Article
Biochemistry & Molecular Biology
Suisui Wang, Jingxiu Bi, Chengjun Li, Bin Li
Summary: This study reveals that the GBL domain of TcLph can recognize pathogens and trigger immune defense responses. The GBL domain is highly conserved and can bind to different types of molecules. Moreover, TcLph is significantly upregulated after infection and its silencing worsens bacterial infection and larval mortality. Therefore, TcLph may play an important role in insect defense against invasive microbes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Immunology
Nouhoum Dibo, Xianshu Liu, Yunfeng Chang, Shuaiqin Huang, Xiang Wu
Summary: Schistosomiasis is still a significant public health problem in tropical and subtropical regions, and its elimination remains challenging. Immune responses are crucial for controlling the disease, but prolonged inflammatory responses contribute to disease progression. Understanding the molecular mechanisms of innate immune responses is important for developing effective therapies and vaccines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Jean-Yves Dube, Fiona McIntosh, Marcel A. Behr
Summary: Pattern recognition receptors Mincle and NOD2 are associated with mycobacterial immunity, but single gene knockout studies have shown mild phenotypes. Researchers hypothesized that dual knockout of Mincle and Nod2 would result in a more severe immune phenotype, but the results showed no further effect compared to Nod2 knockout alone.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna E. Gauthier, Randi D. Rotjan, Jonathan C. Kagan
Summary: This review examines the history of LPS as a mammalian PAMP protein, recent data on LPS structure and its role in mammalian immune activation, and compares these activities across different eukaryotes. The authors discuss the reasons why LPS has immune-stimulatory effects in some organisms but not others, and propose two hypotheses about the evolution of PAMP structure.
Review
Immunology
Guang Han Ong, Benedict Shi Xiang Lian, Takumi Kawasaki, Taro Kawai
Summary: Adjuvants enhance vaccine potency by activating innate immune responses, which in turn stimulate acquired immune responses against pathogens. Current research focuses on the effectiveness of PAMPs and DAMPs as adjuvants, as well as gaining a comprehensive understanding of the immune reactions to agonists for PRRs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Fisheries
Jhonatas Teixeira Viana, Rafael dos Santos Rocha, Rodrigo Maggioni
Summary: Lectins are important pattern recognition receptors in the immune system of L. vannamei, involved in multiple immune response pathways.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Zhi Zong, Zhengkui Zhang, Liming Wu, Long Zhang, Fangfang Zhou
Summary: Innate antiviral immunity is the first line of defense against viral pathogens, relying on pattern recognition receptors to recognize pathogen-associated molecular patterns and initiate signaling cascades producing proinflammatory cytokines and IFN-I. The ubiquitin system, specifically DUBs, plays crucial roles in regulating immune responses, with viral DUBs counteracting host immunity. The potential of utilizing DUBs as therapeutic targets for infectious diseases is discussed, along with the challenges.
Review
Immunology
Jin Kyung Seok, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: Inflammation is a host protection mechanism that can eliminate invasive pathogens from the body, but chronic inflammation may lead to various inflammatory and autoimmune diseases. Recent studies have shown the significant contribution of the NLRP3 inflammasome to the pathology of various inflammatory diseases. Understanding the activation regulation of NLRP3 inflammasome by multiple signaling pathways, post-translational modifications, and cellular organelles is crucial for the development of therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Fisheries
Lage Cerenius, Kenneth Soderhall
Summary: Melanin production by different types of phenoloxidases provides immunity to a variety of pathogens, while proPO in arthropods exhibits multiple activities such as cytokine and microbiocidal activities. Pathogens influence proPO activation and the types of immune effects produced.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Liu, Ao Zhang, Na Guo, Qiang Hao, Fuhua Li
Summary: In this study, a ficolin gene Ptficolin was characterized from the swimming crab Portunus trituberculatus. Ptficolin showed higher expression in stomach and hepatopancreas, and could recognize and eliminate invading pathogens, playing an important role in hemolymph coagulation in crabs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Alice J. West, Virginie Deswaerte, Alison C. West, Linden J. Gearing, Patrick Tan, Brendan J. Jenkins
Summary: Results from studying the role of NLRP3 in gastric cancer suggest that NLRP3 does not play a major role in promoting inflammasome-driven gastric tumorigenesis. Additionally, cellular processes associated with tumorigenesis and inflammasome activation levels were similar between mice with and without NLRP3. Further investigations are needed to identify the key inflammasome-associated PRR implicated in GC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Karolina Sidor, Aldona Jeznach, Grazyna Hoser, Tomasz Skirecki
