Review
Cardiac & Cardiovascular Systems
Yanze Wu, Ting Jiang, Jinghai Hua, Zhiping Xiong, Kai Dai, Hui Chen, Lei Li, Jingtian Peng, Xiaoping Peng, Zeqi Zheng, Wenjun Xiong
Summary: Cardiovascular disease is one of the leading causes of death and illness. Mitochondrial dysfunction and excessive production of ROS can lead to oxidative damage and contribute to cardiovascular diseases. The role of PINK1/Parkin-mediated mitophagy in maintaining cardiac homeostasis and regulating metabolic transition is significant. Understanding and modulating PINK1/Parkin-mediated mitophagy may have therapeutic implications for cardiovascular diseases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Shohel Akhter, Julie Elizabeth Goodwin
Summary: The endothelium plays a crucial role in controlling vascular inflammation and function. The glucocorticoid receptor (GR) in endothelial cells negatively regulates vascular inflammation through the suppression of Wnt signaling. GR also affects fibrosis in various organs by modulating the fatty acid oxidation pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Huanjiao Jenny Zhou, Lingfeng Qin, Quan Jiang, Katie N. Murray, Haifeng Zhang, Busu Li, Qun Lin, Morven Graham, Xinran Liu, Jaime Grutzendler, Wang Min
Summary: The study reveals that mice with brain EC-specific deletion of Pdcd10 develop genuine CCM lesions, allowing visualization of vascular dynamics, and uncovers the mechanisms of CCM initiation and formation.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Audrey Le Floc'h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Dharani Ajithdoss, Kaitlyn Gayvert, Annabel Romero Hernandez, Olivier Herbin, Amanda Tay, Pamela Farrales, Chandrashekhar K. Korgaonkar, Hao Pan, Sweta Shah, Vishal Kamat, Ishita Chatterjee, Jon Popke, Adelekan Oyejide, Wei Keat Lim, Jee H. Kim, Tammy Huang, Matthew Franklin, William Olson, Thomas Norton, Lorah Perlee, George D. Yancopoulos, Andrew J. Murphy, Matthew A. Sleeman, Jamie M. Orengo
Summary: The study generated an antibody called REGN7257, which can bind to IL-2RG with high affinity and effectively block signaling of all gamma c cytokines, thus inhibiting T cell-mediated diseases. By using REGN7257, the researchers found that gamma c cytokines play a key role in mouse models of graft-versus-host disease (GVHD) and multiple sclerosis, suggesting that inhibition of gamma c cytokine signaling is a potential strategy for the management of T cell-mediated diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Chander K. Negi, Sabbir Khan, Hubert Dirven, Lola Bajard, Ludek Blaha
Summary: Nonalcoholic fatty liver disease (NAFLD) is a global concern affecting 25% of the population, with risk factors including environmental toxicants. Environmental contaminants like flame retardants (FRs) may impact the immune and inflammatory signaling pathways of NAFLD, contributing to disease progression. Further research on pharmacotherapeutic molecules targeting these pathways is needed to address knowledge gaps in NAFLD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Lu Wang, Jinxuan Wang, Jianxiong Xu, Weixi Qin, Yuming Wang, Shisui Luo, Guixue Wang
Summary: The P2Y receptor family, primarily activated by ATP, ADP, UTP, and UDP, plays a crucial role in platelet aggregation, vascular remodeling, and atherosclerosis. Inhibition of P2Y12 receptor-induced diseases with inhibitors like ticagrelor and clopidogrel still faces challenges, such as limited antithrombotic effects.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Shilpi Singh, Abha Meena, Suaib Luqman
Summary: Baicalin has shown significant anti-proliferative potential in various cancer cell lines, attracting interest as a potential chemotherapeutic modality. However, its clinical use is limited by low bioavailability, fast metabolism, and other factors. Improving pharmacokinetics and pharmacodynamics, as well as addressing knowledge and technology gaps, are essential for establishing baicalin as an effective and safe compound for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sylwia Iwanczyk, Tomasz Lehmann, Artur Cieslewicz, Artur Radziemski, Katarzyna Malesza, Michal Wrotynski, Pawel Piotr Jagodzinski, Marek Grygier, Maciej Lesiak, Aleksander Araszkiewicz
Summary: The study evaluated plasma concentrations of pro and antiangiogenic factors in patients with coronary artery abnormal dilation (CAAD) and found significantly higher levels of VEGF in CAAD patients, indicating the importance of pathological angiogenesis and inflammation in the pathogenesis of coronary artery aneurysmal dilatation.
