Article
Biochemistry & Molecular Biology
Ji Yeong Yang, Jong-Bae Kim, Pyeongjae Lee, Sa-Hyun Kim
Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Infectious Diseases
Ligang Liu, Milap C. C. Nahata
Summary: Helicobacter pylori is a common cause of infections worldwide and its resistance to antibiotics is increasing. Amoxicillin is the preferred treatment, but many patients have penicillin allergy. For patients with true allergy, Vonoprazan-Clarithromycin-Metronidazole and bismuth quadruple therapy have shown excellent eradication rates. Vonoprazan-based therapy is better tolerated and can be considered as first-line treatment. Levofloxacin or sitafloxacin-based regimens have moderate eradication rates but potential serious adverse effects. Cephalosporins like cefuroxime can be an alternative to amoxicillin. Choosing the most effective antibiotic regimen can improve clinical outcomes in H. pylori infection with penicillin allergy.
Review
Biochemistry & Molecular Biology
Ho-Yu Ng, Wai K. Leung, Ka-Shing Cheung
Summary: Despite the global decline in prevalence, efforts are needed to optimize H. pylori treatment regimens due to increasing antibiotic resistance. Advancements in sequencing technology have helped broaden our understanding of molecular mechanisms behind resistance and facilitated testing of antibiotic susceptibility. Establishing routine antibiotic susceptibility surveillance programs and enforcing antibiotic stewardship are important for managing H. pylori in a sustainable manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Materials Science, Biomaterials
Yuan Qin, Yeh-Hsing Lao, Haixia Wang, Jiabin Zhang, Ke Yi, Zhuanggui Chen, Jing Han, Wantong Song, Yu Tao, Mingqiang Li
Summary: H. pylori infection is the main cause of most digestive diseases, and traditional oral medication is limited in its efficacy, while nanomedicine offers efficient and effective targeted drug delivery solutions.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Medicine, General & Internal
Yaobin Ouyang, Wenjing Zhang, Chen He, Yin Zhu, Nonghua Lu, Yi Hu
Summary: Compared with bismuth-containing quadruple therapy (BQT), susceptibility-guided therapy (SGT) has higher efficacy and similar safety as the first-line treatment for Helicobacter pylori infection.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Yeonmi Lee, Sun-Mi Lee, Jiwan Choi, Seoon Kang, Seongjun So, Deokhoon Kim, Ji-Yong Ahn, Hwoon-Yong Jung, Jin-Yong Jeong, Eunju Kang
Summary: The study revealed that different mitochondrial haplogroups may be associated with Helicobacter pylori infection and gastric disease, with individuals carrying specific haplogroups showing higher apoptotic rates and impaired mitochondrial function following infection. Mitochondrial DNA mutations were also found to accumulate more in the H. pylori-positive population, with a higher percentage of mutations in RNA genes or nonsynonymous protein-coding regions compared to the H. pylori-negative population.
Article
Multidisciplinary Sciences
Oddmund Nestegard, Behrouz Moayeri, Fred-Arne Halvorsen, Tor Tonnesen, Sveinung Wergeland Sorbye, Eyvind Paulssen, Kay-Martin Johnsen, Rasmus Goll, Jon Ragnar Florholmen, Kjetil K. Melby
Summary: This study characterized the antimicrobial resistance pattern of H. pylori before and after treatment, and found that clarithromycin resistance was more frequent in the treatment-resistant group. No resistance was observed for amoxicillin and levofloxacin.
