Article
Rheumatology
Ignatius Ryan Adriawan, Faranaz Atschekzei, Oliver Dittrich-Breiholz, Panagiotis Garantziotis, Stefanie Hirsch, Linus Maximillian Risser, Maike Kosanke, Reinhold Ernst Schmidt, Torsten Witte, Georgios Sogkas
Summary: The study found that GCA patients' Tregs have dysregulated pro-inflammatory genes and functions, associated with low glycolysis and calcium signaling pathways in Tregs.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Immunology
Maha Abdeladhim, Jodi L. Karnell, Sadiye Amcaoglu Rieder
Summary: This paper systematically reviews the role of different checkpoint pathways in Treg homeostasis and function, emphasizing the importance of co-stimulatory and co-inhibitory pathways in regulating Treg. Insights from clinic and experimental studies on the effect of therapeutics on Treg biology are also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
N. Eiza, M. Garty, E. Staun-Ram, A. Miller, Z. Vadasz
Summary: Research found that sema3A expression on Tregs and serum levels in MS patients were decreased, while sema4A levels were increased. Additionally, sema3A and sema4A were found to have positive/negative correlations with the severity of MS. Targeting sema3A and sema4A could be a potential therapeutic approach for MS.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Assaf Gottlieb, Hoai Phuong T. Pham, John William Lindsey
Summary: This study presents a method to stimulate T lymphocytes in multiple sclerosis patients and controls using non-suppressive brain homogenate. The results suggest that the brain-responding cells from MS patients may be pathogenic based on mRNA expression and their T-cell receptor repertoire shows minimal overlap with virus antigens.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lourdes Rocamora-Reverte, Franz Leonard Melzer, Reinhard Wuerzner, Birgit Weinberger
Summary: The immune system is a tightly regulated network, where regulatory T cells play an important role in maintaining immune homeostasis. Different types of T cells have regulatory functions in modulating immune responses, and the aging process can affect the composition of immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Elien Grajchen, Melanie Loix, Paulien Baeten, Beatriz F. Corte-Real, Ibrahim Hamad, Sam Vanherle, Mansour Haidar, Jonas Dehairs, Jelle Y. Broos, James M. Ntambi, Robert Zimmermann, Rolf Breinbauer, Piet Stinissen, Niels Hellings, Sanne G. S. Verberk, Gijs Kooij, Martin Giera, Johannes V. Swinnen, Bieke Broux, Markus Kleinewietfeld, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Summary: The imbalance between pathogenic and protective T cell subsets is a key feature of autoimmune disorders such as multiple sclerosis (MS). The molecular mechanisms underlying the impact of fatty acid metabolism on T cell physiology and autoimmunity are poorly understood. The study reveals that fatty acid desaturation by SCD1 acts as an endogenous brake on regulatory T-cell differentiation and enhances autoimmunity, suggesting potential therapeutic strategies for autoimmune disorders such as MS.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Janne Verreycken, Paulien Baeten, Bieke Broux
Summary: Multiple sclerosis (MS) is an autoimmune disorder characterized by demyelination and neurodegeneration in the central nervous system. Regulatory T cells (Tregs), which have the ability to suppress immune reactions and regenerate, may have therapeutic potential for MS. However, Tregs in people with MS are functionally impaired. To exert their anti-inflammatory and regenerative effects in the brain, Tregs must first migrate across the blood-brain barrier (BBB).
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Immunology
Jin-Kwan Lee, Seo-Young Koo, Hye-Mi Nam, Jee-Boong Lee, Jiwon Ko, Kyung-Mo Kim, Eun-Ji Park, Tae Jin Kim, Ho Lee, Heounjeong Go, Chang-Woo Lee
Summary: The Ssu72 phosphatase plays a crucial role in T-cell differentiation and function by regulating Tregs development and cytokine response. Deletion of Ssu72 disrupts the balance between effector T cells and Tregs in the periphery, resulting in impaired mucosal tolerance in patients. Ssu72 interacts with PLCγ1 to modulate T-cell receptor signaling and Treg development.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Tracoyia Roach, Laurence Morel
Summary: Immune homeostasis relies on the balance between effector T cells and regulatory T cells. Studies have identified genetic factors that maintain the stability and suppressive function of regulatory T cells, which could potentially be targeted for therapeutic intervention against autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sebastian Bittner, Brigitte Ruhland, Veronika Hofmann, Lisa Schmidleithner, Kathrin Schambeck, Asmita Pant, Philipp Stueve, Michael Delacher, Bernd Echtenacher, Matthias Edinger, Petra Hoffmann, Michael Rehli, Claudia Gebhard, Nicholas Strieder, Thomas Hehlgans, Markus Feuerer
Summary: In this study, the researchers introduced synthetic biosensors called artificial immune receptors (AIRs) to modulate regulatory T cells (Treg cells). These AIRs enable Treg cells to sense inflammation and activate specific signaling pathways. In animal models, Treg cells expressing AIRs provided better protection against graft-versus-host disease compared to control Treg cells. The expression and signaling of these artificial immune receptors in human Treg cells suggest the potential application of Treg cell-based therapy for various inflammation-driven diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Minato Hirano, Gaddiel Galarza-Munoz, Chloe Nagasawa, Geraldine Schott, Liuyang Wang, Alejandro L. Antonia, Vaibhav Jain, Xiaoying Yu, Steven G. Widen, Farren B. S. Briggs, Simon G. Gregory, Dennis C. Ko, William S. Fagg, Shelton Bradrick, Mariano A. Garcia-Blanco
Summary: This study identified genes associated with increased susceptibility to multiple sclerosis (MS) and revealed the important role of DDX39B gene in immune tolerance by controlling the expression of MS susceptibility genes and immune-related genes.