Summary: The NLRP3 inflammasome is a powerful intracellular sensor of danger and disturbances that can cause various inflammatory diseases. 1-MNA reduces the activation of the NLRP3 inflammasome and may be a potential therapeutic target for NLRP3-related disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Kengo Nozaki, Lupeng Li, Edward A. Miao
Summary: Intracellular pathogens pose a significant threat to animals. Innate immune sensors detect these pathogens and trigger cell death responses, eliminating the infection and promoting immune responses. Pathogens evolve strategies to evade these sensors.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Article
Immunology
Marie-Christine Bartens, Amanda J. Gibson, Graham J. Etherington, Federica Di Palma, Angela Holder, Dirk Werling, Sam Willcocks
Summary: Research suggests that there are differences in the response to mycobacterial antigens between Brown Swiss and Holstein Friesian cattle, potentially due to single nucleotide polymorphisms in the TLR2 gene.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Angela Holder, Jeannine Kolakowski, Chloe Rosentreter, Ellen Knuepfer, Sabine A. F. Jegouzo, Oliver Rosenwasser, Heather Harris, Lotta Baumgaertel, Amanda Gibson, Dirk Werling
Summary: Innate immune receptors form complexes with secondary receptors to activate multiple signaling pathways, regulating homeostasis and immunity. A bovine homologue of Mincle (boMincle) has been characterized to be structurally and functionally similar to the human orthologue (huMincle), although there are some differences. BoMincle is predominantly expressed by myeloid cells, but mRNA transcripts were also detected in granulocytes, B cells, and T cells. BoMincle has the potential to recognize endogenous ligands, suggesting its role in homeostasis in cattle.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Zoology
Kakeru Yokoi, Yuuki Hayakawa, Daiki Kato, Chieka Minakuchi, Toshiharu Tanaka, Masanori Ochiai, Katsumi Kamiya, Ken Miura
JOURNAL OF INVERTEBRATE PATHOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Mizue Imai, Tomohide Saio, Hiroyuki Kumeta, Takeshi Uchida, Fuyuhiko Inagaki, Koichiro Ishimori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Cell Biology
Yoshihiro Kobashigawa, Shinjiro Amano, Kaito Yoza, Rika Himeno, Shun Amemiya, Hiroshi Morioka, Mariko Yokogawa, Hiroyuki Kumeta, Joseph Schlessinger, Fuyuhiko Inagaki
Article
Cell Biology
Kaito Yoza, Rika Himeno, Shinjiro Amano, Yoshihiro Kobashigawa, Shun Amemiya, Natsuki Fukuda, Hiroyuki Kumeta, Hiroshi Morioka, Fuyuhiko Inagaki
Article
Cell Biology
Akinori Yamasaki, Yasunori Watanabe, Wakana Adachi, Kuninori Suzuki, Kazuaki Matoba, Hiromi Kirisako, Hiroyuki Kumeta, Hitoshi Nakatogawa, Yoshinori Ohsumi, Fuyuhiko Inagaki, Nobuo N. Noda
Article
Biochemistry & Molecular Biology
Natsuki Fukuda, Kentaro Noi, Lidong Weng, Yoshihiro Kobashigawa, Hiromi Miyazaki, Yukari Wakeyama, Michiyo Takaki, Yusuke Nakahara, Yuka Tatsuno, Makiyo Uchida-Kamekura, Yoshiaki Suwa, Takashi Sato, Naoki Ichikawa-Tomikawa, Motoyoshi Nomizu, Yukio Fujiwara, Fumina Ohsaka, Takashi Saito, Katsumi Maenaka, Hiroyuki Kumeta, Shoko Shinya, Chojiro Kojima, Teru Ogura, Hiroshi Morioka
Article
Multidisciplinary Sciences
Eui Jae Sung, Masasuke Ryuda, Hitoshi Matsumoto, Outa Uryu, Masanori Ochiai, Molly E. Cook, Na Young Yi, Huanchen Wang, James W. Putney, Gary S. Bird, Stephen B. Shears, Yoichi Hayakawa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Zoology
Ko Katoh, Masazumi Iwasaki, Shouhei Hosono, Atsushi Yoritsune, Masanori Ochiai, Makoto Mizunami, Hiroshi Nishino
ZOOLOGICAL LETTERS
(2017)
Article
Biochemistry & Molecular Biology
Soichiro Kawagoe, Hiroshi Nakagawa, Hiroyuki Kumeta, Koichiro Ishimori, Tomohide Saio
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemical Research Methods
Neil J. Stewart, Hiroyuki Kumeta, Mitsushi Tomohiro, Takuya Hashimoto, Noriyuki Hatae, Shingo Matsumoto
JOURNAL OF MAGNETIC RESONANCE
(2018)
Article
Multidisciplinary Sciences
Mariko Yokogawa, Takashi Tsushima, Nobuo N. Noda, Hiroyuki Kumeta, Yoshiaki Enokizono, Kazuo Yamashita, Daron M. Standley, Osamu Takeuchi, Shizuo Akira, Fuyuhiko Inagaki
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Hiroyuki Kumeta, Haruka Nakayama, Kenji Ogura
SCIENTIFIC REPORTS
(2017)
Article
Food Science & Technology
Yukiko Horie, Hideyuki Nemote, Jin Fujita, Shigeo Ikegawa, Yasuhiro Kumaki, Yuki Ohnishi, Hiroyuki Kumeta, Makoto Demura, Tomoyasu Aizawa
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI
(2019)
Article
Biochemistry & Molecular Biology
Zihao Song, Yuki Ohnishi, Seiji Osada, Li Gan, Jiaxi Jiang, Zhiyan Hu, Hiroyuki Kumeta, Yasuhiro Kumaki, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe, Kazuo Yamauchi, Tomoyasu Aizawa
Summary: NMR-based metabolomics is widely used in research to identify biomarkers and investigate the pathogenesis of diseases. This study applied a low-field NMR spectrometer to analyze the metabolic profile of ulcerative colitis model mice and compared it with high-field NMR. The results showed high comparability and accurate quantification of metabolites using the low-field NMR.
Article
Biochemistry & Molecular Biology
Masasuke Ryuda, Miku Tabuchi, Hitoshi Matsumoto, Takashi Matsumura, Masanori Ochiai, Yoichi Hayakawa
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2018)