Article
Biology
Wei Liu, Ling-Li Zeng, Hui Shen, Zong-Tan Zhou, Dewen Hu
Summary: The human cerebral cortex shows greater heterogeneity in gene expression compared to nonhuman primates and rodents. This heterogeneity is particularly pronounced in the cerebellar cortex, which is associated with the emergence of novel functions in the human brain. Additionally, cortical areas with higher gene expression heterogeneity tend to be located in the multimodal association cortex and express genes with higher evolutionary rates, suggesting that this spatial distribution of gene expression may be shaped by evolution and favour the specialization of higher cognitive functions.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Carolina B. D'Andrea, Scott Marek, Andrew N. Van, Ryland L. Miller, Eric A. Earl, Stephanie B. Stewart, Nico U. F. Dosenbach, Bradley L. Schlaggar, Timothy O. Laumann, Damien A. Fair, Evan M. Gordon, Deanna J. Greene
Summary: This study used functional connectivity MRI to investigate the development of visual pathways in children and adults. The results showed that children have stronger functional connectivity between the brainstem motor area and the facial somatosensory cortical network compared to adults. Additionally, children's thalamus showed more integration with multiple networks, while there were no developmental differences in cerebellar connectivity.
Article
Clinical Neurology
Cedric Gollion, Fleur Lerebours, Federico Nemmi, Germain Arribarat, Fabrice Bonneville, Vincent Larrue, Patrice Peran
Summary: This study found a functional connectivity between the insula subregions and vermis VI in patients with migraine with aura during the resting state. This connectivity may reflect the cardiovascular features of migraine with aura.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Behavioral Sciences
Chuqi Li, Yanyang Zhang, Wenxin Wang, Tao Zhou, Xinguang Yu, Hong Tao
Summary: This study investigates the effects of excessive cortisol on the structure and function of the hippocampus in patients with Cushing's disease. Results show that Cushing's disease patients have smaller volumes in all four hippocampal subregions and altered functional connectivity with high-order networks. The intrinsic hippocampal functional connectivity is associated with the quality of life in Cushing's disease patients.
BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Petra Ludowicy, Daniela Czernochowski, Jaione Arnaez-Telleria, Kshipra Gurunandan, Thomas Lachmann, Pedro M. Paz-Alonso
Summary: This fMRI study examined the effects of correct answer feedback and learning methods on memory improvement. The results showed that memory performance can be enhanced through feedback. The prefrontal cortex and superior parietal lobe play important roles in retrieving previously restudied items, while the lateral temporo-parietal areas are more active when retrieving previously tested items. Performance feedback also increases hippocampal activation and strengthens functional connectivity between the hippocampus, supramarginal gyrus, ventral striatum, and lateral temporo-parietal cortex. The findings reveal the main functional dynamics and connectivity nodes underlying memory benefits from additional performance feedback.
Article
Neurosciences
Monica Margoni, Davide Poggiali, Sofia Zywicki, Martina Rubin, Andrea Lazzarotto, Silvia Franciotta, Maria Giulia Anglani, Francesco Causin, Francesca Rinaldi, Paola Perini, Massimo Filippi, Paolo Gallo
Summary: The study found that atrophy in the red nucleus in early relapse-onset MS patients is associated with cerebellar and midbrain white matter lesions, possibly due to anterograde axonal degeneration starting from these regions. This suggests that RN atrophy could serve as a potential marker for neurodegeneration or cerebellar damage in RMS.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Ge Wang, Xianghe Liu, Min Zhang, Kangrun Wang, Chaorong Liu, Yayu Chen, Wenyue Wu, Haiting Zhao, Bo Xiao, Lily Wan, Lili Long
Summary: This study aimed to investigate the cerebellar structural and functional changes in temporal lobe epilepsy (TLE) and their association with clinical information. The results showed widespread gray matter atrophy, diffusion abnormalities, and altered functional connectivity in the cerebellum of TLE patients. These changes were associated with cognitive impairments, indicating the importance of the cerebellum in TLE.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Ruiyang Ge, Elizabeth Gregory, Jian Wang, Nicholas Ainsworth, Wei Jian, Chunlin Yang, Gang Wang, Fidel Vila-Rodriguez
Summary: This study is the first quantitative fMRI study to investigate the neural correlates of MST treatment for MDD patients. The results showed that increased functional connectivity between the subgenual anterior cingulate cortex and the parietal cortex was associated with clinical improvement, while greater decrease in functional connectivity between the right anterior hippocampus and the prefrontal cortex was correlated with lesser clinical and cognitive improvements.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Fatemeh Fadaie, Hyo M. Lee, Benoit Caldairou, Ravnoor S. Gill, Viviane Sziklas, Joelle Crane, Boris C. Bernhardt, Seok-Jun Hong, Andrea Bernasconi, Neda Bernasconi
Summary: The study revealed bidirectional disruptions of sensory-paralimbic functional organization in TLE patients, which might contribute to cognitive impairments in multiple domains. Associations with paralimbic microstructure and sensorimotor atrophy suggest that system-level imbalance likely reflects complementary structural processes, ultimately leading to a broad spectrum of cognitive impairments.
