Article
Biochemistry & Molecular Biology
Shunfeng Hu, Shuai Ren, Yiqing Cai, Jiarui Liu, Yang Han, Yi Zhao, Juan Yang, Xiangxiang Zhou, Xin Wang
Summary: PTGDS is highly expressed in DLBCL and correlates with poor prognosis. It promotes cell proliferation in DLBCL, while its inhibitor AT56 has anti-tumor effects in DLBCL therapy.
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Cell Biology
Chao Chen, Jun Guan, Xinyu Gu, Qingfei Chu, Haihong Zhu
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with high incidence rates. Over-expression of PGE2 in HCC cells plays a role in tumor progression through various pathways. Drugs targeting the COX-2/PGE2 axis can inhibit tumor progression, but may have severe side effects. Therefore, a combination of selective EP antagonists and traditional anti-tumoral drugs is recommended for better outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Magdiel Inggrid Setyawati, Qin Wang, Nengyi Ni, Jie Kai Tee, Katsuhiko Ariga, Pu Chun Ke, Han Kiat Ho, Yucai Wang, David Tai Leong
Summary: Traditional nanomedicine relies on tumor induced EPR effect for drug delivery. Here the authors show that gold nanoparticles are independently able to induce leakiness at tumor vasculature to enhance the tumor killing effect.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Alison Domingues, Alessandro Fantin
Summary: The vascular endothelium acts as a selective barrier to regulate macromolecule exchange, but its integrity is compromised in various pathological conditions, leading to increased vascular hyperpermeability. VEGFA is a potent permeability factor, and NRP1 may play a fundamental role in regulating VEGFA-induced responses in vascular endothelial cells.
Article
Plant Sciences
Lijie Liu, Hanjing Gao, Tao Wen, Tao Gu, Shuang Zhang, Zhiyong Yuan
Summary: Tanshinone IIA has been found to significantly reduce tumor formation, decrease intestinal permeability, and reduce neutrophil infiltration in mice with colitis-associated colorectal tumorigenesis. The mechanism involves downregulation of the NF-kappa B signaling pathway and inhibition of intestinal inflammation, suggesting its therapeutic potential for colorectal cancer.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Food Science & Technology
Tao Wang, Panpan Wang, Li Yin, Xiuchao Wang, Yuanyuan Shan, Yanglei Yi, Yuan Zhou, Bianfang Liu, Xin Wang, Xin Lue
Summary: L. plantarum KX041 effectively improves colorectal cancer by modulating gut microbiota, reducing inflammation, maintaining intestinal permeability, and attenuating oxidative stress.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Biochemistry & Molecular Biology
Olga A. Zhunina, Nikita G. Yabbarov, Andrey V. Grechko, Antonina V. Starodubova, Ekaterina Ivanova, Nikita G. Nikiforov, Alexander N. Orekhov
Summary: Mitochondrial dysfunction is closely associated with various human pathologies, with ROS and RNS playing a critical role in causing protein and mtDNA damage and leading to the development of diseases. Recent studies have identified numerous mtDNA mutations linked to different human pathologies, each having distinct effects in disease progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tameille Valentine, Lydia Hardowar, Jasmine Elphick-Ross, Richard P. Hulse, Mark Paul-Clark
Summary: Chemotherapy-induced neuropathies cause sensory disturbances and pain in cancer patients, and current analgesic strategies are ineffective due to a lack of understanding of the underlying causes. Research on the immune-neuronal interactions across different cancer therapy drug classes may lead to better pain management for cancer survivors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Md Zahid Akhter, Jagdish Chandra Joshi, Vijay Avin Balaji Ragunathrao, Mark Maienschein-Cline, Richard L. Proia, Asrar B. Malik, Dolly Mehta
Summary: The study demonstrates the generation of a population of S1PR1(+) EC is crucial for mediating endothelial repair and restoring vascular homeostasis in inflammatory vascular injury states. This transition of cells is induced by S1P and involves key genes such as SPHK1 and SPNS2, which are regulated by transcription factors EGR1 and STAT3.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jin-Ho Park, Ha-Hyeon Shin, Hyun-Seung Rhyu, So-Hee Kim, Eun-Seok Jeon, Byung-Kwan Lim
Summary: Research has shown that Coxsackievirus and adenovirus receptor (CAR) plays a crucial role in vascular endothelial cell junctions, with CAR deletion leading to increased vascular permeability and inflammatory cell infiltration. However, in a mouse model, CAR deletion did not significantly increase CVB3-induced myocarditis, although tissue virus titers were higher in CAR-eKO compared to WT mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Dong Cho, Nguyen Thi Thanh Nhan, Christopher Zhou, Kayeman Tu, Tara Nguyen, Nicolene A. Sarich, Kaori H. Yamada
