Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Article
Nutrition & Dietetics
Yebing Zhang, Haoyue Ding, Lei Xu, Suli Zhao, Shouna Hu, Aiguo Ma, Yan Ma
Summary: This study found that lutein supplementation can protect against male reproductive damage caused by excessive alcohol intake through its antioxidant, anti-inflammatory, and anti-apoptotic properties.
Article
Biochemistry & Molecular Biology
Mathias Flensted-Jensen, Martin Gram, Flemming Dela, Jorn Wulff Helge, Steen Larsen
Summary: In this study involving 12 sedentary obese individuals at risk of developing T2D, it was found that high intensity interval training (HIT) significantly decreased ROS production, increased antioxidant protein levels, and improved mitochondrial respiratory capacity within a short period of time. These findings suggest that a relatively small amount of HIT can effectively enhance antioxidant status and lower oxidative stress in muscle cells, potentially protecting against the development of cardiovascular disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Tryfonas Tofas, Ioannis G. Fatouros, Dimitrios Draganidis, Chariklia K. Deli, Athanasios Chatzinikolaou, Charalambos Tziortzis, George Panayiotou, Yiannis Koutedakis, Athanasios Z. Jamurtas
Summary: Chronic regular exercise has positive effects on cardiovascular function and redox status in CAD patients. Cardiovascular training had the most significant impact on blood pressure and redox status, while resistance and combined training also showed positive effects on some redox-related variables. However, these beneficial effects were lost after a three-month detraining period.
Review
Biochemistry & Molecular Biology
Min-Tser Liao, Chia-Chao Wu, Shu-Fang Vivienne Wu, Mei-Chen Lee, Wan-Chung Hu, Kuo-Wang Tsai, Chung-Hsiang Yang, Chien-Lin Lu, Sheng-Kang Chiu, Kuo-Cheng Lu
Summary: The ongoing COVID-19 pandemic poses significant challenges to healthcare systems globally with a wide range of symptoms and varied severity depending on factors like age, sex, and comorbidities. Aging contributes to immune dysfunction which may exacerbate the risk of infection in elderly patients, emphasizing the importance of antiviral and anti-inflammatory interventions.
Review
Physiology
Sara Zieba, Mateusz Maciejczyk, Anna Zalewska
Summary: Alcohol abuse and smoking have been shown to have negative effects on the oral environment, including salivary gland dysfunction, DNA damage leading to precancerous lesions, and deterioration of periodontal health.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Luiza Amaral, Jaqueline Pontes Batista, Igor Moraes Mariano, Ludimila Ferreira Goncalves, Julia Buiatte Tavares, Adriele Vieira de Souza, Douglas C. Caixeta, Renata R. Teixeira, Erick P. de Oliveira, Foued S. Espindola, Guilherme Morais Puga
Summary: Postmenopausal women often have cardiometabolic diseases and higher oxidative stress. Exercise, such as Mat Pilates, can be beneficial, but its physiological effects need further investigation. This study aimed to explore the impact of 12 weeks of Mat Pilates on redox status in postmenopausal women with cardiometabolic diseases. The results showed no significant changes in redox markers between the groups, except for greater reductions in total antioxidant capacity in the SINGLE group.
Article
Ophthalmology
Akiko Hanyuda, Bernard A. Rosner, Janey L. Wiggs, Kazuno Negishi, Louis R. Pasquale, Jae H. Kang
Summary: This prospective cohort study assessed the association between total alcohol intake and individual alcoholic beverage intake and the incidence of exfoliation glaucoma/glaucoma suspect (XFG/XFGS) status. The results showed that long-term alcohol consumption was associated with an increased risk of XFG/XFGS.
