Article
Cell Biology
Andrey Elchaninov, Polina Vishnyakova, Maria Kuznetsova, Elena Gantsova, Viktoria Kiseleva, Anastasiya Lokhonina, Maria Antonova, Aiaz Mamedov, Anna Soboleva, Dmitry Trofimov, Timur Fatkhudinov, Gennady Sukhikh
Summary: The role of the immune system and spleen in liver repair was investigated in this study. The loss and regeneration of liver volume significantly affected the cytological architecture and gene expression profiles of the spleen. The study found a decrease in Ki-67+ cells, CD115+ macrophages, Ly6C+ cells, and CD3+CD8+ cytotoxic lymphocytes during the recovery phase.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Food Science & Technology
Jiawen Lu, Ying Yang, Elisabeth Varga, Doris Marko, Qiang Yu, Jianhua Xie, Chang Li, Yi Chen
Summary: This study used RNA-Seq to screen the MAPK signaling pathway as one of the crucial pathways for PSG-F-2 pretreatment against AA-induced damage in IEC-6 cells. Western blot and immunofluorescence confirmed the RNA-Seq data, and revealed that PSG-F-2 protects intestinal cells from AA-induced damage through the MAPK/ERK signaling pathway. The findings suggest that PSG-F-2 can be used as a daily dietary supplement to protect intestinal cells from thermal processing hazards caused by AA.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Anqi Xie, Hao Wan, Lei Feng, Boyun Yang, Yiqun Wan
Summary: In this study, Anoectochilus formosanus polysaccharide (AFP) was obtained through water extraction and alcohol precipitation. The immunoregulatory activity of AFP was evaluated through various experiments, showing its potential as a natural immunomodulator. AFP exhibited the ability to stimulate cytokine production and enhance immunity in mice. Furthermore, it alleviated immune toxicity and showed promising results for further application and utilization.
Article
Food Science & Technology
Dan Su, Aitong Lei, Chunchao Nie, Yi Chen
Summary: The protective effects of Ganoderma atrum polysaccharide (PSG-1) on acrylamide-induced intestinal damage in mice were investigated. PSG-1 pretreatment effectively prevented injury by reducing intestinal permeability and serum D-lactate acid levels, increasing goblet and IgA secreting cells, decreasing oxidative stress, inflammation, and enhancing tight junction proteins. Furthermore, PSG-1 was found to exert its protective effects through the TLR4/MyD88/NF-kappa B signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Applied
Fangfang Wu, Huihua Huang
Summary: The hetem polysaccharide fraction (HEP-W) from Hericium erinaceus displayed a flexible random coil conformation and continuous fiber network structure, showing immunomodulatory activities by enhancing immune responses in mice. This suggests that HEP-W could be explored as a natural and effective immunomodulatory agent.
CARBOHYDRATE POLYMERS
(2021)
Article
Biology
Andrey Elchaninov, Polina Vishnyakova, Anastasiya Lokhonina, Viktoria Kiseleva, Egor Menyailo, Maria Antonova, Aiaz Mamedov, Irina Arutyunyan, Galina Bolshakova, Dmitry Goldshtein, Xuhui Bao, Timur Fatkhudinov, Gennady Sukhikh
Summary: Splenectomy can have serious postoperative complications, such as sepsis and cancers. Heterotopic autotransplantation of the spleen is a possible solution to this problem. This study aimed to monitor the dynamics of lymphocyte populations, the monocyte-macrophage system, and megakaryocytopoiesis in murine splenic autografts.
BIOLOGICAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Xiangying Zhou, Nan Cao, Danning Xu, Yunbo Tian, Xu Shen, Danli Jiang, Yunmao Huang, Wanyan Li, Bingxin Li
Summary: This study aimed to explore the mechanism by which Atractylodes macrocephala Koidz (PAMK) alleviates cyclophosphamide (CTX)-induced ferroptosis in thymocytes. The results showed that PAMK had a significant alleviating effect on thymus damage and thymocyte ferroptosis in goslings. Therefore, PAMK can be used as a natural alternative to antibiotics as a feed additive for immunomodulatory effects on goslings.
