Article
Plant Sciences
Chun Fai Wong, Cheuk Ka Poon, Tsz Wai Ng, Hok Him Pan, Eng Cheng Khaw, Ki Fong Tsang, Yan Wing Mui, Yuk Hong Lo, Mui Fung Hao, Chun Hay Ko
Summary: This study evaluated the anti-inflammatory and toxicology effects of H. cordata essential oil-containing formulation, H16 aerosol, in vivo. The study found that H16 aerosol had anti-inflammatory and antipyretic effects, and it was safe for use. This suggests that H16 aerosol could be a new herbal therapy and contribute to the modernization of herbal medicine.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zhao Wu, Xinyu Deng, Qichao Hu, Xiaolin Xiao, Jing Jiang, Xiao Ma, Mingquan Wu
Summary: Houttuynia cordata, a traditional medicinal plant widely used in Asia, contains flavonoids and volatile oils as its main active components. It demonstrates immunomodulatory, anti-inflammatory, and antibacterial properties. Studies have shown its significant effects in treating lung cancer, liver cancer, and other tumors.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Si Wang, Lei Li, Yuhan Chen, Qian Liu, Shengyu Zhou, Ning Li, Yueying Wu, Jiali Yuan
Summary: This article summarizes the potential mechanisms by which Houttuynia cordata thunb. and related traditional Chinese medicine preparations alleviate inflammatory bowel disease (IBD) by regulating the intestinal microenvironment. It also discusses the medicinal and edible safety of Houttuynia cordata thunb., providing ideas for further research and development and more treatment options for IBD patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Medicinal
Shahzad Rafiq, Haihong Hao, Muhammad Ijaz, Ahmed Raza
Summary: Houttuynia cordata is a widely distributed herbaceous plant in Asia, known for its multiple chemical constituents and medicinal properties. It has anti-inflammatory, anti-bacterial, anti-viral, anti-oxidant, and antitumor effects, and regulates immunity. However, further research is needed to understand its mechanisms of action.
Review
Agronomy
Qing Luo, Ping-Hong Meng, Da-Wei Jiang, Zhong-Ming Han, Zhen-Hui Wang, Guo-Fei Tan, Jian Zhang
Summary: This review summarizes studies on the phyto-physiological chemistry, molecular biology, and genomics of Houttuynia cordata Thunb. It provides a basis for genetic breeding, genomic advance, and cultivation of this valuable plant resource for medicinal applications and vegetable production.
Article
Biochemistry & Molecular Biology
Chen-Hsiang Lin, Louis Kuoping Chao, Li-Yun Lin, Chin-Sheng Wu, Lee-Ping Chu, Chien-Hsueh Huang, Hsin-Chun Chen
Summary: This study identified the volatile compounds in H. cordata using HS-SPME and direct injection combined with GC and GC-MS. Different parts of the plant were found to contain different compounds. The leaves contained (Z)-3-hexenal, beta-myrcene, etc., the stems contained geranyl acetate and nerolidol, and the rhizomes contained alpha-pinene, beta-pinene, etc. HS-SPME extraction produced more monoterpenes, while direct injection had higher contents of aliphatic ketones, terpene esters, etc.
