Article
Cell Biology
Kiran Pandey, Xiao-Wen Yu, Adam Steinmetz, Cristina M. Alberini
Summary: An increase in autophagy following learning is essential for long-term memory formation, but not necessary for the increase in protein synthesis. The upregulation of autophagy proteins is due to active translation of their mRNA rather than changes in total mRNA levels.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Toshimichi Hata, Tatsuya Yamashita, Taisuke Kamada
Summary: Interval timing, particularly in the range of seconds or minutes, is common in organisms. Studies on animals have indicated the crucial role of the dorsal hippocampus in the formation of long-term duration memories, with interventions leading to lower timing accuracy in probe sessions. These findings suggest the importance of the dorsal hippocampus in interval timing and long-term memory formation.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Michael S. Humphreys, Gerald Tehan, Oliver Baumann, Shayne Loft
Summary: The existence of a special state in short-term memory, where recently encountered items do not need to be retrieved, was tested using a probe-recognition paradigm and delayed recognition test. The results indicate that this special state is not important and cannot be used to define short-term memory.
CURRENT PSYCHOLOGY
(2023)
Article
Plant Sciences
Ryo Tsukimoto, Kazuho Isono, Takuma Kajino, Satoshi Iuchi, Akihisa Shinozawa, Izumi Yotsui, Yoichi Sakata, Teruaki Taji
Summary: This study identified the SLOH5 gene and revealed the importance of mitochondrial fission and function in long-term heat tolerance in Arabidopsis.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Emmanouela Kallergi, Akrivi-Dimitra Daskalaki, Angeliki Kolaxi, Come Camus, Evangelia Ioannou, Valentina Mercaldo, Per Haberkant, Frank Stein, Kyriaki Sidiropoulou, Yannis Dalezios, Mikhail M. Savitski, Claudia Bagni, Daniel Choquet, Eric Hosy, Vassiliki Nikoletopoulou
Summary: Autophagy is required for pruning dendritic spines and long-term depression (LTD), a major form of synaptic plasticity. LTD induces the biogenesis of autophagic vesicles in dendrites to facilitate the degradation of postsynaptic proteins. Autophagy plays a crucial role in dendritic spine pruning and synaptic plasticity.
NATURE COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Toshiro Sakamoto, Joi Yashima
Summary: The prefrontal cortex is crucial for long-term social recognition memory in mice, while its role in short-term memory is unclear. It also plays a significant role in social motivation but has no impact on anxiety-related behavior or general activity.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Immunology
Lukas W. Unger, Moritz Muckenhuber, Benedikt Mahr, Christoph Schwarz, Nina Pilat, Nicolas Granofszky, Heinz Regele, Thomas Wekerle
Summary: This study investigated the combination therapy of CTLA4-Ig and CD40L blockade in a murine heart transplantation model. The results showed that only complete interruption of CD40-CD40L signaling achieved long-term graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francisca Bertin, Guillermo Moya-Alvarado, Eduardo Quiroz-Manriquez, Andres Ibacache, Andres Kohler-Solis, Carlos Oliva, Jimena Sierralta
Summary: Dlg protein interacts with NRs in the adult brain of fruit flies and plays an important role in short-term memory. However, the role of Dlg protein is crucial for development and synaptic function in the larval NMJ synapse despite the absence of NRs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Baiwei Liu, Xinyu Li, Jan Theeuwes, Benchi Wang
Summary: It has been traditionally believed that information retrieved from long-term memory (LTM) needs to be brought back into working memory (WM). However, this study demonstrates that retrieval from LTM is possible even when WM capacity is fully occupied. EEG results indicate that retrieving items from LTM while WM is fully engaged enhances the suppression of alpha oscillations, suggesting alternative mechanisms for accessing LTM when WM is fully occupied.
Article
Psychology, Mathematical
Roy Shoval, Nurit Gronau, Tal Makovski
Summary: Previous research has shown that meaningful images have a greater capacity for visual long-term memory (VLTM), but the capacity and limits of a pure VLTM that is independent of conceptual information still need to be determined. The results of three experiments demonstrated that there is no massive VLTM for meaningless stimuli, and memory for visual properties per-se is overall poor, particularly for meaningless items.