Article
Biochemistry & Molecular Biology
Candelaria Martin-Gonzalez, Onan Perez-Hernandez, Alen Garcia-Rodriguez, Pedro Abreu-Gonzalez, Paula Ortega-Toledo, Camino Maria Fernandez-Rodriguez, Julio Cesar Alvisa-Negrin, Antonio Martinez-Riera, Emilio Gonzalez-Reimers
Summary: Excessive alcohol intake is associated with abnormal accumulation of muscle and fat, and serum myostatin may play a role in these alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Carolina Di Fabrizio, Veronica Giorgione, Asma Khalil, Colin E. Murdoch
Summary: Human pregnancy can be affected by various pathologies, including gestational diabetes mellitus and hypertensive disorders, which can have severe consequences. Health issues during pregnancy and postpartum contribute significantly to maternal mortality and morbidity. This review focuses on the latest evidence on oxidative stress in pregnancy complications, early diagnosis, and potential therapies.
Article
Biochemistry & Molecular Biology
Gianni Paulis, Giovanni De Giorgio
Summary: This study describes three cases of Peyronie's disease patients who achieved complete resorption of plaque through antioxidant treatment, providing useful experience for urological clinical practice.
Review
Biochemistry & Molecular Biology
Fernando Bartolome, Eva Carro, Carolina Alquezar
Summary: Oxidative stress is the imbalance between reactive oxygen species (ROS) production and the antioxidant capacity of cells. The human brain is highly susceptible to oxidative stress, making it an essential component in the pathophysiology of neurodegenerative diseases such as tauopathies. However, there currently exist no effective therapies for these diseases. Although antioxidant therapies have shown promise in preclinical studies, clinical trials have been disappointing. To develop effective antioxidant therapies, a complete understanding of the molecular mechanisms underlying oxidative stress in tauopathies is crucial.
Review
Biochemistry & Molecular Biology
Izabela Korczowska-Lacka, Bartosz Slowikowski, Thomas Piekut, Mikolaj Hurla, Natalia Banaszek, Oliwia Szymanowicz, Pawel P. Jagodzinski, Wojciech Kozubski, Agnieszka Permoda-Pachuta, Jolanta Dorszewska
Summary: In diseases of the central nervous system, oxidative stress load commonly exceeds the body's antioxidant capacity. Endogenous antioxidants such as enzymes and exogenous antioxidants like vitamins and polyphenols play a significant role in preventing oxidative damage. However, the clinical efficacy and effectiveness of these antioxidants in neurological diseases need further research and definition.
Review
Biochemistry & Molecular Biology
Munsoo Han, Dabin Lee, Sang Hag Lee, Tae Hoon Kim
Summary: Oxidative stress plays a crucial role in redox metabolism in various physiological and pathological conditions, and antioxidants are important in treating associated diseases. Allergic rhinitis significantly impacts daily function and quality of life, with a high socioeconomic burden and prevalence, with recent studies focusing on the role of oxidative stress and antioxidants in this condition.
Review
Toxicology
Silvia Vivarelli, Chiara Costa, Michele Teodoro, Federica Giambo, Aristidis Michael Tsatsakis, Concettina Fenga
Summary: Non-communicable diseases (NCDs) are major global causes of mortality and morbidity. Unhealthy lifestyle habits are closely associated with NCDs, and improving these habits may help alleviate symptoms and prolong the life expectancy of affected individuals. Polyphenols (PPLs) derived from plants have shown positive results in preventing and treating NCDs and are considered safe.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
N. V. Tyshko, N. S. Nikitin, S. I. Shestakova, E. O. Sadykova, M. D. Trebukh, G. V. Guseva, N. V. Trusov, I. V. Aksenov, K. S. Golokhvast, A. Tsatsakis, V. A. Tutelyan
Summary: In a chronic model experiment on rats, the liver morphology, intensity of apoptosis, and activity of xenobiotic metabolism enzymes were studied after exposure to a mixture of 6 pesticides and lifelong diets with adequate and insufficient supply of water-soluble vitamins. The dose of each pesticide in the mixture did not exceed the acceptable daily intake (1 ADI). The findings suggest that chronic exposure to low doses of anthropogenic toxicants combined with permanent vitamin deficiency can cause various liver changes, including increased apoptosis activity, depletion of the cytochrome P450 system, steatosis, and inflammatory infiltration, posing a potential health risk.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Gennadiy Onishchenko, Natalia Nikolayeva, Valery Rakitskii, Alexandra Ilnitskaya, Andrey Filin, Aleksei Korolev, Elena Nikitenko, Elena Denisova, Andreas Tsakalof, Ekaterina Guseva, Sergey Kuzmin, Aristidis Tsatsakis
Summary: This study evaluated the health effects of combined or separate exposure to hazardous factors in plasma technology occupational environment on animal models. The results showed that exposure to noise or its combination with chemical factors led to non-specific changes in the CNS, especially in the case of joint exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Kourti, Maria V. V. Alvanou, Zoi Skaperda, Fotis Tekos, Georgios Papaefstathiou, Panagiotis Stathopoulos, Demetrios Kouretas
Summary: An extract from brine samples obtained through the Greek style debittering process of Kalamon olive fruits showed strong antioxidant capacity and DNA-protective activity. The extract consisted mainly of hydroxytyrosol, verbascoside, and tyrosol. In cell-free assays, the extract demonstrated radical scavenging ability, while in cell cultures, it exhibited cell type specific responses and protected against H2O2-induced DNA damage. Overall, this study highlights the potential of table olive wastewaters as a valuable source of bioactive compounds for various industries.
