Article
Environmental Sciences
Wonhyoung Park, Sunwoo Park, Whasun Lim, Gwonhwa Song
Summary: Research results indicate that bifenthrin inhibits cell proliferation and viability, induces cell cycle arrest and apoptosis in both porcine trophectoderm and uterine luminal epithelial cells. Bifenthrin also damages mitochondria, induces reactive oxygen species production, leading to endoplasmic reticulum stress and calcium dysregulation in the cells. Finally, bifenthrin alters MAPK/PI3K signaling pathway and expression of pregnancy-related genes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Qiang Gao, Fan Fei, Bin Huang, Xue Song Meng, Tao Zhang, Kui-Feng Zhao, Hai-Bin Chen, Rui Xing, Bao-Liang Liu
Summary: Ammonia exposure in Takifugu rubripes resulted in reduced hematological parameters, altered plasma components, increased antioxidant enzyme levels, and elevated heat shock protein expression, ultimately leading to an inflammatory response. This study sheds light on the mechanisms involved in ammonia-induced aquatic toxicology in marine fish, providing valuable insights for their captive management.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Petek Piner Benli, Merve Kaya, Yusuf Kenan Daglioglu
Summary: This study found that Fucoidan has a protective effect against sulfoxaflor-induced hematological/biochemical alterations and oxidative stress.
Article
Environmental Sciences
Anwesha Das, Sarbashri Bank, Srilagna Chatterjee, Nirvika Paul, Kunal Sarkar, Arindam Chatterjee, Santanu Chakraborty, Chaitali Banerjee, Anasuya Majumdar, Madhusudan Das, Sudakshina Ghosh
Summary: This study aimed to investigate the effect of the synthetic pyrethroid bifenthrin (BF) on mitochondrial DNA copy number variation in the edible fish Punitus sophore. Results showed that BF reduced the expression level of mitochondria COI gene, inhibited complex IV activity, and led to oxidative stress and mitochondrial dysfunction. BF also induced neurotoxicity by inhibiting AchE activity and caused an imbalance in antioxidant enzyme activity. Molecular docking and simulation analysis predicted that BF binds to the active sites of the enzyme. These findings suggest that the reduction of mtDNAcn could be a potential biomarker to assess BF-induced toxicity in aquatic ecosystems.
Article
Biochemistry & Molecular Biology
Oriana Simonetti, Tiziana Bacchetti, Gianna Ferretti, Elisa Molinelli, Giulio Rizzetto, Luisa Bellachioma, Annamaria Offidani
Summary: The study revealed that children with atopic dermatitis (AD) have higher levels of lipid peroxidation and lower antioxidant defense, with abnormal activity of PON enzymes, indicating a relationship between oxidative stress and inflammation in AD patients.
Review
Biochemistry & Molecular Biology
Innocent Uzochukwu Okagu, Rita Ngozi Aguchem, Chinonso Anthony Ezema, Timothy Prince Chidike Ezeorba, Ozoemena Emmanuel Eje, Joseph Chinedum Ndefo
Summary: Malaria is a dangerous disease that causes a high number of hospital visits and deaths, particularly in children in sub-Saharan Africa. Despite existing interventions, such as vector control and treatment, the burden of the disease remains significant. Previous studies have reported the emergence of drug-resistant malaria parasites and poor access to effective antimalarial drugs as key factors contributing to the persistence of infections. Furthermore, the complex nature of malaria pathogenesis has hindered progress in combating the disease. Recent studies have identified various complex interactions and changes in blood composition induced by malaria parasites. However, there is a lack of comprehensive understanding of these alterations. This review discusses the molecular mechanisms of reported hematological and biochemical changes induced by malaria parasite infections, including anemia, thrombocytopenia, leukopenia, dyslipidemia, hypoglycemia, oxidative stress, and liver and kidney malfunctions. Additionally, the study explores strategies to limit the evasion of the immune response by malaria parasites in order to combat malaria and its complications.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eleni Tsiplakou, Christina Mitsiopoulou, Chrysoula Karaiskou, Marica Simoni, Athanasios C. Pappas, Federico Righi, Kyriaki Sotirakoglou, Nikolaos E. Labrou
Summary: The study showed that sesame meal improves the oxidative status of both the organism and the milk in mid-lactation goats, particularly in reducing protein carbonyls content.
