Article
Oncology
Nai-Shan Zheng, Xiang-Yu Zhao, Ding Wei, Jin-Lin Miao, Ze-Kun Liu, Yu-Le Yong, Ren-Yu Zhang, Yi-Xiao Guo, Lin He, Bin Wang, Xiu-Xuan Sun, Hai-Jiao Yang, Tian-Jiao Zhang, Qian He, Xiao-Min Li, Hai Zhang, Rong Hou, Peng Lin, Ying-Ming Xu, Xiao-Jun Huang, Zhi-Nan Chen, Huijie Bian
Summary: CD147-CAR T cell therapy shows potent anti-tumor activity against T cell acute lymphoblastic leukemia (T-ALL) and potential safety towards normal cells and CD147-deficient cells.
Article
Hematology
Nico Gagelmann, Gerald Georg Wulf, Johannes Duell, Bertram Glass, Pearl van Heteren, Bastian von Tresckow, Monika Fischer, Olaf Penack, Francis Ayuk, Herrmann Einsele, Udo Holtick, Julia Thomson, Peter Dreger, Nicolaus Kroeger
Summary: Hematotoxicity after CAR-T therapy can be managed with hematopoietic stem cell boost (HSCB), which showed a quick response and improved outcomes for sustained moderate to severe neutropenia. 31 patients received HSCB, with an overall neutrophil response rate of 84% and a median response time of 9 days. Patients with shorter duration of neutropenia had significantly better survival outcomes compared to those with longer duration. The 1-year overall survival rate was 59%.
Review
Immunology
Emma L. Bishop, Nancy Gudgeon, Sarah Dimeloe
Summary: Dynamic metabolic pathway changes play a key role in regulating T cell activity, with tissue microenvironment influencing metabolic status and overall phenotype. Interaction with cytokines and hormones are additional signals integrated by T cells to determine their metabolic phenotype and immune function. Further research on these interactions and mechanisms is important for understanding T cell metabolism and its implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yutong Liu, Kwasi Adu-Berchie, Joshua M. Brockman, Matthew Pezone, David K. Y. Zhang, Jingyi Zhou, Jason W. Pyrdol, Hua Wang, Kai W. Wucherpfennig, David J. Mooney
Summary: This study uses nanotechnology to improve adoptive T cell transfer (ACT) therapies by metabolically labeling T cells with unnatural sugar nanoparticles, allowing direct conjugation of antitumor cytokines onto the T cell surface. This approach effectively enhances the efficacy of ACT therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Yunmin Jung
Summary: This review summarizes the current understanding of the pre-organization of key surface receptors on the plasma membrane of resting T cells and discusses their potential role in early T cell activation events.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Erica Franceschini, Sara De Biasi, Margherita Digaetano, Elena Bianchini, Domenico Lo Tartaro, Lara Gibellini, Marianna Menozzi, Stefano Zona, Giuseppe Tarantino, Milena Nasi, Mauro Codeluppi, Giovanni Guaraldi, Paolo Magistri, Fabrizio Di Benedetto, Marcello Pinti, Cristina Mussini, Andrea Cossarizza
Summary: This study examined changes in T-cell phenotype and function in HIV+ and HIV- patients undergoing immunosuppressive treatment after orthotopic liver transplant (OLT). The findings showed that HIV- transplant patients had more exhausted or inflammatory T cells compared to HIV+ transplant patients, potentially due to previous immunosuppression from HIV infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Patricia de Leon, Rodrigo Canas-Arranz, Sira Defaus, Elisa Torres, Mar Forner, Maria J. Bustos, Concepcion Revilla, Javier Dominguez, David Andreu, Esther Blanco, Francisco Sobrino
Summary: Based on the experiments, dendrimeric peptide constructs that display both B-cell and T-cell epitopes play a key role in the development of foot-and-mouth disease virus (FMDV) vaccines. The T-3D peptide was identified as an immunodominant epitope, inducing more IFN-gamma expressing cells in pigs. CD4(+) T-cells were the major subset contributing to IFN-gamma expression upon in vitro recall, with most CD4(+)IFN-gamma(+) cells showing a memory and multifunctional phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Matthew Bell, Stephen Gottschalk
