Article
Biology
Yuri Elias Rodrigues, Cezar M. Tigaret, Helene Marie, Cian O'Donnell, Romain Veltz
Summary: Discovering the rules of synaptic plasticity is crucial for understanding brain learning. Existing models either lack flexibility to fit experimental data or are too complex to interpret. To overcome these limitations, we propose a new plasticity rule based on a geometrical readout mechanism that accurately predicts plasticity outcomes. Our model successfully reproduces various experimental conditions and suggests that spike timing irregularity strongly affects plasticity outcome. This modelling approach can be applied to other synapses to discover their plasticity rules.
Article
Neurosciences
Yixing Du, Faith H. Brennan, Phillip G. Popovich, Min Zhou
Summary: This study investigates the role of microglia in regulating the structure and function of astrocytes in the mouse hippocampus, revealing that depletion of microglia disrupts astrocyte syncytial isopotentiality and dye coupling, leading to reduced synaptic transmission in neurons. Activation of microglia enhances synaptic transmission, while leaving astrocyte network function unaffected.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Review
Pharmacology & Pharmacy
Samuel S. Newton, Monica Sathyanesan
Summary: Cognitive deficits are common in psychiatric disorders, such as major depression and schizophrenia, and play a significant role in functional impairment. Targeted treatments for cognitive deficits are limited, with a need for more efficacious treatments. Erythropoietin (Epo) shows promising procognitive effects in psychiatric disorders, supporting a neurotrophic drug development approach.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Article
Biochemistry & Molecular Biology
Candice M. Roux, Pierre Lecouflet, Jean-Marie Billard, Elise Esneault, Marianne Leger, Pascale Schumann-Bard, Thomas Freret
Summary: Acute hippocampal slice preparations have been commonly used in studying the anti-amnesic properties of drug candidates on long-term potentiation (LTP). Genetic background is crucial in experimental design, considering the availability of various transgenic mouse models. In this study, LTP was compared between inbred and outbred mice, showing reduced LTP magnitude in outbred mice due to lower responsiveness to theta-frequency during conditioning stimuli. Overall, this study highlights the importance of considering animal models in electrophysiological experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alexander Maltsev, Pavel M. Balaban
Summary: The study shows that blockade of protein synthesis and specific serine/threonine phosphatases (PP1 and PP2A) can lead to a switch from impaired long-term potentiation (LTP) to long-term depression (LTD). Additionally, it is found that these phosphatases influence both basal synaptic transmission and stimulation-induced synaptic plasticity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marlene F. Pereira, Ines M. Amaral, Catia Lopes, Catarina Leitao, Daniela Madeira, Joao P. Lopes, Francisco Q. Goncalves, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
Summary: The study shows that L-alpha-aminoadipate (L-AA) affects astrocytes differently and impairs synaptic plasticity and memory. Injection of L-AA negatively impacts hippocampal long-term potentiation (LTP) and hippocampal-dependent memory in mice. D-serine administration can partially rescue the reduction in hippocampal LTP induced by L-AA exposure.
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Douglas A. Formolo, Thomas H. Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S. Kranz, Suk-Yu Yau
Summary: Sub-chronic treatment with AdipoRon has antidepressant- and anxiolytic-like effects in mice, independent of changes in hippocampal neurogenesis and synaptic plasticity.
Article
Immunology
Yuxing Yan, Xinxin Xu, Renwen Chen, Shian Wu, Zhuo Yang, Hui Wang, Tao Zhang
Summary: Depression is a common mental disorder mainly caused by chronic stress, and activation of MST1 in the hippocampus has been linked to impairments in synaptic plasticity, neuronal dysfunction, and neuroinflammation. Down-regulation of MST1 has shown to protect against stress-induced behavioral dysfunctions in mice models, indicating that MST1 may be a potential target for future antidepressant development.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Yanping Liu, Qiang Liu, Haibi Wang, Yongkang Qiu, Jiatao Lin, Weifeng Wu, Ning Wang, Wei Dong, Jie Wan, Chen Chen, Shuai Li, Hui Zheng, Yuqing Wu
Summary: This study aimed to investigate the role of SIRT1 in cognitive impairment caused by chronic pain. The results showed that reduced SIRT1 expression in the hippocampus led to impaired synaptic plasticity and cognitive dysfunction. Increasing SIRT1 expression or enzyme activity could improve the impaired synaptic plasticity and cognitive dysfunction.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Xueqing Chai, Xiaolin Li, Wenxin Zhang, Xiaoyue Tan, Haiyun Wang, Zhuo Yang
Summary: The study revealed that legumain knockout significantly improved cognitive function and reduced neuroinflammation in a chronic cerebral hypoperfusion mouse model. This suggests that legumain may serve as a potential target for future cerebral ischemia treatments.
Article
Clinical Neurology
Maria Mensch, Jade Dunot, Sandy M. Yishan, Samuel S. Harris, Aline Blistein, Alban Avdiu, Paula A. Pousinha, Camilla Giudici, Marc Aurel Busche, Peter Jedlicka, Michael Willem, Helene Marie
Summary: The study discovered that both A eta-alpha and A eta-beta peptides acutely impair LTP at low nanomolar concentrations ex vivo, with the N-terminus being a primary site of activity. The research also showed that A eta-beta inhibits neuronal activity in vivo, similar to A eta-alpha, and confirmed the impairment of LTP by A eta-alpha in vivo.
ALZHEIMERS RESEARCH & THERAPY
(2021)