Article
Surgery
Sarah Rehou, Lauar de Brito Monteiro, Christopher Auger, Carly M. Knuth, Abdikarim Abdullahi, Mile Stanojcic, Marc G. Jeschke
Summary: Propranolol improves outcomes and has anti-inflammatory effects in severely burned patients by modulating essential metabolic pathways.
Article
Critical Care Medicine
Nguyen Nhu Lam, Phan Quoc Khanh, Nguyen Hai An
Summary: This study investigated the safety and efficacy of propranolol on adult patients with severe burns. The results showed that propranolol was effective in reducing energy expenditure, limiting hepatomegaly, and accelerating wound healing in patients.
Review
Medicine, Research & Experimental
Chenchen Geng, Siyan Pang, Ruyin Ye, Jiwen Shi, Qingling Yang, Changjie Chen, Wenrui Wang
Summary: Tumor cells can produce energy through glycolysis even under hypoxic conditions, and they mainly rely on glycolysis for energy production even under aerobic conditions, known as the Warburg effect. Conventional tumor therapeutic drugs lack targeting and have limited efficacy. To improve therapeutic efficacy, extensive research has been conducted on nanocarriers targeting key glycolytic enzymes and transporters, combined with other therapeutic approaches, providing a new strategy for targeted glycolytic treatment of tumors and a theoretical reference for achieving efficient targeted tumor treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Muhammad Nasir Kalam, Muhammad Fawad Rasool, Faleh Alqahtani, Imran Imran, Asim Ur Rehman, Naveed Ahmed
Summary: This study aimed to understand the differences in propranolol pharmacokinetics between healthy and cirrhosis populations, using a whole-body PBPK model. The developed model effectively described propranolol disposition in both populations, with increased plasma concentration and decreased drug clearance observed in progressive stages of cirrhosis. This PBPK model can have implications in predicting propranolol dosing in cirrhosis patients with different disease severities.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Chemistry, Multidisciplinary
Imke Rudnik-Jansen, Kenneth A. Howard
Summary: The Neonatal Fc Receptor (FcRn) plays a significant role in cancer therapeutics by prolonging drug half-life and offering new therapeutic opportunities. Understanding the altered FcRn expression in solid tumors and its role in tumor metabolism and growth is crucial for tailored drug designs in cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Medicinal
Huan He, Yu Zhang, Juan Xu, Yuanyuan Li, Huaxiang Fang, Yi Liu, Silong Zhang
Summary: Compound 13c has been discovered as a potential clinical drug candidate for suppressing KRAS-driven tumors by disrupting the interaction between SOS1 and KRAS. It shows low risk of drug-drug interaction and cardiac side effects.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Chao-Yi Wu, Huang-Yu Yang, Jenn-Haung Lai
Summary: Synovial inflammation and destruction of articular cartilage and bone are key characteristics of autoimmune arthritis. Current treatments targeting proinflammatory cytokines and Janus kinases have shown promise, but many patients still lack adequate disease control. Recent advances in understanding the imbalance of immune cells and bone cells in autoimmune arthritis have highlighted new therapeutic targets, particularly focused on synovial fibroblasts. This commentary comprehensively reviews the interactions between synovial fibroblasts, bone cells, and immune cells and their contributions to the immunopathogenesis of autoimmune arthritis, providing insights into novel treatment approaches.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Laida Elberdin, Rosa M. Fernandez-Torres, Maria Mateos, Maria Outeda, Eva Blanco, Maria I. Gomez-Besteiro, Isabel Martin-Herranz, Eduardo Fonseca
Summary: This study found a positive correlation between ustekinumab concentration and clinical response in psoriatic patients, suggesting ustekinumab concentration could be used to predict treatment efficacy. The presence of anti-ustekinumab antibodies may serve as a potential cause for treatment failure.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ludovica Di Martino, Valeria Tosello, Edoardo Peroni, Erich Piovan
Summary: Acute leukemias are the most common hematologic tumors in adolescents and young adults, with metabolic reprogramming playing a crucial role in their pathogenesis and treatment. This review summarizes the main metabolic pathways contributing to the growth, redox balance, and drug resistance of leukemia cells, identifying vulnerabilities that could be targeted for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Tanya Solomon, Aleksandra Filipovska, Livia Hool, Helena Viola
Summary: Sarcomeric gene mutations are associated with hypertrophic cardiomyopathy (HCM), and current drug therapeutics are effective in symptom relief but do not prevent disease progression. Patients may have variable responses to treatment due to heterogeneity in disease manifestations, and understanding mutation-specific mechanisms may guide therapeutic strategies. Preclinical and clinical studies suggest that a preventative therapeutic approach and consideration of mutation-specific mechanisms may be more efficacious in treating HCM.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Critical Care Medicine
Carly M. Knuth, Sarah Rehou, Dalia Barayan, Marc G. Jeschke
Summary: Sepsis has become the leading cause of death in burn patients, leading to significant morbidity and longer hospitalization. However, sepsis in burn patients is poorly understood. This study compared clinical, metabolic, and inflammatory markers in septic and nonseptic burn patients using different sepsis definitions, and identified temporal biomarker alterations that could improve sepsis diagnosis accuracy in burn patients.
Review
Biochemistry & Molecular Biology
Li Huang, Ming Li, Chunyan Deng, Jiayi Qiu, Kexin Wang, Mengyuan Chang, Songlin Zhou, Yun Gu, Yuntian Shen, Wei Wang, Ziwei Huang, Hualin Sun
Summary: The maintenance of muscle homeostasis is crucial for life and health. Skeletal muscle atrophy not only reduces people's quality of life and increases morbidity and mortality, but also causes a significant socioeconomic burden. Unfortunately, no effective treatment has been developed for skeletal muscle atrophy due to an incomplete understanding of its molecular mechanisms.
