Article
Neurosciences
Renee Chasse, Alexey Malyshev, Roslyn Holly Fitch, Maxim Volgushev
Summary: Theoretical and modeling studies suggest that heterosynaptic plasticity enhances discriminative learning and repetitive learning in Hebbian-type systems. Experimental manipulation of adenosine A1 receptors (A1Rs) to impair heterosynaptic plasticity resulted in impaired synaptic plasticity and deficits in visual discrimination learning in A1R KO mice. These results provide experimental evidence for the role of heterosynaptic plasticity in organism-level learning and suggest it as a potential target for interventions to enhance new learning.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maura Ferrer-Ferrer, Shaobo Jia, Rahul Kaushik, Jenny Schneeberg, Izabela Figiel, Stepan Aleshin, Andrey Mironov, Motahareh Safari, Renato Frischknecht, Jakub Wlodarczyk, Oleg Senkov, Alexander Dityatev
Summary: This study investigates the functional importance of neurotrypsin (NT) in synaptic plasticity, learning, and memory extinction. The results show that NT-deficient mice exhibit impaired long-term potentiation, contextual fear memory deficits, and sociability deficits. This highlights the crucial role of NT in synaptic formation and strengthening.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Daniela Madeira, Catia R. Lopes, Ana P. Simoes, Paula M. Canas, Rodrigo A. Cunha, Paula Agostinho
Summary: The study found that silencing the A(2A)R gene in astrocytes leads to deficits in hippocampal synaptic plasticity and memory. Astrocytic A(2A)R control astrocytic morphology and influence hippocampal synaptic plasticity and memory in adult mice.
Article
Multidisciplinary Sciences
Yulia Dembitskaya, Charlotte Piette, Sylvie Perez, Hugues Berry, Pierre J. Magistretti, Laurent Venance
Summary: The study shows that glucose and lactate play different roles in memory engram and neural computation. Lactate is important for high-stimulation load activity patterns and high attentional load in cognitive tasks, while glucose is sufficient for less demanding neural computation and learning tasks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Ping Liao, Qing-Yun Wu, Sen Li, Kai-Bin Hu, Hui-Lin Liu, Hai-Yan Wang, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wang
Summary: Abscisic acid (ABA) is a hormone found in plants and animals that regulates blood glucose and inflammation. It has therapeutic effects on obesity, diabetes, atherosclerosis, and inflammatory diseases. Studies have shown that ABA can cross the blood-brain barrier and improve learning, memory, and cognitive ability in the central nervous system. Additionally, it plays a crucial role in improving Alzheimer's disease, depression, and anxiety.
Article
Immunology
Ivan Ballasch, Esther Garcia-Garcia, Cristina Vila, Anna Perez-Gonzalez, Anna Sancho-Balsells, Jessica Fernandez, David Soto, Mar Puigdellivol, Xavier Gasull, Jordi Alberch, Manuel J. Rodriguez, Josep M. Canals, Albert Giralt
Summary: In the last two decades, microglia have been recognized as important contributors to neurological disorders, not only through their immunological functions, but also through their ability to modulate synaptic and neural activity. The Ikzf1 gene, which plays crucial roles in regulating the function of circulating monocytes and lymphocytes, was found to be specifically expressed in adult microglia in the brain. Studies using Ikzf1 deficient mice revealed spatial learning deficits, impaired hippocampal function, and altered microglial morphology, suggesting that Ikzf1 is involved in microglial state and function. Furthermore, altered levels of Ikzf1 were observed in neurological disorder models and Alzheimer's disease patients, indicating its potential role in disease pathology.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Timothy Tadros, Maxim Bazhenov
Summary: Relational memory is critical for mammalian reasoning. Sleep plays a crucial role in offline processing and improving the ability to make indirect associations.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Yifeng Rang, Huan Liu, Chunhong Liu
Summary: This review summarizes the mechanisms underlying Nonylphenol (NP)-induced learning and memory impairment and proposes possible therapeutic methods. Through behavior tests and other studies, oxidative stress, neurotransmitter disorder, synaptic plasticity impairment, and neuron injury are identified as key factors contributing to learning and memory deficits. In addition, chronic inflammation and increased gut permeability are also suggested to be associated with NP-induced learning and memory impairment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Immunology
