Review
Oncology
Giuseppe Nigri, Niccolo Petrucciani, Elena Belloni, Alessio Lucarini, Paolo Aurello, Francesco D'Angelo, Salomone di Saverio, Alessandro Fancellu, Giovanni Ramacciato
Summary: The literature is conflicting regarding the feasibility and survival outcomes of DP-CAR, but it can be a therapeutic option for patients with locally advanced pancreatic cancer. Overall complications rates were higher in DP-CAR group, yet survival outcomes were similar.
Article
Oncology
Yosuke Inoue, Akio Saiura, Takafumi Sato, Atsushi Oba, Ono Yoshihiro, Yoshihiro Mise, Hiromichi Ito, Yu Takahashi
Summary: This study investigated the technical details and efficacy of distal pancreatectomy with celiac axis resection and left gastric artery flow preservation in patients with pancreatic ductal adenocarcinoma. The results showed that ischemic complications mainly occurred in patients with reconstructed LGA, pancreatic fistula was the most common complication, and preoperative therapy improved 3-year overall survival rates for patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dakyum Shin, Sarang Hong, Yejong Park, Bong Jun Kwak, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Song Cheol Kim, Dae Wook Hwang
Summary: This study analyzed the clinical and oncologic outcomes of distal pancreatectomy with celiac axis resection (DP-CAR) for pancreatic body and tail cancer with celiac axis involvement. The results showed that despite associated morbidity and mortality, DP-CAR should be considered as the only therapeutic option for carefully selected patients when performed by a highly experienced group.
Article
Oncology
Haitham Triki, Damien Bergeat, Marie Bougard, Fabien Robin, Laurent Sulpice
Summary: The modified Appleby procedure has been shown to be effective in treating locally advanced PDAC, providing better local control and treatment outcomes for selected patients who have undergone neoadjuvant therapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Pietro Addeo, Martina Guerra, Philippe Bachellier
Summary: Arterial reconstruction during DP-CAR can reduce the occurrence of postoperative ischemic events, despite a higher rate of venous resection in the reconstruction group. This technique should be performed in high-volume centers and deserves further comparison with standard technique on a larger scale.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
So Jeong Yoon, Sang-Jae Park, Yoo-Seok Yoon, Tae-Ho Hong, Jin-Young Jang, Hee Joon Kim, Jin Seok Heo, Dae Wook Hwang, In Woong Han
Summary: This study investigated the surgical and oncologic outcomes of distal pancreatectomy with celiac axis resection (DP-CAR) in patients with pancreatic cancer. The results showed that DP-CAR is a feasible option for achieving curative resection with fair survival outcomes in patients with borderline resectable or locally advanced pancreatic cancer.
Article
Gastroenterology & Hepatology
Jade Fawaz, Maxime Barat, Sebastien Gaujoux
Summary: With the advancement of FOLFIRINOX and neoadjuvant radiotherapy, the surgical indications for adenocarcinoma have expanded, allowing for caudal pancreatectomy with resection of the celiac trunk in locally advanced cases. This procedure requires rigorous patient selection, surgical expertise, and experience in interventional radiology.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Surgery
Lu Liu, Tian-Xiang Liu, Wan-Xia Huang, Zhong Yang, Shang Wang, Ming-Xu Da, Yang Dong
Summary: Distal pancreatectomy with En-bloc celiac axis resection (DP-CAR) is a surgical procedure for treating locally advanced pancreatic body/tail cancer. Compared to distal pancreatectomy (DP), DP-CAR has worse efficacy and prognosis survival, but can provide better survival benefits and quality of life compared to palliative treatment.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Pavan Rao, Carl R. Schmidt, Brian A. Boone
Summary: The manuscript outlines the technical conduct of robotic DP-CAR, which is a safe and feasible approach for resecting malignant pancreatic tumors involving the celiac artery. The procedure involves careful dissection and preservation of important blood vessels, along with intra-operative ultrasound confirmation to ensure patient safety and surgical success.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Oncology
Pierre-Emmanuel Colombo, Francois Quenet, Pierre Alric, Anne Mourregot, Mathias Neron, Fabienne Portales, Philippe Rouanet, Guillaume Carrier
Summary: The resectability of pancreatic carcinoma is closely related to vascular extension. Recent advances in PC treatment emphasize the importance of achieving a good pathological response through chemotherapy and chemoradiation before surgery. This case of a 66-year-old man with locally advanced pancreatic cancer demonstrates the key steps and technical challenges of the surgical procedure, highlighting the significance of experienced surgical teams in achieving successful outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Min Li, Rongxi Shen, Sizhen Wang, Daojun Zhu, Xinbo Wang
