Article
Multidisciplinary Sciences
Kairit Eha, Tonis Pehk, Ivo Heinmaa, Aleksei Kaleda, Katrin Laos
Summary: In this study, short-term heat treatment was found to have a significant impact on the structure, molecular weight, and gel rheology of commercial carrageenans. Heat caused desulphation and degradation of furcellaran galactans, leading to a decrease in viscosity and gel hardness. Storage modulus values of carrageenan gels decreased with increasing treatment temperature, with the greatest decrease seen in kappa/lambda-carrageenan gels.
Article
Chemistry, Multidisciplinary
Tanushree Das, Snehasis Mishra, Sayoni Nag, Krishna Das Saha
Summary: In this study, green gold nanoparticles (BTE-GNPs) prepared from black tea extract were used to examine the chemosensitivity of colon cancer cells (HCT116) to doxorubicin. The results showed that BTE-GNPs significantly enhanced the cytotoxic effect of doxorubicin in HCT116 cells, leading to apoptosis through a ROS-dependent pathway.
Article
Biochemistry & Molecular Biology
Supriyo Bera, Suvranil Ghosh, Asif Ali, Mahadeb Pal, Pinak Chakrabarti
Summary: This study investigates the impact of graphene oxide (GO) on tubulin structure using biophysical techniques, revealing that GO disrupts the structural integrity of the protein and slows down tubulin polymerization. GO exhibits greater toxicity towards human colon cancer cells, inducing apoptosis through the disruption of microtubule assembly and arrest in the S phase of the cell cycle. Additionally, GO does not cause significant harm to the control human embryonic kidney epithelial cells (HEK293), suggesting its potential use in cancer therapeutics and nanomedicine.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Irina M. Yermak, Anna O. Kravchenko, Eleonora Khasina, Ekaterina S. Menchinskaya, Evgeny A. Pislyagin, Ekaterina Sokolova, Galina N. Likhatskaya, Dmitry L. Aminin
Summary: The study demonstrates that the CRG/Ech complex has anti-inflammatory effects by reducing the production of ROS and NO, and can prevent endotoxin-induced damage and lower the levels of proinflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Tuuli E. I. Salo, Sari Niinisto, Tuuli E. Korhonen, Helena Pastell, Heli Reinivuo, Hanna-Mari Takkinen, Jorma Ilonen, Jorma Toppari, Mikael Knip, Riitta Veijola, Suvi M. Virtanen
Summary: This study investigated the intake and sources of dietary fibre among Finnish children using new CODEX-compliant values. The intake of fibre was associated with age, sex, and breastfeeding status. Cereal products, fruits, and vegetables were identified as major sources of dietary fibre.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Carla Guzman-Pincheira, Jonathan Espinoza, Samuel Duran-Aguero, Ana Maria Obregon, Fabiola Fuentealba
Summary: The objective of this study is to provide updated data on the intake of total dietary fibre in Chile and identify the main food sources. The results show that 90% of the population do not meet the recommended intake and bread is the major contributor. These data are crucial for developing strategies to improve diet quality.
Article
Food Science & Technology
Ke Qi Lau, Mohd Redzwan Sabran, Siti Raihanah Shafie, Sook Wah Chan
Summary: This study incorporated sugarcane bagasse into noodles at different ratios and found that 5% incorporation resulted in the closest value to commercial noodles in terms of fiber content and dialyzable glucose concentration, while also maintaining high overall acceptability.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Poushali Das, Sayan Ganguly, Syed Rahin Ahmed, Masoomeh Sherazee, Shlomo Margel, Aharon Gedanken, Seshasai Srinivasan, Amin Reza Rajabzadeh
Summary: Flexible polymeric thin films, reinforced with heteroatom-doped carbon dots (CDs), have been fabricated with antioxidant and UV-resistant properties. The CDs showed stability in aqueous media and exhibited sustained release behavior in different food simulants. The films also demonstrated excellent water vapor impermeability and toughness.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Poushali Das, Sayan Ganguly, Syed Rahin Ahmed, Masoomeh Sherazee, Shlomo Margel, Aharon Gedanken, Seshasai Srinivasan, Amin Reza Rajabzadeh
Summary: Flexible, antioxidant, and UV-resistant polymeric thin films reinforced with heteroatom-doped carbon dots have been fabricated using a simple physical compounding strategy. These films, along with CD-reinforced thermoplastic starch/kappa-carrageenan hybrid films, exhibit strong antioxidant activity for improving the shelf-life of agro-products.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Nutrition & Dietetics
Sarah J. Eustis, Gabrielle Turner-McGrievy, Swann A. Adams, James R. Hebert
Summary: Measuring and leveraging food motives and values are essential in improving dietary outcomes, as they can help create personalized approaches, inform intervention content, elucidate differences in data analysis, and tailor public health nutrition messages. Each measure has strengths and shortcomings to consider for informing nutritional recommendations at different levels.