Summary: CAR T cell therapy is effective for hematological malignancies, but there is a need to improve its efficacy for solid tumors and brain tumors. Several approaches are being pursued to enhance the antitumor activity of CAR T cells, including augmenting signal 3 of T cell activation and improving the function of CAR T cells in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Juan Carlos Ruiz-Rodriguez, Luis Chiscano-Camon, Adolf Ruiz-Sanmartin, Clara Palmada, Ivan Bajana, Gloria Iacoboni, Camilo Bonilla, Alejandra Garcia-Roche, Erika Paola Plata-Menchaca, Carolina Maldonado, Marcos Perez-Carrasco, Monica Martinez-Gallo, Clara Franco-Jarava, Manuel Hernandez-Gonzalez, Ricard Ferrer
Summary: This case report discusses the treatment process of a HLH patient, including diagnosis, treatment options, and the effectiveness of using Cytosorb(R) for cytokine hemoadsorption. Through cytokine hemoadsorption therapy, the patient's cytokine levels were successfully reduced, leading to significant hemodynamic improvement.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Nicholas N. Jarjour, Kelsey M. Wanhainen, Changwei Peng, Noah V. Gavil, Nicholas J. Maurice, Henrique Borges da Silva, Ryan J. Martinez, Talia S. Dalzell, Matthew A. Huggins, David Masopust, Sara E. Hamilton, Stephen C. Jameson
Summary: Interleukin-15 (IL-15) is a central regulator of memory CD8+ T cells and can stimulate their proliferation and expansion. IL-15 sensitivity is an important feature of memory CD8+ T cell populations, with therapeutic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Molly Javier Uyeda, Robert A. A. Freeborn, Brandon Cieniewicz, Rosa Romano, Ping (Pauline) Chen, Jeffrey Mao-Hwa Liu, Benjamin Thomas, Esmond Lee, Alma-Martina Cepika, Rosa Bacchetta, Maria Grazia Roncarolo
Summary: This study reveals that BHLHE40 is highly expressed in human Tr1 cells and regulates CD4(+) T cells by inhibiting IL-10 and promoting IFN-gamma secretion. Although BHLHE40 is not essential for differentiation of CD4(+) T cells into Tr1 cells, its overexpression induces the expression of specific surface markers. These findings highlight a novel mechanism for BHLHE40 as a regulator of IL-10 and IFN-gamma in human T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Mark Lukas Muller, Lars Peglau, Lawrence D. F. Moon, Stefan Gross, Juliane Schulze, Johanna Ruhnau, Antje Vogelgesang
Summary: NT-3 has an attenuating effect on immune responses in cells from stroke patients and controls, possibly mediated through regulation of TrkC receptors. Treatment with NT-3 reduces the percentage of activated cells and decreases the production of cytokines, except for IL-21.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aigul Kh. Valiullina, Ekaterina A. Zmievskaya, Irina A. Ganeeva, Margarita N. Zhuravleva, Ekaterina E. Garanina, Albert A. Rizvanov, Alexey V. Petukhov, Emil R. Bulatov
Summary: In recent years, adoptive cell therapy has gained new applications in the field of oncology, particularly with the development of CAR-T cells for treating malignant B-cell neoplasms. However, the use of CAR-T therapy for solid tumors remains a challenge. This study evaluated the cytotoxicity of 2nd generation CAR-T cells on various solid tumor cell lines and demonstrated a correlation between cytokine secretion and tumor cell confluence. This approach may have potential for assessing CAR-T cell efficacy and cytokine release syndrome risks in solid tumor treatment.