Article
Immunology
Chia-Jung Kuo, Cheng-Han Lee, Ming-Ling Chang, Cheng-Yu Lin, Wey-Ran Lin, Ming-Yao Su, Cheng-Hsun Chiu, Chi-Nan Tseng, Yu-Shan Wu, Cheng-Tang Chiu, Chih-Ho Lai
Summary: The study showed a high antimicrobial resistance rate among patients with refractory Helicobacter pylori, especially for clarithromycin and levofloxacin dual resistance.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Hyun Woo Kim, Hyun Jun Woo, Ji Yeong Yang, Jong-Bae Kim, Sa-Hyun Kim
Summary: The study found that hesperetin inhibits the growth of H. pylori by affecting the expression of key genes related to replication, transcription, motility, adhesion, and virulence factors. Additionally, hesperetin decreases the translocation of CagA and VacA proteins, indicating its potential as a natural product for the eradication of H. pylori.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Olga P. Nyssen, Dino Vaira, Angeles Perez Aisa, Luis Rodrigo, Manuel Castro-Fernandez, Laimas Jonaitis, Bojan Tepes, Liudmila Vologzhanina, Maria Caldas, Angel Lanas, Alfredo J. Lucendo, Luis Bujanda, Juan Ortuno, Jesus Barrio, Jose M. Huguet, Irina Voynovan, Jorge Perez Lasala, Aiman Silkanovna Sarsenbaeva, Luis Fernandez-Salazar, Javier Molina-Infante, Natasa Brglez Jurecic, Miguel Areia, Antonio Gasbarrini, Juozas Kupcinskas, Dmitry Bordin, Ricardo Marcos-Pinto, Frode Lerang, Marcis Leja, Gyorgy M. Buzas, Yaron Niv, Theodore Rokkas, Perminder Phull, Sinead Smith, Oleg Shvets, Marino Venerito, Vladimir Milivojevic, Ilkay Simsek, Vincent Lamy, Peter Bytzer, Lyudmila Boyanova, Lumir Kunovsky, Christoph Beglinger, Michael Doulberis, Wojciech Marlicz, Adrian Goldis, Ante Tonkic, Lisette Capelle, Ignasi Puig, Francis Megraud, Colm O' Morain, Javier P. Gisbert
Summary: The study evaluated the effectiveness and safety of second-line empiric treatment for H pylori infection by European gastroenterologists. For patients who failed previous eradication treatment attempts, treatment regimens including quinolone triple therapies and levofloxacin-bismuth quadruple therapy showed optimal eradication rates.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Akiko Shiotani, Priya Roy, Hong Lu, David Y. Graham
Summary: The diagnosis and therapy of Helicobacter pylori infection have evolved significantly with a focus on optimizing treatments to achieve high cure rates and the use of susceptibility profiling. Ioncreased antimicrobial resistance has led to restriction of certain antibiotics to susceptibility-based therapies, and the availability of PCR testing has allowed for rapid detection of resistance. Current recommendations include using only highly effective therapies locally and performing test-of-cure to inform the community about effective treatments.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Immunology
Xiaoqiong Tang, Yalin Shen, Xiaona Song, Mohammed Benghezal, Barry J. Marshall, Hong Tang, Hong Li
Summary: This study assessed the applicability of broth microdilution as a routine susceptibility testing method for Helicobacter pylori. The results showed a good correlation between the MICs obtained by the broth microdilution method and the agar dilution method, indicating that the broth microdilution method is suitable for susceptibility testing of clinical H. pylori isolates.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Kallirroi Kotilea, Samy Cadranel, Assaad Salame, Julie Nguyen, Tania Mahler, Veronique Yvette Miendje Deyi, Laurine Verset, Patrick Bontems
Summary: The 10-day quadruple therapy containing CBS, ESO, AMO, and MET is a safe and effective treatment for H. pylori eradication in children, especially for previously treated patients and those infected with double resistant strains.
Review
Medicine, General & Internal
Malek Shatila, Anusha Shirwaikar Thomas
Summary: Helicobacter pylori is a prevalent organism that infects a large population and is closely associated with the risk of gastric cancer. Diagnosis can be achieved non-invasively or invasively, and treatment involves acid suppression and antibiotic therapy. Eradication of H. pylori is essential, and post-eradication follow-up is crucial. There have been recent advances in both diagnosis and treatment of H. pylori.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yaping Cao, Jian Zhang, Yuan Liu, Lifeng Zhang, Lu Wang, Jie Wang, Ying Qi, Huanhuan Lv, Juan Liu, Lijuan Huo, Xiaoguo Wei, Yongquan Shi
Summary: The study found that bismuth pectin capsules and bismuth pectin granules have similar efficacy and safety in eradicating H. pylori compared to bismuth potassium citrate, with no significant differences observed among the groups.