Article
Microbiology
Mark Paul Selda Rivarez, Anja Pecman, Katarina Bacnik, Olivera Maksimovic, Ana Vucurovic, Gabrijel Seljak, Natasa Mehle, Ion Gutierrez-Aguirre, Maja Ravnikar, Denis Kutnjak
Summary: In agroecosystems, the diversity and role of viruses in non-crop plants is less known. This study used high-throughput sequencing to explore viral diversity in tomatoes and weeds at a nation-wide scale, detecting 125 viruses, including novel species. The presence of viruses in both tomatoes and weeds suggests possible exchange between the two, with implications for weed management and tomato health.
Article
Virology
Liping Guo, Xiaoyu Lu, Xue Liu, Ping Li, Junyu Wu, Fan Xing, Hong Peng, Xiaojun Xiao, Mang Shi, Zhigang Liu, Xiao-Dong Li, Deyin Guo
Summary: This study characterized the diversity and abundance of viruses present in medically important mites, identifying 47 genetically distinct viruses belonging to 17 virus families or supergroups. The most commonly identified viruses were found to be members of Picornavirales, with potential implications for parallel evolution. The comprehensive screening of RNA virome in mites provides significant insights into the diversity and evolution of RNA viruses in these organisms and their potential role in human diseases.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Artemis Rumbou, Thierry Candresse, Susanne von Bargen, Carmen Buettner
Summary: The focus of plant virology has mainly been on horticultural and field crops, with little information available on viruses infecting forest trees. Utilization of next-generation sequencing has revealed a significant number of viruses in forest trees and urban parks. In this study, a novel Emaravirus was identified and named MaMaV from sycamore maple showing leaf mottle symptoms, representing a new addition to the Emaravirus genus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Magda Bletsa, Bram Vrancken, Sophie Gryseels, Ine Boonen, Antonios Fikatas, Yiqiao Li, Anne Laudisoit, Sebastian Lequime, Josef Bryja, Rhodes Makundi, Yonas Meheretu, Benjamin Dudu Akaibe, Sylvestre Gambalemoke Mbalitini, Frederik Van de Perre, Natalie Van Houtte, Jana Tesikova, Elke Wollants, Marc Van Ranst, Oliver G. Pybus, Jan Felix Drexler, Erik Verheyen, Herwig Leirs, Joelle Gouy de Bellocq, Philippe Lemey
Summary: The study screened small mammal samples from sub-Saharan Africa and confirmed the presence of hepaciviruses in rodents. Eighty samples were found positive for hepaciviruses, increasing the diversity of three different rodent hepacivirus lineages, and evidence of recombination within specific host lineages was also detected.
Article
Virology
Fan Zhang, Zhihao Ren, Xiaomeng Guo, Yiting Wang, Fanzeng Meng, Weifeng Shi, Xinping Wang, Xuan Dong
Summary: Three novel RNA viruses and one nervous necrosis virus were identified in lined seahorse through meta-transcriptomic sequencing. The diversity and cross-species transmission of viruses pose a threat to this species.
Article
Veterinary Sciences
Yajing Guo, Guangzhi Yan, Shengnan Chen, Hui Han, Jiaming Li, Haoquan Zhang, Shicheng Luo, Mingjie Liu, Qingqing Wu, Qingxian Li, Changchun Tu, Liangzong Huang, Wenjie Gong
Summary: A new porcine parvovirus, named PPV8, was identified in pig herds in Guangdong province, China. It shares some similarities with known porcine parvoviruses but also has distinct characteristics. The virus has been detected in multiple regions in China for over two decades.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Ye Xu, Jiabao Xu, Tong Liu, Peiwen Liu, Xiao-Guang Chen
Summary: This study conducted virus metagenomics analysis on Aedes albopictus in Guangzhou, China, and identified both known and novel viruses. The findings reveal the diversity and prevalence of viruses in mosquito populations, emphasizing the need for continued surveillance and research on their potential impact on public health, as well as the importance of understanding the virome of Aedes albopictus and its potential role in transmitting plant viruses.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Yun Feng, Qin-yu Gou, Wei-hong Yang, Wei-chen Wu, Juan Wang, Edward C. Holmes, Guodong Liang, Mang Shi
Summary: This study used meta-transcriptomic sequencing to analyze mosquitoes collected from a bat-dwelling cave and a nearby village in Yunnan province, China. A total of 162 eukaryotic virus species were identified, with 101 being novel. Analysis of the virome showed differences in viral compositions and abundance levels between warmer and colder months, a strong host structure at the mosquito species level, and no significant differences between male and female mosquitoes. Some viruses were found to be ubiquitous throughout the year and across multiple mosquito species, while others were season and/or host specific.
