Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization

Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours

(2014) Cameron E. Snell et al.   PLoS One

Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II

(2013) Libin Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells

(2013) Qinsheng Dai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

(2013) L Wei et al.   Cell Death & Disease

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells

(2012) Min Xu et al.   TOXICOLOGY LETTERS

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Neuronal Sirt3 Protects against Excitotoxic Injury in Mouse Cortical Neuron Culture

(2011) Sun Hee Kim et al.   PLoS One

Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress

(2010) Peter Storz   ANTIOXIDANTS & REDOX SIGNALING

Inhibitors to understand molecular mechanisms of NAD+-dependent deacetylases (sirtuins)

(2010) Michael Lawson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria

(2010) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

MAC related mitochondrial pathway in oroxylin A induces apoptosis in human hepatocellular carcinoma HepG2 cells

(2009) Wei Liu et al.   CANCER LETTERS

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Interaction between Single Nucleotide Polymorphisms in Selenoprotein P and Mitochondrial Superoxide Dismutase Determines Prostate Cancer Risk

(2008) M. L. Cooper et al.   CANCER RESEARCH

Regulation of hexokinase binding to VDAC

(2008) John G. Pastorino et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis

(2008) Judith C. Sluimer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA