☆ 4.8 Article

Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 107, 期 2, 页码 866-871

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NATL ACAD SCIENCES
DOI: 10.1073/pnas.0913351107

关键词

herpes simplex virus; neurotropism; membrane fusion; Varicella-zoster virus; virus entry

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Multidisciplinary Sciences

资金

  1. Ministry of Education, Science and Culture, Japan
  2. Takeda Science Foundation
  3. Uehara Memorial Foundation
  4. Naito Foundation

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Varicella-zoster virus (VZV) and herpes simplex virus (HSV) are prevalent neurotropic herpesviruses that cause various nervous system diseases. Similar to other enveloped viruses, membrane fusion is an essential process for viral entry. Therefore, identification of host molecules that mediate membrane fusion is important to understand the mechanism of viral infection. Here, we demonstrate that myelin-associated glycoprotein (MAG), mainly distributed in neural tissues, associates with VZV glycoprotein B (gB) and promotes cell-cell fusion when coexpressed with VZV gB and gH/gL. VZV preferentially infected MAG-transfected oligodendroglial cells. MAG also associated with HSV-1 gB and enhanced HSV-1 infection of promyelocytes. These findings suggested that MAG is involved in VZV and HSV infection of neural tissues.

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