期刊
PREVENTIVE MEDICINE
卷 54, 期 -, 页码 S124-S129出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ypmed.2012.01.004
关键词
Lactoferrin; Lactoperoxidase; Proline-rich polypeptide; Influenza; Infection; Immunity; Phagocytosis; NK cells; Lymphocyte migration
资金
- Sterling Technology Inc., Brookings, South Dakota
- Sterling Technology Inc
Objective: To evaluate acute effects of bovine colostrum low-molecular weight fraction (CLMWF) on selected aspects of innate immune function in healthy human subjects. Methodology: A placebo-controlled, double-blinded, randomized cross-over trial involving 12 healthy subjects, age 22-72, was conducted at NIS Labs during the year 2010. Placebo or 150 mg CLMWF was given orally. Blood was drawn immediately before and at 1 and 2 h after consumption. Results: A single dose of CLMWF, when compared to placebo, resulted in rapid increase in phagocytic activity of monocytes at 1 h (P<0.12) and polymorphonuclear cells at 1 h (P<0.08) and 2 h (P<0.03) after consumption. Observations included increased numbers of CD3(+) T cells (P<0.05), and a transient reduction in circulating CD3(-)CD56(+) natural killer (NK) cells at 1 h (P<0.04), returning to normal levels at 2 h after consumption (P<0.96). The relative increase of NK cells from 1 to 2 h after consumption was not associated with an increase in CD69 or CD25 activation markers, suggesting that new NK cells were mobilized into circulation. Conclusion: The increased phagocytic activity and rapid transient changes in NK cell numbers suggest that upon consumption, interaction of CLMWF with immune cells in the gut mucosa triggers immediate events with systemic consequences. (C) 2012 Elsevier Inc. All rights reserved.
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