Article
Cell Biology
Melanie Tingler, Amelie Brugger, Kerstin Feistel, Axel Schweickert
Summary: This study reveals the role of Dmrt2 transcription factor in LRO ciliogenesis and sLRO cell specification in the formation of the vertebrate left-right axis, as well as its functional connection to somitogenesis and LR determination.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Sport Sciences
Guilherme Defante Telles, Cleiton Augusto Libardi, Miguel Soares Conceicao, Felipe Cassaro Vechin, Manoel Emilio Lixandrao, Flavia Regina Rotea Mangone, Ana Carolina Pavanelli, Maria Aparecida Nagai, Donny Michael Camera, John A. Hawley, Carlos Ugrinowitsch
Summary: This study aimed to compare the time course changes in DNA methylation and mRNA expression for selected myogenic regulatory factors immediately after, 4 h after, and 8 h after a single bout of resistance exercise, high-intensity interval exercise, and concurrent exercise. The results showed that the mean methylation across all CpGs analyzed was reduced after 4 and 8 h in response to all exercise protocols. In addition, all exercise bouts increased mRNA expression over time.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biology
Anieli G. Pereira, Mariana B. Grizante, Tiana Kohlsdorf
Summary: Developmental pathways involve the interaction of transcription factors and cis-regulatory elements, forming transcription factor-regulatory element (TF-RE) units. Independent origins of similar phenotypes may involve changes in different parts of these units. This study focuses on the independent origins of the rib-associated lumbar (RAL) morphotype and finds that sequence variations in either component of the TF-RE unit can result in the independent origins of the RAL morphotype.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biology
Scott A. Rankin, Jeffrey D. Steimle, Xinan H. Yang, Ariel B. Rydeen, Kunal Agarwal, Praneet Chaturvedi, Kohta Ikegami, Michael J. Herriges, Ivan P. Moskowitz, Aaron M. Zorn
Summary: This study in Xenopus and mouse embryos reveals molecular links between Tbx5 and retinoic acid signaling in the development of the heart and lungs, uncovering a conserved signaling cascade that coordinates cardiopulmonary development. The research provides insight into the interrelationship between heart and lung development, which is important for understanding congenital defects and the evolution of cardiopulmonary systems.
Article
Cell Biology
Long Zhao, Chenyu Li, Chen Guan, Ning Song, Hong Luan, Congjuan Luo, Wei Jiang, Quandong Bu, Yanfei Wang, Lin Che, Yan Xu
Summary: Studies have shown that in the early stage of acute kidney injury, the expression of SRF is significantly elevated, making it a potential early diagnostic biomarker. Analysis of microarray data related to kidney injury revealed a dramatic increase in SFR in mouse renal tissue 2-4 hours after ischemia/ reperfusion.
Review
Biochemistry & Molecular Biology
John Oloche Onuh, Hongyu Qiu
Summary: SRF, a member of the MADS box transcription factor family, is widely expressed in all cell types and regulates downstream genes by interacting with various cofactors. Recent studies on the molecular mechanisms of SRF activation have highlighted its importance in physiological and pathological conditions. This knowledge may provide new opportunities for understanding disease pathogenesis and identifying potential therapeutic targets.
Article
Clinical Neurology
Ru Li, Jiaxin Li, Yuanyuan Liu, Dazhi Li, Lijun Chu, Jian Zhang, Xingguang Luo, Yong Zhang
Summary: The study aimed to explore the predictive value of serum BDNF levels for the diagnosis of PD and the association between serum BDNF levels and treatment response to escitalopram in PD patients. The baseline serum BDNF levels were lower in PD patients compared to healthy controls, and higher baseline serum BDNF levels predicted better treatment response to escitalopram in PD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Nutrition & Dietetics
Yali Wang, Peng Du, Qi Xiao, Jianfeng Li, Xiao Liu, Jinfeng Tan, Xingjian Zhang
Summary: This study found that patients with high serum albumin levels had a lower risk of atrial fibrillation compared to those with low albumin levels, and for every 10 g/L increase in serum albumin level, the risk of atrial fibrillation decreased by 36%.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Li Liu, Ke Sun, Yajun Luo, Bingshu Wang, Yuyu Yang, Long Chen, Shaojiang Zheng, Teng Wu, Pingxi Xiao
Summary: In this study, the involvement of MRTF-A, a transcriptional regulator, in diabetic cardiomyopathy was investigated. The results showed that MRTF-A was up-regulated in the hearts of mice with diabetic cardiomyopathy. Mechanistically, SRF bound to the MRTF-A gene promoter and activated its transcription in response to pro-diabetic stimuli. Deletion of MRTF-A in cardiomyocytes exacerbated the deterioration of cardiac function in mice with diabetic cardiomyopathy.
Article
Multidisciplinary Sciences
Yi Ding, Leticia Oliveira-Ferrer, Eike Vettorazzi, Karen Legler, Karin Milde-Langosch, Linn Woelber, Anna Jaeger, Katharina Prieske, Volkmar Mueller, Barbara Schmalfeldt, Sascha Kuerti
Summary: This study investigated the potential of vascular endothelial growth factor C (VEGF-C) in serum as a predictive biomarker for response to antiangiogenic therapy in ovarian cancer patients. The results showed that patients with higher levels of VEGF-C in serum had significantly increased chances of response to bevacizumab treatment. Therefore, VEGF-C serum level may serve as a useful biomarker for evaluating treatment response to bevacizumab.
Article
Cardiac & Cardiovascular Systems
Kathleen C. Woulfe, Danielle A. Jeffrey, Julie Pires Da Silva, Cortney E. Wilson, Jennifer H. Mahaffey, Edward Lau, Dobromir Slavov, Frehiwet Hailu, Anis Karimpour-Fard, Karen Dockstader, Michael R. Bristow, Brian L. Stauffer, Shelley D. Miyamoto, Carmen C. Sucharov
Summary: In pediatric dilated cardiomyopathy (pDCM), treatment with phosphodiesterase 3 inhibitors (PDE3i) leads to the expression of an SRF isoform lacking exon 5 (SRFdel5) which improves cardiac function by regulating PLN phosphorylation and calcium reuptake. In contrast, adult DCM patients do not show the same increase in SRFdel5 expression in response to PDE3i, suggesting a unique molecular mechanism in pediatric versus adult DCM response to therapy. Additionally, overexpression of SRFdel5 in cardiomyocytes promotes faster calcium reuptake and increased PLN phosphorylation, while full length SRF attenuates calcium reuptake through blunted phosphorylation of PLN.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Bidisha Paul, Rejenae Dockery, Valery M. Valverde, Daniel R. Buchholz
Summary: Corticosteroids play a critical role in development and stress responses in vertebrates. A new gene called frzb has been identified as a marker for corticosterone response in frog tadpole tails, making it useful for hormone treatments and endocrine disruption studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Yunfeng Lin, Jia Li, Haichao Zhao, Anne McMahon, Kelly McGhee, Shan Yan
Summary: Cells have evolved DDR pathways to respond to DNA replication stress or damage. APE1 directly associates with ssDNA to recruit ATRIP independently of RPA. Moreover, APE1 interacts with RPA70 and RPA32 through distinct motifs. These findings indicate that APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner in the ATR DDR pathway.