Article
Biochemistry & Molecular Biology
Yong Pil Hwang, Gi Ho Lee, Thi Hoa Pham, Mi Yeon Kim, Chae Yeon Kim, Seung Yeon Lee, Eun Hee Han, Chul Yung Choi, Seong Deok Hwang, Sunyoung Ahn, Hye Gwang Jeong
Summary: Compared to CTX-induced immunosuppressed mice, mice orally administered CLM showed significantly increased spleen and thymus indexes, alleviated body weight loss, and elevated levels of natural killer (NK) cytotoxicity, lymphocyte proliferation, and cytokine production in the serum. Treatment with CLM also induced phagocytic activity, nitric oxide (NO) production, and mRNA expression of immunomodulatory cytokines in RAW264.7 macrophages, indicating its potential as an immunomodulatory agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jing Xie, Dongmei Lin, Jing Li, Tonghui Zhou, Shuqian Lin, Zhanxi Lin
Summary: The study investigated the immunomodulatory effects of Ganoderma lucidum polysaccharide peptide (GLPP) in cyclophosphamide-induced immunosuppressive mice. GLPP administration significantly alleviated immune damage and improved immune organ indexes, cytokine secretion, and immunoglobulin A levels. Metabolite analysis revealed that GLPP treatment reversed alterations in the fecal metabolome profile, suggesting its potential immunomodulatory activity via various metabolic pathways.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Benoit R. Gauthier, Diana Rubio-Contreras, Juan Carlos Gomez-Rosado, Luis Cristobal Capitan-Morales, Abdelkrim Hmadcha, Bernat Soria, Christian Claude Lachaud
Summary: Mesothelial cells are a type of epithelial cells that line serous cavities and visceral organs. They have immunoregulatory properties and can inhibit lymphocyte proliferation and suppress activated B cells. They can also modify macrophage activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Yao Cui, Wenjing Sun, Qinmei Li, Kaijun Wang, Yuhan Wang, Feifei Lv, Xiaogang Chen, Xiaomin Peng, Ying Wang, Jiang Li, Hongbin Si
Summary: The study demonstrates that Caulis Spatholobi polysaccharide (CSP) has protective effects on immune function, intestinal mucosal barrier, and intestinal microflora in cyclophosphamide-induced immunosuppressed chickens. CSP can increase body weight, immune organ index, and the secretion of cytokines and immunoglobulins in chickens. Additionally, it reduces intestinal injury, improves intestinal health, and enhances the abundance of Lactobacillus in the intestine.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Guoyong Jiang, Aitong Lei, Yi Chen, Qiang Yu, Jianhua Xie, Ying Yang, Tongji Yuan, Dan Su
Summary: The study demonstrated that Ganoderma atrum polysaccharide (PSG-1) has protective effects against acrylamide-induced liver, spleen, kidneys, and intestine damage in rats by alleviating inflammatory response and oxidative stress, and protecting intestinal integrity and barrier function.
Article
Plant Sciences
Yuyuan Li, Zengjie Lei, Yuling Guo, Yujia Liu, Xiujie Guo, Xiuli Wang, Jian Che, Jieli Yuan, Chaoran Wang, Ming Li
Summary: This study established an in vitro fermentation model of Ganoderma lucidum and Raphani Semen with a probiotic mixture and found that probiotic fermentation enhanced the immunostimulatory activity of these traditional Chinese medicines. The study also demonstrated that probiotic fermentation can modulate the gut microbiota, improve intestinal integrity, and repair immunosuppression-induced intestinal damage.