Shunqin Fan, Xijun Wang, Ning Gao, Songli Wei
Summary: In a rat model, electroacupuncture pretreatment was found to improve learning and memory deficits induced by recurrent propofol exposure. It also enhanced hippocampal synaptic plasticity, activated the pCREB/BDNF pathway, and inhibited neuronal apoptosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yuya Sakimoto, Paw Min-Thein Oo, Makoto Goshima, Itsuki Kanehisa, Yutaro Tsukada, Dai Mitsushima
Summary: The hippocampus plays a key role in contextual memory, with long-term strengthening of glutamatergic transmission and enhancement of GABA(A) receptor-mediated inhibitory synapses after learning. Rapid plasticity at inhibitory synapses following contextual learning may facilitate encoding of memories and prevent cognitive dysfunction in hippocampal pathologies such as Alzheimer's disease, autism spectrum disorders, and epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Nastaran Golitabari, Forouzan Mohammadian, Ali-Akbar Salari, Mohammad Amani
Summary: This study found that early life exposure to PCP can negatively affect the synaptic function of CA1 neurons in the hippocampus of adult rats, including inhibiting long-term potentiation and depression, and causing significant changes in complex response profiles.
Article
Physics, Fluids & Plasmas
Wenxuan Zou, Chan Li, Haiping Huang
Summary: In this study, the authors propose a spike and slab distribution to model the individual connections in recurrent neural networks for temporal credit assignment. They derive a mean-field algorithm to train the network and apply the method to classification and multisensory integration tasks. The study uncovers important connections in the network and reveals different types of neural selectivity.
Article
Neurosciences
Liliana Dias, Catia R. Lopes, Francisco Q. Goncalves, Ana Nunes, Daniela Pochmann, Nuno J. Machado, Angelo R. Tome, Paula Agostinho, Rodrigo A. Cunha
Summary: This study demonstrated the functional interaction between P2X7R and A(2A)R in regulating microglia reactivity in response to repeated stress, indicating a potential cooperation between these two purinergic systems in controlling brain function. The results show that antagonists of P2X7R and A(2A)R can attenuate the behavioral modifications caused by repeated stress, and their effects on calcium levels in microglial cells suggest a complex interplay between these two receptors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Xingzhi He, Jiarui Li, Guangjun Zhou, Jing Yang, Sam McKenzie, Yanjun Li, Wenwen Li, Jun Yu, Yang Wang, Jing Qu, Zhiying Wu, Hailan Hu, Shumin Duan, Huan Ma
Summary: This study shows a positive correlation between hippocampal oscillatory strength and excitatory monosynaptic drive onto inhibitory neurons in freely behaving mice. By manipulating experience-dependent E -> I synaptic input/plasticity, the researchers were able to demonstrate its role in memory function. Deleting a specific protein affected long-term memory and brain wave rhythms.
Article
Neurosciences
Smita Yadav, Juan A. Oses-Prieto, Christian J. Peters, Jing Zhou, Samuel J. Pleasure, Alma L. Burlingame, Lily Y. Jan, Yuh-Nung Jan
Article
Anesthesiology
Nicholas A. Telischak, Jeremy J. Heit, Lucas W. Campos, Omar A. Choudhri, Huy M. Do, Xiang Qian
Article
Neurosciences
Eung Chang Kim, Jiaren Zhang, Weilun Pang, Shuwei Wang, Kwan Young Lee, John P. Cavaretta, Jennifer Walters, Erik Procko, Nien-Pei Tsai, Hee Jung Chung
NEUROBIOLOGY OF DISEASE
(2018)
Article
Behavioral Sciences
Eung Chang Kim, Jaimin Patel, Jiaren Zhang, Heun Soh, Justin S. Rhodes, Anastasios Tzingounis, Hee Jung Chung
GENES BRAIN AND BEHAVIOR
(2020)
Article
Clinical Neurology
Bing Huang, Ming Yao, QiLiang Chen, Huidan Lin, Xindan Du, Hao Huang, Xian Zhao, Huy Do, Xiang Qian
JOURNAL OF NEUROSURGERY
(2020)
Article
Anesthesiology
Bing Huang, Ming Yao, QiLiang Chen, Xindan Du, Zhang Li, Keyue Xie, Yong Fei, Huy Do, Xiang Qian
Summary: This study describes the method and clinical efficacy of awake CT-guided PBC for TN treatment. The technique resulted in improved outcomes with a low recurrence rate and overall mild side effects. Patients experienced significant facial hypoesthesia or resolution of TN symptoms, demonstrating the effectiveness and safety of this approach compared to traditional PBC under fluoroscopy guidance and general anesthesia.