Article
Immunology
Guanrong Feng, Jinyong Zhang, Ying Zhang, Chenghui Li, Duo Zhang, Yiquan Li, Hongning Zhou, Nan Li, Pengpeng Xiao
Summary: In this study, 5,500 mosquitoes were collected from three locations in China, and their viromes were analyzed using metagenomic sequencing and PCR confirmation. Chikungunya virus, Getah virus, and Ross river virus were identified among the mosquito viromes. High homology was found between some of the detected sequences and known viruses, but numerous unknown viruses were also discovered.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Shixing Yang, Yumin He, Xu Chen, Ullah Kalim, Yan Wang, Shuyu Yang, Haifeng Qi, Hengzheng Cheng, Xiang Lu, Xiaochun Wang, Quan Shen, Wen Zhang
Summary: Raccoon dogs, as an ancient species of Canidae, carry various viruses, some of which have been detected from recent development in raccoon dog breeding. A study on the virome in raccoon dog feces from a farm in Jilin Province, China, identified DNA or RNA viruses mainly from seven families. This research contributes to a better understanding of the virome in raccoon dogs and provides valuable information for viral disease monitoring, prevention, and treatment in these animals.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Lei Yue, Chang Li, Mingzhu Xu, Min Wu, Jiahui Ding, Jiangxia Liu, Xiaonan Zhang, Zhenghong Yuan
Summary: By utilizing advanced microscopy techniques, researchers have successfully revealed some key aspects of the Hepatitis B Virus (HBV) replication process at the single-cell level, including the slow kinetics of replication, the variability in different cells, and the mechanisms of viral action within cells.
Article
Multidisciplinary Sciences
Mathew Fisher, Michelle Nebroski, Jennifer Davies, Eugene Janzen, Daniel Sullivan, Oliver Lung
Summary: The complete genome of a novel torque teno virus species, TTEqV2, was obtained from the lung and liver tissue of a Quarter Horse gelding that died of nonsuppurative encephalitis in Alberta, Canada. This circular genome, approved as a new species by the International Committee on Taxonomy of Viruses, contains characteristic features of torque teno virus genomes and is the first complete genome from the Mutorquevirus genus. Phylogenetic analysis showed that TTEqV2 clusters with the only other reported member of the Mutorquevirus genus, TTEqV1.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Nannan Li, Cixiu Li, Tao Hu, Juan Li, Hong Zhou, Jingkai Ji, Jiangli Wu, Weipeng Kang, Edward C. Holmes, Weifeng Shi, Shufa Xu
Summary: Through meta-transcriptomic sequencing of nearly 2000 samples collected across China, researchers have revealed the diversity and prevalence of honeybee viruses, as well as the existence of novel genetic variants associated with China. The study highlights the widespread distribution and genetic diversity of honeybee viruses, suggesting the importance of understanding and mitigating viral infectious diseases in honeybees.
