Article
Cardiac & Cardiovascular Systems
Michelle D. Kelsey, Adam J. Nelson, Jennifer B. Green, Christopher B. Granger, Eric D. Peterson, Darren K. McGuire, Neha J. Pagidipati
Summary: Cardiovascular disease is a major concern for individuals with type 2 diabetes mellitus, and aggressive risk factor management is crucial for these high-risk patients. Recommendations and guidelines from professional societies in cardiology, endocrinology, nephrology, and general medicine in the United States and Europe provide guidance on cardiovascular risk reduction for patients with type 2 diabetes mellitus. While there are some differences in risk stratification, treatment targets for low-density lipoprotein-cholesterol and blood pressure, as well as the use of specific medications, overall there is significant alignment across recommendations from different professional societies.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Masaru Kitazawa, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Takaaki Sato, Taeko Osawa, Masahiro Ishizawa, Hiroshi Suzuki, Yasuhiro Matsubayashi, Kazuya Fujihara, Takaho Yamada, Hirohito Sone
Summary: Intervention with a smartphone app and intermittently scanned continuous glucose monitoring can improve glycemic control and lead to decreased carbohydrate intake and weight loss.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Gyldenkerne, Martin Bodtker Mortensen, Johnny Kahlert, Pernille Gro Thrane, Kevin Kris Warnakula Olesen, Henrik Toft Sorensen, Reimar Wernich Thomsen, Michael Maeng
Summary: Newly diagnosed type 2 diabetes mellitus significantly increases the risk of cardiovascular disease in patients, especially among younger individuals. Compared to the general population, individuals with type 2 diabetes have a significantly higher 10-year risk of developing cardiovascular events, occurring at least 12 years earlier.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Neha J. Pagidipati, Prakash Deedwania
Summary: Despite extensive research on risk-reduction strategies, cardiovascular disease and renal disease remain major causes of mortality and morbidity among patients with type 2 diabetes mellitus. Understanding cardiovascular-renal-metabolic disease states holistically is crucial for providing integrated care to individuals with these conditions.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
David G. Marrero, Robert M. Blew, Kelly N. B. Palmer, Kyla James, Denise J. Roe, Melanie D. Hingle
Summary: The EPIC El Rio Families Study aims to evaluate the effects of a 13-week behavioral lifestyle intervention on T2DM risk factors in at-risk mothers and their 8- to 12-year-old children. This group randomized trial will assess reduction in excess body weight, hemoglobin A1c, blood pressure, and changes in lifestyle behaviors, with potential for high replication and dissemination.
Article
Cardiac & Cardiovascular Systems
Suriya Prausmueller, Michael Resl, Henrike Arfsten, Georg Spinka, Raphael Wurm, Stephanie Neuhold, Philipp E. Bartko, Georg Goliasch, Guido Strunk, Noemi Pavo, Martin Clodi, Martin Huelsmann
Summary: In individuals with type 2 diabetes mellitus, the new ESC/EASD risk stratification model showed limited performance compared to the SCORE and single NT-proBNP assessment in predicting 10-year cardiovascular disease and all-cause fatal events. Score and NT-proBNP had significantly higher C-indices for predicting CVD and all-cause death compared to the ESC/EASD risk model.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Shih-Chun Pan, Ching-Chun Huang, Bing-Yu Chen, Wei-Shan Chin, Yue Leon Guo
Summary: This study aimed to determine whether air pollutants modify the effects of gestational diabetes mellitus (GDM) on the occurrence of diabetes mellitus (DM). The results showed that exposure to high levels of PM2.5 and O-3 increases the risk of DM, and GDM acts synergistically with PM2.5 exposure in DM development.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Emilia Huvinen, Jari Lahti, Miira M. Klemetti, Paula H. Bergman, Katri Raikkonen, Marju Orho-Melander, Hannele Laivuori, Saila B. Koivusalo
Summary: This study aimed to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. The results demonstrated an interaction between genetic risk and lifestyle intervention, suggesting that lifestyle intervention may need to be tailored according to genetic risk.
Review
Food Science & Technology
Qianyu Qu, Penggang He, Yuqi Zhang, Shujuan Yang, Peibin Zeng
Summary: Probiotics have shown beneficial effects in the treatment of type 2 diabetes, especially in animal models. However, the translation of these findings to humans is limited by the differences between experimental animal models and humans.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sebastian Hoerber, Rainer Lehmann, Louise Fritsche, Juergen Machann, Andreas L. Birkenfeld, Hans-Ulrich Haering, Norbert Stefan, Martin Heni, Andreas Fritsche, Andreas Peter
Summary: Lifestyle intervention over one year significantly reduces coagulation factor activities, improves coagulation status, and lowers the risk of thrombosis. In addition to body weight, reducing liver fat, improving insulin sensitivity, and decreasing low-grade inflammation also contribute to improvements in hemostasis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Cristina Rey-Renones, Jose Miguel Baena-Diez, Isabel Aguilar-Palacio, Cristina Miquel, Maria Grau
Summary: Individuals with type 2 diabetes are at higher risk for developing and dying from cancer, possibly due to metabolic abnormalities such as obesity. Understanding this link can aid in designing personalized preventive strategies.
Article
Endocrinology & Metabolism
Yao Chen, Lilin Yao, Shuheng Zhao, Mengchu Xu, Siwei Ren, Lu Xie, Lei Liu, Yin Wang
Summary: This study used machine learning to build aging and disease models, revealing a close relationship between oxidative aging and type 2 diabetes mellitus (T2DM). The results identified key factors such as nutritional metabolism, inflammation response, mitochondrial function, and protein homeostasis in the interplay between oxidative aging and T2DM. The study integrated various risk factors in T2DM and confirmed the theories of oxi-inflamm-aging and cellular senescence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Piotrowska, Katarzyna Zgutka, Marta Tkacz, Maciej Tarnowski
Summary: Diabetes is a major healthcare problem, especially for pregnant women, and requires an appropriate approach. Gestational diabetes mellitus and type 2 diabetes mellitus share many similarities and induce oxidative stress and cellular stress signaling. The risk of diabetes during pregnancy can lead to complications for both the mother and fetus. Physical activity is not only important for treating the negative effects of diabetes, but also for preventing its progression and reversing changes. Regular training sessions have a positive effect on the immune status of diabetic patients, mothers, and fetuses, causing changes in immune cell levels, cytokine activation, production and secretion, as well as microRNA, which improve overall well-being.
Article
Nutrition & Dietetics
Armando Pena, Micah L. Olson, Stephanie L. Ayers, Dorothy D. Sears, Sonia Vega-Lopez, Abigail T. Colburn, Gabriel Q. Shaibi
Summary: Obesity is linked to chronic inflammation and may increase the risk of type 2 diabetes in youth. This study investigated the relationship between inflammatory biomarkers and insulin sensitivity, beta-cell function, and response to lifestyle intervention in Latino youth with obesity. The findings showed that obesity-related inflammatory mediators were associated with T2D risk factors but were not affected by lifestyle intervention in Latino youth.
Article
Cardiac & Cardiovascular Systems
David D. Berg, Filipe A. Moura, Andrea Bellavia, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Itamar Raz, Erin A. Bohula, Robert P. Giugliano, Jeong-Gun Park, Mark W. Feinberg, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
Summary: A risk model for atherothrombosis in patients with type 2 diabetes mellitus (T2DM) was developed and validated using data from 42,181 patients. The model identified 16 independent predictors of myocardial infarction (MI) or ischemic stroke (IS). The model performed well in validation and has the potential to improve risk assessment and clinical decision-making.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