Article
Biology
Jaime James, Yifei Chen, Clara M. Hernandez, Florian Forster, Markus Dagnell, Qing Cheng, Amir A. Saei, Hassan Gharibi, Gonzalo Fernandez Lahore, Annika astrand, Rajneesh Malhotra, Bernard Malissen, Roman A. Zubarev, Elias S. J. Arner, Rikard Holmdahl
Summary: PTPN22 mutation is associated with chronic autoimmune diseases. The mutation enhances T cell signaling and activation, leading to a stronger inflammatory response and development of autoimmune arthritis. The activity of PTPN22 is regulated by oxidation, and the mutation increases the protein's sensitivity to oxidation.
Article
Biochemistry & Molecular Biology
Valentina Rubino, Anna Teresa Palatucci, Giuliana La Rosa, Angela Giovazzino, Francesco Aruta, Simona Damiano, Flavia Carriero, Mariarosaria Santillo, Rosa Iodice, Paolo Mondola, Giuseppina Ruggiero, Giuseppe Terrazzano
Summary: Reactive oxygen species (ROS) play a role in T-cell activation, with SOD-1 production and secretion influenced by antigen-dependent activation. In patients with MS, SOD-1 levels are associated with T cell function and regulatory T cell populations, impacting cytokine secretion.
Review
Immunology
Martina Kunkl, Carola Amormino, Valentina Tedeschi, Maria Teresa Fiorillo, Loretta Tuosto
Summary: This review summarizes the changes and behavior of astrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis, as well as the contribution of pathogenic T cell subsets and CD8(+) T cells to astrocytic modifications and pathological outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Stefan Rosenberger, Reinmar Undeutsch, Reza Akbarzadeh, Justus Ohmes, Philipp Enghard, Gabriela Riemekasten, Jens Y. Humrich
Summary: Treg cells play a regulatory role in controlling the activation and expansion of autoreactive CD4(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Alice W. Lee, Wura Jacobs, Elena Chan, Becky Nguyen, Dung N. Hua, John N. Ho, Priscilla Yuen, Thai Van Nguyen
Article
Oncology
Eunjung Lee, Doanvo Namphuong, MiHee Lee, Zayar Soe, Alice W. Lee, Cam Van Doan, Dennis Deapen, Giske Ursin, Darcy Spicer, Peggy Reynolds, Anna H. Wu
CANCER CAUSES & CONTROL
(2020)
Article
Public, Environmental & Occupational Health
Alice W. Lee, Anna H. Wu, Ashley Wiensch, Bhramar Mukherjee, Kathryn L. Terry, Holly R. Harris, Michael E. Carney, Allan Jensen, Daniel W. Cramer, Andrew Berchuck, Jennifer Anne Doherty, Francesmary Modugno, Marc T. Goodman, Aliya Alimujiang, Mary Anne Rossing, Kara L. Cushing-Haugen, Elisa V. Bandera, Pamela J. Thompson, Susanne K. Kjaer, Estrid Hogdall, Penelope M. Webb, David G. Huntsman, Kirstin B. Moysich, Galina Lurie, Roberta B. Ness, Daniel O. Stram, Lynda Roman, Malcolm C. Pike, Celeste Leigh Pearce
Article
Oncology
Katharine K. Brieger, Siri Peterson, Alice W. Lee, Bhramar Mukherjee, Kelly M. Bakulski, Aliya Alimujiang, Hoda Anton-Culver, Michael S. Anglesio, Elisa Bandera, Andrew Berchuck, David D. L. Bowtell, Georgia Chenevix-Trench, Kathleen R. Cho, Daniel W. Cramer, Anna DeFazio, Jennifer A. Doherty, Renee T. Fortner, Dale W. Garsed, Simon A. Gayther, Aleksandra Gentry-Maharaj, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Estrid Hogdall, David G. Huntsman, Hui Shen, Allan Jensen, Sharon E. Johnatty, Susan J. Jordan, Susanne K. Kjaer, Jolanta Kupryjanczyk, Diether Lambrechts, Karen McLean, Usha Menon, Francesmary Modugno, Kirsten Moysich, Roberta Ness, Susan J. Ramus, Jean Richardson, Harvey Risch, Mary Anne Rossing, Britton Trabert, Nicolas Wentzensen, Argyrios Ziogas, Kathryn L. Terry, Anna H. Wu, Gillian E. Hanley, Paul Pharoah, Penelope M. Webb, Malcolm C. Pike, Celeste Leigh Pearce
GYNECOLOGIC ONCOLOGY
(2020)
Article
Oncology