Article
Virology
Marie-Celine Zanella, Diem-Lan Vu, Krisztina Hosszu-Fellous, Dionysios Neofytos, Chistian Van Delden, Lara Turin, Antoine Poncet, Federico Simonetta, Stavroula Masouridi-Levrat, Yves Chalandon, Samuel Cordey, Laurent Kaiser
Summary: Metagenomics identified previously unrecognized viruses in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients, highlighting their potential as sources of infection. This observational cohort study aimed to investigate the prevalence and dynamics of DNA and RNA viruses in the plasma of allo-HSCT recipients for one year post-transplant. TTV infection was observed in 97% of patients, followed by HPgV-1 (prevalence: 26-36%). Viral loads for TTV and HPgV-1 peaked at month 3. Multiple Polyomaviridae viruses were detected in over 10% of patients. HPyV6 and HPyV7 had a prevalence of 27% and 12% respectively at month 3, while CMV had a prevalence of 27%. The other viruses had low prevalence rates, and co-infections were observed in 72% of patients at month 3. Further research is needed to understand the relationship between these viral infections, immune reconstitution, and clinical outcomes.
Article
Biology
Martial Marbouty, Agnes Thierry, Gael A. Millot, Romain Koszul
Summary: The study applied metagenomic Hi-C approach to analyze healthy human gut samples, revealing a large infection network of bacteriophages in the gut microbiota, with over 6000 interactions identified. Results showed that 5% of the phages may be actively replicating, and 17 members of the crAss-like phage family were successfully identified with their bacterial hosts.
Article
Biochemistry & Molecular Biology
Xiaoyu Che, Mady Hornig, Michaeline Bresnahan, Camilla Stoltenberg, Per Magnus, Pal Suren, Siri Mjaaland, Ted Reichborn-Kjennerud, Ezra Susser, W. Ian Lipkin
Summary: This study suggests that immune activation may be a risk factor for autism spectrum disorders (ASDs) and identifies potential immune biomarkers for early diagnosis. The findings highlight the importance of gestational immunopathology in ASD and reveal sex-specific differences.
MOLECULAR PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Lise J. Estcourt, Claudia S. Cohn, Monica B. Pagano, Claire Iannizzi, Nina Kreuzberger, Nicole Skoetz, Elizabeth S. Allen, Evan M. Bloch, Gregory Beaudoin, Arturo Casadevall, Dana V. Devine, Farid Foroutan, Thomas J. Gniadek, Ruchika Goel, Jed Gorlin, Brenda J. Grossman, Michael J. Joyner, Ryan A. Metcalf, Jay S. Raval, Todd W. Rice, Beth H. Shaz, Ralph R. Vassallo, Jeffrey L. Winters, Aaron A. R. Tobian
Summary: This article introduces the therapeutic application of convalescent plasma for COVID-19 patients and provides corresponding clinical practice guidelines. The guidelines include recommendations for the use of convalescent plasma for outpatients and inpatients, as well as for prophylactic application. For high-risk patients, it is recommended to transfuse convalescent plasma in addition to standard care, while for hospitalized patients without detectable SARS-CoV-2 antibodies, it is suggested to transfuse convalescent plasma in addition to standard care.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Hematology
Jose A. Cancelas, Jamie R. Genthe, Moritz Stolla, Neeta Rugg, S. Lawrence Bailey, Shawnagay Nestheide, Beth Shaz, Samantha Mack, Kadi Schroeder, Waseem Anani, Zbigniew M. Szczepiorkowski, Larry J. Dumont, Subramanian Yegneswaran, Laurence Corash, Nina Mufti, Richard J. Benjamin, Anna C. Erickson
Summary: This study evaluated the performance of Amotosalen/UVA pathogen-reduced platelet components (PRPCs) stored for 7 days through in vitro and in vivo analysis, and found that they exhibited similar characteristics to fresh platelets.
