Review
Oncology
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Summary: Several adjuvant treatments have been evaluated for preventing HCC recurrence after curative liver resection, with antiviral therapy and postoperative adjuvant transarterial chemoembolization showing promising results. However, further large-scale randomized controlled trials are needed to confirm their efficacy in different patient populations.
FRONTIERS OF MEDICINE
(2021)
Article
Surgery
Suk Kyun Hong, Xue-Li Jin, Sanggyun Suh, Su Young Hong, Kwangpyo Hong, Eui Soo Han, Jeong-Moo Lee, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: This study identified different clinical factors associated with early and late recurrence after curative resection of hepatocellular carcinoma. Tumor size was associated with early recurrence, while liver stiffness measurement (LSM) was associated with late recurrence. An LSM cut-off value of 7.4 kPa is recommended for predicting recurrence.
WORLD JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Wencui Li, Lizhu Han, Bohan Xiao, Xubin Li, Zhaoxiang Ye
Summary: This study aimed to identify the independent risk factors for AFP-NHCC and construct an individual prediction nomogram of early recurrence. The researchers found several independent predictors for early recurrence of AFP-NHCC and developed an effective nomogram. This nomogram could assist physicians in making more accurate personalized treatment decisions for AFP-NHCC patients.
Article
Health Care Sciences & Services
Yu-Syuan Chen, Shih-Yu Yang, Pei-Ming Wang, Chih-Chi Wang, Chee-Chien Yong, Ding-Wei Chen, Yueh-Wei Liu, Ching-Hui Chuang, Pao-Yuan Huang, Chih-Chien Yao, Yen-Po Lin, Ming-Chao Tsai
Summary: Concurrent cholecystectomy may reduce recurrence in early-stage HCC after curative resection, but does not significantly impact overall survival. Further studies are needed to confirm these results.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Bong Kyung Bae, Hee Chul Park, Gyu Sang Yoo, Moon Seok Choi, Joo Hyun Oh, Jeong Il Yu
Summary: This retrospective study evaluated the significance of systemic inflammatory markers (SIMs) in intrahepatic recurrence (IHR) of early-stage hepatocellular carcinoma (HCC) after curative treatment. The study found that SIMs were significantly associated with the prognosis of early-stage HCC patients who received initial curative treatment. The prognostic significances of SIMs were consistent for IHR-free survival, early and late IHR, and overall survival.
Article
Oncology
Pinxiong Li, Lei Wu, Zhenhui Li, Jiao Li, Weitao Ye, Zhenwei Shi, Zeyan Xu, Chao Zhu, Huifen Ye, Zaiyi Liu, Changhong Liang
Summary: The study explored the usefulness of spleen radiomics features on predicting early and late recurrences of HCC patients after curative resection. The spleen radiomics signature was identified as an independent risk factor for early recurrence and the mixed model integrating various factors showed improved predictive performance. In late recurrence analysis, the spleen radiomics signature was found to be the only prognostic factor associated with late recurrence of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Riccardo Nevola, Rachele Ruocco, Livio Criscuolo, Angela Villani, Maria Alfano, Domenico Beccia, Simona Imbriani, Ernesto Claar, Domenico Cozzolino, Ferdinando Carlo Sasso, Aldo Marrone, Luigi Elio Adinolfi, Luca Rinaldi
Summary: Hepatocellular carcinoma (HCC) is the most common liver neoplasm with increasing incidence rates. Long-term outcomes of potentially curative treatments are affected by high recurrence rates, with early recurrence being caused by the spread of the primary neoplasm and related to tumor burden, and late recurrence being independent of the primary neoplasm. Early HCC recurrence has a poorer prognosis than late recurrence, and different predictors exist for each type of recurrence. Understanding predictive factors and recurrence risk stratification is important for guiding treatment strategies and post-treatment surveillance.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Tao Wei, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Silvia Silva, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Razvan Grigorie, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Yi Lv, Luca Aldrighetti, Timothy M. Pawlik
Summary: The study found that setting the time point for recurrence at 8 months is beneficial for distinguishing early from late recurrence, with early recurrence patients typically having shorter survival time and post-recurrence survival, as well as less likely to receive curative treatment. Curative-intent retreatment for late recurrence patients is associated with similar overall survival compared to patients without recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Hideko Ohama, Atsushi Hiraoka, Fujimasa Tada, Kanako Kato, Yoshiko Fukunishi, Emi Yanagihara, Masaya Kato, Hironobu Saneto, Hirofumi Izumoto, Hidetaro Ueki, Takeaki Yoshino, Shogo Kitahata, Tomoe Kawamura, Taira Kuroda, Yoshifumi Suga, Hideki Miyata, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Tomoyuki Ninomiya, Yoichi Hiasa
Summary: This study compared the therapeutic efficacy differences between surgical resection and radiofrequency ablation for initial recurrent early-stage hepatocellular carcinoma. The results showed no significant differences in regard to recurrence-free survival or overall survival between the two treatment methods.
Article
Oncology
Jun-Cheng Wang, Jing-Yu Hou, Jian-Cong Chen, Cai-Ling Xiang, Xian-Hai Mao, Bing Yang, Qiang Li, Qing-Bo Liu, Jinbin Chen, Zhi-Wei Ye, Wei Peng, Xu-Qi Sun, Min-Shan Chen, Qun-Fang Zhou, Yao-Jun Zhang
Summary: In this study, novel nomograms were developed to predict postoperative recurrence and survival of patients with single large and huge hepatocellular carcinoma. The nomograms showed high accuracy and reliability in predicting outcomes for these patients, as confirmed by validation in internal and external cohorts.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Shih-Yu Yang, Chih-Chi Wang, Kuang-Den Chen, Yueh-Wei Liu, Chih-Che Lin, Ching-Hui Chuang, Yu-Chieh Tsai, Chih-Chien Yao, Yi-Hao Yen, Chang-Chun Hsiao, Tsung-Hui Hu, Ming-Chao Tsai
Summary: This study revealed that statin use may have a chemopreventive effect on HCC recurrence after curative resection. Factors such as age, liver cirrhosis, diabetes, number of tumors, tumor size, and vascular invasion were identified as independent risk factors for HCC recurrence, while statin use and antiviral therapy significantly reduced the risk of recurrence.
Article
Surgery
Yanfang Zhang, Xuezhong Lei, Liangliang Xu, Xiaoju Lv, Mingqing Xu, Hong Tang
Summary: The nomograms constructed in this study have good performance in predicting early recurrence for hepatocellular carcinoma without macrovascular invasion before and after surgery, and they have guiding significance for doctors in determining treatment methods and selecting patients for regular monitoring or adjuvant therapy.
Article
Multidisciplinary Sciences
Jing-Houng Wang, Wei-Feng Li, Chee-Chien Yong, Yueh-Wei Liu, Sheng-Nan Lu, Chih-Chi Wang
Summary: This study investigated the role of LS and metabolic factors in predicting HCC recurrence for patients with early stage HCC. It was found that LS was positively correlated with fibrosis stage, and patients with LS>8.5 kPa and HOMA-IR>2.3 had the highest recurrence rate after 1-year post resection.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
Article
Oncology
Rui Liao, Xu-Fu Wei, Ping Che, Kun-Li Yin, Lei Liu
Summary: This study developed two nomograms based on the China liver cancer staging system to predict the outcomes of patients with hepatocellular carcinoma after curative resection. The nomograms showed better prognostic abilities for postoperative survival and recurrence-free survival compared to the Tumor-Node-Metastasis 8th edition and Barcelona Clinic Liver Cancer staging systems.
FRONTIERS IN ONCOLOGY
(2022)