Article
Reproductive Biology
Kurumi Fukuda, Masafumi Muraoka, Yuzuru Kato, Yumiko Saga
Summary: The gene expression profile of pre-granulosa cells in mice undergoes significant changes during primordial follicle formation, with oocyte development playing a crucial role in this process.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Yingjun Chen, Qinghua Liu, Ruiyan Liu, Chan Yang, Xiaodong Wang, Zaohong Ran, Shanshan Zhou, Xiang Li, Changjiu He
Summary: This study in a mouse model revealed that early folliculogenesis requires a minimum of two weeks, with different stages showing specific characteristics such as oocyte size at Type 4-5 stage and theca folliculi formation at PD10-12. The study also highlighted the importance of the PD22-23 period for studying puberty initiation, providing valuable insights into the biological events of this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Sara Khaleghi, Farideh Eivazkhani, Somayeh Tavana, Ashraf Moini, Marefat Ghaffari Novin, Petkov Stoyan, Hamid Nazarian, Rouhollah Fathi
Summary: The study aimed to construct an Artificial Ovary by seeding Human Ovarian Cortical Cells into Human ovarian Decellularized Cortical Tissue, and assessed its ability to produce new ovarian follicles and hormone secretion after xenotransplantation.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Jiaqi Zhang, Wenbo Liu, Guangyue Li, Chengpeng Xu, Xiaoqing Nie, Dandan Qin, Qizhi Wang, Xukun Lu, Jianqiao Liu, Lei Li
Summary: Alternative splicing is an important mechanism for regulating organogenesis and fertility. BCAS2 plays a crucial role in mouse oocytes, participating in oocyte development through regulating splicing and influencing follicular development.
Article
Cell Biology
Srija Bhagavatula, Elisabeth Knust
Summary: This study reveals that the localization of Crumbs protein (Crb) is regulated by mRNA localization element and Egalitarian (Egl), with mutations affecting its position in oocytes. The findings suggest an important role for the Drosophila 3' -UTR in translation regulation in specific tissues.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Maria Giovanna Riparbelli, Veronica Persico, Giuliano Callaini
Summary: During early oogenesis in Drosophila, there are specific spatial interactions between somatic and germ cells, indicating inherent asymmetry between the anterior and posterior regions of the egg chambers. The oocyte is located at the posterior end, giving the egg chamber distinct asymmetry.
Article
Genetics & Heredity
Allison N. Beachum, Kaitlin M. Whitehead, Samantha McDonald, Daniel N. Phipps, Hanna E. Berghout, Elizabeth T. Ables
Summary: Gamete production in mammals and insects is regulated by cell signaling pathways, with nuclear receptor signaling playing a key role in reproduction. The NR5A subfamily is essential for gonad development and sex steroid production in mammals and has a similar function in fruit flies. Ftz-f1 is crucial for egg chamber survival in fruit flies before stage 10, highlighting the importance of nuclear receptors in controlling reproduction.
G3-GENES GENOMES GENETICS
(2021)
Review
Developmental Biology
Claude Robert
Summary: The determinants of oocyte quality are still uncertain, but the oocyte plays a central role in reproductive success. Communication between cumulus cells and the oocyte is crucial for proper oogenesis and the resulting gamete quality. While most efforts to improve oocyte quality focus on systemic endocrine signaling, local control within ovarian follicles through cellular cooperation may also be important.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Cell Biology
Jana Jankovicova, Petra Secova, L'ubica Horovska, Lucia Olexikova, Linda Dujickova, Alexander Makarevich, Katarina Michalkova, Jana Antalikova
Summary: This study provides new information about the distribution of tetraspanins CD9, CD81, CD151, CD82, and CD63 during different stages of follicular development in cattle. It reveals the possible cooperation between CD9, CD63, and integrin alpha V in similar areas of ovarian tissue. The distribution patterns of CD151, CD82, and CD63 on immature and mature bovine oocytes are also described. The unique localization of CD63 and CD82 in the zona pellucida suggests their involvement in transzonal projections. The immunofluorescent analysis is supported by in silico data, confirming the expression of tetraspanins in ovarian cells and oocytes across species.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Biology
Amrita Mukherjee, Michaela Schuppe, Andrew D. Renault
Summary: The eggshell surrounding insect eggs functions as a barrier against predators and desiccation. This study reveals that a lipid-modifying enzyme called wunen is essential for the production of a functional eggshell and fertility in Drosophila females. Understanding the role of this enzyme in other organisms, including humans, may provide insights into its involvement in diseases like coronary artery disease.