Article
Public, Environmental & Occupational Health
Ourania Anesti, Nafsika Papaioannou, Catherine Gabriel, Achilleas Karakoltzidis, Vazha Dzhedzheia, Ioannis Petridis, Antonios Stratidakis, Mike Dickinson, Milena Horvat, Janja Snoj Tratnik, Aristidis Tsatsakis, Spyros Karakitsios, Dimosthenis A. A. Sarigiannis
Summary: This study presents an integrated approach to investigating the impact of perinatal exposure to metals on child neurodevelopment in two cohorts carried out in Slovenia and Greece. The study found that heavy metal exposure during the perinatal period is associated with impaired mitochondrial respiration and oxidative stress, leading to developmental disorders in children. Additionally, factors such as diet, proximity to pollution sources, and socioeconomic and demographic characteristics also play a role in child neurodevelopment.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Medicinal
Betul Cicek, Ahmet Hacimuftuoglu, Mehmet Kuzucu, Ahmet Cetin, Yesim Yeni, Sidika Genc, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Mustafa Gul, Serhat Hayme, Dimitris Matthaios, Dimitra P. P. Vageli, Sotirios G. G. Doukas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: According to population-based studies, lung cancer is the most common cause of cancer-related deaths worldwide in males, and its incidence among females is also increasing alarmingly. Sorafenib (SOR), a multitargeted protein kinase inhibitor used for the treatment of hepatocellular carcinoma and renal cell carcinoma, has been the subject of interest in preclinical and clinical trials for lung cancer. This study aimed to investigate the effects of SOR in diethylnitrosamine (DEN)-induced lung carcinogenesis and explore its mechanisms of action. The results showed that SOR reduced the levels of SOX-2, TNF-alpha, and IL-1 beta, and alleviated the histopathological damage caused by DEN-induced lung carcinogenesis. Immunohistochemical and immunofluorescence analysis also revealed that SOR treatment decreased the expression of COX-2 and JNK in DEN-intoxicated rats. These findings suggest that SOR inhibits lung precancerous lesions induced by DEN through reducing inflammation and SOX-2 levels.
Article
Environmental Sciences
Konstantin Pikula, Konstantin Kirichenko, Vladimir Chernousov, Sergey Parshin, Alexander Masyutin, Yulia Parshina, Anton Pogodaev, Alexander Gridasov, Aristidis Tsatsakis, Kirill Golokhvast
Summary: This study evaluated the aquatic toxicity of two suspension samples obtained from underwater welding using electrode and flux-cored wire on marine microalgae Attheya ussuriensis and Porphyridium purpureum. The results showed that the suspension obtained from welding with electrode had an acute toxic impact on A. ussuriensis, while both suspensions had chronic toxicity with a 40% growth rate inhibition in this microalga. However, P. purpureum showed tolerance to both suspensions due to the presence of an exopolysaccharide covering that prevented the toxic impact of metal cations.