Article
Immunology
Sabine Tischer-Zimmermann, Elisabeth Salzer, Tamires Bitencourt, Nelli Frank, Christine Hoffmann-Freimueller, Julia Stemberger, Britta Maecker-Kolhoff, Rainer Blasczyk, Volker Witt, Gerhard Fritsch, Wolfgang Paster, Thomas Lion, Britta Eiz-Vesper, Rene Geyeregger
Summary: This study aims to improve the manufacturing process of Aspergillus fumigatus-specific T cells (ATCs) and enable immediate and sustained treatment for patients with invasive aspergillosis (IA). The results showed that the use of Asp-lysate as stimulation resulted in a significantly higher enrichment efficiency of IFN-gamma(+) ATCs compared to PepMix. Additionally, predominantly CD4(+) helper T cells with a central-memory phenotype were expanded, while CD8(+) T cells mainly showed an effector-memory phenotype, regardless of the stimulus.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Alicia S. Wilson, Katrina L. Randall, Jessica A. Pettitt, Julia Ellyard, Antje Blumenthal, Anselm Enders, Benjamin J. Quah, Tobias Bopp, Christopher R. Parish, Anne Bruestle
Summary: This study reveals the mechanism by which neutrophil extracellular traps (NETs) directly activate T cells and specifically enhance Th17 cell differentiation. This suggests a direct link between neutrophils, NETs, and T cell autoimmunity.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Igor Sazonov, Dmitry Grebennikov, Andreas Meyerhans, Gennady Bocharov
Summary: Mathematical modelling is important for understanding the infection process of SARS-CoV-2 in cells. This study transforms a deterministic model into a stochastic one and uses it to compute statistical characteristics of the virus's life cycle. The results show the strong inhibitory effects of type I IFN response on viral progeny.
Article
Mathematics
Nicholas Bessonov, Gennady Bocharov, Vitaly Volpert
Summary: This paper discusses a nonlocal reaction-diffusion equation that describes the development of viral infection in tissue, considering the distribution of viruses in the space of genotypes, the antiviral immune response, and genotype-dependent virus death. The study shows that infection spreads as a reaction-diffusion wave. By reducing the 2D problem to a 1D problem, the existence and stability of the wave can be proven in some specific cases. In general, this reduction provides an approximation of the 2D problem. The analysis of the reduced problem helps determine how viral load and virulence depend on genotype distribution, immune response strength, and immunity level.
Article
Ecology
Anton A. Goncharov, Anna S. Gorbatova, Alena A. Sidorova, Alexei Tiunov, Gennady A. Bocharov
Summary: The study aimed to reconstruct the kinetic mechanisms determining the biomass of Fusarium species in agroecosystems and find optimal ways to manipulate detrital food web structure to minimize Fusarium contamination. The research identified three model parameters with the strongest impact on Fusarium biomass, highlighting promising mechanisms to reduce Fusarium species in soil.
ECOLOGICAL MODELLING
(2022)
Article
Oncology
Sara Fioretti, Courtney A. Matson, Kenneth M. Rosenberg, Nevil J. Singh
Summary: Research shows that under CAR-T cell immunotherapy, normal B cells can downregulate the expression of CD19 to evade attack, and this downregulation is reversible. This finding is significant for improving immunotherapy and minimizing B cell depletion during treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Gennady Bocharov, Dmitry Grebennikov, Paula Cebollada Rica, Eva Domenjo-Vila, Valentina Casella, Andreas Meyerhans
Summary: This study describes recent progress in the clinical handling of chronic virus infections and emphasizes the understanding of virus-host interaction dynamics as well as the involvement of multiple immune system components in functional cure strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Mathematics
Alexander S. Bratus, Nicholas Leslie, Michail Chamo, Dmitry Grebennikov, Rostislav Savinkov, Gennady Bocharov, Daniil Yurchenko
Summary: Pancreatic cancer is a challenging issue in contemporary medicine due to its slow development, specific location, and symbiotic effect between cancer and normal cells. This study formulates and calibrates a mathematical model for pancreatic cancer using the quasispecies framework. The model incorporates mutation probabilities, cell death rates, and the elimination of cancer cells by CD8 T cells. The computational predictions obtained from the model are consistent with empirical data, suggesting its potential for investigating other types of cancer and treatment procedures.
Article
Mathematics
Dmitry Grebennikov, Antonina Karsonova, Marina Loguinova, Valentina Casella, Andreas Meyerhans, Gennady Bocharov
Summary: A mathematical model of the immune response to SARS-CoV-2 infection has been developed and calibrated using data from human challenge studies. The model helps us understand the pathogenesis of COVID-19 and predict patient infectivity.
Article
Mathematics, Applied
Dmitry S. Grebennikov, Valerya V. Zheltkova, Gennady A. Bocharov
Summary: This study elaborates a computational framework to characterize the complexity of mathematical models in immunology. The framework uses the Minimum Description Length criterion to balance the goodness-of-fit and complexity of the models. The study also evaluates key numerical details of four immune response models.