Article
Engineering, Environmental
Francisco Carlos da Silva Junior, Thais Agues-Barbosa, Ana Carolina Luchiari, Silvia Regina Batistuzzo de Medeiros
Summary: The study demonstrates the genotoxic and neurotoxic effects of Retene on zebrafish, indicating the potential to induce DNA micronuclei formation and behavioral changes. The results suggest that alterations in oxidative stress and mRNA expression of neurotransmitter systems may contribute to these effects.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Environmental Sciences
Xiuge Gao, Xiaoxiao Liu, Xinhao Song, Pei Teng, Hui Ji, Lin Peng, Yawei Qiu, Dawei Guo, Shanxiang Jiang
Summary: The study found that maduramicin has lethal toxicity to crayfish, affecting their biochemical parameters and tissue structure. After exposure, crayfish developed a certain degree of resistance to maduramicin.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agriculture, Dairy & Animal Science
Dicky Aldian, Laila Dini Harisa, Hiroki Mitsuishi, Ke Tian, Atsushi Iwasawa, Masato Yayota
Summary: The physiological mechanism related to the improvement of physiological stress tolerance in ruminants fed diverse forage was investigated. The results showed that feeding diversified forage can increase feed intake and digestibility, as well as enhance total antioxidant capacity. Feeding a mixture of Sudan grass and alfalfa hay or a combination of different types of forage altered the levels of metabolites in the serum, thereby improving the physiological stress tolerance.
Article
Environmental Sciences
Jamaan S. Ajarem, Ahmad K. Hegazy, Gamal A. Allam, Ahmed A. Allam, Saleh N. Maodaa, Ayman M. Mahmoud
Summary: This study evaluated the levels of heavy metals in Plantago ovata and domestic goats in the eastern region of Saudi Arabia, which were influenced by the petroleum industry. The results showed that the petroleum industry increased the levels of lead, cadmium, nickel, and vanadium in both the plant and animal samples, leading to liver and kidney injury, oxidative stress, and upregulation of pro-inflammatory and apoptosis markers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Nagwa Mohamed, Dalia H. El-Kashef, Ghada M. Suddek
Summary: Flavocoxid demonstrated a potential protective effect in acetic acid-induced colitis model, by attenuating oxidative stress, inflammation, and apoptosis in colonic tissues of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jose-Luis Garcia-Gimenez, Concepcion Garces, Carlos Roma-Mateo, Federico Pallardo
Summary: Epigenetic regulation of gene expression plays a crucial role in cellular response to environmental changes, but cellular imbalance can lead to pathological conditions. Oxidative stress and free radicals can influence histone modifications, affecting gene expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Young-Bin Yu, Jae-Ho Choi, Cheol Young Choi, Ju-Chan Kang, Jun-Hwan Kim
Summary: The aim of this study is to assess the toxic effects of polyethylene microplastics (PE-MPs) on crucian carp by examining bioaccumulation, hematological parameters, and antioxidant responses. Results showed that the accumulation of PE-MPs in different tissues of crucian carp increased with the concentration, with the highest accumulation in the intestine, followed by the gills and liver. Hematological parameters, plasma components, and antioxidant responses were significantly affected by PE-MPs in a concentration-dependent manner. Exposure to >= 32 mg/L of PE-MPs resulted in a significant decrease in red blood cells, hemoglobin content, and hematocrit values. Additionally, exposure to >= 32 mg/L of PE-MPs induced oxidative stress in the liver, gills, and intestine, leading to elevated levels of superoxide dismutase, catalase, and glutathione S-transferase, and decreased glutathione levels. The interaction between PE-MPs and exposure periods did not produce significant changes.
