期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 106, 期 7, 页码 2212-2217出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0809253106
关键词
Calcium signaling; CREB; Dendritic growth; Na,K-ATPase signaling; Neuronal development
资金
- Swedish Research Council [Dnr 2005-6682]
- Foundation for Strategic Research (CEDB)
- Knut och Alice Wallenbergs Stiftelse (CLICK)
- Ake Wibergs Stiftelse
- Jeanssons Stiftelser
- Magnus Bergvalls Stiftelse
- Fredrik och Ingrid Thurings Stiftelse
- Swedish Society for Medical Research
Dendritic growth is pivotal in the neurogenesis of cortical neurons. The sodium pump, or Na,K-ATPase, is an evolutionarily conserved protein that, in addition to its central role in establishing the electrochemical gradient, has recently been reported to function as a receptor and signaling mediator. Although a large body of evidence points toward a dual function for the Na,K-ATPase, few biological implications of this signaling pathway have been described. Here we report that Na,K-ATPase signal transduction triggers dendritic growth as well as a transcriptional program dependent on cAMP response element binding protein ( CREB) and cAMP response element (CRE)-mediated gene expression, primarily regulated via Ca2+/calmodulin-dependent protein (CaM) kinases. The signaling cascade mediating dendritic arbor growth also involves intracellular Ca2+ oscillations and sustained phosphorylation of mitogen-activated protein (MAP) kinases. Thus, our results suggest a novel role for the Na,K-ATPase as a modulator of dendritic growth in developing neurons.
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