Article
Chemistry, Multidisciplinary
Maruthupandi Mannarsamy, Muneshwar Nandeshwar, Gopendra Muduli, Ganesan Prabusankar
Summary: In this study, the synthesis of a novel cyclic zinc(II) complex and its application as a catalyst for condensation reactions and compound synthesis were reported. The complex showed excellent efficiency in catalyzing reactions and synthesizing compounds under mild reaction conditions.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Kabir M. Uddin, Mohiuddin Sakib, Siam Siraji, Riaz Uddin, Shofiur Rahman, Abdullah Alodhayb, Khuloud A. Alibrahim, Ajoy Kumer, M. Mahbubul Matin, Md. Mosharef H. Bhuiyan
Summary: In this study, two novel series of derivatives (1-6) were synthesized using microwave-assisted Knoevenagel condensation. The synthesized compounds were characterized and evaluated for their pharmacodynamics, toxicity profiles, and biological activities. In silico studies, including prediction of activity spectra for substances (PASS) and absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies, were conducted. Molecular docking and molecular dynamics (MD) simulation were employed to investigate the binding mode, interaction sites, and thermodynamic stability of the derivatives. Compound 3 showed promising potential as a new anticancer and antiparasitic drug, but further research is needed to validate its efficacy.
Article
Chemistry, Organic
Kanchan D. Gavali, Pawan R. Kudale, Ganesh U. Chaturbhuj
Summary: A piperidinium borate, an organic conjugate base, is found to be an effective catalyst for promoting Knoevenagel condensation between aromatic, heterocyclic, a, b unsaturated aldehydes and aliphatic, cyclic ketones with active methylenes under mild conditions. The catalyst can be easily prepared from boric acid and piperidine. The method offers advantages of mild reaction conditions, wide availability of starting materials, higher product yields, and simple separation of products by filtering and washing with water. It has been successfully used for the synthesis of AMG 837, a new GPR40 agonist intermediate, with excellent catalyst recyclability and reusability.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yan-Fang Zhou, Dan-Ni Yan, Shao-Jun Hu, Li-Peng Zhou, Li-Xuan Cai, Qing-Fu Sun
Summary: Bronsted-base active sites on a Pd4L2 cage enable enhanced catalytic efficiency, wide substrate scope, and high turnover number (TON) for the one-pot photooxidation/Knoevenagel condensation reaction under mild conditions.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Maria-Anna Karadendrou, Ioanna Kostopoulou, Vasiliki Kakokefalou, Andromachi Tzani, Anastasia Detsi
Summary: Aurones, minor flavonoids with diverse bioactivities, can be efficiently synthesized using L-proline-based natural deep eutectic solvents (NaDES) as catalysts and solvents, and ultrasound irradiation as an energy source. The reaction yields high purity aurones, with the added benefit of recyclability and reusability of NaDES.
Article
Chemistry, Multidisciplinary
Joel Andersen, Hunter Starbuck, Tia Current, Scott Martin, James Mack
Summary: In recent years, chemists and engineers have found the utility of using twin-screw extruders for large-scale organic chemistry mechanochemically. Commercially available ball mills lack strict temperature control, but by modifying an in-house temperature-controlled ball mill, the research successfully carried out an example of extrusion.
Article
Chemistry, Organic
Anusueya Kumari, Muthiah Suresh, Raj Bahadur Singh
Summary: The proposed structure of Tabasesquiterpene A, an illudalane type of sesquiterpene, has been successfully synthesized in twelve steps with an overall yield of 40%. Key transformations include intramolecular Freidel-Crafts acylation, ortho-selective formylation, Knoevenagel condensation, and reduction of lactone. NMR spectroscopic data of the synthetic sample differs from natural Tabasesquiterpene A.
Article
Chemistry, Multidisciplinary
Srinivasan Prabhakaran, Sivan Velmathi
Summary: The synthesis of bis phenyl pyrazolone piperidinium salt derivatives from the reaction between an aromatic aldehyde, 3-methyl-5-phenyl pyrazolone and piperidine in ethanol is described. The reaction proceeds via Knoevenagel condensation followed by hydrogen bond formation, giving good yields of products without the need for column chromatography. The products were confirmed by spectroscopic techniques such as FT-IR, H-1, C-13 & DEPT 135-NMR and HR-MS.