Article
Hematology
Christopher R. France, Janis L. France, Dominic W. Ysidron, Caroline D. Martin, Louisa Duffy, Debra A. Kessler, Mark Rebosa, Shiraz Rehmani, Victoria Frye, Beth H. Shaz
Summary: This study investigated the motivators and barriers of young, first-time blood donors and found that prosocial motivation was the most commonly reported motivator, while fear was the most commonly reported barrier. The reported motivators and barriers were not significantly related to donation behavior, but certain barriers such as fear of fainting/dizziness, fear of needles/pain, personal commitments conflicting with donating, and perceiving oneself as unsuited to donate for health reasons were significantly associated with donation behavior. Differences in motivators and barriers were also observed among different sexes, races, and ethnicities.
Meeting Abstract
Cell & Tissue Engineering
Bryan Kraft, Linda Brown, Margaret Scott, Frank Vrionis, Ralph Palumbo, Jesse Troy, Emily Poehlein, Lynn Cheatham, Lingye Chen, Joanne Kurtzberg, Raha Manyara, Khalid Hanafy, Beth Shaz
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Meeting Abstract
Cell & Tissue Engineering
April Ozamiz, Kevin Shoulars, Pamela Noldner, Beth Shaz, Joanne Kurtzberg
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Meeting Abstract
Cell & Tissue Engineering
Dana S. Guggenheim, Joanne Kurtzberg, Beth Shaz
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Meeting Abstract
Cell & Tissue Engineering
Roberta Parrott, Pamela Noldner, Li Xu, Anthony Filiano, Beth Shaz, Joanne Kurtzberg
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Education, Scientific Disciplines
James R. Stubbs, Beth H. Shaz, Ralph R. Vassallo, John D. Roback
Summary: This passage mainly discusses the platelet collection system based on volunteer nonremunerated donors and apheresis platelet collections, which usually provides therapeutic support for hundreds of thousands of patients annually. However, during the coronavirus disease 2019 pandemic, especially during the Omicron wave, the system experienced significant failures and severe shortages. Four initiatives are proposed to reinforce the existing platelet pipeline and buffer the platelet supply against future unexpected disruptions.
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM
(2022)
Article
Multidisciplinary Sciences
Ethan D. Borre, Evan Myers, Marianne Hamilton Lopez, Joanne Kurtzberg, Beth Shaz, Jesse Troy, Gillian D. Sanders Schmidler
Summary: This study used a Markov microsimulation to model the long-term clinical and economic outcomes of potential cord blood therapy in autism spectrum disorder (ASD). The results showed that cord blood therapy can be a cost-effective intervention under certain circumstances.
Article
Cell & Tissue Engineering
Beth H. Shaz, Bryan D. Kraft, Jesse D. Troy, Emily Poehlein, Lingye Chen, Lynn Cheatham, Raha Manyara, Khalid Hanafy, Linda Brown, Margaret Scott, Ralph Palumbo, Frank Vrionis, Joanne Kurtzberg
Summary: This study explores the feasibility and safety of using allogeneic human umbilical cord derived mesenchymal stromal cells (hCT-MSCs) for treating COVID-19-related acute respiratory distress syndrome (ARDS). The results show that this treatment method is feasible and safe in clinical practice, without any related adverse reactions. However, further research is needed to explore its safety and efficacy.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Cell & Tissue Engineering
Beth H. Shaz
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Cell & Tissue Engineering
B. Shaz, R. Schaefer, M. Fontaine, P. Norris, D. McKenna, B. Miyazawa, P. Jin, J. Reems, D. Stroncek, M. Takanashi, D. C. Marks, H. Geng, S. Pati
Meeting Abstract
Hematology
Eldad A. Hod, Gary M. Brittenham, Zachary Bitan, Yona Feit, Jordan Gaelen, Francesca La Carpia, Luke Sandoval, Alice Zhou, Joseph Schwartz, Donald McMahon, Debra A. Kessler, Beth H. Shaz, Richard O. Francis, Steven L. Spitalnik
Meeting Abstract
Cell & Tissue Engineering
B. Shaz, B. Kraft, J. Troy, E. Poehlein, L. Chen, L. Cheatham, R. Manyara, K. Hanafy, L. Brown, M. Scott, R. Palumbo, F. Vrionis, J. Kurtzberg