Article
Food Science & Technology
Yu-Fei Yao, Le-Feng Wang, Su-Mei Chen, Rui-Ting Wu, Fei-Yue Long, Wen-Juan Li
Summary: This study aimed to investigate the antinociceptive and anti-inflammatory activities of an ethanol-soluble acidic component from Ganoderma atrum and the possible mechanisms involved. The results showed that this component could relieve thermal pain in mice and reduce acetic acid-induced writhing responses. It was also found to control inflammation by reducing phagocytosis, nitric oxide, and IL-1 beta, while up-regulating IL-10 and mannose receptor. The study demonstrated the antinociceptive and anti-inflammatory capacities of this component, with a key role played by the mannose receptor.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Wei-Lun Qiu, Hung-Chih Lo, Mei-Kuang Lu, Tung-Yi Lin
Summary: In this study, Ganoderma lucidum mycelia were harvested at different cultural stages to obtain GPS and GSPS. The results showed that GPS and GSPS isolated from mycelia cultured for 49 days exhibited the best anticancer effect and inhibited lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Pei Wang, Jinchao Su, Pei Ding, Bo Mao, Mengshuai Ren, Kun Xu, Shuo Tian, Yan Li, Ximin Tian, Junqiao Wang
Summary: This paper combines thermal radiation metasurfaces with information coding and infrared imaging technology to design tunable radiation coding metasurfaces. By controlling the spatial arrangement of different pixel structures, the spatial distribution of infrared emission can be controlled to carry patterns, characters, or digital information. This metasurface has higher security and flexibility and can be applied in fields such as infrared anticounterfeiting and information encryption.
DIAMOND AND RELATED MATERIALS
(2023)
Review
Chemistry, Applied
Junqiao Wang, Jing Zhao, Shaoping Nie, Mingyong Xie, Shaoping Li
Summary: This review summarizes the recent research progress on MALDI mass spectrometry (MS) detection in food carbohydrates, including the improvement of ionization efficiency, the application in structure characterization of polysaccharides, and the quantitative study and mass spectrometry imaging.
Article
Physics, Multidisciplinary
Bo Chu, Facheng Zhong, Taozheng Hu, Yan Li, Rujiang Yan, Li Shao, Fanguang Zeng, Pei Ding, Yinxiao Du, Ping Gu, Junqiao Wang, Zhuo Chen
Summary: A blue-light-blocking film consisting of transparent medium embedded with plasmonic nanoparticles that selectively absorb harmful blue light has been developed. It can block harmful blue light (415-455 nm) while maintaining high transparency for long wavelength light (lambda (0) > 500 nm).
Article
Biochemistry & Molecular Biology
Shuping Chen, Junqiao Wang, Nan Dong, Qiuyue Fang, Yanli Zhang, Chunhua Chen, Steve W. W. Cui, Shaoping Nie
Summary: Polysaccharides from Cordyceps sinensis showed promising effects on experimental acute ulcerative colitis in mice. They alleviated colitis symptoms, inhibited NF-kappa B pathway activation, and modulated the gut microbiota composition. These findings suggest that Cordyceps sinensis polysaccharides have potential as a treatment for ulcerative colitis.
Article
Medicine, General & Internal
Quanjiang Li, Qiang Yu, Beibei Gong, Youquan Ning, Xinwei Chen, Jinming Gu, Fajin Lv, Juan Peng, Tianyou Luo
Summary: The study aimed to develop radiomics models based on MR images to distinguish early-stage and advanced-stage nasopharyngeal carcinoma (NPC). Seven radiomics models were constructed using data from 329 patients. Model A (including contrast-enhanced T1WI, T1WI, and T2WI images) showed the best classification performance in the training cohort, effectively distinguishing early-stage from advanced-stage NPC patients. This study is of great importance for improving the accuracy of NPC staging and treatment.
Correction
Optics
Ran Li, Junqiao Wang, Mengke Ren, Wenhan Zhao, Mengyue He, Shuai Sun, Yu Mao, Shuo Tian, Yan Li, Pei Ding
OPTICS COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Xueli Bian, Jing Wang, Junqiao Wang
Summary: This study aims to adapt and validate the Chinese version of SCIDS for assessing nursing staff's competence in dementia care in Chinese long-term care settings. The results show that SCIDS-C has good reliability and validity, making it an appropriate tool to evaluate nursing staff's competence in providing dementia care.
