Article
Microbiology
Carine Laurence Yehouenou, Bert Bogaerts, Sigrid C. J. De Keersmaecker, Nancy H. C. Roosens, Kathleen Marchal, Edmond Tchiakpe, Dissou Affolabi, Anne Simon, Francis Moise Dossou, Kevin Vanneste, Olivia Dalleur
Summary: The study utilized whole-genome sequencing to investigate antimicrobial resistance and phylogenomic relationships among 19 ESBL-positive E.coli isolates collected from surgical site infections in Benin in 2019. The findings revealed diverse sequence types and the presence of various resistance genes, highlighting the potential of WGS as an effective early warning system for emerging pathogens and antimicrobial resistance.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Food Science & Technology
Ryan Pearce, Beate Conrady, Luca Guardabassi
Summary: The objective of this study was to assess the prevalence and types of extended-spectrum β-lactamase (ESBL)-producing bacteria in retail seafood. A literature review found that the median prevalence of ESBL-contaminated products globally was 19.4%, with significantly higher rates in Asia compared to Europe and Africa. Among the analyzed isolates, 44.8% were ESBL-positive, with CTX-M being the predominant type (93.6%).
Article
Microbiology
Bejan Mahmud, Meghan A. Wallace, Kimberly A. Reske, Kelly Alvarado, Carol E. Muenks, David A. Rasmussen, Carey-Ann D. Burnham, Cristina Lanzas, Erik R. Dubberke, Gautam Dantas
Summary: ESBL-producing Escherichia coli is becoming increasingly prevalent, driven by the spread of ESBL-encoding plasmids. This study provides an in-depth genomic investigation of clinical ESBL-like E. coli isolates, revealing a comprehensive map of plasmid sharing across different boundaries. Through sequence-based network analysis, specific plasmid lineages responsible for disseminating major ESBLs have been identified. This work highlights the importance of plasmid-mediated spread in the dissemination of ESBLs and provides valuable insight into the factors underlying the increased prevalence of these genes in clinical settings.
Correction
Multidisciplinary Sciences
Swaine L. Chen, Ying Ding, Anucha Apisarnthanarak, Shirin Kalimuddin, Sophia Archuleta, Sharifah Faridah Syed Omar, Partha Pratim De, Tse Hsien Koh, Kean Lee Chew, Nadia Atiya, Nuntra Suwantarat, Rukumani Devi Velayuthan, Joshua Guo Xian Wong, David C. Lye
Summary: The paper has been amended and the revised version can be accessed through a link at the top of the paper.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Marcelina Osinska, Aneta Nowakiewicz, Przemyslaw Zieba, Sebastian Gnat, Dominik Lagowski, Aleksandra Troscianczyk
Summary: In this research, we investigated the resistance of cephalosporin-resistant E. coli strains in wild animals to antimicrobial agents. The study found that these strains had various resistance genes and showed multidrug-resistant profiles. It was observed that most of the strains produced ESBL enzymes, particularly CTX-M-1 and TEM. The resistance patterns of the strains were not always consistent with their sequence types and gene profiles.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Infectious Diseases
He Ma, Bingjie Lai, Chunfang Zan, Xin Di, Xinran Zhu, Ke Wang
Summary: This study identified four genes (speG, Hdac10, GLO1 and Ppcdc) that may be associated with the drug-resistant mechanism of Escherichia coli. The expression of the GLO1 gene only affects PER-beta-lactamases.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Wei-Hung Cheng, Wan-Yu Shao, Man-Yu Wen, Pei-Yi Su, Cheng-Hsun Ho
Summary: In this study, cefepime- and aztreonam-nonsusceptible H. influenzae strains were isolated and the molecular basis of their resistance to cefepime and aztreonam was investigated. Genetic variations associated with cefepime and aztreonam nonsusceptibility were identified and their effects on drug susceptibility were demonstrated.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Environmental Sciences
Michael Biggel, Sarah Hoehn, Andrea Frei, Kira Dassler, Christoph Jans, Roger Stephan
Summary: The study reveals the spread of E. coli ST131 lineage through wastewater and surface water, posing a significant challenge to public health and water management.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Babafela Awosile, Jessica Eisnor, Matthew E. Saab, Luke Heider, J. T. McClure
Summary: This study aimed to determine the occurrence of antimicrobial resistance to the extended-spectrum cephalosporins in Escherichia coli isolates from retail meat products in the Maritime Provinces of Canada. It was found that selective culture significantly improved the recovery of ESC-resistant E. coli isolates from retail meat samples. The study demonstrated the presence of ESBL-and AmpC-resistance genes in retail meat products in the Maritime Provinces of Canada.
CANADIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Infectious Diseases
Rongrong Li, Huaming Xu, Hao Tang, Jilu Shen, Yuanhong Xu
Summary: This study investigated the resistance and virulence characteristics of ESBLs-producing Escherichia coli in bloodstream infections. The results showed that the most common resistance gene was blaCTX-M, the most common multi-locus sequence typing was ST131, and there was a correlation between the classification of E. coli and specific virulence factors. Most resistance genes could be transferred between bacteria through plasmids. Therefore, it is necessary to strengthen the monitoring of ESBLs-producing isolates in the medical environment.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Multidisciplinary Sciences
Yu-Long Zhang, Fang-Yuan Huang, Lin-Li Gan, Xin Yu, Dong-Jie Cai, Jing Fang, Zhi-jun Zhong, Hong-rui Guo, Yue Xie, Jun Yi, Zhi-sheng Wang, Zhi-Cai Zuo
Summary: The study revealed a high prevalence of ESBL-producing E. coli in beef cattle farms in the Sichuan-Chongqing circle of China, with CTX-M and SHV being the predominant ESBL genes. The results call for health concerns regarding ESBL-producing E. coli infections and provide the first comprehensive research report on this topic in Chinese beef cattle.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Supram Hosuru Subramanya, Indira Bairy, Yang Metok, Bharat Prasad Baral, Dipendra Gautam, Niranjan Nayak
Summary: This study in rural subsistence farming communities in the Kaski district of Nepal found a high rate of gut colonization by ESBL-producing Enterobacteriaceae, while there was limited colonization by CPE.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Nguyen Thanh Viet, Vu Van Du, Nghiem Duc Thuan, Hoang Van Tong, Nguyen Linh Toan, Can Van Mao, Nguyen Van Tuan, Srinivas Reddy Pallerla, Dennis Nurjadi, Thirumalaisamy P. Velavan, Ho Anh Son
Summary: The study in Vietnam found that 30% of pregnant women had colonization of E. coli and Klebsiella species in their birth canals, with 47% of them producing ESBL. Carapenem resistance was low overall, but over 20% of Klebsiella species were resistant. This highlights the need for surveillance and molecular typing to combat the high rate of ESBL-producers and carbapenem resistance in Enterobacterales in Vietnam.
Article
Public, Environmental & Occupational Health
Eva Raphael, M. Maria Glymour, Henry F. Chambers
Summary: The prevalence of ESBL-E. coli bacteriuria increased at a faster rate in healthcare-associated settings than in the community between 2014 and 2020. Male gender was associated with ESBL-E. coli bacteriuria in both settings, while additional risks such as age > 65 and Latinx race/ethnicity were observed only in the community.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Infectious Diseases
Antonio Mandujano, Diana Veronica Cortes-Espinosa, Jose Vasquez-Villanueva, Paulina Guel, Gildardo Rivera, Karina Juarez-Rendon, Wendy Lizeth Cruz-Pulido, Guadalupe Aguilera-Arreola, Abraham Guerrero, Virgilio Bocanegra-Garcia, Ana Veronica Martinez-Vazquez
Summary: This study investigated the antimicrobial resistance profile of ESBL-producing E. coli among food-producing animals in Tamaulipas, Mexico. A total of 200 fecal samples were collected and 5.0% of the strains were confirmed as ESBL producers. High percentage of antimicrobial resistance was observed against gentamicin, tetracycline, and streptomycin. The study suggests that food-producing animals may serve as reservoirs and contribute to the spread of ESBL-producing bacteria.
Article
Veterinary Sciences
A. L. Lawson, H. B. Carslake, J. Kane-Smyth, T. W. Maddox, A. M. Talbot
Summary: Three horses were identified with marked mineralisation of the longitudinal odontoid ligament on CT examination, a finding not previously reported in the literature. While the significance of this finding to clinical problems remains speculative, further investigation into the association between mineralisation of the longitudinal odontoid ligament and compatible clinical signs is warranted. This case report aims to describe three cases with this unique mineralisation identified on CT examination.
EQUINE VETERINARY EDUCATION
(2021)
Article
Veterinary Sciences
Thomas Cox, Thomas W. Maddox, Robert Pettitt, Brandan Wustefeld-Janssens, John Innes, Eithne Comerford
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2020)
Article
Veterinary Sciences
Cajsa M. Isgren, Nicola J. Williams, Owen D. Fletcher, Dorina Timofte, Richard J. Newton, Thomas W. Maddox, Peter D. Clegg, Gina L. Pinchbeck
Summary: The study described the antimicrobial resistance patterns of bacteria from clinical samples in the UK in 2018, revealing high rates of multidrug resistance in SSI/CRI/orthopaedic infections. Analysis of resistance in pathogens like E. coli and Staphylococcus species showed that some bacteria lacked readily available treatments for adult horses in the UK.