PSYCHONOMIC BULLETIN & REVIEW
(2023)
Article
Biochemistry & Molecular Biology
Li Meng, Cai-Ping Du, Chun-Yuan Lu, Kun Zhang, Lin Li, Jing-Zhi Yan, Xiao-Yu Hou
Summary: This study revealed that neuronal activity induced SUMOylation of Akt1 by SUMO1, mediated by PIAS3, which enhanced Akt1's enzymatic activity and facilitated its phosphorylation. This process is involved in ERK1/2-BDNF/Arc and mTOR-4E-BP1 signaling pathways, contributing to long-lasting excitatory synaptic responses and synaptic plasticity.
Article
Neurosciences
Irene Navarro-Lobato, Mariam Masmudi-Martin, Maria E. Quiros-Ortega, Celia Gaona-Romero, Marta Carretero-Rey, Cristina Rey Blanes, Zafar U. Khan
Summary: By overexpressing a memory enhancer called RGS14(414) in the perirhinal cortex of male rats, object recognition memory (ORM) was enhanced and short-term ORM was converted into long-term ORM within a key temporal window of 40 to 60 minutes post-exposure. During this conversion, 14-3-3 zeta upregulation facilitated the process, while beyond 60 minutes, it mediated the consolidation of stable memory into long-lasting ORM by regulating BDNF signaling.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Show Inami, Takaomi Sakai
Summary: Environmental light and circadian photoreceptors play important roles in maintaining long-term memory in fruit flies.
NEUROSCIENCE RESEARCH
(2022)
Article
Engineering, Biomedical
Jianhua Zhang, Julia Griesbach, Marsel Ganeyev, Anna-Katharina Zehnder, Peng Zeng, Gian Nutal Schaedli, Anke de Leeuw, Yuxiao Lai, Marina Rubert, Ralph Mueller
Summary: The study reveals that mechanical stimulation can promote the formation of 3D bioprinted bone organoids, and long-term mechanical loading is necessary for increasing the density and stiffness of the organoids, as well as promoting osteoblast differentiation.
Article
Cell Biology
Arnaldo Carreira-Rosario, Varsha Bhargava, Jens Hillebrand, Rahul K. Kollipara, Mani Ramaswami, Michael Buszczakl
DEVELOPMENTAL CELL
(2016)
Article
Genetics & Heredity
Saumitra Dey Choudhury, Zeeshan Mushtaq, Suneel Reddy-Alla, Sruthi S. Balakrishnan, Rajan S. Thakur, Kozhalmannom S. Krishnan, Padinjat Raghu, Mani Ramaswami, Vimlesh Kumar
Review
Biochemistry & Molecular Biology
Indulekha P. Sudhakaran, Mani Ramaswami
Article
Neurosciences
Elena A. Kuklin, Stephen Alkins, Baskar Bakthavachalu, Maria C. Genco, Indulekha Sudhakaran, K. Vijay Raghavan, Mani Ramaswami, Leslie C. Griffith
JOURNAL OF NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Helen C. Barron, Tim P. Vogels, Timothy E. Behrens, Mani Ramaswami
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Neurosciences
Baskar Bakthavachalu, Joern Huelsmeier, Indulekha P. Sudhakaran, Jens Hillebrand, Amanjot Singh, Arnas Petrauskas, Devasena Thiagarajan, M. Sankaranarayanan, Laura Mizoue, Eric N. Anderson, Udai Bhan Pandey, Eric Ross, K. VijayRaghavan, Roy Parker, Mani Ramaswami
Article
Biology
Beatriz Blanco-Redondo, Nidhi Nuwal, Susanne Kneitz, Tulip Nuwal, Partho Halder, Yiting Liu, Nadine Ehmann, Nicole Scholz, Annika Mayer, Joerg Kleber, Thilo Kaehne, Dominique Schmitt, Madhumala K. Sadanandappa, Natalja Funk, Viera Albertova, Charlotte Helfrich-Foerster, Mani Ramaswami, Gaiti Hasan, Robert J. Kittel, Tobias Langenhan, Bertram Gerber, Erich Buchner
JOURNAL OF EXPERIMENTAL BIOLOGY
(2019)
Article
Neurosciences
Ankita Chodankar, Madhumala K. Sadanandappa, Krishnaswamy VijayRaghavan, Mani Ramaswami
JOURNAL OF NEUROSCIENCE
(2020)
Editorial Material
Psychiatry
Kareen Heinze, Helen C. Barron, Emma K. Howes, Mani Ramaswami, Matthew R. Broome