Article
Biochemistry & Molecular Biology
Mingyue Zou, Xiaobo Hu, Yujing Wang, Junhui Wang, Fangyuan Tang, Yong Liu
Summary: In this study, a hot buffer soluble Houttuynia cordata polysaccharide (HBHP-3) with a molecular weight of 397.4 kDa was isolated. HBHP-3 effectively inhibited NO secretion and the mRNA expression of pro-inflammatory cytokines in macrophages in a dose-dependent manner. Furthermore, HBHP-3 inhibited the activation of the NF-Kappa B pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemical Research Methods
Haitao Du, Jie Ding, Ping Wang, Guisheng Zhang, Dandan Wang, Qingyun Ma, Na Li, Tiefeng Sun
Summary: This study investigated the anti-RSV mechanism of Houttuynia cordata Thunb using network pharmacology and bioinformatics, identifying potentially active compounds, targets, and pathways. The results suggest that H. cordata Thunb exerts its anti-RSV effect by regulating several key signaling pathways.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Biology
Arun Bahadur Gurung, Mohammad Ajmal Ali, Joongku Lee, Mohammad Abul Farah, Khalid Mashay Al-Anazi, Fahad Al-Hemaid
Summary: The study explores the potential of bioactive compounds from H. cordata as inhibitors of the SARS-CoV-2 RdRp enzyme, identifying several active constituents with high affinity for the drug target. Molecular docking experiments demonstrate stable complexes between these compounds and the target enzyme, with analysis revealing key residues contributing significantly to binding free energy through MM-PBSA and MM-GBSA.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Ecology
Lei Liu, Lingliang Guan, Haoxiang Zhao, Yi Huang, Qiuyu Mou, Ke Liu, Tingting Chen, Xuying Wang, Ying Zhang, Bo Wei, Jinyao Hu
Summary: The study used the Maxent model to simulate the potential distribution of Houttuynia cordata under current and future climate scenarios. It found that the suitable habitat area of H. cordata is mainly affected by factors such as annual precipitation and temperature. The simulation results showed an increasing trend in the suitable regional area of H. cordata under different climate change scenarios, with expansion towards the north.
ECOLOGICAL INFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Hien Giang Pham, Manh Tuan Ha, Thao Quyen Cao, Thi Thanh Le, Byung Sun Min
Summary: The chemical investigation of Houttuynia cordata Thunb. led to the isolation of nine alkaloids. The structures of the isolated compounds were characterized based on NMR spectroscopy and comparison with literature values. This study reported the isolation of compound 6 (N-benzoyl tyramine) from the family Saururaceae and compound 9 (2,3-dihydroxy-4(hydroxymethyl)-tetrahydrofuran-l-yl]pyridine-4,5-diol) from plant origin for the first time. These findings contribute to the understanding of the chemotaxonomic knowledge of H. cordata.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Peifu Kong, Junichi Peter Abe, Akiko Nakagawa-izumi, Mikio Kajiyama, Toshiharu Enomae
Summary: This study developed an antibacterial agent for food packaging using Houttuynia cordata Thunb. essential oils extracted and encapsulated with beta-cyclodextrins. The encapsulated extract showed significant inhibitory activity against Bacillus subtilis.
Article
Plant Sciences
Tin-Yun Ho, Hsin-Yi Lo, Guan-Ling Lu, Pei-Yung Liao, Chien-Yun Hsiang
Summary: This study used bioluminescent imaging and gene expression profiling to demonstrate, for the first time, that Houttuynia cordata has lung meridian-guiding effects and exhibits potent anti-inflammatory potential in the upper respiratory tract. The NF-κB and IL-18 pathways are associated with the anti-inflammatory mechanism of Houttuynia cordata against LPS-induced airway inflammation. Additionally, chlorogenic acid and quercitrin may be involved in the anti-inflammatory properties of Houttuynia cordata.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nan Wang, Yanbin Zhu, Dandan Li, Wangdui Basang, Yiqiu Huang, Kening Liu, Yuxin Luo, Lu Chen, Chunjin Li, Xu Zhou
Summary: The main volatile oil component 2-methyl nonyl ketone (MNK) from Houttuynia Cordata Thunb (H.cordata) has been found to have a protective effect against lipopolysaccharide (LPS)-induced mastitis. MNK enhanced cell viability, reduced reactive oxygen species (ROS) production and inflammatory response. It inhibited the activation of Toll-like receptor 4-nuclear factor-kappa B (TLR4-NF-kappa B) signaling pathway and reduced the production of pro-inflammatory cytokines. MNK also induced Heme Oxygenase-1 (HO-1) production through the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Applied
Shuai Zhang, Huixia Zhang, Shiqi Chen, Liu Yang, Xin Chen, Haiyang Jiang
Summary: This study used GC-MS and chemometrics to determine the types and relative contents of volatile substances, especially 2-undecanone, in different parts of Houttuynia cordata Thunb. The results showed that the accumulation of 2-undecanone, D-limonene, and alpha-pinene were significantly higher in subterranean stems than in other organs. The study also identified the related KEGG pathway-limonene and pinene degradation. These findings can serve as a reference for the industrial extraction and utilization of volatile compounds from different parts of Houttuynia cordata Thunb.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)