EQUINE VETERINARY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Leonardos Mageiros, Guillaume Meric, Sion C. Bayliss, Johan Pensar, Ben Pascoe, Evangelos Mourkas, Jessica K. Calland, Koji Yahara, Susan Murray, Thomas S. Wilkinson, Lisa K. Williams, Matthew D. Hitchings, Jonathan Porter, Kirsty Kemmett, Edward J. Feil, Keith A. Jolley, Nicola J. Williams, Jukka Corander, Samuel K. Sheppard
Summary: This study identifies genetic elements associated with pathogenicity in avian E. coli using population genomics and pangenome-wide association studies, revealing the underlying mechanisms of pathogenicity in poultry.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
David A. Singleton, Pisut Pongchaikul, Shirley Smith, Rebecca J. Bengtsson, Kate Baker, Dorina Timofte, Stephen Steen, Matthew Jones, Larry Roberts, Fernando Sanchez-Vizcaino, Susan Dawson, P-J M. Noble, Alan D. Radford, Gina L. Pinchbeck, Nicola J. Williams
Summary: This study aimed to monitor antimicrobial resistance in companion animals in the UK, finding that the most commonly isolated bacteria in dogs and cats were Escherichia coli, with some bacteria showing resistance to multiple drugs. Genotypic characterization proved to be an efficient method for identifying important resistance trends in companion animals on a national scale.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
E. F. Groat, N. J. Williams, G. Pinchbeck, B. Warner, A. Simpson, V. M. Schmidt
Summary: Dogs fed raw meat are more likely to carry antimicrobial-resistant Escherichia coli and Salmonella species compared to dogs fed non-raw diets. This poses a potential public health issue, especially for households with vulnerable members.
JOURNAL OF SMALL ANIMAL PRACTICE
(2022)
Article
Veterinary Sciences
Anna Ehrle, Svenja Lilge, Peter D. Clegg, Thomas W. Maddox
Summary: Flexor tendon injuries are a common cause of lameness and early retirement in equine athletes, with advanced imaging modalities such as MRI and CT becoming more widely used for detection and monitoring. Future developments in tendon imaging aim to prevent injury by gaining enhanced structural information about the tendon architecture.
VETERINARY JOURNAL
(2021)
Review
Veterinary Sciences
Anna Ehrle, Svenja Lilge, Peter D. Clegg, Thomas W. Maddox
Summary: Flexor tendon injuries are a major cause of lameness in performance horses, impacting equine welfare and the horse industry. Recent research focuses on identifying subclinical tendon damage for prevention and better treatment outcomes. New imaging technologies like elastography show potential to change the clinical approach to equine flexor tendon imaging.
VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Alexandra Royden, Robert Christley, Alison Prendiville, Nicola J. Williams
Summary: Campylobacter is a leading cause of human bacterial diarrhoeal disease globally, with poultry meat products contributing significantly to the cases. Farmers recognize the importance of biosecurity but have concerns about the current measures and heavy burden of responsibility placed on them.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Alice E. Maher, Gustavo Burin, Philip G. Cox, Thomas W. Maddox, Susannah C. R. Maidment, Natalie Cooper, Emma R. Schachner, Karl T. Bates
Summary: In this article, the authors examine the relationship between body size, shape, and segment proportions and ecology in 410 tetrapod models. They find that body proportions play a pivotal role in the ecological diversity of tetrapods, with variable allometric relationships and differential scaling in different-sized animals.
NATURE COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Chiara Mattei, Anna Oevermann, Daniela Schweizer, Julien Guevar, Thomas W. Maddox, Kathryn L. Fleming, Emanuele Ricci, Marco Rosati, Roberta Biserni, John F. Griffin, Angie Rupp, Rodrigo Gutierrez-Quintana, Isabelle Masseau, Kimberly M. Newkirk, Silke Hecht, Swan Specchi
Summary: This retrospective, multi-center study describes the MRI features of central nervous system IVL in dogs and compares them with histopathological findings. The MRI findings include multifocal lesions, abnormal diffusion areas, and meningeal enhancement, which are consistent with the histopathological findings of subarachnoid hemorrhages and ischemic and hemorrhagic infarctions.
VETERINARY RADIOLOGY & ULTRASOUND
(2023)
Article
Veterinary Sciences
Rita Goncalves, Thomas W. Maddox, Stephanie Phillipps, Aran Nagendran, Camilla Cooper, Rocio Orlandi, Rory Fentem, Gemma L. Walmsley
Summary: A neurodisability scale (NDS) was developed to assess the severity of inflammatory diseases in the central nervous system (MUO) in dogs. The NDS showed good reliability when used prospectively, but no association with long-term outcome was found.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Crystal White, Thomas W. Maddox, Jeremy R. Mortier
Summary: This study evaluated resident perceptions of the ECVDI residency training programs and found that 88% of respondents enjoyed their training, and 73.5% agreed they felt ready to work as a veterinary radiologist. However, a significant percentage of respondents reported not receiving appropriate guidance in research and exam preparation.
VETERINARY RADIOLOGY & ULTRASOUND
(2023)
Article
Immunology
David A. Singleton, Gina L. Pinchbeck, Alan D. Radford, Elena Arsevska, Susan Dawson, Philip H. Jones, Peter-John M. Noble, Nicola J. Williams, Fernando Sanchez-Vizcaino
EMERGING INFECTIOUS DISEASES
(2020)
Article
Veterinary Sciences
Erika Bersan, Thomas Maddox, Gemma Walmsley, Martina Piviani, Rachel Burrow
JOURNAL OF FELINE MEDICINE AND SURGERY OPEN REPORTS
(2020)