期刊
PREVENTIVE MEDICINE
卷 46, 期 4, 页码 298-302出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ypmed.2007.11.010
关键词
endometrial neoplasms; calcium; dietary; vitamin D; diet; dietary supplements
资金
- NCI NIH HHS [K07 CA095666, K07 CA095666-05] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [K07CA095666] Funding Source: NIH RePORTER
Objective. In response to a recent ecologic study of UV exposure and endometrial cancer incidence, we present the epidemiologic evidence on the relation between intake of vitamin D and its metabolically related nutrient, calcium, and the occurrence of endometrial cancer. Methods. We conducted a systematic literature review and meta-analysis of vitamin D and calcium in relation to endometrial cancer, including peer-reviewed manuscripts published up to May 2007. Random and fixed effects summary estimates were computed. Results. Pooled analyses of the three case-control studies of dietary vitamin D and endometrial cancer uncovered heterogeneous results that were not significant in random or fixed effects analyses. Cut-points for the highest vitamin D intakes ranged from >244 to >476 IU/day. Qualitatively similar findings were observed for dietary calcium. Only two studies provided estimates for calcium supplements (random effects OR = 0.62, 95% CI 0.39-0.99; fixed effects OR = 0.62, 95% CI 0.42-0.93, for top vs. bottom category, p for heterogeneity = 0.25). Conclusions. The limited epidemiological evidence suggests no relation between endometrial cancer in the ranges of dietary vitamin D examined, and suggests a possible inverse association for calcium from supplements. Prospective studies, ideally including plasma 25(OH) D to estimate vitamin D input from diet and sun exposure, are needed to further explore these hypotheses. (C) 2007 Elsevier Inc. All rights reserved.
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