Article
Environmental Sciences
Andrea C. Crupkin, Ariana B. Fulvi, Fernando G. Iturburu, Sandra Medici, Julieta Mendieta, Ana M. Panzeri, Mirta L. Menone
Summary: Azoxystrobin is a widely used systemic fungicide that inhibits mitochondrial respiration in target fungi, but its effects on non-target organisms are not well studied. This research evaluated biomarkers of oxidative stress, hematological, physiological, and genotoxicity in cichlid fish exposed to environmentally relevant concentrations of AZX, showing negative effects at realistic concentrations and highlighting the importance of considering developmental stage on biomarker evaluation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Public, Environmental & Occupational Health
Lakshay Mahajan, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood
TOXICOLOGY AND INDUSTRIAL HEALTH
(2018)
Article
Pharmacology & Pharmacy
Lakshay Mahajan, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood
BMC PHARMACOLOGY & TOXICOLOGY
(2018)
Article
Environmental Sciences
Muneer Ahmad Dar, Adil Mehraj Khan, Rajinder Raina, Pawan Kumar Verma, Nasir Manzoor Wani
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Environmental Sciences
Parvinder Singh, Pawan Kumar Verma, Rajinder Raina, Shilpa Sood, Priyanka Sharma
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2020)
Article
Optics
Nitin Dubey, Joseph Rosen, Israel Gannot
Article
Education, Scientific Disciplines
Apeksha Saraf, Nidhi Dubey, Nitin Dubey, Mayank Sharma
Summary: Polymeric nanoparticles offer a promising strategy for targeted delivery of dietary phytochemicals in colon cancer treatment. Curcumin, a well-known dietary phytochemical with anti-cancer properties, faces challenges due to hydrophobicity and poor selectivity towards tumor tissues. By utilizing a combination of pH-sensitive and biodegradable polymers, dual-functional nanoparticles loaded with curcumin demonstrated enhanced cytotoxicity against colon cancer cells, making them a potential carrier system for effective delivery of poorly water-soluble dietary phytochemicals.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Apeksha Saraf, Nidhi Dubey, Nitin Dubey, Mayank Sharma
Summary: Globally, cancer is a major cause of death with colon cancer being a significant contributor. Current cancer treatments have side effects, leading to exploration of natural compounds like DADS. DADS from garlic has shown anticancer activity against colon cancer, but its poor water solubility limits its clinical use.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Optics
Nitin Dubey, Ravi Kumar, Joseph Rosen
Summary: This paper introduces a new type of SHWS with improved measurement accuracy by using the COACH principle and replacing the lenslet array with an array of coded phase masks, resulting in a lower mean square wavefront error. Experimental results confirm a decrease in error by one order of magnitude compared to the regular SHWS.
Article
Multidisciplinary Sciences
Nitin Dubey, Joseph Rosen
Summary: Interferenceless coded aperture correlation holography (I-COACH) is a coherent digital holographic technique with lateral and axial resolution similar to a regular lens-based imaging system. This study explores the imaging capabilities of different point spread holograms (PSHs), such as continuous, dot-based, and sparse island-shaped PSHs, using parameters such as visibility, signal-to-noise ratio (SNR), and the product of visibility with SNR.
SCIENTIFIC REPORTS
(2022)
Review
Imaging Science & Photographic Technology
Daniel Smith, Shivasubramanian Gopinath, Francis Gracy Arockiaraj, Andra Naresh Kumar Reddy, Vinoth Balasubramani, Ravi Kumar, Nitin Dubey, Soon Hock Ng, Tomas Katkus, Shakina Jothi Selva, Dhanalakshmi Renganathan, Manueldoss Beaula Ruby Kamalam, Aravind Simon John Francis Rajeswary, Srinivasan Navaneethakrishnan, Stephen Rajkumar Inbanathan, Sandhra-Mirella Valdma, Periyasamy Angamuthu Praveen, Jayavel Amudhavel, Manoj Kumar, Rashid A. Ganeev, Pierre J. Magistretti, Christian Depeursinge, Saulius Juodkazis, Joseph Rosen, Vijayakumar Anand
Summary: Indirect-imaging methods involve optical recording and computational reconstruction, using optical modulators to convert light from the object into intensity distributions that are then numerically processed to reconstruct the object's image. The nonlinear reconstruction (NLR) method, developed in 2017, shows promising results for reconstructing object images modulated by various optical elements. This review investigates the performance of NLR for deterministic and stochastic optical fields, presenting both simulation and experimental results.
JOURNAL OF IMAGING
(2022)
Article
Nanoscience & Nanotechnology
Vijayakumar Anand, Svetlana Khonina, Ravi Kumar, Nitin Dubey, Andra Naresh Kumar Reddy, Joseph Rosen, Saulius Juodkazis
Summary: This study proposes a 3D incoherent imaging method using a rotating point spread function, achieving higher focal depth. Under experimental conditions, the nonlinear reconstruction method performs better than other reconstruction methods. This imaging method may have significant implications for incoherent imaging, fluorescence microscopy, and astronomical imaging.
NANOSCALE RESEARCH LETTERS
(2022)
Article
Multidisciplinary Sciences
Rajinder Raina, Pawan K. Verma, Rajinder Peshin, Harpreet Kour
Article
Chemistry, Multidisciplinary
Adil Mehraj Khan, Rajinder Raina, Nitin Dubey, Pawan Kumar Verma
DRUG AND CHEMICAL TOXICOLOGY
(2018)
Article
Toxicology
Lakshay Mahajan, Pawan Kumar Verma, Rajinder Raina, Nrip K. Pankaj, Shilpa Sood, Maninder Singh
TOXICOLOGY REPORTS
(2018)