Article
Clinical Neurology
Nicolas Fissolo, Agustin Pappolla, Jordi Rio, Luisa M. M. Villar, Santiago Perez-Hoyos, Alex Sanchez, Lucia Gutierrez, Xavier Montalban, Manuel Comabella
Summary: The study aimed to identify biomarkers associated with treatment response in patients with multiple sclerosis treated with oral therapies. The results showed that serum levels of CXCL13 and TNF-alpha were significantly decreased in patients with no evidence of disease activity (NEDA) after 1 year of treatment. Therefore, CXCL13 can serve as a biomarker for treatment response and identify optimal responders to the treatment.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Alexander Guenter, Vithiyanjali Sothilingam, Michael M. Orlich, Alfred Nordheim, Mathias W. Seeliger, Regine Muehlfriedel
Summary: This study further investigated the effects of MC SRF deficiency on the vasculature and function of the mature retina. Mutant retinal blood vessels exhibited various morphological and functional alterations, including vascular bulging, arteriovenous anastomoses formation, and retinal detachment. These changes resulted in irregular retinal blood pressure and flow distribution, leading to hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Bridget D. DeLay, Mark E. Corkins, Hannah L. Hanania, Matthew Salanga, Jian Min Deng, Norihiro Sudou, Masanori Taira, Marko E. Horb, Rachel K. Miller
Article
Genetics & Heredity
Bridget D. DeLay, Mark E. Corkins, Hannah L. Hanania, Matthew Salanga, Jian Min Deng, Norihiro Sudou, Masanori Taira, Marko E. Horb, Rachel K. Miller
Article
Developmental Biology
Stryder M. Meadows, Matthew C. Salanga, Paul A. Krieg
Article
Anatomy & Morphology
Matthew C. Salanga, Stryder M. Meadows, Candace T. Myers, Paul A. Krieg
DEVELOPMENTAL DYNAMICS
(2010)
Article
Anatomy & Morphology
Carlos M. Moran, Matthew C. Salanga, Paul A. Krieg
DEVELOPMENTAL DYNAMICS
(2011)
Article
Toxicology
Matthew C. Salanga, Nadja R. Brun, Rene D. Francolini, John J. Stegeman, Jared Goldstone
TOXICOLOGICAL SCIENCES
(2020)
Article
Ecology
Daesik Park, Catherine R. Propper, Guangning Wang, Matthew C. Salanga
Summary: By studying the genetic allelic variation and expression of as3mt gene in fish populations in different arsenic concentration environments, it was found that fish from high arsenic concentration site had significantly lower expression of as3mt gene, while fish populations in low arsenic environments had more SNPs. This suggests that gene expression related to arsenic detoxification plays a crucial role in influencing responses to arsenic toxicity.
Review
Biochemistry & Molecular Biology
Cristy M. Salanga, Matthew C. Salanga
Summary: This article discusses the consequences of forward genetic screens and the revolutionizing impact of the CRISPR/Cas system on reverse genetics. Studies have shown the presence of compensation mechanisms in genotype to phenotype relationships, which has important implications for gene loss-of-function research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Nathan Cruz, Robert Buscaglia, Matthew Salanga, Robert Kellar
Summary: Uranium, a heavy metal used in military and industrial applications, is often mined from the Southwest region of the United States. Research shows that uranium released into soil and water during the mining process may pose threats to human and environmental health. Studies indicate that skin exposure to uranium can have cytotoxic effects on cells and may interfere with wound healing processes.
Article
Developmental Biology
Wil Ratzan, Rosalia Falco, Cristy Salanga, Matthew Salanga, Marko E. Horb
DEVELOPMENTAL BIOLOGY
(2017)
Meeting Abstract
Zoology
A. M. Tarrant, R. R. Helm, M. C. Salanga
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2017)
Article
Biophysics
S Kumar, IZ Maxwell, A Heisterkamp, TR Polte, TP Lele, M Salanga, E Mazur, DE Ingber
BIOPHYSICAL JOURNAL
(2006)
Article
Cell Biology
TP Lele, J Pendse, S Kumar, M Salanga, J Karavitis, DE Ingber
JOURNAL OF CELLULAR PHYSIOLOGY
(2006)
Meeting Abstract
Oncology
Carlos R. Estrada, Matthew Salanga, W. Bruce Harrell, Diane Bielenberg, David Zurakowski, Matthew R. Palmer, Michael R. Freeman, Rosalyn M. Adam