Summary: This study aimed to evaluate the postoperative outcomes of DP-CAR surgery for pancreatic neck-body cancer. The results showed that there were no significant differences in major complications and mortality between DP-CAR and traditional DP surgery. However, patients in the DP-CAR group experienced more gastric ulcer, delayed gastric emptying, and elevated levels of postoperative hepatic enzymes. DP-CAR surgery is safe and can achieve satisfactory resection and survival outcomes.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Toru Nakamura, Ken-Ichi Okada, Masayuki Ohtsuka, Ryota Higuchi, Hidenori Takahashi, Kazuyuki Nagai, Michiaki Unno, Yoshiaki Murakami, Atsushi Oba, Moriaki Tomikawa, Atsushi Kato, Akihiko Horiguchi, Masafumi Nakamura, Shintaro Yagi, Sohei Satoi, Itaru Endo, Ryosuke Amano, Ippei Matsumoto, Yoichi M. Ito, Takukazu Nagakawa, Satoshi Hirano
Summary: The study evaluated the volume and mortality of DP-CAR surgery, as well as the effectiveness of preoperative arterial embolization for ischaemic gastropathy. The conclusion suggests that DP-CAR surgery can be safely performed in general pancreatic surgery centers, and there is no oncological advantage for resectable tumors close to the bifurcation of the splenic artery.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Medicine, Research & Experimental
Nicolae Bacalbasa, Irina Balescu, Mihai Dimitriu, Cristian Balalau, Florentina Furtunescu, Florentina Gherghiceanu, Daniel Radavoi, Camelia Diaconu, Ovidiu Stiru, Cornel Savu, Vladislav Brasoveanu, Claudia Stoica, Ioan Cordos
Summary: This case report presents a 44-year-old male patient diagnosed with locally advanced pancreatic adenocarcinoma invading the celiac axis. After discussing the risks and benefits, the patient consented to an extended surgical procedure with negative resection margins achieved. It suggests that surgery can be safely performed with curative intent in selected cases with celiac axis invasion.
Article
Gastroenterology & Hepatology
Yoshiaki Murakami, Naoya Nakagawa, Naru Kondo, Yasushi Hashimoto, Kenjiro Okada, Shingo Seo, Hiroyuki Otsuka
Summary: This study analyzed the clinical data of patients undergoing distal pancreatectomy and those undergoing en bloc celiac axis resection following neoadjuvant chemotherapy, finding that despite the increased morbidity with DP-CAR, it may bring a similar survival impact to DP in patients with borderline resectable or locally advanced pancreatic body carcinoma.
Article
Oncology
Ryan K. Schmocker, Michael J. Wright, Ding Ding, Michael J. Beckman, Ammar A. Javed, John L. Cameron, Kelly J. Lafaro, William R. Burns, Matthew J. Weiss, Jin He, Christopher L. Wolfgang, Richard A. Burkhart
Summary: Modern chemotherapeutics have improved disease control for locally advanced pancreatic cancer (LAPC) patients. Surgical strategy such as distal pancreatectomy with celiac axis resection (DP-CAR) is being considered more frequently. DP-CAR can be performed with low mortality and manageable morbidity, with outcomes similar to resection of borderline resectable and resectable disease.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Lindsey M. Zhang, Elaine O. Cheung, Joshua S. Eng, Meixi Ma, Caryn D. Etkin, Gaurava Agarwal, Tait D. Shanafelt, Taylor S. Riall, Thomas Nasca, Karl Y. Bilimoria, Yue-Yung Hu, Julie K. Johnson
Summary: This study presents a conceptual model for surgical resident well-being, with eight domains including Efficiency and Resources, Faculty Relationships and Engagement, Meaning in Work, etc. The confirmatory factor analysis (CFA) demonstrated acceptable fit of the proposed 8-domain model.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Joal D. Beane, Jeffrey D. Borrebach, Andrew Billderback, Amblessed E. Onuma, Mohamed A. Adam, Amer H. Zureikat, Henry A. Pitt
Summary: Enucleation of PNETs in only 11% of patients results in shorter operative time, less transfusions, lower morbidity, and shorter postoperative length of stay compared to resection.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Diamantis Tsilimigras, J. Madison Hyer, Adrian Diaz, Dimitrios Moris, Alizeh Abbas, Mary Dillhoff, Jordan M. Cloyd, Aslam Ejaz, Joal D. Beane, Allan Tsung, Timothy M. Pawlik
Summary: Patients undergoing resection of hepatocellular carcinoma at NCI-designated hospitals had improved outcomes compared to those treated at CoC-accredited centers, with lower odds of complications and 90-day mortality, as well as better survival. Additionally, Medicare payments for liver resection were comparable across centers with different accreditation statuses.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Gastroenterology & Hepatology
Jacqueline Dauch, Mohammad Hamidi, Amanda K. Arrington, Catherine L. O'Grady, Chiu-Hsieh Hsu, Bellal Joseph, Taylor S. Riall, Mohammad Khreiss
Summary: This study aimed to assess the impact of frailty on short-term outcomes after hepatectomy for colorectal liver metastasis (CRLM). Using the Modified Frailty Index (mFI), patients were divided into categories. The study found that frailty is associated with increased post-operative complications.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Yazan Ashouri, Chiu-Hsieh Hsu, Taylor S. Riall, Ioannis T. Konstantinidis, Felipe B. Maegawa