Review
Biochemistry & Molecular Biology
Chloe Bernhard, Damien Reita, Sophie Martin, Natacha Entz-Werle, Monique Dontenwill
Summary: Tumor metabolism is a potential target for cancer therapies, particularly for the treatment of glioblastoma, a resistant brain tumor. Glioma stem cells play a critical role in therapy resistance, making their elimination crucial for patients' long-term survival. Recent advancements have revealed the heterogeneous nature of glioblastoma metabolism and the specific metabolic traits of cancer stem cells, providing insights for therapeutic approaches targeting these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Martina Kluenemann, Sergej Andrejev, Sonja Blasche, Andre Mateus, Prasad Phapale, Saravanan Devendran, Johanna Vappiani, Bernd Simon, Timothy A. Scott, Eleni Kafkia, Dimitrios Konstantinidis, Katharina Zirngibl, Eleonora Mastrorilli, Manuel Banzhaf, Marie-Therese Mackmull, Felix Hoevelmann, Leo Nesme, Ana Rita Brochado, Lisa Maier, Thomas Bock, Vinita Periwal, Manjeet Kumar, Yongkyu Kim, Melanie Tramontano, Carsten Schultz, Martin Beck, Janosch Hennig, Michael Zimmermann, Daniel C. Sevin, Filipe Cabreiro, Mikhail M. Savitski, Peer Bork, Athanasios Typas, Kiran R. Patil
Summary: Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs by bioaccumulating them intracellularly without chemically modifying them. This process can alter drug availability and bacterial metabolism, with implications for microbiota composition, pharmacokinetics, side effects and drug responses, potentially in an individualized manner.
Article
Oncology
Runxian Wang, Zhenya Liu, Zhiyao Fan, Hanxiang Zhan
Summary: Effector, memory, and exhaustion are the three phenotypes of CD8+ T cells. In the tumor microenvironment, metabolic dysfunction plays a crucial role in immune escape. Factors such as nutrition competition, PD-1 signals, and interactions between cancer cells and CD8+ T cells cause metabolic reprogramming, including energy metabolism failure and abnormal lipid metabolism. The incompatibility of metabolic patterns among the three phenotypes leads to unresponsiveness to immune checkpoint blockade therapy. Therefore, combination therapy of immune checkpoint blockade and drugs targeting abnormal lipid metabolism shows promise in improving cancer therapy.
Review
Surgery
Teresa Nunez-Villaveiran, Patrick Feasel, Sean Keenan, Rachel Aliotta, David Bosler, Duncan Stearns, Wilma Bergfeld, Raffi Gurunluoglu
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2019)
Article
Otorhinolaryngology
Teresa Nunez-Villaveiran, Beatriz Berenguer Frohner, Pilar Rodriguez Urcelay, Raimundo Lopez Sanchez, Carmen Marin Molina, Elena de Tomas Palacios
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2013)
Article
Surgery
Teresa Nunez-Villaveiran, Vahe Fahradyan, Neil L. McNinch, Ashley Valentine, Heather Larson, Ananth S. Murthy
ANNALS OF PLASTIC SURGERY
(2020)
Article
Surgery
Teresa Nunez-Villaveiran, Vahe Fahradyan, Edoardo Dalla Pozza, Majid Rezaei, Richard L. Drake, Lyman M. Jellema, Abelardo Garcia-de-Lorenzo, Frank A. Papay, Bahar Bassiri Gharb, Antonio Rampazzo
PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Article
Surgery
Jesus Gonzalez Martinez, Asia Torres Perez, Maria Gijon Vega, Teresa Nunez-Villaveiran
PLASTIC AND RECONSTRUCTIVE SURGERY
(2020)
Article
Public, Environmental & Occupational Health
Teresa Nunez-Villaveiran, Alejandro Gonzalez-Castro, Emilio Nevado-Losada, Abelardo Garcia-de-Lorenzo, Pau Garro
Summary: The study revealed that during the COVID-19 outbreak in Spain in Spring 2020, the majority of ICUs were able to rapidly expand critical care capacity by increasing bed capacity and adjusting staffing.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Review
Surgery
Teresa Nunez-Villaveiran, Paul Zamora, Jaume Masia, Manuel Fernandez-Garrido
Summary: This article introduces a new strategy for reconstructing the ankle after distal fibular sarcoma resection, and presents a case study along with a literature review. The reconstruction method achieved good results, with the patient having a successful functional recovery after surgery.
Editorial Material
Surgery
Ahmad Saad, Teresa Nunez-Villaveiran, Ana Torres-Maczassek
AESTHETIC SURGERY JOURNAL
(2022)
Article
Surgery
Manuel Fernandez-Garrido, Teresa Nunez-Villaveiran, Paul Zamora, Jaume Masia, Xavier Leon
Summary: This study describes a variation of the SCIP flap based on the superficial branch of the SCIA. The design of the flap allows for a larger and reliable vascular pedicle, facilitating the reconstruction of large and complex defects in the head, neck, and limbs. The success rate of reconstruction with this flap was high, although complications were present in a percentage of patients.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Letter
Surgery
Gloria Alsina-Rius, Teresa Nunez-Villaveiran, Armando Davila, Bartolome Ferreira-Montenegro
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Surgery
O. Canadas-Moreno, O. Cases-Perera, T. Nunez-Villaveiran, C. Diaz-Molina
EUROPEAN JOURNAL OF PLASTIC SURGERY
(2020)
Article
Surgery
Elena Bravo, Teresa Nunez-Villaveiran
EUROPEAN JOURNAL OF PLASTIC SURGERY
(2014)
