Article
Biochemistry & Molecular Biology
Balint Botz, Gabor Kriszta, Kata Bolcskei, Adam Istvan Horvath, Attila Mocsai, Zsuzsanna Helyes
Summary: The study showed that capsaicin-sensitive peptidergic sensory nerves play a crucial anti-inflammatory role in the early phase of rheumatoid arthritis, characterized by reduced cellular and vascular inflammatory components through the release of anti-inflammatory neuropeptides. These fibers may serve as important gatekeepers in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Claire Bocciarelli, Nadege Cordel, Raphael Leschiera, Matthieu Talagas, Christelle Le Gall-Ianotto, Weiguo Hu, Pascale Marcorelles, Gaelle Bellemere, Stephanie Bredif, Joachim Fluhr, Laurent Misery, Nicolas Lebonvallet
Summary: Pruritus is a common symptom during acute ZIKV infection and is often associated with dysautonomic manifestations, suggesting involvement of the peripheral nervous system. This study aimed to develop a functional human model for ZIKV infection by co-culturing keratinocytes and sensory neurons derived from induced pluripotent stem cells. The expression of ZIKV entry receptors in these cells indicates the potential for ZIKV infection.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pawel Janikiewicz, Barbara Wasilewska, Urszula Mazur, Amelia Franke-Radowiecka, Mariusz Majewski, Agnieszka Bossowska
Summary: The study revealed that GUA significantly influences the sensory innervation of the porcine urinary bladder, potentially serving as a tool for investigating the plasticity of bladder innervation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhangfu Fang, Fang Yi, Yang Peng, Junfeng (Jim) Zhang, Liting Zhang, Zheng Deng, Fagui Chen, Chenhui Li, Yaowei He, Chuqin Huang, Qingling Zhang, Kefang Lai, Jiaxing Xie
Summary: The study demonstrated that the TRPA1 antagonist HC-030031 reduced airway inflammation and hyperresponsiveness in a murine allergic rhinitis model by targeting TRPA1, leading to decreased type-2 inflammation in nasal mucosa and improved nose-scratching events, as well as reduced leucocyte numbers and IL-8 levels in the BAL fluid.
Article
Immunology
Mikiko Okano, Kiyoshi Hirahara, Masahiro Kiuchi, Miki Onoue, Chiaki Iwamura, Kota Kokubo, Takahisa Hishiya, Yuki Morimoto, Yuzuru Ikehara, Akira Murakami, Nobuyuki Ebihara, Toshinori Nakayama
Summary: This study identified a subset of memory-type pathogenic Th2 cells that preferentially expressed IL1rl1-encoding ST2 and Calca-encoding calcitonin-gene-related peptide (CGRP) in the inflammatory conjunctiva. The IL-33-ST2-CGRP axis in memory Th2 cells controlled the axonal elongation of the peripheral sensory C-fiber and the induction of severe itch. It suggests that this axis could be a potential therapeutic target for severe itch in allergic conjunctivitis.
Article
Biotechnology & Applied Microbiology
B. Dnate' Baxter, Eric D. Larson, Laetitia Merle, Paul Feinstein, Arianna Gentile Polese, Andrew N. Bubak, Christy S. Niemeyer, James Hassell, Doug Shepherd, Vijay R. Ramakrishnan, Maria A. Nagel, Diego Restrepo
Summary: TRPM5-expressing microvillous cells may play a potential role in viral infection of the olfactory epithelium, involved in inflammatory response. Similar to SCCs and brush cells in the airway epithelium, and tuft cells in the intestine, the transcriptome of TRPM5-expressing microvillous cells suggests their likely involvement in the inflammatory response elicited by viral infection of the olfactory epithelium.
Article
Endocrinology & Metabolism
Yun Liu, Tiancheng Xu, Xuan Wang, Mengjiang Lu, Yaling Wang, Xin Song, Mingqian Yuan, Meirong Gong, Qian Li, Zhi Yu, Bin Xu
Summary: Electroacupuncture (EA) has a favorable impact on blood glucose stability, but prior research has not adequately considered sex differences. This study found that the TRPV1-CGRP-β cell pathway is crucial for maintaining glucose metabolism in male mice, while female mice have other routes for preserving glucose homeostasis. Additionally, male mice have a more pronounced sympathetic innervation of the pancreas, while female mice primarily rely on cholinergic pathways.
NEUROENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Attila Gabor Szollosi, Attila Olah, Erika Lisztes, Zoltan Griger, Balazs Istvan Toth
Summary: Pruritus, or itch, is a common symptom associated with various skin and immune disorders. Despite significant progress in understanding the molecular mechanisms behind acute and chronic itch, there are still gaps in our knowledge, making the clinical management of pruritic conditions challenging. Recent research has highlighted the interactions between pruriceptive sensory neurons and different cutaneous cell types, particularly in inflammatory conditions, where these cells release mediators that excite the itch-sensing fibers. There is also bidirectional communication, with sensory neurons releasing mediators that maintain an inflamed and itchy tissue environment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Francesco De Virgiliis, Valeria Maria Oliva, Burak Kizil, Christoph Scheiermann
Summary: The nervous system communicates with immune cells through neurotransmitters and neuropeptides to respond to immune threats and maintain system homeostasis. Lymph nodes, as the sites of adaptive immune responses, are extensively innervated by peripheral nerves that secrete neurotransmitters and neuropeptides. Time-dependent fluctuations in nerve activity may play a role in coordinating immunity in a circadian fashion.