Summary: Excessive VEGF-A signaling induces vascular leakage and angiogenesis. KIF13B-mediated recycling of internalized VEGFR2 through Rab11-positive recycling vesicle regulates endothelial permeability. Inhibition of KIF13B-mediated VEGFR2 trafficking mitigates vascular leakage in models of blinding eye disease wet AMD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Chong Zhang, Honglv Chen, Qiaoling He, Yiqin Luo, Andong He, Ailin Tao, Jie Yan
Summary: The study found that fibrinogen is upregulated in the colon of DSS-treated mice and in patients with ulcerative colitis. Inhibition of fibrinogen significantly alleviated DSS-induced colitis. Fibrinogen regulates colitis by modulating vascular permeability through activating AKT and depolymerizing microfilament, suggesting it as a potential target for anti-colitis treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Akane Hayashi, Naoaki Sakamoto, Koji Kobayashi, Takahisa Murata
Summary: Pharmacological DP1 stimulation decreases intestinal permeability by stimulating mucus secretion.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cell Biology
Xin Zhang, Kexin Wang, Xingbo Feng, Jian Wang, Yali Chu, Chunmeng Jia, Qingsi He, Cheng Chen
Summary: The study revealed that HIF1 alpha R282 is methylated by PRMT3, which is essential for its stability and oncogenic function. Using MPG-peptide to inhibit HIF1 alpha expression offers a new therapeutic strategy for colorectal cancer resistant to anti-angiogenesis therapy.
CELL DEATH & DISEASE
(2021)
Article
Dermatology
S. Inagaki, T. Nakamura, Y. Hamasaki, K. Yamamoto-Hanada, T. Fukuie, M. Narita, T. Shimosawa, T. Murata, Y. Ohya
Summary: The level of urinary PGD(2)metabolites in children with AD is similar to healthy controls, even in cases of severe disease.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hyojin Park, Jessica Furtado, Mathilde Poulet, Minhwan Chung, Sanguk Yun, Sungwoon Lee, William C. Sessa, Claudio A. Franco, Martin A. Schwartz, Anne Eichmann
Summary: This study demonstrates the critical role of ALK1 in controlling endothelial cell polarization against blood flow direction and promoting vein-to-artery migration, while identifying integrin-YAP/TAZ signaling blockers as potential targets for preventing vascular malformations in patients with hereditary hemorrhagic telangiectasia.
Letter
Allergy
Yusuke Inuzuka, Kiwako Yamamoto-Hanada, Tatsuro Nakamura, Tatsuo Shimosawa, Takahisa Murata, Yukihiro Ohya
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Biochemistry & Molecular Biology
Kana Miyata, Daiki Horikami, Yuri Tachibana, Teruko Yamamoto, Tatsuro Nakamura, Koji Kobayashi, Takahisa Murata
Summary: Allergic rhinitis is a common allergic inflammatory disease that causes nasal congestion and rhinorrhea. The study found that a metabolite called 15-HEDE plays a role in vascular changes and nasal congestion. It dilates blood vessels by activating K-V channels and increases vascular permeability, potentially exacerbating the symptoms of allergic rhinitis.
Article
Behavioral Sciences
Naoaki Sakamoto, Koji Kobayashi, Teruko Yamamoto, Sakura Masuko, Masahito Yamamoto, Takahisa Murata
Summary: In this study, an automated grooming detection method was developed using image analysis and artificial intelligence to distinguish facial grooming from body grooming in mice. The method achieved high sensitivity and positive predictive rates, and showed strong correlation with human observations.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yusuke Miyazaki, Koji Kobayashi, Seiji Matsushita, Naoyuki Shimizu, Takahisa Murata
Summary: The research developed an SLA measurement system using image analyses to study the movement behavior of BALB/c mice. The study observed the effects of habituation, age, and sex on the mice's spontaneous locomotor activity and found some differences. The findings contribute to a better understanding of animal behavior in their natural breeding environment.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Biology
Joseph Wayne M. Fowler, Rong Zhang, Bo Tao, Nabil E. Boutagy, William C. Sessa
Summary: The relationship between cholesterol homeostasis and immunity in leukocytes has been extensively studied, but not much is known about this relationship in vascular endothelium cells. This study reveals the role of cholesterol and the transcription regulator SREBP2 in the inflammatory response of endothelial cells.