Review
Medicine, General & Internal
Qiliang Chen, Erdong Chen, Xiang Qian
Summary: Effective pain management is crucial in perioperative care, and the excessive use of opioids has contributed to the current opioid epidemic. Implementing multimodal analgesia and enhanced recovery after surgery pathways has been shown to significantly improve postoperative outcomes. The future of improving perioperative pain management may lie in the incorporation of personalized metrics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eung Chang Kim, Jiaren Zhang, Andy Y. Tang, Eric C. Bolton, Justin S. Rhodes, Catherine A. Christian-Hinman, Hee Jung Chung
Summary: This study reveals that impaired axonal surface expression of K(v)7 channels in KCNQ2-related epileptic encephalopathy is associated with epileptic seizures, cognitive and behavioral deficits, and neuronal loss.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Shashank Pant, Jiaren Zhang, Eung Chang Kim, Kin Lam, Hee Jung Chung, Emad Tajkhorshid
Summary: Research using molecular dynamics simulations and electrophysiology has revealed the allosteric role of phosphatidylinositol-4,5-bisphosphate (PIP2) in the activation of K(v)7.2 channels, influencing protein conformation and correlated motions.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
QiLiang Chen, Dae Ik Yi, Josiah Nathan Joco Perez, Monica Liu, Steven D. Chang, Meredith J. Barad, Michael Lim, Xiang Qian
Summary: This article reviews the latest findings on the pathophysiology of trigeminal neuralgia (TN) and examines them in relation to current surgical and pharmacologic management for TN patients. Understanding the underlying biology of TN could help scientists and clinicians identify novel treatment targets and improve current treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yanfeng Zhang, Yujia Luo, Yachao Ruan, Xiang Qian, Zhiying Feng
Summary: Early diagnosis of SAPHO syndrome is challenging due to its similarity with other spine-related diseases and infections. This case report highlights the importance of considering osteoarticular and dermatological manifestations in the diagnosis of SAPHO syndrome and the effectiveness of biological agents in treating refractory cases.
INTERNATIONAL MEDICAL CASE REPORTS JOURNAL
(2023)
Article
Medicine, General & Internal
Roxana Garcia, QiLiang Chen, Edmund Posadas, Johnathan Tran, Albert Kwon, Xiang Qian
Summary: Complex orofacial pain disorders, such as trigeminal neuralgia (TN) and atypical facial pain (AFP), were treated with continuous ketamine infusion in this retrospective case series. Results showed that TN patients had significant and sustained pain relief while AFP patients did not respond to the treatment. This suggests a fundamental difference between these two facial pain disorders and supports the use of continuous ketamine infusion for refractory TN.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Anesthesiology
Mingjie Huang, QiLiang Chen, Songbin Wu, Jiabin Huang, Wuping Sun, Shaomin Yang, Xiang Qian, Lizu Xiao
Summary: tSNRS provides similar therapeutic efficacy compared to tSCS for patients with unilateral PHN and offers technical advantages.
Review
Neurosciences
Xiangyang Mei, Yixin Yang, Jinsong Zhao, Yongjie Wang, QiLiang Chen, Xiang Qian, Xiangyao Li, Zhiying Feng
Article
Anesthesiology
Jed M. Paul, Daniel S. Orlovich, John W. Patton, Xiang Qian