Summary: The study aimed to evaluate APRI as a predictor of postoperative liver failure. The research found that APRI was a better predictor of postoperative liver failure, with a cutoff value of 0.365. Additionally, APRI was independently associated with perioperative bleeding complications requiring transfusions.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Mohammad Hamidi, Catherine L. O'Grady, Sacha D. Brown, Amanda K. Arrington, Lilah Morris-Wiseman, Taylor S. Riall, Mohammad Khreiss
Summary: Lower preoperative eGFR levels (<60 mL/min/1.73m(2)) in patients undergoing pancreatectomy are associated with adverse outcomes, including prolonged length of stay, adverse discharge disposition, higher complication rates, and increased mortality risk.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
James E. Wiseman, Lilah F. Morris-Wiseman, Chiu-Hsieh Hsu, Taylor S. Riall
Summary: Operative time for laparoscopic cholecystectomy is primarily determined by patient and disease-specific factors, with resident level having no impact on conversion to open or complication rates. The influence of attending surgeons on operative time is more significant than that of resident levels.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Surgery
Yazan Ashouri, Katherine Ho, Helen Ho, Chiu-Hsieh Hsu, Iman Ghaderi, Taylor S. Riall, Ioannis T. Konstantinidis, Felipe B. Maegawa
Summary: The study found that compared to open pancreatoduodenectomy, minimally invasive pancreatoduodenectomy (MIPD) was associated with a higher rate of adequate lymphadenectomy and a shorter length of stay. However, there were no significant differences in the surgical margins status, 90-day mortality, and overall survival between the two approaches.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Anya L. Greenberg, Veronica F. Sullins, Timothy R. Donahue, Varuna M. Sundaram, Pierre F. Saldinger, Celia M. Divino, Nicholas E. Anton, Dimitrios Stefanidis, Linda M. Reilly, Richard J. Egan, Col Kristen J. Beals, Taylor S. Riall, Quan-Yang Duh, Rita A. Mukhtar, Kenzo Hirose, Carter C. Lebares
Summary: Emotional regulation is valued in surgical education for its positive impact on performance and well-being. However, implementing emotional regulation curricula faces challenges.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Oncology
Yu Wang, Farhan Z. Ilyas, Mahsa Kheradmandi, Diamantis I. Tsilimigras, Valerie P. Grignol, Carlo Contreras, Philip N. Tsichlis, Raphael E. Pollock, Joal D. Beane
Summary: Soft tissue sarcomas (STS) are a biologically diverse and poor prognosis group of mesenchymal tumors. Surgical resection is the main treatment method, but some patients are not eligible for surgery and there is a high rate of tumor recurrence in operated patients. Conventional systemic therapies are not effective. Aberrant activation of the AKT pathway is found in many cancers, including STS. Despite decades of research on EGFRs and its downstream effectors PI3K and AKT/mTOR, targeting the AKT pathway for advanced sarcoma remains challenging with no improvement in prognosis.
MOLECULAR CANCER RESEARCH
(2022)
Review
Medicine, General & Internal
Kristin E. Morrill, Rogelio Robles-Morales, Melissa Lopez-Pentecost, Raigam J. Martinez Portilla, Ahlam A. Saleh, Meghan B. Skiba, Taylor S. Riall, Jessica D. Austin, Rachel Hirschey, Elizabeth T. Jacobs, Lena Spotleson, Timothy P. Hanna
Summary: This review and meta-analysis aims to evaluate factors associated with treatment delays among patients with five common cancers. The study will search scientific databases for relevant articles and use statistical analysis and narrative synthesis to summarize and evaluate the impact of these factors on treatment delays.
Article
Surgery
Annie Laurie Benzie, Shankar Logarajah, Muhammad B. Darwish, Kei Nagatomo, Edward E. Cho, Taylor S. Riall, D. Rohan Jeyarajah
Summary: This study aims to explore the prevalence of burnout among surgical fellows and identify potential protective or predisposing factors. The results indicate a low rate of burnout among fellows, which may be attributed to self-selecting effect, mentoring, increased specialization, and autonomy. Further investigation is warranted to understand the factors contributing to burnout in this population.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
D. Brock Hewitt, Joal D. Beane, Valerie P. Grignol, Carlo M. Contreras
Summary: Surgical delay is associated with increased rates of lymph node involvement and decreased overall survival in patients with cutaneous melanoma.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Alessandro La Ferlita, Nipin Sp, Marina Goryunova, Giovanni Nigita, Raphael E. Pollock, Carlo M. Croce, Joal D. Beane
Summary: Soft-tissue sarcomas (STS), a rare and diverse group of tumors, have various subtypes characterized by differences in tumor biology and clinical outcomes. Small non-coding RNAs (sncRNAs), including miRNAs and tRNA-derived ncRNAs, play important roles in STS tumorigenesis and differentiation. However, the translation of these findings into clinical applications, such as biomarkers or therapeutic targets, remains challenging. This review summarizes the current understanding of sncRNAs in STS, with a focus on liposarcoma, and discusses their potential as novel biomarkers and therapeutic targets.
MOLECULAR CANCER RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Yadira Villalvazo, Mohammad Khreiss, Sacha D. Brown, Amanda K. Arrington, Taylor S. Riall