Article
Food Science & Technology
Dan Su, Jiawen Lu, Chunchao Nie, Ziyan Guo, Chang Li, Qiang Yu, Jianhua Xie, Yi Chen
Summary: This study aimed to investigate the effects of AA and OTA individually and collectively on Caco-2 cells. The results showed that AA and OTA significantly inhibited Caco-2 cell viability, decreased TEER values, and increased LY permeabilization, LDH release, and ROS levels. Furthermore, AA and OTA treatment led to increased levels of IL-1 beta, IL-6, and TNF-alpha, while IL-10 levels decreased. Western blot analysis revealed that AA and OTA damaged the intestinal barrier by reducing the expression of tight junction proteins.
Article
Food Science & Technology
Xin Wang, Liyuan Rong, Mingyue Shen, Qiang Yu, Yi Chen, Jinwang Li, Jianhua Xie
Summary: This study investigated the effects of four food supplements (vitamins, minerals, salt, and sugar) on swallowing characteristics and food properties for dysphagia patients. The results showed that all samples belonged to level 4 in the IDDSI framework and exhibited shear thinning behavior, which is beneficial for dysphagia patients. The sensory evaluation demonstrated that dysphagia foods made with rice starch, perilla seed oil, and whey isolate protein, combined with both vitamins and 0.5% salt and sugar, scored the highest.
Article
Food Science & Technology
Yuzhen Hong, Mingyue Shen, Qiang Yu, Yi Chen, Jianhua Xie
Summary: The aim of this study was to investigate the improvement effect of Mesona chinensis Benth polysaccharide (MP) on cyclophosphamide (CTX) induced liver injury in mice. The results showed that MP could alleviate liver injury and promote the production of short chain fatty acids (SCFAs).
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biotechnology & Applied Microbiology
Hao Zhang, Chunhua Chen, Yanli Zhang, Hongmei Yin, Jielun Hu, Yadong Zhong, Shaoping Nie, Mingyong Xie
Summary: This study comprehensively investigated and compared the fermentation characteristics of indigestible glucans (IGs) with different structural properties and their effects on the gut microbiota. The results showed that different IGs were utilized by the gut microbiota at varying rates, and some remained unfermented after 48 hours. During fermentation, IGs released mono-, di-, or trisaccharides and lowered the pH of the broth, while producing short-chain fatty acids. The analysis also revealed that different IGs selectively promoted the proliferation of specific bacteria in the gut.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Jie Tang, Chaoran Yang, Xiaoting Qin, Jingyu Si, Xuewen Dong, Xiaobo Hu, Qiang Yu
Summary: A cellulose degrading strain (Penicillium griseofulvum) was used to ferment and modify soluble dietary fiber (SDF) extracted from Citrus aurantium L. (CAL). The fermentation process improved the structure characteristics and adsorption properties of CAL-SDF, resulting in an increased SDF yield. The modified SDF showed improved thermal stability, water solubility, and adsorption capacities. The study suggests that Penicillium griseofulvum can be used as a potential strain for modifying CAL-SDF to enhance its functional properties. Overall, the modification process has significant potential in increasing the value proposition of CAL. Evaluation: 8 out of 10.
Article
Biochemistry & Molecular Biology
Qianhuang Xiao, Wenqi Huang, Quanyong Wu, Hedi Xu, Yanli Zhang, Jingrui Yang, Shuigen Bian, Huizi Tan, Shaoping Nie
Summary: A sedentary lifestyle, unhealthy diet, and antibiotic use have been associated with an increased incidence of metabolic disorders and inflammation. This study focused on the effects of pectin, an edible polysaccharide, with different esterification degrees on mice treated with a high-fat diet and low-dose antibiotics. The results showed that different types of pectin had differential effects on metabolic health, inflammatory markers, gut microbiota, and serum metabolome.
Article
Food Science & Technology
Xiaoting Qin, Xuewen Dong, Jie Tang, Yi Chen, Jianhua Xie, Yanan Cheng, Bing Zheng, Xiaobo Hu, Qiang Yu
Summary: Ultrafine grinding treatment was used to process grapefruit peel, and the structural properties and adsorption capacities of extracted soluble dietary fibers (SDFs) were comparatively analyzed. The results showed that ultrafine grinding treatment reduced the crystallinity and thermal stability of SDFs, while increasing the pectin content. SDFs treated with ultrafine grinding were found to promote bacterial proliferation and stimulate the production of short-chain fatty acids by probiotic strains.
