summary: This review provides a comprehensive analysis of the interactions between marine Gram-positive pathogens and fish hosts, which cause economic losses in global marine fish aquaculture. Understanding these host-pathogen interactions is crucial for developing effective prophylactic measures and treatments.
Article
Biochemistry & Molecular Biology
Hong Zhang, Jiang Wu, Zhihui Lyu, Jiqiang Ling
Summary: Aminoacyl-tRNA synthetases are crucial enzymes for protein synthesis, and mutations in these enzymes can lead to neurological disorders. Editing defects in alanyl-tRNA synthetase (AlaRS) cause neurodegeneration in mice and microcephaly in humans, but the cellular impact in eukaryotes is not well understood. This study reveals that AlaRS editing defects activate the general amino acid control pathway, attenuate the heatshock response, downregulate carbon metabolism, and inhibit protein synthesis in yeast cells, contrasting with effects seen in other aaRSs editing deficiencies. Supplying extra carbon source partially rescues the heat sensitivity caused by AlaRS editing deficiency.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Travis Walton, Wen Zhang, Li Li, Chun Pong Tam, Jack W. Szostak
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Medicine, Research & Experimental
Kook Son, Jae-Sung You, Mee-Sup Yoon, Chong Dai, Jong Hyun Kim, Nidhi Khanna, Aditi Banerjee, Susan A. Martinis, Gyoonhee Han, Jung Min Han, Sunghoon Kim, Jie Chen
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Biochemistry & Molecular Biology
Christopher S. Weitzel, Li Li, Zhang Changyi, Kristen K. Eilts, Nicholas M. Bretz, Alex L. Gatten, Rachel J. Whitaker, Susan A. Martinis
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Endocrinology & Metabolism
Richie D. Barclay, Joseph W. Beals, Jenny Drnevich, Brian S. Imai, Peter M. Yau, Alexander V. Ulanov, Neale A. Tillin, Martha Villegas-Montes, Scott A. Paluska, Peter W. Watt, Michael De Lisio, Nicholas A. Burd, Richard W. Mackenzie
METABOLISM-CLINICAL AND EXPERIMENTAL
(2020)
Article
Multidisciplinary Sciences
Sangwon Byun, Sunmi Seok, Young-Chae Kim, Yang Zhang, Peter Yau, Naoki Iwamori, H. Eric Xu, Jian Ma, Byron Kemper, Jongsook Kim Kemper
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Alister Burt, C. Keith Cassidy, Peter Ames, Maria Bacia-Verloop, Megghane Baulard, Karine Huard, Zaida Luthey-Schulten, Ambroise Desfosses, Phillip J. Stansfeld, William Margolin, John S. Parkinson, Irina Gutsche
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Corina N. D'Alessandro-Gabazza, Tetsu Kobayashi, Taro Yasuma, Masaaki Toda, Heejin Kim, Hajime Fujimoto, Osamu Hataji, Atsuro Takeshita, Kota Nishihama, Tomohito Okano, Yuko Okano, Yoichi Nishii, Atsushi Tomaru, Kentaro Fujiwara, Valeria Fridman D'Alessandro, Ahmed M. Abdel-Hamid, Yudong Ren, Gabriel V. Pereira, Christy L. Wright, Alvaro Hernandez, Christopher J. Fields, Peter M. Yau, Shujie Wang, Akira Mizoguchi, Masayuki Fukumura, Junpei Ohtsuka, Tetsuya Nosaka, Kensuke Kataoka, Yasuhiro Kondoh, Jing Wu, Hirokazu Kawagishi, Yutaka Yano, Roderick I. Mackie, Isaac Cann, Esteban C. Gabazza
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Marcelo C. R. Melo, Rafael C. Bernardi, Cesar de la Fuente-Nunez, Zaida Luthey-Schulten
JOURNAL OF CHEMICAL PHYSICS
(2020)
Article
Multidisciplinary Sciences
Anustup Poddar, Muhammad S. Azam, Tunc Kayikcioglu, Maksym Bobrovskyy, Jichuan Zhang, Xiangqian Ma, Piyush Labhsetwar, Jingyi Fei, Digvijay Singh, Zaida Luthey-Schulten, Carin K. Vanderpool, Taekjip Ha
Summary: Base-pairing interactions are crucial for intermolecular target recognition, with even a single base-pair mismatch causing significant differences in activity. Hfq directly facilitates sRNA-mRNA annealing in vivo. Single base-pair mismatches prolong the time it takes to find and destroy the target.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Biochemical Research Methods
Zaida Luthey-Schulten
Article
Multidisciplinary Sciences
Sean P. Carney, Wen Ma, Kevin D. Whitley, Haifeng Jia, Timothy M. Lohman, Zaida Luthey-Schulten, Yann R. Chemla
Summary: The study utilized optical tweezers to directly measure the stepping behavior of UvrD as it processes a DNA hairpin, revealing a variable step size averaging around 3 base pairs. Analysis of ATP hydrolysis kinetics showed that UvrD moves one base pair at a time but non-uniformly releases nascent single strands, suggesting a conserved mechanism among other non-hexameric helicases.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
David M. Bianchi, James F. Pelletier, Clyde A. Hutchison, John Glass, Zaida Luthey-Schulten
Summary: In this study, a whole-cell kinetic model of JCVI-syn3A was presented, and computational analyses were applied to elucidate the functions of several previously uncharacterized genes. Characterization of these genes can enhance the predictive power of the cell model and deepen our understanding of biophysical processes and pathways at the cell scale.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Biology
C. Keith Cassidy, Benjamin A. Himes, Dapeng Sun, Jun Ma, Gongpu Zhao, John S. Parkinson, Phillip J. Stansfeld, Zaida Luthey-Schulten, Peijun Zhang
COMMUNICATIONS BIOLOGY
(2020)
Article
Ophthalmology
Erotides Capistrano da Silva, Justine Arrington, Peter M. Yau, Kathryn M. Smith-Fleming, Igor Frederico Canisso, Bianca da Costa Martins
Summary: The study identified a high similarity in protein composition between bovine amniotic membranes and the cornea, supporting the potential use of bovine amniotic membranes in treating corneal diseases. By using high-throughput proteomic analysis, the researchers found numerous proteins shared between the two tissues, highlighting the promise of bovine amniotic membranes as a therapeutic option for corneal conditions.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)