Review
Chemistry, Multidisciplinary
Farhad Soheilmoghaddam, Madeleine Rumble, Justin Cooper-White
Summary: Many existing clinical treatments are limited in their ability to completely restore decreased or lost tissue and organ function. The increasing demand for new medical interventions has led to the development of promising fields such as gene therapy, tissue engineering, and regenerative medicine. Success in these fields relies on biomaterials that provide necessary biological cues for cell fate, necessitating a shift towards rapid synthesis and characterization practices.
Article
Biology
Aude I. Segaliny, Jayapriya Jayaraman, Xiaoming Chen, Jonathan Chong, Ryan Luxon, Audrey Fung, Qiwei Fu, Xianzhi Jiang, Rodrigo Rivera, Xiaoya Ma, Ci Ren, Jan Zimak, Per Niklas Hedde, Yonglei Shang, George Wu, Weian Zhao
Summary: Researchers have developed a high throughput, single-cell functional screening platform for efficient discovery and isolation of rare functional bispecific antibodies (BsAbs). The platform demonstrated high screening efficiency in a CD19xCD3 BiTE model and identified novel BiTEs with unique properties. This single-cell platform has the potential to increase the discovery efficiency of new immunotherapeutics and enable the design of generalizable principles based on an in-depth understanding of sequence, structure, and function relationships.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Katharina A. Fransen, Sarah H. M. Av-Ron, Tess R. Buchanan, Dylan J. Walsh, Dechen T. Rota, Lana Van Note, Bradley D. Olsen
Summary: The development of biodegradable plastics has been driven by the increasing plastic pollution. However, limited research on polymer biodegradation has hindered innovation due to costly and slow measurement methods. To tackle this issue, a high-throughput polymer synthesis and biodegradation method were utilized to generate a dataset for 642 chemically distinct polyesters and polycarbonates. The results showed that biodegradability depended on the length of the aliphatic repeat unit, with shorter chains and side chains improving biodegradability. Aromatic backbone groups generally hindered biodegradability, but ortho- and para-substituted benzene rings were more degradable than meta-substituted rings. In addition, ether groups in the backbone improved biodegradability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Physical
Matthew Bain, Jose L. Godinez Castellanos, Stephen E. Bradforth
Summary: High-repetition-rate lasers have the potential to revolutionize ultrafast spectroscopy by enabling routine analysis for machine learning models in the design of photochemical syntheses. In this study, we combine innovations in line scan cameras and micro-electro-mechanical grating modulators with high-pressure liquid chromatography pumps to develop a transient absorption spectrometer that can characterize photoreactions in minutes. Additionally, we demonstrate the utility of this technique in exploring the effects of conformational modification on excited-state processes.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Alice M. Shipley, Michael J. Hutcheon, Richard J. Needs, Chris J. Pickard
Summary: This study examines the landscape of binary hydrides across the periodic table from 10 to 500 GPa using a crystal structure prediction method, establishes a critical temperature model to predict potential high-temperature superconductors, and conducts optimizations to speed up calculations. It identifies 36 dynamically stable superconductors above 100 K, with 18 exhibiting superconductivity above 200 K.
Article
Chemistry, Multidisciplinary
Xiao Lu, Zhiji Luo, Ruili Huang, Donald C. Lo, Wenwei Huang
Summary: The efficiency and scalability of detecting the formation of new chemical bonds in high-throughput synthesis is limited by conventional, time-consuming, and labor-intensive methods for product detection. This study presents a miniaturizable purification method using inexpensive equipment to rapidly and efficiently isolate quaternary ammonium-tagged products from reaction mixtures, enabling the establishment of a high-throughput reaction discovery platform. Through validation in a screen of 1536 reactions, one previously unreported transformation was identified.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
Jiahong Shen, Vinay I. Hegde, Jiangang He, Yi Xia, Chris Wolverton
Summary: This study aims to explore the potential applications of mixed-anion materials and provides numerous possible synthesis directions through theoretical research. It predicts that many new ternary oxypnictides may be stable and synthesizable, and offers experimental synthesis guidance for tungsten oxynitride.
