Article
Medicine, General & Internal
Jin-Young Choi, Hyunseong Kim, Ha-Yeh-Rin Koo, Jaeyoon You, Dong-Soo Yu, Young-Bok Lee, Minho Lee
Summary: This study analyzed the scalp microbiome of patients with psoriasis scalp lesions and found that the diversity of the scalp microbiome and the relative abundance of Pseudomonas are associated with the severity of scalp psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Pa-Fan Hsiao, Yi-Ting Huang, Po-Hsuan Lu, Ling-Ya Chiu, Tzu-Han Weng, Chi-Feng Hung, Nan-Lin Wu
Summary: This study investigates the expression and regulation of TXNIP in psoriasis, as well as its role in skin keratinocyte differentiation and EGFR signaling.
Review
Immunology
Masahiro Kamata, Yayoi Tada
Summary: Psoriasis is an immune-mediated disease in which immune cells and skin cells interact, leading to aberrant differentiation and proliferation of keratinocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Tuntas Rayinda, Sheila M. McSweeney, Nikolina Lalagianni, Lu Liu, Alyson Guy, David Fenton, Catherine M. Stefanato, Nick Dand, John A. McGrath, Christos Tziotzios
Summary: This report presents a case study of an 18-year-old white British woman with HTSS1, who had the inability to grow long scalp hair. Whole exome sequencing identified a novel pathogenic nonsense variant in the CDSN gene, which encodes corneodesmosin. This case expands the genotype-phenotype paradigm of HTSS1 by describing distinct clinical and histopathological features.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Siying Li, Xin Luo, Suhan Zhang, Yuwen Su, Min Deng, Yanshan Zhu, Peng Zhang, Ruifang Wu, Ming Zhao
Summary: This study suggests that ferroptosis activation due to iron overload may be a novel mechanism underlying the formation of skin lesions in individuals with psoriasis.
Review
Dermatology
Xingyu Jiang, Rongcan Shi, Rui Ma, Xinyi Tang, Yu Gong, Zengyang Yu, Yuling Shi
Summary: Psoriasis is a chronic immune-mediated inflammatory skin disease. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis of psoriasis. Dysregulated miRNAs in psoriasis significantly affect keratinocyte proliferation and/or differentiation processes, as well as inflammation progress. Moreover, miRNAs also influence the function of immune cells in psoriasis. Possible miRNA-based therapy for psoriasis, such as the topical delivery of exogenous miRNAs, miRNA antagonists, and miRNA mimics, have also been discussed.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Immunology
Kaixuan Ren, Yumin Xia
Summary: Lipocalin 2 plays a crucial role in the pathogenesis of psoriatic inflammation by exerting versatile effects on skin resident cells and infiltrating immune cells. Neutralizing lipocalin 2 or relevant cytokines can alleviate psoriasis, highlighting lipocalin 2 as an effective interfering target.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Soyeon Jang, Soyoung Jang, Si-Yong Kim, Jiwon Ko, Eungyung Kim, Ji Yeong Park, Hyejin Hyung, Jin Hong Lee, Su-Geun Lim, Sijun Park, Junkoo Yi, Heon-Jin Lee, Myoung Ok Kim, Hyun-Shik Lee, Zae Young Ryoo
Summary: Psoriasis, an autoimmune skin disease, is characterized by plaques. Lin28a was found to exacerbate psoriasis by downregulating let-7 expression levels and causing abnormal keratinocyte proliferation. Overexpression of Lin28a resulted in hyperproliferation and abnormal differentiation in keratinocytes, worsening psoriasis symptoms.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
You-Wang Lu, Yong-Jun Chen, Nian Shi, Lu-Hui Yang, Hong-Mei Wang, Rong-Jing Dong, Yi-Qun Kuang, Yu-Ye Li
Summary: In this study, genes and cytokines related to the pathogenesis of psoriasis were identified through gene expression analysis. These findings may contribute to the diagnosis and treatment of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Shengyuan Hua, Yu Ding, Jia Zhang, Qiufang Qian, Ming Li
Summary: This study aimed to definitively diagnose three pediatric patients suspected of HS in two unrelated Chinese families through whole-exome sequencing, identifying novel accompanying phenotypes such as teeth dysplasia, and inferring potential genotype-phenotype correlations for LSS mutations for the first time.
JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yujun Sheng, Leilei Wen, Xiaodong Zheng, Mengqing Li, Dan Wang, Sixian Chen, Ran Li, Lili Tang, Fusheng Zhou
Summary: Psoriasis is an autoimmune skin disorder influenced by genetic, epigenetic, and environmental factors. The study found that specific methylation sites in the CYP2S1 gene region may participate in the development of psoriasis by affecting keratinocyte proliferation and immune response.
