Review
Cell Biology
Nitesh D. Sharma, Esra'a Keewan, Ksenia Matlawska-Wasowska
Summary: Involvement of the Central Nervous System in acute leukemia is associated with poor prognosis and lower overall survival. Existing therapies pose significant toxicities. Leukemic cells can adapt and survive in the CNS microenvironment. Understanding the mechanisms of leukemic cell survival in the CNS microenvironment is crucial for developing more effective therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Megan M. Nelson, J. Damon Hoff, Mya L. Zeese, Gabriel Corfas
Summary: PARP1 plays a novel role in brain development by regulating Cajal-Retzius (CR) cells, neuronal density, and cell adhesion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zheng Ying, Na Ye, Qilian Ma, Fan Chen, Ningning Li, Xuechu Zhen
Summary: Significant evidences show that sub-cellular organelle dynamics play a critical role in physiological and pathological events, making them attractive drug targets. However, drug development in this field is still limited despite extensive studies on the biological mechanisms. This review explores the potential of targeting organelle dynamics in the central nervous system, specifically mitochondrial dynamics and ER-organelle membrane contact dynamics, for treating neurodegenerative diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Neurosciences
Nasim Bahram Sangani, Ana Rita Gomes, Leopold M. G. Curfs, Chris P. Reutelingsperger
Summary: Extracellular Vesicles (EVs) are membrane particles secreted by cells, carrying various biomolecules to facilitate communication between neural cells. They play a crucial role in CNS development by stimulating neural cell proliferation, differentiation, and mediating interactions between neurons and oligodendrocytes during myelination. Understanding the presence and contribution of EVs in CNS developmental milestones is essential for research in this area.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Cell Biology
Eduardo Cosendey Bockmann, Rafael Brito, Lucianne Fragel Madeira, Luzia da Silva Sampaio, Ricardo Augusto de Melo Reis, Guilherme Rapozeiro Franca, Karin da Costa Calaza
Summary: The active principles of Cannabis sativa have potential therapeutic effects, but their impact on embryonic development needs careful evaluation. The presence of endocannabinoid system components during early CNS development has been described, but their physiological effects are not yet well established. The altered effects of the endocannabinoid system on cell proliferation, migration, differentiation, and cell death are still uncertain.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemical Research Methods
Ying Xin, Pin Lyu, Junyao Jiang, Fengquan Zhou, Jie Wang, Seth Blackshaw, Jiang Qian
Summary: Intercellular communication plays a crucial role in multicellular organisms. Previous studies have identified feedback loops as key signaling motifs in development, regeneration, and cancer progression. Existing computational methods for predicting cell-cell communication are unable to identify feedback loops.
Review
Oncology
Toby A. Eyre, Kerry J. Savage, Chan Y. Cheah, Tarec C. El-Galaly, Katharine L. Lewis, Pamela McKay, Matthew R. Wilson, Andrew M. Evens, Sabela Bobillo, Diego Villa, Matthew J. Maurer, Kate Cwynarski, Andres Ferreri
Summary: This Review provides a detailed discussion on the relapse of diffuse large B-cell lymphoma in the central nervous system, summarizing current prophylaxis strategies and associated clinical and biological features, while also offering insights into possible future developments.
Article
Multidisciplinary Sciences
Filippo Bonafe, Francesco Decataldo, Isabella Zironi, Daniel Remondini, Tobias Cramer, Beatrice Fraboni
Summary: Research on electrolyte-gated and organic electrochemical transistor (OECT) architectures aims to develop a highly biocompatible interface for amplifying bioelectronic signals at the site of detection. This study presents a model experiment to simulate the detection of a single cell using impedance sensing, and provides clear guidelines for optimizing OECTs as single cell sensors. The experimental results demonstrate significant gain compared to traditional electrode-based impedance sensors.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Junyang Li, Lei Fan, Yanfang Li, Tanyong Wei, Cheng Wang, Feng Li, Hua Tian, Dong Sun
Summary: By coating the microrobot with a bioactive nanostructured titanate surface, cell adhesion is enhanced, reducing cell loss in blood flow environments and promoting cell viability, proliferation, and differentiation. This research presents a novel microrobotic platform that influences cell behavior through surface nanotopography, offering a new approach for microrobot cell delivery.
Review
Immunology
Zahra Telikani, Ebony A. Monson, Markus J. Hofer, Karla J. Helbig
Summary: The central nervous system (CNS) is composed of various cell types and protected by anatomical barriers. The different cell types distributed in different brain regions are the main targets of several neurotropic viruses. It has been found that viral susceptibility within the CNS is not absolute and different cell types initiate specific antiviral responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Arek Kendirli, Clara de la Rosa, Katrin F. Laemmle, Klara Eglseer, Isabel J. Bauer, Vladyslav Kavaka, Stephan Winklmeier, La Zhuo, Christian Wichmann, Lisa Ann Gerdes, Tania Kuempfel, Klaus Dornmair, Eduardo Beltran, Martin Kerschensteiner, Naoto Kawakami
Summary: This study identifies key regulators of T cell entry to the central nervous system (CNS) in a multiple sclerosis (MS) model using a CRISPR screen. The researchers found several essential brakes and facilitators of T cell migration, including the transcription factor ETS1 and functional modules centered around adhesion molecule α4-integrin, chemokine receptor CXCR3, and GRK2 kinase. Single-cell analysis of MS patients' T cells confirmed the correlation between the expression of these regulators and the ability of CD4+ T cells to reach the CNS.