TRENDS IN NEUROSCIENCES
(2022)
Article
Neurosciences
Dustin P. Green
Summary: The Mas-related G-protein-coupled receptor (Mrgpr) family, known for their functional diversity, plays a role in both itch and pain modulation. Originally characterized in small-diameter nociceptive neurons, recent discoveries suggest that Mrgpr's may provide a new target for the treatment of pathological pain.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Xulin Li, Liping Wang
Summary: This article introduces the importance of communication between the nervous system and the viscera in maintaining homeostasis, as well as the application of emerging techniques in research.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Critical Care Medicine
Raquel Cuevas-Diaz Duran, Yong Li, Anibal Garza Carbajal, Yanan You, Carmen W. Dessauer, Jiaqian Wu, Edgar T. Walters
Summary: Chronic pain caused by neuropathic conditions is associated with changes in gene and protein expression in sensory neurons. Comparison of transcriptional signatures of DRGs across different models can highlight pain-associated alterations. These findings show that DRGs exhibit complex transcriptional responses to neural and tissue injury, and certain genes may play a fundamental role in promoting neuropathic pain.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Cell & Tissue Engineering
Putianqi Wang, Noelyn Kljavin, Thi Thu Thao Nguyen, Elaine E. Storm, Bryan Marsh, Jian Jiang, William Lin, Hari Menon, Robert Piskol, Frederic J. de Sauvage
Summary: Neurons play a crucial role in regulating the regeneration of intestinal epithelial cells, as they stimulate the production of IL-22 from ILC3s to promote epithelial repair. This adrenergic-ILC3 axis is essential for intestinal regeneration.
Article
Multidisciplinary Sciences
Ali Ahmadi, Mohammad Balood, Katiane Roversi, Maryam Ahmadi, Moutih Rafei, Sebastien Talbot
Summary: Somatosensory neurons detect noxious stimuli and interact with the immune system to protect homeostasis. Recent studies show that they directly respond to foreign antigens, immune cell-derived cytokines, and microbes. The release of neuropeptides by nociceptors can control inflammation. Sensory neurons also interact with immune cells through cell-cell contact.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Chemistry, Multidisciplinary
Lin Liu, Zhitao Xiong, Daqiang Hu, Guotao Wu, Ping Chen
CHEMICAL COMMUNICATIONS
(2013)
Article
Chemistry, Multidisciplinary
Lin Liu, Zhitao Xiong, Daqiang Hu, Guotao Wu, Bin Liu, Ping Chen
Article
Chemistry, Multidisciplinary
Jianhui Wang, Ping Chen, Hongge Pan, Zhitao Xiong, Mingxia Gao, Guotao Wu, Chu Liang, Cao Li, Bo Li, Jieru Wang
Article
Gastroenterology & Hepatology
Suna Yapali, Nizar Talaat, Anna S. Lok
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2014)
Editorial Material
Gastroenterology & Hepatology
Suna Yapali, Anna S. Lok
Article
Physics, Applied
M. R. Uddin, S. Majety, J. Li, J. Y. Lin, H. X. Jiang
JOURNAL OF APPLIED PHYSICS
(2014)
Article
Medicine, Research & Experimental
Ji-Tian Xu, Jian-Yuan Zhao, Xiuli Zhao, Davinna Ligons, Vinod Tiwari, Fidelis E. Atianjoh, Chun-Yi Lee, Lingli Liang, Weidong Zang, Dolores Njoku, Srinivasa N. Raja, Myron Yaster, Yuan-Xiang Tao
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Engineering, Chemical
Zhenxiao Cai, Claudia Wee, Mark M. Benjamin
JOURNAL OF MEMBRANE SCIENCE
(2013)
Article
Dermatology
Giulio Fortuna, Nita Chainani-Wu, Francina Lozada-Nur, Massimo Aria, Rodrigo Cepeda-Valdes, Annamaria Pollio, M. Peter Marinkovich, Adriana E. Martinez-Salazar, Michele D. Mignogna, Anna L. Bruckner, Julio Cesar Salas-Alanis
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2013)
Article
Virology
Karen Kwei, Xiaoli Tang, Anna S. Lok, Camille Sureau, Tamako Garcia, Jisu Li, Jack Wands, Shuping Tong
JOURNAL OF VIROLOGY
(2013)
Article
Oncology
Dean Ornish, Jue Lin, June M. Chan, Elissa Epel, Colleen Kemp, Gerdi Weidner, Ruth Marlin, Steven J. Frenda, Mark Jesus M. Magbanua, Jennifer Daubenmier, Ivette Estay, Nancy K. Hills, Nita Chainani-Wu, Peter R. Carroll, Elizabeth H. Blackburn
Article
Neurosciences
S. -Q. He, L. Han, Z. Li, Q. Xu, V. Tiwari, F. Yang, X. Guan, Y. Wang, S. N. Raja, X. Dong, Y. Guan
Article
Dentistry, Oral Surgery & Medicine
Nita Chainani-Wu, Crystal Chang, A. J. Gross, S. S. Yom, Sol Silverman
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2014)
Article
Chemistry, Physical
Jilei Liu, Chee Kok Poh, Da Zhan, Linfei Lai, San Hua Lim, Liang Wang, Xiaoxu Liu, Nanda Gopal Sahoo, Changming Li, Zexiang Shen, Jianyi Lin
Article
Chemistry, Physical
Linfei Lai, Jixin Zhu, Zhenggang Li, Denis Y. W. Yu, Shuran Jiang, Xiaoyi Cai, Qingyu Yan, Yeng Ming Lam, Zexiang Shen, Jianyi Lin