Article
Chemistry, Multidisciplinary
Bindi Sanghavi, Hemant P. Soni
Summary: Fe3O4@L-Arginine and Fe3O4@L-Histidine nanoparticles were synthesized and used as catalysts for sequential Knoevenagel condensation and Michael addition reactions. Optimized reaction parameters resulted in high yields of 97% in Knoevenagel adducts and 70% in Michael products under solvent-free conditions at 80 degrees C. However, Fe3O4@L-Histidine NPs did not show any catalytic activity for the sequential Michael addition. The reasons behind the high activities of Fe3O4@L-Arginine NPs have been discussed, and the catalyst could be reused for 5 cycles with consistent activity and selectivity. This optimized protocol offers high isolated yields, cost savings in solvents, and falls within the domain of green chemistry.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Inorganic & Nuclear
Nuno Reis Conceicao, Beatriz P. Nobre, Anirban Karmakar, Antonio M. F. Palavra, Kamran T. Mahmudov, M. Fatima C. Guedes da Silva, Armando J. L. Pombeiro
Summary: The replacement of conventional organic solvents by green solvents is a sustainable approach in chemical processes. In this study, a new zinc (II) coordination polymer is reported and its potential as a catalyst in the Knoevenagel condensation reaction is investigated. It is found that water is the most suitable co-solvent in scCO(2) medium, and the catalyst shows good recyclability and stability.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Sonia Mancipe, Valentina Coca, Juan-Carlos Castillo, Hugo Rojas, Maria Helena Brijaldo, Claudia Castaneda, Jose Jobanny Martinez, Gustavo Pablo Romanelli
Summary: In this study, the catalytic activity of Mg(OH)(2) and MgO materials were investigated, along with the reaction between HMF and malononitrile under solvent-free conditions. The combination of synthesis methods were found to affect the properties of the catalysts, and water played a crucial role in achieving high yields. High yields near 90% were achieved using a simple and inexpensive method.
COMPTES RENDUS CHIMIE
(2023)
Article
Chemistry, Multidisciplinary
Na Liu, Feng Wu, Jie Xu, Fei Wang, Bing Xue, Jun Luo
Summary: In this study, CN/SBA15 catalysts were prepared by impregnation method and applied in the Knoevenagel condensation reaction. The catalysts were characterized by various analytical techniques and the results showed that the introduction of carbon nitride maintained the ordered mesoporous structure of SBA-15. The distribution of nitrogen-containing functional groups in the CN/SBA15 catalysts could be controlled by adjusting the calcination temperature. The CN/SBA15-400 catalysts exhibited excellent catalytic activity in the Knoevenagel condensation reaction.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Organic
Paloma Gomes de Abrantes, Poliana Gomes de Abrantes, Joao Marcos Gomes de Oliveira Ferreira, Juliana Alves Vale
Summary: Knoevenagel condensation was optimized using an environmentally friendly condition consisting of a binary mixture of ethanol:water (3:7, v/v) and NaCl salt as a promoter. The proposed system provides easy isolation of products through simple filtration, with optimal yields ranging from 83% to 97% in a short-time reaction at room temperature.
SYNTHETIC COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Siwei Zhao, Yujing Zhang, Jidao Li, Limin Qi, Yuxin Tang, Jia Zhu, Jian Zhi, Fuqiang Huang
Summary: In order to enhance the zinc ion conductivity and suppress dendrite growth, researchers have designed a heteroanionic zinc ion conductor (ZnyO1-xFx) as a protective layer. By tuning the F content and thickness, the coated anode shows a low overpotential of 20.4 mV for 1000 h cycle life and high stability for 1000 cycles. This work sheds light on the development of high-performance Zn-based energy storage devices.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Long Gao, Wenyao Li, Huaijun Tang, Jing Qin, Shiyou Lu, Meifang Zhang, Kaixin Yang, Yuxiang Jiao
Summary: Luminescent covalent organic frameworks (COFs) containing triazine units were synthesized and used as metal-free phosphors for LEDs. These COFs had a hexagonal pore structure and an eclipsed stacking mode. When combined with GaN-based blue-emitting chips, a series of white LEDs with different color temperatures and performances were fabricated using the COFs as yellow phosphors. The best performing cold white LED had a CCT of 5743 K, a CRI of 83.1, a CIE chromaticity coordinate of (0.33, 0.29), and an LE of 18.18 lm center dot W-1.
EUROPEAN POLYMER JOURNAL
(2023)