Review
Biochemistry & Molecular Biology
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen
Summary: Sphingosine-1-phosphate (S1P) is a crucial sphingolipid molecule that regulates cardiovascular functions through binding and activating multiple G protein-coupled receptors in different cell types. It affects cell proliferation, migration, differentiation, and apoptosis through various downstream signaling pathways. Abnormal S1P levels are associated with cardiovascular disorders, and further research is needed to explore the potential therapeutic use of S1P in these diseases.
Article
Cell Biology
Jong Min Hong, Jin-Woo Lee, Dong-Seung Seen, Jae-Yeon Jeong, Won-Ki Huh
Summary: The heteromerization between CXCR4 and LPA1 has been investigated, showing its important role in cancer cells and providing insights into the regulatory mechanism of CXCR4 through heteromer formation. The findings suggest a potential therapeutic approach using combined CXCR4 and LPA1 inhibitors for cancer and inflammatory diseases associated with these receptors.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Wenquan Hu, Zhong Liu, Valerie Salato, Paula E. North, Joyce Bischoff, Suresh N. Kumar, Zhi Fang, Sujith Rajan, M. Mahmood Hussain, Qing R. Miao
Summary: Infantile hemangioma is characterized by rapid growth and slow involution of disorganized blood vessels. NGBR was found to be highly expressed in the proliferating phase of hemangioma but decreased in the involuting phase. Knockdown of NGBR in HemSCs attenuated RAS activation and inhibited cell migration and proliferation, suggesting its role in controlling growth and differentiation of hemangioma stem cells.
Article
Multidisciplinary Sciences
Xingwen Da, Ziyan Li, Xiaofan Huang, Zuhan He, Yubing Yu, Tongtong Tian, Chengqi Xu, Yufeng Yao, Qing K. Wang
Summary: Thoracic aortic aneurysm (TAA) causes numerous sudden deaths annually, yet there is no effective pharmacologic intervention. This study demonstrates that AGGF1 can effectively inhibit TAA-associated arterial inflammation and remodeling in three different mouse models. AGGF1 expression is decreased in the ascending aortas of these models as well as in human TAA patients. Pirfenidone, a drug used for pulmonary fibrosis, also shows potential in inhibiting TAA-associated vascular inflammation and remodeling. Therefore, AGGF1 and TGF-β inhibition therapies hold promise for treating TAA.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Mar Coll, Silvia Arino, Celia Martinez-Sanchez, Ester Garcia-Pras, Javier Gallego, Anna Moles, Beatriz Aguilar-Bravo, Delia Blaya, Julia Vallverdu, Teresa Rubio-Tomas, Juan Jose Lozano, Elisa Pose, Isabel Graupera, Andrea Fernandez-Vidal, Albert Pol, Ramon Bataller, Jian-Guo Geng, Pere Gines, Mercedes Fernandez, Pau Sancho-Bru
Summary: The study found that ductular reaction cells promote angiogenesis in chronic liver disease through the Slit2-Robo1 pathway and play a key role in the liver wound-healing response.
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yoshiyuki Mishima, Shunji Ishihara
Summary: Irritable bowel syndrome (IBS) is a chronic functional disorder affecting the gastrointestinal tract, with the dysregulation of the brain-gut-microbiome (BGM) axis potentially playing a major role in its pathogenesis. Serotonin is a key neurotransmitter involved in IBS pathology, and genome studies have identified susceptible genes. Treatment strategies targeting 5-HT have shown effectiveness in certain IBS cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)