Review
Agriculture, Dairy & Animal Science
Go Nagamatsu
Summary: In female reproduction, the limited number of oocytes stored in primordial follicles plays a key role in achieving a continuous ovulatory cycle. Regulation of primordial follicle dormancy and activation is essential for reproductive sustainability. The discovery of mechanisms such as the importance of hypoxia and ECM compression for primordial follicle maintenance provides insight into potential treatments for premature ovarian insufficiency.
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2021)
Article
Biochemical Research Methods
Allen W. Lynch, Christina Theodoris, Henry Long, Myles Brown, X. Shirley Liu, Clifford A. Meyer
Summary: MIRA is a comprehensive methodology that compares gene expression and chromatin accessibility in single cells to infer regulatory mechanisms driving cell fate transitions. It models cell states and regulatory potential of gene loci to represent cell states in an efficient and interpretable latent space, and reveals the variable influence of local accessibility on transcription at different gene loci.
Article
Cell & Tissue Engineering
Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao
Summary: A large number of pelage HF-MSCs can be quickly and conveniently isolated from adult mice using a two-step Ficoll density gradient sedimentation method. These cells possess similar characteristics and functions as whisker HF-MSCs and can promote hair growth by secreting exosomes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Genetics & Heredity
Yi-Chia Huang, Kuan-Han Chen, Yu-Yang Chen, Liang-Hsuan Tsao, Tsung-Han Yeh, Yu-Chia Chen, Ping-Yen Wu, Tsu-Wei Wang, Jenn-Yah Yu
Summary: The study reveals that Innexin 2 plays a crucial role in controlling the flattening process of stretched cells (StCs), while the impact of gap junction proteins on StC morphogenesis is not significant.
G3-GENES GENOMES GENETICS
(2021)
Article
Multidisciplinary Sciences
Ruby Boateng, Nathaniel Boechat, Philipp P. Henrich, Ewelina Bolcun-Filas
Summary: Female fertility and reproductive lifespan are determined by the quality and quantity of ovarian oocyte reserve, which is influenced by three waves of oocyte elimination. Immunofluorescence and 3D visualization offer a new approach to study oocyte development. Research demonstrates that this method can quantitatively measure oocyte attrition during ovarian development in mice.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Astronomy & Astrophysics
Oleh Savchuk, Volodymyr Vovchenko, Volker Koch, Jan Steinheimer, Horst Stoecker
Summary: This study points out that the variance of net-baryon distribution normalized by the Skellam distribution baseline, kappa(2)[B - (B) over bar]/ < B + ($) over bar >, can sensitively detect possible modifications of (anti)baryon yields due to B (B) over bar annihilation in the hadronic phase. The corresponding measurements can place stringent limits on the magnitude of the B (B) over bar annihilation and its inverse reaction. Through Monte Carlo simulations and analysis of experimental data, it is found that this effect exists in net-proton fluctuations and can be distinguished by measuring kappa(2)[B + (B) over bar]/ < B + (B) over bar >, which is significantly suppressed by annihilations at the LHC.
Article
Physics, Particles & Fields
D. Benisty, E. Guendelman, A. van de Venn, D. Vasak, J. Struckmeier, H. Stoecker
Summary: An extension to the Einstein-Cartan action is discussed in terms of cosmological solutions. The dynamics of torsion, represented by a time-like axial vector, is invoked by a novel kinetic term. It is shown that this kinetic term gives rise to dark energy, while the quadratic torsion term represents a stiff fluid that leads to a bouncing cosmology solution.
