期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 7, 页码 2418-2422出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0811400106
关键词
hypocretin; narcolepsy; paradoxical sleep; REM sleep; slow wave sleep
资金
- Canadian Institutes of Health Research [CIHR 82762]
- National Institutes of Health [RO1 MH-60119-01A]
Neurons containing melanin-concentrating hormone (MCH) are codistributed with neurons containing orexin (Orx or hypocretin) in the lateral hypothalamus, a peptide and region known to be critical for maintaining wakefulness. Evidence from knockout and c-Fos studies suggests, however, that the MCH neurons might play a different role than Orx neurons in regulating activity and sleep wake states. To examine this possibility, neurons were recorded across natural sleep-wake states in head-fixed rats and labeled by using the juxtacellular technique for subsequent immunohistochemical identification. Neurons identified as MCH+ did not fire during wake (W); they fired selectively during sleep, occasionally during slow wave sleep (SWS) and maximally during paradoxical sleep (PS). As W-Off/Sleep-On, the MCH neurons discharged in a reciprocal manner to the W-On/Sleep-Off Orx neurons and could accordingly play a complementary role to Orx neurons in sleep wake state regulation and contribute to the pathophysiology of certain sleep disorders, such as narcolepsy with cataplexy.
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