期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 105, 期 7, 页码 2349-2353出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0712227105
关键词
inositol phosphate kinase; inositol polyphosphate; knockout mouse
资金
- NIDA NIH HHS [K05 DA000074, DA00074] Funding Source: Medline
- NIMH NIH HHS [R01 MH018501, R37 MH018501, MH18501] Funding Source: Medline
Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy beta-phosphates that can pyrophosphorylate proteins and regulate various cellular processes. They are formed by a family of inositol hexakisphosphate kinases (IP6Ks). We have created mice with a targeted deletion of IP6K1 in which production of inositol pyrophosphates is markedly diminished. Defects in the mutants indicate important roles for IP6K1 and inositol pyrophosphates in several physiological functions. Male mutant mice are sterile with defects in spermiogenesis. Mutant mice are smaller than wild-type despite normal food intake. The mutants display markedly lower circulating insulin.
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