Article
Oncology
Ozgur Celebi, Ali Taghizadehghalehjoughi, Demet Celebi, Robin Mesnage, Kirill Sergeevich Golokhvast, Andreea Letitia Arsene, Demetrios A. Spandidos, Aristidis Tsatsakis
Summary: The gut microbiota is important for maintaining health and regulating immune response. Probiotics and vitamins can improve microbial population and prevent tight junction protein breakdown. The study evaluated the effects of vitamins and probiotics on Escherichia coli and Staphylococcus aureus.
MOLECULAR MEDICINE REPORTS
(2023)
Editorial Material
Substance Abuse
Cornel Radu-Loghin, Karina Mocanu, Hani Al Gouhmani, Constantine Vardavas, Ioanna Lagou, Zinovia Plyta, Aikaterini Papathanasaki, Stella Vogiatzidaki, Alexander Vardavas, Manolis Tzatzarakis, Aristidis Tsatsakis, Filip-pos Filippidis, Christina Kyriakos, Esteve Fernandez, Olena Tigova, Cristina Martinez, Anna Mar Lopez Luque, Marius Eremia, Lucia Maria Lotrean, Antigona Trofor, Thomas Wenzl, Bill Simpson, Pippa Powell, Polina Starchenko, Angeliki Bakou, Eleni Asimaki, Victoria Vivilaki
TOBACCO PREVENTION & CESSATION
(2023)
Article
Chemistry, Medicinal
Sidika Genc, Tarik Yagci, Dimitra P. Vageli, Riza Dundar, Panagiotis G. Doukas, Sotirios G. Doukas, Maria Tolia, Nikolaos Chatzakis, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This study found that serum exosomal miR-223, miR-146, and PTEN expression were significantly decreased, while miR-21 expression was significantly increased in LSCC patients. In addition, CRP and vitamin B12 levels were also altered. These results suggest that the expression of serum exosomal miR-223, miR-146, miR-21, as well as the changes in CRP and vitamin B12 levels, may serve as potential indicators of LSCC.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Oncology
Aristidis Tsatsakis, Elisavet Renieri, Dimitris Tsoukalas, Ana Maria Buga, Evangelia Sarandi, Elena Vakonaki, Persefoni Fragkiadaki, Athanasios Alegakis, Dragana Nikitovic, Daniela Calina, Demetrios A. Spandidos, Anca Oana Docea
Summary: This study evaluated the effects of a novel telomerase activator on telomere length and telomerase activity in aged rats. The nutraceutical formulation was found to reduce telomere shortening rate at lower dose and increase telomere length at higher dose. Telomerase activity was also increased in the treated rats.
MOLECULAR MEDICINE REPORTS
(2023)
Review
Medicine, Research & Experimental
Fotios Kakridonis, Spyros G. Pneumatikos, Elena Vakonaki, Aikaterini Berdiaki, Manolis N. Tzatzarakis, Persefoni Fragkiadaki, Demetrios A. Spandidos, Stella Baliou, Petros Ioannou, Eleftheria Hatzidaki, Dragana Nikitovic, Aristidis Tsatsakis, Elias Vasiliadis
Summary: This review summarizes the potential of telomere shortening as a biomarker for detecting the onset of osteoporosis. It found a weak association between telomere length and osteoporosis in some studies, suggesting that telomere shortening may be used as a biomarker for tracking the development and progression of osteoporosis.
BIOMEDICAL REPORTS
(2023)
Article
Medicine, General & Internal
Claire Chrysanthi Karpodini, Themistoklis Tsatalas, Ioannis Giannakopoulos, Mattias Romare, Giannis Giakas, Panagiotis V. Tsaklis, Petros C. Dinas, Aline Nogueira Haas, Sokratis G. Papageorgiou, Efthalia Angelopoulou, Matthew A. Wyon, Yiannis Koutedakis
Summary: The aim of this study is to investigate the acute effects of a specially designed musicokinetic program on patients with Parkinson's disease, including anxiety levels, kinematic and kinetic parameters, and frontal cortex hemodynamic responses during gait initiation and walking. The study will be conducted as a blind cross-over randomized control trial with 13 volunteers attending a 45-minute musicokinetic program in synchronous and asynchronous formats. Gait biomechanics and frontal cortex hemodynamic responses will be measured using motion analysis and near-infrared spectroscopy, respectively, while anxiety levels will be assessed with the Hamilton Anxiety Rating Scale.