Article
Clinical Neurology
Raffaello Bonacchi, Alessandro Meani, Elisabetta Pagani, Olga Marchesi, Massimo Filippi, Maria A. Rocca
Summary: This study confirmed the relevance of cerebellar gray matter and connecting structures damage in explaining cognitive dysfunction and physical disability in multiple sclerosis patients. Data-driven MRI clustering analysis can improve our understanding of the correlation between MRI findings and clinical manifestations.
JOURNAL OF NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Tom Chambers, Richard Anney, Peter N. Taylor, Alexander Teumer, Robin P. Peeters, Marco Medici, Xavier Caseras, D. Aled Rees
Summary: The study found that a history of hypothyroidism was associated with significant reductions in cerebellar and pallidum gray matter volumes, partly mediated by increases in body mass index. It was also observed that polygenic scores for hypo- and hyperthyroidism had opposing influences on gray matter volumes, with no evidence of regional genetic pleiotropy with ADHD for either hypo- or hyperthyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Laura M. McNair, Graeme F. Mason, Golam M. Chowdhury, Lihong Jiang, Xiaoxian Ma, Douglas L. Rothman, Helle S. Waagepetersen, Kevin L. Behar
Summary: Anaplerosis, mediated by pyruvate carboxylase (PC) in astroglia, varies across different brain regions. The rate of PC contributes to oxidative glucose consumption and is positively correlated with glutamate/glutamine cycling.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Neurosciences
Yuchao Jiang, Mingjun Duan, Hui He, Dezhong Yao, Cheng Luo
Summary: This study aimed to summarize the brain changes on sMRI and fMRI after ECT in patients with schizophrenia, and explore the relationship between these changes and symptom remission.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Neurosciences
Paul-Noel Rousseau, M. Mallar Chakravarty, Christopher J. Steele
Summary: This study used tractography derived from diffusion imaging data to investigate the connections between the pons and the cerebellum. The results revealed a relationship between the connectivity of cerebellar lobules and the location of the pons, which furthers our understanding of the cerebellum and provides important context for future research on the role of the cerebellum in health and disease.
