期刊
PRENATAL DIAGNOSIS
卷 29, 期 7, 页码 691-696出版社
WILEY
DOI: 10.1002/pd.2278
关键词
cellular RNA in maternal blood; pre-eclampsia; anti-oxidant enzymes; heme oxygenase-1; fetal cells; nucleic acids and proteins; RNA
资金
- JAOG Ogyaa Donation Foundation (JODF)
- Ministry of Education, Science, Sport and Culture of Japan [20591930, 20591309]
- Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [20591309, 20591930] Funding Source: KAKEN
Objective To assess the alterations of mRNA expressions associated with oxidative stress in file cellular component of blood front pregnant women with pre-eclampsia. Methods Peripheral blood samples were obtained from pregnant women With and without pre-eclampsia. Cellular RNA Was subjected to a reverse transcription polymerase chain reaction (PCR) assay in order to examine the mRNA distribution among women with pre-eclampsia (n = 24) and control subjects (n = 24) during 35-41 weeks of gestation. The data were analyzed by non-parametric statistics. Results Significant differences between the pre-eclampsia subjects and the controls were observed in the gene expressions associated with oxidative stress. Lower values in the pre-eclampsia group were found for heme oxygenase (HO)-1. HO-2, catalase and superoxide dismutase (SOD). The HO-1. HO-2 and the catalase levels significantly correlated with proteinuria, and the HO-2 level with systolic blood pressure. Conclusion Significantly lower, concentrations of HO-1. HO-2, SOD and catalase are found in the cellular component of blood from pre-eclamptic patients. The values correlate with the severity of, pre-eclampsia. These findings indicate that enhanced oxidative stress mid a decrease in the number of anti-oxidant enzymes may be associated with pre-eclampsia. Copyright (C) 2009 John Wiley & Sons. Ltd.
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