Article
Biochemistry & Molecular Biology
Xuewei Xia, Qianmin Lin, Ning Zhao, Jinzi Zeng, Jiajia Yang, Zhiyuan Liu, Riming Huang
Summary: Dietary phytochemicals, such as soyasaponins, have been found to play a significant role in the prevention and treatment of colon cancer. In this study, the researchers screened the anti-colon cancer activity of a specific type of soyasaponin, soyasaponins I (SsI), and found that it had an inhibitory effect on the proliferation of colon cancer cell lines HCT116 and LoVo. Further analysis revealed that SsI may exert its effects through influencing amino acid metabolism and the estrogen signaling pathway. This study suggests the potential application of SsI in the treatment of colon cancer.
Review
Biochemistry & Molecular Biology
Gaetana Napolitano, Gianluca Fasciolo, Paola Venditti
Summary: Mitochondria in aerobic eukaryotic cells not only produce energy but also harmful substances such as ROS, and possess an efficient antioxidant system to detoxify these substances. As ROS production increases, mitochondria are damaged and release more harmful substances, but their antioxidant system can detoxify exogenous ROS at the expense of reducing the equivalents generated in mitochondria.
Article
Chemistry, Medicinal
Milena Alvarez-Vinas, Sandra Rivas, Maria Dolores Torres, Herminia Dominguez
Summary: The development of greener processes for the sustainable utilization of raw materials is increasingly demanded for environmental and economic reasons. A rapid and chemical-free technique for the extraction of hybrid kappa/iota (6/4) carrageenan from Sarcopeltis (ex Gigartina) skottsbergii was proposed. The extracted carrageenans showed suitable rheological properties for commercial uses, and the microwave-assisted hydrothermal treatment was found to be an efficient tool for carrageenan extraction without the need for chemicals.
Article
Food Science & Technology
Danielle Renzi, Takara Stanley, Jessica Waxler, Hang Lee, Barbara Pober, Marianne Nordstrom
Summary: This study investigated the relationship between predicted dietary intake and body weight differences in adults with Williams syndrome. The study found that deviations in dietary intake and behaviors related to food were associated with increased body mass index (BMI) and weight gain.
FOOD & NUTRITION RESEARCH
(2023)
Article
Nutrition & Dietetics
Lorene Akissoe, Youna M. Hemery, Yann E. Madode, Christele Icard-Verniere, Isabelle Rochette, Christian Picq, Djidjoho J. Hounhouigan, Claire Mouquet-Rivier
Summary: Regular consumption of cowpea-based dishes in Southern Benin contributes significantly to the recommended nutrient intake (RNI), providing a substantial amount of energy, fiber, magnesium, folate, protein, zinc, and potassium. With a high prevalence of cowpea consumption in both urban and rural areas, maintaining this dietary habit is crucial for environmental and health benefits.
Article
Chemistry, Physical
Punuri Jayasekhar Babu, Mukesh Doble, Ashok M. Raichur
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Engineering, Industrial
T. Hanas, T. S. Sampath Kumar, Govindaraj Perumar, Mukesh Doble, Seeram Rarnakrishna
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
(2018)
Article
Education & Educational Research
Alanna Higgins Joyce, Maya Raman, Jennifer L. Beaumont, Heather Heiman, Mark Adler, Suzanne M. Schmidt
BMC MEDICAL EDUCATION
(2019)
Article
Materials Science, Multidisciplinary
A. Sandeep Kranthi Kiran, Merum Sireesha, Raghavendra Ramalingam, Atish Kizhakeyil, Navin Kumar Verma, Rajamani Lakshminarayanan, T. S. Sampath Kumar, Mukesh Doble, Seeram Ramakrishna
JOURNAL OF MATERIALS SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Kartik Mitra, Prasanth Ghanta, Sushank Acharya, Gayathri Chakrapani, Basavaraju Ramaiah, Mukesh Doble
Summary: The study presents a pharmacophore and molecular dynamics-based approach for drug repositioning and lead identification against SARS-CoV-2 dual targets. Six FDA-approved drugs and twelve natural products were identified through pharmacophore-based virtual screening. Molecular dynamics analysis revealed the importance of flexibility of the 3CLp connecting loop and the correlation between van der Waals size and binding affinity with 3CLp, as well as the negative correlation between total polar surface area and binding affinity with PLp.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Prasanth Ghanta, Shweta Sinha, Mukesh Doble, Basavaraju Ramaiah