Review
Biochemistry & Molecular Biology
Andreas Orsmond, Lara Bereza-Malcolm, Tom Lynch, Lyn March, Meilang Xue
Summary: The skin barrier consists of a physical barrier in the epidermis and an immune barrier in both dermis and epidermis, which cooperate to maintain skin homeostasis and human health. Dysregulation can lead to various skin diseases, with psoriasis being one of the most prevalent due to disrupted barrier function. Recent research has focused on understanding disease pathogenesis involving keratinocytes, immune cells, genetic and environmental factors, and advancements in current and future treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Defri Rizaldy, Manami Toriyama, Hiroko Kato, Runa Fukui, Fumitaka Fujita, Motoki Nakamura, Fumihiro Okada, Akimichi Morita, Ken J. Ishii
Summary: This study revealed an increase in ciliated cells in skin samples from patients with atopic dermatitis (AD) and psoriasis, with the formation of primary cilia being modulated by stimulation of keratinocytes using Th2 and Th17 cytokines. This modulation was associated with an increase in JNK phosphorylation, which may impair keratinocyte differentiation under inflammatory stress conditions in both AD and psoriasis patients.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
F. Bruni, A. Alessandrini, M. Starace, G. Orlando, B. M. Piraccini
Summary: This study described different clinical patterns of scalp psoriasis and their trichoscopic correlations, which may assist clinicians in diagnosing even in atypical presentations and prescribing appropriate therapeutic regimens.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Medicine, General & Internal
Xue-Yan Chen, Zhao-Yuan Wang, Yuan Zhou, Li-Ran Ye, Xiao-Yong Man
Summary: The skin serves as the outermost barrier between the human body and the external environment. In psoriasis, an inflammatory microenvironment called the epidermal immunological microenvironment (EIME) is formed by immune cells residing within or infiltrating the epidermis, leading to complex interactions with keratinocytes, nerves, and microbiota. This study proposes that psoriasis is a chronic inflammatory disease mediated by keratinocyte-neuro-immune cell units (KNICUs), which arise from interactions between activated epidermal keratinocytes, nerves, immune cells, and the skin microbiota, forming a complex interaction framework. Multiple KNICUs gather to establish circulatory and amplified loops, creating a collective force to initiate and sustain psoriasis.
FRONTIERS IN MEDICINE
(2023)
Article
Allergy
Jessy S. Deshane, David T. Redden, Meiqin Zeng, Marion L. Spell, Jaroslaw W. Zmijewski, John T. Anderson, Rohit J. Deshane, Amit Gaggar, Gene P. Siegal, Edward Abraham, Mark T. Dransfield, David D. Chaplin
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2015)
Article
Immunology
Y. Jung, T. Wen, M. K. Mingler, J. M. Caldwell, Y. H. Wang, D. D. Chaplin, E. H. Lee, M. H. Jang, S. Y. Woo, J. Y. Seoh, M. Miyasaka, M. E. Rothenberg
MUCOSAL IMMUNOLOGY
(2015)
Article
Anatomy & Morphology
Yaiko Hara, Kenjiro Wake, Kouji Inoue, Noriyuki Kuroda, Akie Sato, Mutsumi Inamatsu, Chise Tateno, Tetsuji Sato
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Hong-Beom Bae, Jaroslaw W. Zmijewski, Jessy S. Deshane, Degui Zhi, Lawrence C. Thompson, Cynthia B. Peterson, David D. Chaplin, Edward Abraham
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2012)
Article
Anatomy & Morphology
Kouji Inoue, Yaiko Hara, Noriyuki Kuroda, Tetsuji Sato
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2013)
Article
Dentistry, Oral Surgery & Medicine
Shunsuke Baba, Noriyuki Kuroda, Chihiro Arai, Yoshiki Nakamura, Tetsuji Sato
ARCHIVES OF ORAL BIOLOGY
(2011)
Article
Pharmacology & Pharmacy
T. Nabe, K. Matsuya, K. Akamizu, M. Fujita, T. Nakagawa, M. Shioe, H. Kida, A. Takiguchi, H. Wakamori, M. Fujii, K. Ishihara, S. Akiba, N. Mizutani, S. Yoshino, D. D. Chaplin
BRITISH JOURNAL OF PHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
Takeshi Nabe, Ayumu Ikedo, Fusa Hosokawa, Maki Kishima, Masanori Fujii, Nobuaki Mizutani, Shin Yoshino, Keiichi Ishihara, Satoshi Akiba, David D. Chaplin
EUROPEAN JOURNAL OF PHARMACOLOGY
(2012)
Article
Biochemistry & Molecular Biology
M. O. Alberti, J. S. Deshane, D. D. Chaplin, L. Pereboeva, D. T. Curiel, J. C. Roth
Article
Immunology
John R. Lukens, Maggie J. Barr, David D. Chaplin, Hongbo Chi, Thirumala-Devi Kanneganti
JOURNAL OF IMMUNOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Jean-Marc Tadie, Hong-Beom Bae, Jessy S. Deshane, Celeste P. Bell, Eduardo R. Lazarowski, David D. Chaplin, Victor J. Thannickal, Edward Abraham, Jaroslaw W. Zmijewski
MOLECULAR MEDICINE
(2012)
Article
Multidisciplinary Sciences
Noriyuki Kuroda, Kouji Inoue, Tadayuki Ikeda, Yaiko Hara, Kenjiro Wake, Tetsuji Sato
Article
Multidisciplinary Sciences
Carlene L. Zindl, Jen-Feng Lai, Yun Kyung Lee, Craig L. Maynard, Stacey N. Harbour, Wenjun Ouyang, David D. Chaplin, Casey T. Weaver
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Microscopy
Kouji Inoue, Noriyuki Kuroda, Tetsuji Sato
Article
Immunology
Pietro De Togni, Josphe Goellner, Nancy H. Ruddle, Philip R. Streeter, Andrea Fick, Sanjeev Mariathasan, Stacy C. Smith, Rebecca Carison, Laurie P. Shonnick, Jena strauss-Schoenberger, John H. Russell, Robert Karr, David D. Chaplin
JOURNAL OF IMMUNOLOGY
(2014)