Summary: In a healthy brain, maintaining balance between excitation and inhibition is crucial for neural stability. Reduced inhibition may be the underlying cause of shared symptoms in autism and psychosis, with altered levels of gamma-aminobutyric acid (GABA) potentially providing a therapeutic target for both disorders.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Biology
Amanjot Singh, Joern Hulsmeier, Arvind Reddy Kandi, Sai Shruti Pothapragada, Jens Hillebrand, Arnas Petrauskas, Khushboo Agrawal, Krishnan Rt, Devasena Thiagarajan, Deepa Jayaprakashappa, K. VijayRaghavan, Mani Ramaswami, Baskar Bakthavachalu
Summary: The research shows that Atx2 modulates the stability/turnover of a large fraction of target mRNAs by interacting with AU-rich elements in 30 UTRs. Atx2 interacts closely with target mRNAs within mRNP granules and contains distinct protein domains that either drive or oppose RNP-granule assembly.
Review
Behavioral Sciences
Camilla Roselli, Mani Ramaswami, Tamara Boto, Isaac Cervantes-Sandoval
Summary: Understanding the molecular mechanisms underlying memory formation, consolidation, and forgetting is crucial in modern neuroscience. Model organisms like Drosophila have been essential in advancing our knowledge, revealing key insights into synaptic and behavioral plasticity in learning and memory processes. Recent studies have led to exciting discoveries regarding the genetic control, transcriptional activity, protein synthesis, and localized changes in neural activity associated with memory formation and consolidation.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Tamara Boto, Mani Ramaswami
Summary: Prior experience influences new learning, as initial sensory experience shapes subsequent learning behavior by establishing memory traces.
Article
Genetics & Heredity
Joern Huelsmeier, Emily Walker, Baskar Bakthavachalu, Mani Ramaswami
Summary: The C-terminal intrinsically disordered region (cIDR) of Atx2 protein plays a crucial role in the progression of neurodegenerative diseases and protein aggregation, contributing to the understanding of unexpected protein-handling function for RNP granules.
G3-GENES GENOMES GENETICS
(2021)
Article
Neurosciences
Swati Trisal, Marcia Aranha, Ankita Chodankar, K. VijayRaghavan, Mani Ramaswami
Summary: Habituated animals have the ability to engage with familiar stimuli, and the override of habituation is explained by disinhibition and potentiation of inhibitory inputs. In the case of Drosophila, inhibitory plasticity contributes to olfactory and gustatory habituation. Exposure to a novel stimulus triggers activity in dopaminergic neurons, which can override gustatory habituation. Activation of sensory neurons or tyrosine hydroxylase-positive neurons can restore the proboscis extension reflex (PER) response to sucrose stimulation. These findings have implications for understanding attentional and sensory override of habituation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Amanjot Singh, Arvind Reddy Kandi, Deepa Jayaprakashappa, Guillaume Thuery, Devam J. Purohit, Joern Huelsmeier, Rashi Singh, Sai Shruti Pothapragada, Mani Ramaswami, Baskar Bakthavachalu
Summary: Cells respond to stress through translational arrest, robust transcriptional changes, and the formation of stress granules (SGs). This study found that SG assembly and stress-induced gene expression alterations appear to be driven by distinctive signaling processes, suggesting that SG assembly and the transcriptional response are two relatively independent mechanisms.
MOLECULAR BIOLOGY OF THE CELL
(2022)