EUROPEAN PHYSICAL JOURNAL C
(2022)
Article
Geosciences, Multidisciplinary
Darius Fenner, Georg Ruempker, Wei Li, Megha Chakraborty, Johannes Faber, Jonas Koehler, Horst Stoecker, Nishtha Srivastava
Summary: This study proposes an automated approach called the Adaptive-Window Volcanic Event Selection Analysis Module (AWESAM) to generate catalogs of volcanic eruptions. The module is capable of reliably detecting both small and frequent events as well as major explosions. Testing on seismic recordings from Stromboli volcano in Italy showed that AWESAM can accurately identify and record volcano events.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Geochemistry & Geophysics
Megha Chakraborty, Darius Fenner, Wei Li, Johannes Faber, Kai Zhou, Georg Ruempker, Horst Stoecker, Nishtha Srivastava
Summary: The detection and characterization of earthquake parameters are crucial in real-time seismological applications. In this study, we propose a multitasking deep learning model, CREIME, which can accurately detect earthquake signals and estimate magnitudes, outperforming traditional methods.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2022)
Article
Astronomy & Astrophysics
David Vasak, Johannes Kirsch, Juergen Struckmeier, Horst Stoecker
Summary: The Covariant Canonical Gauge Gravity (CCGG), a modification of the Einstein-Hilbert theory, provides an explanation for the origin of the cosmological constant. This theory, based on canonical transformation theory and the De Donder-Weyl Hamiltonian formulation, modifies the Einstein-Hilbert Lagrangian of the gravitational field. It predicts that the total energy-momentum of the space-time and matter system is zero, and the observed cosmological constant is a small correction related to deviations from flat geometry and the complex dynamical geometry of space-time.
ASTRONOMISCHE NACHRICHTEN
(2023)
Article
Developmental Biology
Travis T. Parsons, Sheila Mosallaei, Laurel A. Raftery
Summary: During Drosophila oogenesis, somatic follicle cells differentiate and secrete components of the eggshell. A timeline of reproducible milestones for centripetal migration, which encloses the oocyte after secretion, is defined using time-lapse imaging of egg chamber explants. Inward migration occurs in two phases, with leading centripetal follicle cells ingressing over the anterior oocyte first and then followed by collective movement of the following cells towards the anterior. E-cadherin is required for normal ingression of the leading cells.
Proceedings Paper
Physics, Atomic, Molecular & Chemical
Roman Poberezhnyuk, Volodymyr Voychenko, Oleh Savchuki, Volker Koch, Mark Gorenstein, Horst Stoecker
Summary: Subensemble is a statistical ensemble that generalizes the grand canonical and canonical ensembles. The subensemble acceptance method (SAM) provides general formulas to correct the cumulants of distributions in heavy-ion collisions for the global conservation of all QCD charges. The method is applicable for an arbitrary equation of state and sufficiently large systems, such as those created in central collisions of heavy ions. New fluctuation measures insensitive to global conservation effects are presented, with main results demonstrated in the contexts of the hadron resonance gas and van der Waals fluid frameworks.
20TH INTERNATIONAL CONFERENCE ON STRANGENESS IN QUARK MATTER, SQM 2022
(2023)
Article
Physics, Nuclear
Volodymyr A. Kuznietsov, Oleh Savchuk, Roman Poberezhnyuk, Volodymyr Vovchenko, Mark I. Gorenstein, Horst Stoecker
Summary: Molecular dynamics simulations are used to investigate the effect of liquid-gas mixed phase on particle number fluctuations in a finite nonrelativistic system with Lennard-Jones potential. A nucleation region of the mixed phase, known as the metastable region, is analyzed using a noninteracting cluster model. Large fluctuations caused by spinodal decomposition are observed, which are influenced by the size of the acceptance region and the liquid phase. A simple geometric model is utilized to study these effects, and the results are compared with direct molecular dynamic simulations.