RUSSIAN JOURNAL OF NUMERICAL ANALYSIS AND MATHEMATICAL MODELLING
(2022)
Article
Virology
Igor Sazonov, Dmitry Grebennikov, Rostislav Savinkov, Arina Soboleva, Kirill Pavlishin, Andreas Meyerhans, Gennady Bocharov
Summary: A mathematical model of HIV-1 life cycle in CD4 T cells was developed, which accounts for the activation of IFN-I response and its suppression of viral replication. The model includes inhibition of viral replication by IFN-induced antiviral factors and their inactivation by viral proteins Vpu and Vif. Both deterministic and stochastic models were constructed to predict the efficiency of IFN-I-induced suppression in different initial conditions, and the heterogeneity of HIV-1 and IFN-I production was characterized statistically.
Article
Biochemical Research Methods
Michael Khristichenko, Yuri Nechepurenko, Dmitry Grebennikov, Gennady Bocharov
Summary: In this work, we present our technology for computing periodic solutions of time-delay systems and discuss its application to the Marchuk-Petrov model of hepatitis B infection. We identify regions in the model parameter space where oscillatory dynamics in the form of periodic solutions exist. These solutions can be interpreted as active forms of chronic hepatitis B. By tracking the period and amplitude of oscillatory solutions, we study the efficacy of antigen presentation by macrophages for T- and B-lymphocytes in the model.
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
(2023)
Article
Immunology
Zvi Grossman, Andreas Meyerhans, Gennady Bocharov
Summary: The systemic bio-organization of humans and other mammals is preprogrammed, but cells can acquire new properties and functions through tuning, re-networking, chromatin remodeling, and adaptive differentiation. Cellular sensory and response properties are shaped by temporal patterns of the signaling environment, comparable to associative brain learning. Efforts to therapeutically enhance the immune system and tissue responses can take advantage of existing integrative modeling approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Alejandro V. Villarino, Arian D. J. Laurence, Fred P. Davisi, Luis Nivelo, Stephen R. Brooks, Hong-Wei Sun, Kan Jiang, Behdad Afzali, Daniela Frasca, Lothar Hennighausen, Yuka Kanno, John J. O'Shea
Summary: This study reveals that STAT5 is a crucial regulator of energy and amino acid metabolism in CD4+ T helper cells, and it plays a role in transcriptional regulation of key enzymes and transporters. Additionally, STAT5 interacts with the mTOR signaling pathway and MYC transcription factor to regulate T-cell metabolism.
SCIENCE IMMUNOLOGY
(2022)
Article
Virology
Anna Toptygina, Dmitry Grebennikov, Gennady Bocharov
Summary: This study aimed to identify biomarkers that can predict the levels of specific immune responses after measles-mumps-rubella vaccination. The researchers measured baseline immune status parameters and response variables in 19 individuals, and found statistically significant correlations between them. They used three feature selection strategies to select predictors and identified optimal linear regression models for predicting vaccination effectiveness against measles-mumps-rubella.
Article
Cell Biology
Eva Domenjo-Vila, Valentina Casella, Ryutaro Iwabuchi, Even Fossum, Mireia Pedragosa, Quim Castellvi, Paula Cebollada Rica, Tsuneyasu Kaisho, Kazutaka Terahara, Gennady Bocharov, Jordi Argilaguet, Andreas Meyerhans
Summary: The contribution of XCR1+ dendritic cells (DCs) and SIRPa+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections is poorly understood. In a mouse model of chronic LCMV infection, XCR1+ DCs were found to be more resistant to infection and highly activated compared to SIRPa+ DCs. Exploiting XCR1+ DCs through expansion or vaccination improved CD8+ T cell functionality and virus control. PD-L1 blockade was found to be more effective when combined with increased frequency of XCR1+ DCs, enhancing the functionality of exhausted CD8+ T cell subsets.
Article
Mathematics
Gennady Bocharov, Willi Jaeger, Jonas Knoch, Maria Neuss-Radu, Manfred Thiel
Summary: The study developed a mathematical model describing the cellular energy metabolism reprogramming under hypoxia, calibrated with over sixty parameters using published data and steady-state identification procedure. The validated model accurately predicted cell metabolism switching behaviors in response to transitioning from normoxic to hypoxic environments, consistent with current understanding of HIF-1's role in hypoxia.
VIETNAM JOURNAL OF MATHEMATICS
(2021)