CHEMISTRY OF MATERIALS
(2021)
Article
Multidisciplinary Sciences
Haiyan Wang, Shasha Li, Qianyu Wang, Zhengshuo Jin, Wei Shao, Yan Gao, Lu Li, Kequan Lin, Lin Zhu, Huili Wang, Xuebin Liao, Dong Wang
Summary: Combination immunotherapy using AKIs has been found to reprogram TIP gene expression, promote T cell infiltration in TNBC, and enhance the efficacy of PD-1, suggesting a novel strategy for discovering combination immunotherapy compounds.
Review
Pharmacology & Pharmacy
Qi Xiao, Fangfei Zhang, Luang Xu, Liang Yue, Oi Lian Kon, Yi Zhu, Tiannan Guo
Summary: This paper summarizes the advances and limitations of biomarkers in cancer research, as well as the important applications of mass spectrometry technology in proteomics. The article emphasizes the role of artificial intelligence technology in clinical studies, as well as the importance of combining computational and statistical methods in biomarker research.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Tsvia Gildor, Mark R. Winter, Majed Layous, Eman Hijaze, Smadar Ben-Tabou de-Leon
Summary: Biomineralization is the process where soft tissues utilize minerals to produce shells, skeletons, and teeth for protection and support. Cells have the remarkable ability to control crystal nucleation, orientation, and stiffness, surpassing current human technologies. Understanding this biological control can advance knowledge of embryo development and offer new approaches to material engineering.
JOURNAL OF STRUCTURAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Elias Taylor, Hannah Wynen, Andreas Heyland
Summary: Thyroid hormones have diverse physiological and developmental functions in animals and can activate both genomic and non-genomic signaling pathways. In sea urchin development, thyroid hormones regulate gene expression through both genomic and non-genomic mechanisms, with genomic signaling being more prominent during later stages of larval development.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Yiwei Zhang, Jiabei Guo, Jiongjia Cheng, Zhenghua Zhang, Fenghua Kang, Xiaoxing Wu, Qian Chu
Summary: Therapeutic peptides have revolutionized treatment for many human diseases. In recent decades, stapled helical peptides have made rapid progress in drug discovery. Compared to unstabilized linear peptides, stapled helical peptides have shown superior binding affinity, selectivity, membrane permeability, and metabolic stability, offering exciting potential for targeting challenging protein-protein interfaces. This Perspective summarizes the recent use of high-throughput screening technologies for identifying potent stapled helical peptides with optimized binding properties, aiming to accelerate the development of stapled helical peptides as the next generation of therapeutic peptides for various human diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Developmental Biology
Abdull J. Massri, Laura Greenstreet, Anton Afanassiev, Alejandro Berrio, Gregory A. Wray, Geoffrey Schiebinger, David R. McClay
Summary: By using scRNA-seq and computational methods, researchers studied the transcriptional changes in cell states of sea urchin embryos from development to larval stage. They found that skeletogenic and primordial germ cell trajectories diverged early, and ectodermal progenitors were distinct from other lineages by the 6th cleavage. Endomesoderm cells originated at the 6th cleavage and diverged into endoderm and mesoderm fates asynchronously.
Article
Immunology
Megan A. Barela Hudgell, L. Courtney Smith
Summary: The SpTrf gene family from the California purple sea urchin is upregulated upon immune challenge and encodes proteins that interact with pathogens. The appearance of gene clusters may have been driven by multiple duplication and deletion events, resulting in the extant genes and family structure. The theoretical evolutionary history of these genes suggests that they have been selected for based on the survival benefits of pathogen binding and host protection in responses to pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xinyu Li, Javen Qinfeng Shi, Alister J. Page
Summary: Despite the current challenges in commercial-scale graphene production using chemical vapor deposition (CVD), this study introduces a new approach combining high-throughput density functional theory and machine learning to identify new prospective catalyst materials with comparable performance to established catalysts. The approach discovered combinations of early- and late-transition metals, including unconventional partners like Zr, Hf, and Nb. This study highlights the importance of finding novel catalyst materials for CVD growth of low-dimensional nanomaterials.