Article
Neurosciences
Arturo Torres-Herraez, Thomas C. Watson, Laure Rondi-Reig
Summary: During sleep, coordinated neuronal oscillations across different brain regions support various physiological functions. This study investigated the coordination between the cerebellum and hippocampus during sleep in mice. The results showed sleep stage-specific coordination of oscillations between these two structures, as well as the modulation of hippocampal activity by cerebellar oscillations. These findings suggest multiple physiological mechanisms that support offline, bidirectional interaction within distributed cerebello-hippocampal networks.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Auntora Sengupta, Joanna O. Y. Yau, Philip Jean-Richard-Dit-Bressel, Yu Liu, E. Zayra Millan, John M. Power, Gavan P. McNally
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
D. J. Jhaveri, A. Tedoldi, S. Hunt, R. Sullivan, N. R. Watts, J. M. Power, P. F. Bartlett, P. Sah
MOLECULAR PSYCHIATRY
(2018)
Editorial Material
Biochemistry & Molecular Biology
Andrew J. Moorhouse, John M. Power
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Neurosciences
Asheeta A. Prasad, Caroline Xie, Chanchanok Chaichim, Jennifer H. Nguyen, Hannah E. McClusky, Simon Killcross, John M. Power, Gavan P. McNally
JOURNAL OF NEUROSCIENCE
(2020)
Article
Geriatrics & Gerontology
Dominic T. Cheng, Alyssa M. Katzenelson, Monica L. Faulkner, John F. Disterhoft, John M. Power, John E. Desmond
NEUROBIOLOGY OF AGING
(2020)
Article
Clinical Neurology
Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Mueller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H. Stevens, John Power, Gary D. Housley, Tim Karl, Michael Kassiou, Yazi D. Ke, Arne Ittner, Lars M. Ittner
Article
Neurosciences
Yu Liu, Philip Jean-Richard-dit-Bressel, Joanna Oi-Yue Yau, Alexandra Willing, Asheeta A. Prasad, John M. Power, Simon Killcross, Colin W. G. Clifford, Gavan P. McNally
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Chanchanok Chaichim, Madeleine J. Cannings, Gadiel Dumlao, John M. Power
Summary: The lateral septum integrates glutamatergic synaptic inputs primarily from hippocampus, sending inhibitory projections to brain regions involved in reward and motivated behavior. This study shows that long-term synaptic depression in the LS is NMDA receptor-dependent, with no apparent sex differences in fast excitatory transmission. These findings suggest that sex differences in glutamatergic transmission observed in vivo are likely due to network activity rather than intrinsic differences.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Behavioral Sciences
Constance Y. Peng, Philip Jean-Richard-dit-Bressel, Sophia Gilchrist, John M. Power, Gavan P. McNally
Summary: The study shows that optogenetic inhibition of VTA dopamine neurons leads to a response-specific, contingency-sensitive suppression of instrumental responding, similar to the effects of aversive events in instrumental preparations.
BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chanchanok Chaichim, Tamara Tomanic, Holly Stefen, Esmeralda Paric, Lucy Gamaroff, Alexandra K. Suchowerska, Peter W. Gunning, Yazi D. Ke, Thomas Fath, John Power
Summary: The study found that, despite being enriched in dendritic spines, overexpression of Tpm3.1 does not significantly alter the morphology or function of dendritic spines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Joanna Oi-Yue Yau, Chanchanok Chaichim, John M. Power, Gavan P. McNally
Summary: The study used transgenic PV-Cre rats to reveal that BLA PV neurons regulate fear learning about aversive events. The research also showed the sensitivity of BLA PV neurons to aversive prediction error and their selectivity for specific sensory features.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Eun A. Choi, Medina Husic, E. Zayra Millan, Sophia Gilchrist, John M. Power, Philip Jean-Richard Dit Bressel, Gavan P. McNally
Summary: This study investigates the decision-making process of mice in the presence of danger and demonstrates how mice balance decision speed and safety. The researchers identify the involvement of the corticothalamic pathway in cognitive control during decision-making under conflict, showing that increased activity in the paraventricular thalamus leads to increased decision caution and longer decision times in the presence of danger.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Caroline Xie, John Power, Asheeta A. Prasad
Summary: In this study, optogenetic modulation of subthalamic nucleus (STN) neuronal activity was found to exert bidirectional control of motor function. The activation of STN in the absence of dopamine led to abnormal involuntary movement in a Parkinson's disease model, which could be rescued by levodopa administration. These findings highlight the importance of dopamine loss and STN overactivity in Parkinson's disease motor deficits and provide insight into the therapeutic mechanism of targeting the STN.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Amy P. Rapp, Timothy J. Hark, John M. Power, Jeffery N. Savas, M. Matthew Oh, John F. Disterhoft
Summary: This study utilized neuroscience techniques to investigate the impact of chronic implantation of tetrodes on learning in male and female mice, revealing gender differences with male mice acquiring the associative learning paradigm faster than female mice. These effects may be related to alterations in the MAPK pathway, acute inflammation, and brain derived neurotrophic factor.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2022)
Article
Neurosciences
Anudeep Bolaram, Taylor E. Coe, John M. Power, Dominic T. Cheng