NATURE NEUROSCIENCE
(2023)
Review
Cell Biology
Hsiang-Wei Huang, Cheng-Chih Chang, Chia-Siu Wang, Kwang-Huei Lin
Summary: Inflammatory processes play a crucial role in the tumor microenvironment, promoting tumor progression through cytokine release and cellular interactions. Immunosuppressive molecules in infiltrating immune and tumor cells inhibit cytotoxic T cells, allowing tumors to evade immune surveillance. Glycosylation and sialylation of overexpressed proteins on cancer cells enhance immune escape and metastasis.
Article
Chemistry, Analytical
Liang Wang, Wei Chen, Hongyun Li, Chaohui Xiong, Feng Sun, Xiaoqing Liu, Yuru Hu, Wenxu Wang, Wenqun Zhong, Zheng Liu
Summary: Mechanical forces have profound effects on cell morphology and migration in a two-dimensional environment. However, the mechanism by which cells migrate in a confined three-dimensional environment is unclear. This study presents a method of fabricating microfluidic chips with DNA-based tension probes to measure force exerted during confined cell migration. The results show that cells exert less force and have increasingly transient interactions in confined spaces.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Peijie Zheng, Chenshu Pan, Chuntao Zhou, Bin Liu, Linlin Wang, Shiwei Duan, Yuemin Ding
Summary: This review systematically analyzes the role and mechanism of Nischarin/IRAS in the CNS, providing necessary references and potential treatment targets for neurological diseases, thereby expanding the direction of Nischarin/IRAS research and facilitating clinical translation.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Materials Science, Composites
Minghui Wu, Qian Ren, Peng Gao, Wenyu Ma, Bin Shen, Long Wang, Wenge Zheng, Ping Cui, Xiaosu Yi
Summary: The incorporation of cell structure within conductive polymer composites (CPCs) significantly enhances electrical properties. An innovative approach involving the enlargement of cell size is proposed to improve electrical conductivity (EC) and electromagnetic interference shielding effectiveness (EMI SE). By modifying the nitrogen (N2) content, polypropylene/carbon nanostructure (PP/CNS) nanocomposite foams with controlled cell sizes were successfully produced.
COMPOSITES COMMUNICATIONS
(2023)
Article
Ophthalmology
Parth R. Shah, Bharesh Chauhan, Charleen T. Chu, Julia Kofler, Ken K. Nischal
Summary: In this study, deep ocular phenotyping of Peters-plus syndrome was performed using anterior segment optical coherence tomography and ultrasound biomicroscopy. The most common ocular phenotype observed was an avascular paracentral ring opacity with relative central clearing. A different phenotype with a large vascularized corneal opacity was also identified.
Article
Neurosciences
Shane P. D'Souza, David Swygart, Sophia R. Wienbar, Brian A. Upton, Kevin X. Zhang, Robert D. Mackin, Anna K. Casasent, Melanie A. Samuel, Gregory W. Schwartz, Richard A. Lang
Summary: Understanding the parts list of sensory components in the retina is crucial for studying the effects of light on behavior, health, and disease. This study reveals the expression patterns of Opn5 in retinal ganglion cells, which are nonhomogenously distributed in the retina with higher densities in the dorsotemporal quadrant. Through molecular and electrophysiological profiling, it is discovered that Opn5-RGCs comprise previously defined RGC types that respond optimally to edges and object motion, expanding the roles of image-forming cells in retinal physiology and function.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Misato Ichise, Kazuto Sakoori, Kei-ichi Katayama, Naoko Morimura, Kazuyuki Yamada, Hiroki Ozawa, Hayato Matsunaga, Minoru Hatayama, Jun Aruga
Summary: Lrtm2 plays a crucial role in protein sorting in striatal projection systems, and its deficiency can cause disturbances in monoamine dynamics and behavior.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Physiology
Nicolas M. Diaz, Shannon A. Gordon, Richard A. Lang, Ethan D. Buhr
Summary: Mammals regulate their body temperature by utilizing internal circadian clocks and thermosensitivity. The preoptic area of the hypothalamus houses temperature-sensitive circadian clocks that are influenced by temperature changes but not by light cues.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kei-ichi Katayama, Naoko Morimura, Katsunori Kobayashi, Danielle Corbett, Takehito Okamoto, Veravej G. Ornthanalai, Hayato Matsunaga, Wakako Fujita, Yoshifumi Matsumoto, Takumi Akagi, Tsutomu Hashikawa, Kazuyuki Yamada, Niall P. Murphy, Soichi Nagao, Jun Aruga
Summary: SLITRK2 deficiency causes aberrant neural network activity, synaptic integrity, vestibular function, and serotonergic function, providing molecular-neurophysiological insight into the brain dysregulation in bipolar disorders.
