Article
Multidisciplinary Sciences
Conrad L. Smart, Alejandro J. Cortese, B. J. Ramshaw, Paul L. McEuen
Summary: We present a method for measuring the thermal properties of materials using temperature-sensing optical wireless integrated circuits (OWiCs). These microscopic and untethered optical sensors eliminate input wires and reduce parasitic effects. The results demonstrate that they can measure the thermal properties of almost any material, ranging from aerogels to metals, and operate over a broad temperature range.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Analytical
Melika Haji Mohammadi, Sterre Mulder, Patricia Khashayar, Alireza Kalbasi, Mostafa Azimzadeh, Amir Reza Aref
Summary: Lab-on-a-chip (LOC) devices have revolutionized the field of metabolic detection by combining the advantages of biosensors and microfluidics. Saliva is now being recognized as a non-invasive alternative biofluid for diagnostics, leading to promising applications of LOCs in analyzing saliva for a wide range of medical situations and diseases. Advancements in utilizing LOCs for detecting various bacteria and viruses, cytokines, metabolites, kidney related diseases, prostate cancer, and oral diseases are being explored with the potential to aid in addressing current pandemics.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
V Karthik, B. Karuna, P. Senthil Kumar, A. Saravanan, R. Hemavathy
Summary: Recently, the decrease in water availability and quality due to industrialization and anthropogenic activities has led to heavy metals becoming significant pollutants in the water environment. Conventional monitoring techniques have drawbacks, and biosensors have emerged as reasonable devices for detecting environmental contaminants. This review summarizes the toxic effect, source, and occurrence of heavy metals, and discusses the use of lab on a chip with suitable recognition materials for heavy metal detection. The lab on a chip is a promising micro-electrical mechanical system device that enables fast, cost-effective, and highly sensitive analysis of heavy metals.
Review
Chemistry, Analytical
Shuaiwen Li, Zihui Chen, Feng Yang, Wanqing Yue
Summary: This article presents a review of recent progress in the integration of emerging 2D materials into LOC devices for the development of high-sensitivity biosensors, discussing the integration methods and sensing principles of both electrochemical and optical LOC biosensors. The challenges and prospects of using 2D materials in LOC biosensors are also examined.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Daphika S. Dkhar, Rohini Kumari, Shweta J. Malode, Nagaraj P. Shetti, Pranjal Chandra
Summary: Lab-on-a-chip (LOC) biosensors have attracted research interest for their potential in personal healthcare and disease diagnostics. This review discusses various fabrication methods and techniques for designing LOC sensing devices, as well as the types of transduction systems that play a crucial role in sensing. The detection of analytes, including small molecules, macromolecules, and cells, is comprehensively reviewed with illustrations and tables.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Alexander A. Minakov, Christoph Schick
Summary: Ultrafast chip nanocalorimetry enables rapid cooling and heating of samples in materials science. By controlling heat transfer through micron-thick membranes, ultrafast cooling and heating can be achieved for tiny samples. The maximum cooling rate can increase with decreasing radius of the hot zone, reaching up to 10^10 K/s under certain conditions.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Giorgio Ventimiglia, Massimiliano Pesaturo, Alastair Malcolm, Salvatore Petralia
Summary: A silicon lab-on-chip, integrating PCR and hybridization microarray, has been developed for nucleic acid detection. The lab-on-chip shows remarkable sensitivity, multiplexing analysis, and specificity for the detection of target sequences.
Review
Chemistry, Analytical
Zahra Khoshbin, Khalil Abnous, Seyed Mohammad Taghdisi, Asma Verdian
Summary: Advancements in liquid crystal technology have led to impressive developments in sensing platforms, enabling high sensitivity and excellent selectivity in biosensors for a wide range of applications. Liquid crystal-based biosensors show promise for label-free, cost-effective, and real-time detection, with the potential to be used on portable smartphone devices for on-site monitoring.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Satish Kasturi, Sri Ramulu Torati, Yunji Eom, CheolGi Kim
Summary: This study developed a microfluidic channel and valves integrated electrochemical biosensor for detecting the neurotoxic beta-amyloid (1-42) biomarker. By forming antibody-antigen complexes on gold microelectrode integrated within fluidic chambers and controlling all measurements using pneumatic valves, the biosensor showed a linear response to various beta-amyloid antigen concentrations with enhanced detection limit and potential for efficient detection of other biomarkers.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Chemistry, Physical
Li Zhang, Huan Xiao, Shun Li, Liming Xu, Bingge Zhao, Qijie Zhai, Yulai Gao
Summary: In this study, the phase transitions of Mg65Zn30Ca5 metallic glass were controlled using nanocalorimetry. The thermodynamic and kinetic features at different heating rates were revealed, and an intermediate amorphous phase was found to facilitate the formation of the Mg7Zn3 crystalline phase. The continuous heating transformation (CHT) diagram for Mg65Zn30Ca5 metallic glass was plotted, and the crystallization kinetics were estimated.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Chemistry, Multidisciplinary
Samaneh Zare Harofte, Madjid Soltani, Saeed Siavashy, Kaamran Raahemifar
Summary: Nowadays, artificial intelligence creates numerous opportunities in the life sciences. Integrating AI with microfluidics can significantly impact various fields of biotechnology.
Article
Biochemical Research Methods
Ning Zhang, Chao Yue, Xiaobo Zhan, Zhi Cheng, Chao Li, Yaohua Du, Feng Tian
Summary: The quantitative analysis of respiratory viruses is important for diagnosis, medicine and prognosis. In this study, a lab-on-a-chip platform combined with an automated control system was used to achieve quantitative analysis of COVID-19 pseudovirus from large-volume nasal swab samples. The method can be extended to other respiratory viruses and sample types.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Sangam Srikanth, U. S. Jayapiriya, Satish Kumar Dubey, Arshad Javed, Sanket Goel
Summary: A simple, cost-effective and miniaturized lab-on-a-chip platform has been developed for simultaneous cultivation and detection of bacteria, with high accuracy in quantifying bacterial concentration and validating viability, as well as real-time and on-field applications.
Article
Materials Science, Multidisciplinary
Zhenzhen Chen, Liang Shen, Xiong Zhao, Hongqiang Chen, Yaxuan Xiao, Yonghai Zhang, Xiaoping Yang, Jinhua Zhang, Jinjia Wei, Nanjing Hao
Summary: Microfluidics, especially acoustofluidics, offers new opportunities in chemical and biomedical engineering by manipulating fluids at the micrometer or submicrometer scale. This review discusses the utility of acoustofluidic technology, summarizes different types of acoustic micromixers, highlights their applications in various fields, and identifies the practical challenges that need to be addressed. Overall, this review provides valuable insights for both academic research and industrial applications.
APPLIED MATERIALS TODAY
(2022)
Review
Pharmacology & Pharmacy
Renata Maia, Violeta Carvalho, Rui Lima, Graca Minas, Raquel O. Rodrigues
Summary: This systematic review summarizes the recent progress in the use of microneedles (MNs) in biomedical applications, including drug delivery, biomarker detection, and their potential integration with microfluidic devices. Although MNs have been extensively utilized in lab-on-a-chip platforms, recent studies have also explored their applicability in organ-on-a-chip models. Overall, the presence of MNs in advanced microfluidic devices offers simplified drug delivery, microinjection, and biomarker detection through integrated biosensors, enabling real-time monitoring of various biomarkers in lab- and organ-on-a-chip platforms.