Article
Biochemistry & Molecular Biology
Joseph Wayne M. Fowler, Nabil E. Boutagy, Rong Zhang, Daiki Horikami, Michael B. Whalen, Casey E. Romanoski, William C. Sessa
Summary: The transcription factor SREBP2 is the main regulator of cholesterol homeostasis and has been implicated in leukocyte immune responses. In this study, the role of SREBP2 in endothelial cells was investigated, revealing its impact on inflammatory chemokine production and interferon response genes.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wenping Zhou, Wenxue Li, Shisheng Wang, Barbora Salovska, Zhenyi Hu, Bo Tao, Yi Di, Ujwal Punyamurtula, Benjamin E. E. Turk, William C. C. Sessa, Yansheng Liu
Summary: The authors used optogenetics and mass spectrometry-based phosphoproteomics to study the effects of different intensities, durations, and patterns of Akt1 activation on phosphorylation circuits, revealing downstream signaling outcomes of Akt1. The study showed that different intensities, durations, and patterns of Akt1 activation lead to distinct phosphorylation profiles in vascular endothelial cells, and also revealed the interaction between Akt1 signaling and growth factor signaling in these cells. The resulting dataset provides an important resource for future studies on AKT signaling and dynamics.
NATURE COMMUNICATIONS
(2023)
Article
Veterinary Sciences
Taiki Kida, Arisa Yamazaki, Koji Kobayashi, Tatsuro Nakamura, Takayuki Nakagawa, Ryohei Nishimura, Takahisa Murata
Summary: This study comprehensively analyzed lipid metabolites in dog urine using LC-MS/MS and identified various metabolites, which is important for the diagnosis and understanding of canine diseases.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Shinya Takenouchi, Yui Kobayashi, Tatsuya Shinozaki, Koji Kobayashi, Tatsuro Nakamura, Tomohiro Yonezawa, Takahisa Murata
Summary: This study analyzed the urinary lipid mediators in cats with feline idiopathic cystitis (FIC) and found that the levels of PUFAs were higher in FIC cats compared to the healthy group. The excretions of certain inflammatory mediators were also less in FIC cats, while the levels of other mediators were higher. These findings provide insights into the pathogenesis and potential future management of FIC in cats.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Review
Gastroenterology & Hepatology
Michele A. Rodrigues, Dawidson A. Gomes, Romina Fiorotto, Mateus T. Guerra, Jittima Weerachayaphorn, Tao Bo, William C. Sessa, Mario Strazzabosco, Michael H. Nathanson
Summary: Fluid and bicarbonate secretion in cholangiocytes is regulated by ITPR3, which localizes to the apical region. This localization is dependent on intact lipid rafts and interactions with CAV1 and MYH9. Disruption of lipid rafts or knockdown of CAV1 or MYH9 impairs ITPR3 localization and secretion.
HEPATOLOGY COMMUNICATIONS
(2022)
Review
Medicine, Research & Experimental
Nabil E. Boutagy, Abhishek K. Singh, William C. Sessa
Summary: Obesity is a major contributor to insulin resistance and type 2 diabetes, increasing the risk of cardiovascular disease. Metabolic changes caused by obesity negatively affect the vasculature, exacerbating disease progression. Understanding the cellular and molecular processes is crucial for optimizing medical therapies.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Ainara G. Cabodevilla, Songtao Tang, Sungwoon Lee, Adam E. Mullick, Jose O. Aleman, M. Mahmood Hussain, William C. Sessa, Nada A. Abumrad, Ira J. Goldberg
Summary: Despite the primary role of LpL in tissue uptake of fatty acids from chylomicrons, studies have shown that an additional pathway exists for transferring dietary lipids to tissues. This pathway involves endothelial cell uptake of chylomicrons, hydrolysis in lysosomes, and subsequent lipid accumulation in cells. Competing with HDL and targeting the scavenger receptor-BI can inhibit this process in vivo, potentially reducing lipid accumulation in tissues and preventing conditions such as eruptive xanthomas.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Qianying Yuan, Abdul Basit, Wenhua Liang, Rihao Qu, Yi Luan, Chunguang Ren, Ao Li, Xin Xu, Xiaoqing Liu, Chun Yang, Andrew Kuo, Richard Pierce, Longbo Zhang, Benjamin Turk, Xin Hu, Fangyong Li, Weixue Cui, Run Li, Danxia Huang, Lili Mo, William C. Sessa, Patty J. Lee, Yuval Kluger, Bing Su, Wenwen Tang, Jianxing He, Dianqing Wu
Summary: Pazopanib ameliorates ALI manifestations by inhibiting the phosphorylation of NADPH oxidase 2 subunit p47(phox) through MAP3K2 and MAP3K3. This drug also reduces edema in human lung transplantation recipients, indicating potential for treating ALI.
SCIENCE TRANSLATIONAL MEDICINE
(2021)