MEDICINA-LITHUANIA
(2023)
Article
Sport Sciences
Juergen M. Steinacker, Willem van Mechelen, Wilhelm Bloch, Mats Boerjesson, Maurizio Casasco, Bernd Wolfarth, Carolin Knoke, Theodora Papadopoulou, Janine Wendt, Hashel Al Tunaiji, Dietrich Andresen, Olena Andrieieva, Norbert Bachl, Victoriya Badtieva, Friedhelm J. Beucher, Cheri A. Blauwet, Jose-Antonio Casajus Mallen, Ju-Ho Chang, German Clenin, Naama Constantini, Demitri Constantinou, Luigi Di Luigi, Lukas Declercq, Stephane Doutreleau, Svitlana Drozdovska, Martine Duclos, Andrea Ermolao, Thomas Fischbach, Anastasia N. Fischer, Chiara Fossati, Jeorge Franchella, Mark Fulcher, Jan C. Galle, Christian Gerloff, Evelina Georgiades, Boris Gojanovic, Marcela Gonzalez Gross, Andy Grote, Martin Halle, Hans Hauner, Matthew Payton Herring, Mikio Hiura, Kerstin Holze, Gerhard Huber, David Hughes, Mark R. Hutchinson, Anca Ionescu, Dina Christina Janse van Rensburg, Anna Jegier, Natasha Jones, Kirsten Kappert-Gonther, Monika Kellerer, Yutaka Kimura, Agrita Kiopa, Bernd Kladny, Gerhard Koch, Elin Kolle, Greg Kolt, Yiannis Koutedakis, Stephan Kress, Susi Kriemler, Jens Kroeger, Christian Kuhn, Roman Laszlo, Ralph Lehnert, Francois J. Lhuissier, Kerstin Luedtke, Shigeru Makita, Pedro Manonelles Marqueta, Winfried Maerz, Kirill Micallef-Stafrace, Mike Miller, Melita Moore, Erich Mueller, Danie Neunhaeuserer, I. Renay Onur, Vahur Oeoepik, Malgorzata Perl, Anastassios Philippou, Hans-Georg Predel, Sebastien Racinais, Algirdas Raslanas, Ruediger Reer, Klaus Reinhardt, Claus Reinsberger, Sandra Rozenstoka, Robert Sallis, Luis B. Sardinha, Martin Scherer, Jasper Schipperijn, Romain Seil, Benedict Tan, Arno Schmidt-Trucksaess, Nils Schumacher, Bernhard Schwaab, Ansgar Schwirtz, Masato Suzuki, Jeroen Swart, Ralph Tiesler, Ulf Tippelt, Eleanor Tillet, Jane Thornton, Bulent Ulkar, Eve Unt, Evert Verhagen, Thomas Weikert, Roberto Vettor, Sheng Zeng, Richard Budgett, Lars Engebretsen, Ugur Erdener, Fabio Pigozzi, Yannis P. Pitsiladis
Summary: Non-communicable diseases, such as coronary heart disease and diabetes, are increasing worldwide due to a lack of physical activity. This leads to negative health outcomes and economic burdens. To address this issue, the 'Hamburg Declaration' was signed, aiming to promote physical activity and improve individual and community health.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Review
Medicine, General & Internal
Efthalia Angelopoulou, Evangelia Stanitsa, Claire Chrysanthi Karpodini, Anastasia Bougea, Dionysia Kontaxopoulou, Stella Fragkiadaki, Christos Koros, Vasiliki Epameinondas Georgakopoulou, George Fotakopoulos, Yiannis Koutedakis, Christina Piperi, Sokratis G. Papageorgiou
Summary: Depression is a common non-motor disorder in Parkinson's disease, affecting both patients and their caregivers. Pharmacological and non-pharmacological treatments are available, but the optimal approach for managing PD depression remains uncertain and challenging.
MEDICINA-LITHUANIA
(2023)