Alice W. Lee, Stacey Rosenzweig, Ashley Wiensch, Susan J. Ramus, Usha Menon, Aleksandra Gentry-Maharaj, Argyrios Ziogas, Hoda Anton-Culver, Alice S. Whittemore, Weiva Sieh, Joseph H. Rothstein, Valerie McGuire, Nicolas Wentzensen, Elisa Bandera, Bo Qin, Kathryn L. Terry, Daniel W. Cramer, Linda Titus, Joellen M. Schildkraut, Andrew Berchuck, Ellen L. Goode, Susanne K. Kjaer, Allan Jensen, Susan J. Jordan, Roberta B. Ness, Francesmary Modugno, Kirsten Moysich, Pamela J. Thompson, Marc T. Goodman, Michael E. Carney, Jenny Chang-Claude, Mary Anne Rossing, Holly R. Harris, Jennifer Anne Doherty, Harvey A. Risch, Lilah Khoja, Aliya Alimujiang, Minh Tung Phung, Katharine Brieger, Bhramar Mukherjee, Paul D. P. Pharoah, Anna H. Wu, Malcolm C. Pike, Penelope M. Webb, Celeste Leigh Pearce
Summary: Incomplete pregnancies are associated with reduced risk of invasive epithelial ovarian cancer, with an inverse association observed for all major histotypes. A greater risk reduction was seen in clear cell ovarian cancer. Future research should focus on understanding the mechanisms underlying this reduced risk.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Editorial Material
Public, Environmental & Occupational Health
Alice W. Lee
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Minh Tung Phung, Alice W. Lee, Anna H. Wu, Andrew Berchuck, Kathleen R. Cho, Daniel W. Cramer, Jennifer Anne Doherty, Marc T. Goodman, Gillian E. Hanley, Holly R. Harris, Karen McLean, Francesmary Modugno, Kirsten B. Moysich, Bhramar Mukherjee, Joellen M. Schildkraut, Kathryn L. Terry, Linda J. Titus, Susan J. Jordan, Penelope M. Webb, Malcolm C. Pike, Celeste Leigh Pearce
Summary: The use of combined oral contraceptives and progestin-only contraceptives is associated with a decreased risk of ovarian cancer. Specifically, the injectable progestin-only contraceptive depot-medroxyprogesterone acetate (DMPA) was found to be associated with a 35% decreased risk of ovarian cancer, with a significant trend of decreasing risk with increasing duration of use. Some studies showed an inverse association between DMPA use and ovarian cancer risk, while others showed increased risk, indicating a need for further investigation into the mechanism of this association.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Public, Environmental & Occupational Health
Alice W. Lee, Roy A. Mendoza, Shehla Aman, Robert Hsu, Lihua Liu
Summary: There are significant differences in thyroid cancer incidence and trends among disaggregated Asian and/or Pacific Islander ethnic subgroups in the United States. Filipinos have the highest incidence rate, while Japanese have the lowest. Asian Indians and/or Pakistanis show an increasing trend in thyroid cancer incidence among females, while Koreans show an increasing trend among males. Disaggregating APIs in research provides critical information for understanding thyroid cancer risk.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Oncology
Minh Tung Phung, Aliya Alimujiang, Andrew Berchuck, Hoda Anton-Culver, Joellen M. Schildkraut, Elisa Bandera, Jenny Chang-Claude, Anne Chase, Jennifer Anne Doherty, Bronwyn Grout, Marc T. Goodman, Gillian E. Hanley, Alice W. Lee, Cindy McKinnon Deurloo, Usha Menon, Francesmary Modugno, Paul D. P. Pharoah, Malcolm C. Pike, Jean Richardson, Harvey A. Risch, Weiva Sieh, Kathryn L. Terry, Penelope M. Webb, Nicolas Wentzensen, Anna H. Wu, Celeste Leigh Pearce
Summary: This study found no association between reproductive factors and survival after an ovarian cancer diagnosis.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Lilah Khoja, Rachel Palmieri Weber, Penelope M. Webb, Susan J. Jordan, Aruna Muthukumar, Jenny Chang-Claude, Renee T. Fortner, Allan Jensen, Susanne K. Kjaer, Harvey Risch, Jennifer Anne Doherty, Holly R. Harris, Marc T. Goodman, Francesmary Modugno, Kirsten Moysich, Andrew Berchuck, Joellen M. Schildkraut, Daniel Cramer, Kathryn L. Terry, Hoda Anton-Culver, Argyrios Ziogas, Minh Tung Phung, Gillian E. Hanley, Anna H. Wu, Bhramar Mukherjee, Karen McLean, Kathleen Cho, Malcolm C. Pike, Celeste Leigh Pearce, Alice W. Lee