Summary: Inflammation plays a crucial role in respiratory diseases. The alkaloids vasicine, vasicinone, and deoxyvasicine from Adhatoda vasica have bronchodilatory activity. The study found that vasicinone has potential as a competitive inhibitor, while vasicine and deoxyvasicine may act as allosteric inhibitors. These alkaloids could be potential leads for designing novel 5-LOX inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Prasanth Ghanta, Mukesh Doble, Basavaraju Ramaiah
Summary: The study evaluated the potential of major alkaloids of A. vasica as inhibitors of COXs, with promising results showing that these alkaloids could be leads for the design of Eicosanoid pathway modulators.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Gandarvakottai Senthilkumar Arumugam, Asmita Sen, Swati S. Dash, Kartik Mitra, Mukesh Doble, Gopalan Rajaraman, Sathyanarayana N. Gummadi
Summary: The ethanolic bark extract of Terminalia arjuna tree contains bio-active compound arjunetin, which exhibits inhibition of catalase activity and potential antiviral activity, particularly against SARS-CoV-2. Molecular docking and dynamics studies show that arjunetin has higher binding affinity than Remdesivir in targeting key proteins of the virus. These findings suggest that arjunetin could be a promising drug candidate against Covid-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Water Resources
Divakar Raj Dinakaran, Hemaiswarya Shanmugam, Indumathi M. Nambi, Mukesh Doble
Summary: This study used uidA and lacZ genes as distinctive biomarkers for rapid and efficient detection of contaminated water resources. A total of 39 water samples from the metropolitan city of Chennai, India were collected and analyzed. The results showed that the performance and amplification efficiency of uidA and lacZ were 99.6% and 103.4% respectively. The qPCR method had a sensitivity of 71.4% in selectively identifying E. coli.
WATER PRACTICE AND TECHNOLOGY
(2022)
Review
Food Science & Technology
Deepa John, S. Sureshkumar, Maya Raman
Summary: Consumers of rice face the risk of diabetes and related health complications, but dietary intervention and identifying rice varieties with low glycemic index can help in managing diabetes. The genetic basis of amylose content in rice varieties can be used to identify rice germplasms with low glycemic index and breed varieties with high grain yield and low glycemic index.
Article
Materials Science, Ceramics
Vimal Kumar Dewangan, T. S. Sampath Kumar, Mukesh Doble, Viju Daniel Varghese
Summary: A novel injectable macroporous apatite bone cement derived from eggshell was developed using gelatin and chitosan as a biopolymeric solution, along with disodium hydrogen phosphate and acetic acid. The cement exhibited good injectability, stability, and degradation properties, and showed potential for repairing low or non-load bearing defects in orthopaedic applications.
CERAMICS INTERNATIONAL
(2022)
Article
Food Science & Technology
V. Radhalakshmi, Maya Raman, Minnu Rose Joy
Summary: Plant-based bioactive components from betel leaves have potential as antioxidant and antimicrobial agents. In this study, the physio-chemical properties, as well as the antioxidant and antimicrobial properties of two cultivars of Piper betel, were investigated. The ethanolic extract of one cultivar showed promising effects on the storage stability of coconut oil. The results highlight the significance of betel leaf extracts in the food and pharmaceutical industry.
Review
Chemistry, Multidisciplinary
Kannan Damodharan, Gandarvakottai Senthilkumar Arumugam, Suresh Ganesan, Mukesh Doble, Sathiah Thennarasu
Summary: Researchers are working tirelessly to develop new vaccines for COVID-19, with over 250 candidates currently in progress, including various types like RNA, DNA, and inactivated virus vaccines. The vaccines work by stimulating immune effectors to target and neutralize pathogens, showcasing a global effort to combat the pandemic.
Article
Chemistry, Multidisciplinary
Swayamsiddha Kar, Gayathri Ramamoorthy, Shweta Sinha, Meera Ramanan, Jeevan Kumar Pola, Nageswara Rao Golakoti, Jagadeesh Babu Nanubolu, Suraj Kumar Sahoo, Rajesh Babu Dandamudi, Mukesh Doble
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Ayarivan Puratchikody, Appavoo Umamaheswari, Navabshan Irfan, Shweta Sinha, S. L. Manju, Meera Ramanan, Gayathri Ramamoorthy, Mukesh Doble
NEW JOURNAL OF CHEMISTRY
(2019)
