Effect of Sub-Acute Oral Exposure of Bifenthrin on Biochemical Parameters in Crossbred Goats

Bifenthrin is an insecticide, used extensively on some crops, including corn. Roughly 70 % of all US-grown hops and raspberries are treated with bifenthrin. The current study on bifenthrin was undertaken to investigate the potential alterations in biochemical parameters, induced by sub-acute oral exposure of bifenthrin, in goats. The animals were randomly divided into two groups. Group A (n = 3) received only tap water and served as control, whereas, Group B goats (n = 4) received bifenthrin by gavage (Telstar 10 EC) at the dose rate of 5 mg Kg(-1) body weight for 28 consecutive days. Bifenthrin exposed group showed significant alterations in the enzyme biochemical parameters. The activities of erythrocyte cholinesterase and plasma cholinesterase reduced significantly from 7th day and 28th day of bifenthrin exposure, respectively. The activity of plasma aspartate aminotransferase and alanine aminotransferase increased significantly from the 21st day of bifenthrin exposure. The activity of acid phosphatase and alkaline phosphatase increased significantly from the 14th day of bifenthrin exposure. All these parameters returned to the non-significant levels by 7th day of post-exposure period. Non-significant alterations in blood urea nitrogen, creatinine and plasma proteins were also observed. The current study thus reveals that sub-acute oral administration of bifenthrin produces reversible liver damage.