Article
Astronomy & Astrophysics
Shriya Soma, Lingxiao Wang, Shuzhe Shi, Horst Stoecker, Kai Zhou
Summary: Neutron star observables, such as masses, radii, and tidal deformability, provide valuable insights into the equation of state (EoS) of dense matter. A new deep learning method that utilizes an automatic differentiation framework for solving inverse problems is introduced. The trained neural network EoS produces precise relationships between pressure, speed of sound, and mass density, consistent with conventional approaches and the observed bound on tidal deformability from the gravitational wave event, GW170817.
Article
Physics, Multidisciplinary
D. N. Poenaru, H. Stoecker, R. A. Gherghescu
Summary: This study investigates superheavy nuclei for the synthesis of isotopes with Z = 119,120. An interesting experiment was carried out at the velocity filter SHIP (GSI Darmstadt) in an attempt to produce 299120 through the fusion reaction 258Cm(54Cr,3n)299120. Alpha decay half-lives are calculated using four models: AKRA, ASAF, UNIV, and semFIS. The energy release (Q) is calculated using the theoretical model of atomic masses WS4.
ROMANIAN REPORTS IN PHYSICS
(2023)
Article
Astronomy & Astrophysics
Elias R. Most, Anton Motornenko, Jan Steinheimer, Veronica Dexheimer, Matthias Hanauske, Luciano Rezzolla, Horst Stoecker
Summary: Binary neutron-star mergers and heavy-ion collisions are connected through the nuclear matter formed during these extreme events. This study compares the conditions in both systems through their geometry and thermodynamics. The results show that low-energy heavy-ion collisions can reproduce states of matter similar to those in binary neutron-star mergers.
Article
Astronomy & Astrophysics
Shile Chen, Oleh Savchuk, Shiqi Zheng, Baoyi Chen, Horst Stoecker, Lingxiao Wang, Kai Zhou
Summary: Feynman path integrals provide a probabilistic perspective for quantum physics by summing over all possible paths to estimate physical observables. This study proposes a Fourier-flow generative model to simulate the Feynman propagator and generate quantum system paths. By accurately estimating the ground-state wave function and low-lying energy levels of harmonic and anharmonic oscillators, our method offers a novel approach to investigating quantum systems using machine learning-assisted Feynman path integral solving.
Article
Physics, Particles & Fields
Lijia Jiang, Horst Stoecker, Jun-Hui Zheng
Summary: By parameterizing the QCD Landau free energy and studying the fluctuations of the QCD chiral order parameter field near the critical point, we find that the discontinuity of the order parameter is replaced by smooth crossover in the equilibrium case, and the corresponding fluctuations are broadened. In addition, we derive the dynamical evolution of the QCD Landau free energy and deduce the dynamical cumulants of the sigma field, showing clear memory effects and rich non-monotonic structures at the hypothetical freeze-out line.
EUROPEAN PHYSICAL JOURNAL C
(2023)
Article
Genetics & Heredity
Takuya Akiyama, Laurel A. Raftery, Kristi A. Wharton
Summary: This review provides a historical account of gene discovery and discusses the advances in BMP signaling field over the past 30 years. While the core BMP pathway is simple, there are multiple layers of regulation behind its versatility and tissue-specific signaling output.
Article
Physics, Nuclear
Roman Poberezhnyuk, Horst Stoecker, Volodymyr Vovchenko
Summary: This article introduces a method of incorporating the low-density properties of isospin symmetric nuclear matter into the excluded-volume model for quarkyonic matter and investigates the effect of variations in the nucleon excluded volume mechanism on the equation of state. The results show that the nuclear liquid undergoes a transition and transforms into quarkyonic matter at densities achievable in intermediate energy heavy-ion collisions, accompanied by a peak in sound velocity. The study also suggests that the baryquark matter scenario is energetically favored for the realization of the Pauli exclusion principle.