Summary: The study evaluated the association between hysterectomy and ovarian cancer, finding a complex relationship that is influenced by hormone therapy use and history of endometriosis. Adjustment for duration of hormone therapy use and endometriosis history is essential to fully understand the association between hysterectomy and ovarian cancer risk. The findings suggest that overall, hysterectomy is not a protective factor against ovarian cancer, but a potential inverse association exists for women with a history of endometriosis.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Alice W. Lee, Valerie Poynor, Archana J. McEligot
Summary: Studies have found a positive association between high intake of phytoestrogens and increased risk of breast cancer and endometrial cancer, with variations in the associations depending on the type of phytoestrogen. Further research is needed to better understand the role of phytoestrogens in disease etiology.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Obstetrics & Gynecology
Minh Tung Phung, Aruna Muthukumar, Britton Trabert, Penelope M. Webb, Susan J. Jordan, Kathryn L. Terry, Daniel W. Cramer, Linda J. Titus, Harvey A. Risch, Jennifer Anne Doherty, Holly R. Harris, Marc T. Goodman, Francesmary Modugno, Kirsten B. Moysich, Allan Jensen, Susanne K. Kjaer, Hoda Anton-Culver, Argyrios Ziogas, Andrew Berchuck, Lilah Khoja, Anna H. Wu, Malcolm C. Pike, Celeste Leigh Pearce, Alice W. Lee
Summary: This study evaluated the associations between 10 well-established ovarian cancer risk factors and the risk of ovarian cancer in women with and without endometriosis. Most risk factor-ovarian cancer associations were similar between the two groups, but there were some differences observed for body mass index, menopausal hormone therapy use, and genital talcum powder use in women with endometriosis.
FERTILITY AND STERILITY
(2022)
Article
Multidisciplinary Sciences
Alice W. Lee, Wura Jacobs, Michelle Tran, Becky Nguyen, Dung N. Hua, John N. Ho, Thai Van Nguyen
Summary: This study identifies specific subgroups in the Vietnamese American community who are at a higher risk of HCV infection and would benefit from targeted interventions. These interventions should focus on improving HCV knowledge and promoting HCV self-risk assessment, as awareness of one's own risk may motivate those likely to be infected to get screened.
Article
Reproductive Biology
Alice W. Lee, Vanessa Eata
Summary: This study examined the association between exposure to phenols and female reproductive health. The results showed a significant positive association between bisphenol A (BPA) exposure and endometriosis, but no significant association with fibroids. The study suggests that BPA may play a role in the pathogenesis of endometriosis.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Oncology
Minh Tung Phung, Penelope M. Webb, Anna DeFazio, Sian Fereday, Alice W. Lee, David D. L. Bowtell, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Beth Y. Karlan, Jenny Lester, Keitaro Matsuo, Francesmary Modugno, James D. Brenton, Toon Van Gorp, Paul D. P. Pharoah, Joellen M. Schildkraut, Karen McLean, Rafael Meza, Bhramar Mukherjee, Jean Richardson, Bronwyn Grout, Anne Chase, Cindy McKinnon Deurloo, Kathryn L. Terry, Gillian E. Hanley, Malcolm C. Pike, Andrew Berchuck, Susan J. Ramus, Celeste Leigh Pearce, Ovarian Canc Assoc Consortium
Summary: This study analyzed the association between 12 lifestyle and personal exposures and having residual disease after surgery in patients with high-grade serous ovarian cancer (HGSC). The use of menopausal estrogen-only therapy (ET) was associated with a lower likelihood of having macroscopic residual disease, while parous women who did not breastfeed also had a lower likelihood of residual disease. These factors could potentially be included in risk stratification models for HGSC patients.
GYNECOLOGIC ONCOLOGY
(2023)