Article
Biology
Vijay K. Jidigam, Onkar B. Sawant, Rebecca D. Fuller, Kenya Wilcots, Rupesh Singh, Richard A. Lang, Sujata Rao
Summary: Research has shown that clock genes are expressed in the mouse embryonic retina, and this expression requires light cues. Deletion of Bmal1 and Per2 from retinal neurons leads to retinal angiogenic defects, indicating that a dysregulated circadian clock primarily drives neovascularization.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Kee-Beom Kim, Dong-Wook Kim, Youngchul Kim, Jun Tang, Nicole Kirk, Yongyu Gan, Bongjun Kim, Bingliang Fang, Jae-ll Park, Yi Zheng, Kwon-Sik Park
Summary: This study characterizes the activity of the WNT pathway in small cell lung cancer (SCLC) and identifies the key role of the WNT5A-RHOA axis in SCLC progression. It provides potential targets for therapeutic interventions and biomarkers to improve patient treatment.
Article
Multidisciplinary Sciences
Kei-ichi Katayama, Yi Zheng, Norimitsu Inoue
Summary: Granule neurons are the most common cell type in the cerebellum. Small Rho GTPases, such as Rac1 and Rac3, play important roles in the migration and development of granule neurons. Deletion of Rac1 and Rac3 genes leads to impaired migration and reduced number of granule neurons, with Rac1 deficiency causing neuronal death prior to migration to the internal granule layer.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Minoru Hatayama, Kei-ichi Katayama, Yukie Kawahara, Hayato Matsunaga, Noriko Takashima, Yoshimi Iwayama, Yoshifumi Matsumoto, Akinori Nishi, Takeo Yoshikawa, Jun Aruga
Summary: Loss of SLITRK1 gene results in altered behavior and increased noradrenergic projections in OCD-related neural circuits. SLITRK1 function is impaired by mutations in patients with schizophrenia and bipolar disorder. This study further elucidates the role of noradrenaline in controlling the development of OCD-related neural circuit.
COMMUNICATIONS BIOLOGY
(2022)
Editorial Material
Construction & Building Technology
Kevin W. Houser, Lisa Heschong, Richard Lang
Article
Cell Biology
Jacob R. Enriquez, Heather A. McCauley, Kevin X. Zhang, J. Guillermo Sanchez, Gregory T. Kalin, Richard A. Lang, James M. Wells
Summary: This study investigates the immediate response of the intestinal epithelium to a high-fat diet using physiological metrics and single-cell transcriptomics. The findings indicate that mice exhibit altered whole-body physiology and increased intestinal epithelial proliferation within one day of high-fat diet exposure. Furthermore, the study reveals a shift towards fatty acid metabolism and an emergence of progenitor cells in response to the high-fat diet.
Article
Multidisciplinary Sciences
Kevin P. Gaitonde, Mutahar Andrabi, Courtney Burger, Shane F. D'Souza, Shruti A. Vemaraju, Bala S. C. Koritala, David Smith, Richard Lang
Summary: Neurons in the hypothalamic preoptic area (POA) regulate homeostatic processes such as thermoregulation and sleep. The QPLOT neurons in the POA, identified by molecular markers, have GPCR signaling pathways that play a crucial role in metabolism regulation.
Article
Immunology
Katsuichi Miyamoto, Mai Minamino, Motoi Kuwahara, Hiroshi Tsujimoto, Katsuki Ohtani, Nobutaka Wakamiya, Kei-ichi Katayama, Norimitsu Inoue, Hidefumi Ito
Summary: Complement is implicated in the development of neuroimmune diseases, but its precise pathological roles are not fully understood. This study retrospectively analyzed serum levels of complement factors in patients with NMOSD and GBS to identify potential biomarkers for disease status prediction. The findings suggest that complement biomarkers, including Ba, sC5b-9, and CFH, in peripheral blood may be useful in understanding the pathological status of NMOSD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Toshihiko Nishioka, Kei-ichi Katayama, Shinji Kumegawa, Kyoichi Isono, Takashi Baba, Hiroshi Tsujimoto, Gen Yamada, Norimitsu Inoue, Shinichi Asamura
Summary: Lymphedema is a complex disease and its molecular pathogenesis is not well understood. This study suggests that complement activation may play a role in the progression of lymphedema, and the accumulation of dead cells due to C3 deficiency may lead to increased infiltration of CD4(+) T cells.
Article
Neurosciences
Brian A. Upton, Gowri Nayak, Ivy Schweinzger, Shane P. D'Souza, Charles V. Vorhees, Michael T. Williams, Brian R. Earl, Richard A. Lang
Summary: Opn3 is the first nonvisual opsin gene discovered in mammals and it is expressed in both the central nervous system and peripheral tissues. The behavioral consequences of Opn3 deficiency were investigated and it was found that Opn3-deficient mice perform similarly to wild-type mice in most behavioral tests, but have an attenuated acoustic startle reflex.